High burden and unmet patient needs in chronic kidney disease

References

• ZhangQLRothenbacherDPrevalence of chronic kidney disease in population-based studies: systematic reviewBMC Public Health2008811718405348
   PubMed Web of Science ®Google Scholar
• CollinsAJFigure 12.1CKD and the Public Health Agenda for Chronic Diseases2 Available from: http://www.worldkidneyday.org/page/prevalence-of-diseaseAccessed February 17, 2012
   Google Scholar
• CoreshJSelvinEStevensLAPrevalence of chronic kidney disease in the United StatesJAMA2007298172038204717986697
   PubMed Web of Science ®Google Scholar
• StevensLALiSWangCPrevalence of CKD and comorbid illness in elderly patients in the United States: results from the Kidney Early Evaluation Program (KEEP)Am J Kidney Dis2010553 Suppl 2S23S3320172445
   PubMed Web of Science ®Google Scholar
• US Renal Data System (USRDS)Costs of CKD2011 USRDS Annual Data Report Volume One: Atlas of Chronic Kidney Disease in the United StatesBethesda, MDNational Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases2011 Available from: http://www.usrds.org/2011/pdf/v1_ch06_11.pdfAccessed February 17, 2012
   Google Scholar
• Nephrology Pharmacy Associates, IncBailieGRJohnsonCAMasonNASt PeterWLChronic Kidney Disease 2006: A Guide to Select NKF-KDOQI Guidelines and RecommendationsNew York, NYNational Kidney Foundation Available from: http://www.kidney.org/professionals/kls/pdf/Pharmacist_CPG.pdfAccessed February 17, 2012
   Google Scholar
• Kidney Disease Outcomes Quality Initiative (KDOQI)KDOQI Clinical Practice Guidelines and Clinical Practice Recommendations for Diabetes and Chronic Kidney DiseaseAm J Kidney Dis2007492 Suppl 2S12S15417276798
   PubMed Web of Science ®Google Scholar
• LevinAHemmelgarnBCulletonBCanadian Society of NephrologyGuidelines for the management of chronic kidney diseaseCMAJ2008179111154116219015566
   PubMed Web of Science ®Google Scholar
• MacGregorMSTaalMWRenal Association Clinical Practice Guideline on detection, monitoring and management of patients with CKDNephron Clin Pract2011118Suppl 1c71c10021555905
   PubMedGoogle Scholar
• National Collaborating Centre for Chronic ConditionsChronic kidney disease: early identification and management of chronic kidney disease in adults in primary and secondary careClinical guideline no. 73 [updated Sep 2008; cited February 17, 2012]. Available from: http://www.guideline.gov/content.aspx?id=14330Accessed February 17, 2012
   Google Scholar
• National Institute for Health and Clinical ExcellenceEarly identification and management of chronic kidney disease in adults in primary and secondary careClinical guideline no. 73 [updated March 30, 2010; cited February 17, 2012]. Available from: http://guidance.nice.org.uk/CG73/Guidance/pdf/EnglishAccessed February 17, 2012
   Google Scholar
• National Kidney FoundationK/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratificationAm J Kidney Dis2002392 Suppl 1S1S26611904577
   PubMed Web of Science ®Google Scholar
• Scottish Intercollegiate Guidelines Network (SIGN)Diagnosis and management of chronic kidney disease: a national guideline [updated 2008; cited February 17, 2012]. Available from: http://www.sign.ac.uk/pdf/sign103.pdfAccessed February 17, 2012
   Google Scholar
• LeveyASAtkinsRCoreshJChronic kidney disease as a global public health problem: approaches and initiatives – a position statement from Kidney Disease Improving Global OutcomesKidney Int200772324725917568785
   PubMed Web of Science ®Google Scholar
• HallanSIOrthSRThe conundrum of chronic kidney disease classification and end-stage renal risk prediction in the elderly – what is the right approach?Nephron Clin Pract20101164c307c31620664285
   PubMedGoogle Scholar
• LeveyASde JongPECoreshJThe definition, classification, and prognosis of chronic kidney disease: a KDIGO Controversies Conference reportKidney Int2011801172821150873
   PubMed Web of Science ®Google Scholar
• Kidney Disease Improving Global Outcomes (KDIGO)Guideline scopeKDIGO guideline for CKD classification and management [web page on the Internet] Available from: http://www.kdigo.org/clinical_practice_guidelines/CKD.phpAccessed February 17, 2012
   Google Scholar
• KronenbergFEmerging risk factors and markers of chronic kidney disease progressionNat Rev Nephrol200951267768919935815
   PubMed Web of Science ®Google Scholar
• KeithDSNicholsGAGullionCMBrownJBSmithDHLongitudinal follow-up and outcomes among a population with chronic kidney disease in a large managed care organizationArch Intern Med2004164665966315037495
   PubMed Web of Science ®Google Scholar
• BaumeisterSEBögerCAKrämerBKEffect of chronic kidney disease and comorbid conditions on health care costs: A 10-year observational study in a general populationAm J Nephrol201031322222920068286
   PubMed Web of Science ®Google Scholar
• KubackiMCarterCHerreraADWangJLopezJMPiechCTHealth plan retention and pharmacy costs of newly diagnosed patients with chronic kidney disease in a managed care populationAmerican Health and Drug Benefits200927283290
   Google Scholar
• LalibertéFBookhartBKVekemanFDirect all-cause health care costs associated with chronic kidney disease in patients with diabetes and hypertension: a managed care perspectiveJ Manag Care Pharm200915431232219422271
   PubMed Web of Science ®Google Scholar
• LondonRSolisAGoldbergGAWadeSChanWWExamination of resource use and clinical interventions associated with chronic kidney disease in a managed care populationJ Manag Care Pharm20039324825514613468
   PubMedGoogle Scholar
• NissensonARCollinsAJHurleyJPetersenHPereiraBJSteinbergEPOpportunities for improving the care of patients with chronic renal insufficiency: current practice patternsJ Am Soc Nephrol20011281713172011461944
   PubMed Web of Science ®Google Scholar
• RobbinsJDKimJJZdonGChanWWJonesJResource use and patient care associated with chronic kidney disease in a managed care settingJ Manag Care Pharm20039323824714613467
   PubMedGoogle Scholar
• ErshlerWBChenKReyesEBDuboisREconomic burden of patients with anemia in selected diseasesValue Health20058662963816283863
   PubMed Web of Science ®Google Scholar
• KhanSAmediaCAJrEconomic burden of chronic kidney diseaseJ Eval Clin Pract200814342243418373575
   PubMed Web of Science ®Google Scholar
• LefebvrePDuhMSButeauSBookhartBModySHMedical costs of untreated anemia in elderly patients with predialysis chronic kidney diseaseJ Am Soc Nephrol200617123497350217082245
   PubMed Web of Science ®Google Scholar
• MoyneurEBookhartBKModySHFournierAAMallettDDuhMSThe economic impact of pre-dialysis epoetin alpha on health care and work loss costs in chronic kidney disease: an employer’s perspectiveDis Manag2008111495818279115
   PubMedGoogle Scholar
• van NootenFEGreenJBrownRFinkelsteinFOWishJBurden of illness for patients with non-dialysis chronic kidney disease and anemia in the United States: review of the literatureJ Med Econ201013224125620438399
   PubMedGoogle Scholar
• WishJSchulmanKLawANassarGHealthcare expenditure and resource utilization in patients with anaemia and chronic kidney disease: a retrospective claims database analysisKidney Blood Press Res200932211011819372704
   PubMed Web of Science ®Google Scholar
• KhanSSKazmiWHAbichandaniRTighiouartHPereiraBJKauszATHealth care utilization among patients with chronic kidney diseaseKidney Int200262122923612081582
   PubMed Web of Science ®Google Scholar
• MeyerABunzemeierHHausbergMImpact of different stages of chronic kidney disease on in-hospital costs in patients with coronary heart diseaseNephrol Dial Transplant20082361955196018083761
   PubMed Web of Science ®Google Scholar
• SchumockGTAndressDLMarxSESterzRJoyceATKalantar-ZadehKAssociation of secondary hyperparathyroidism with CKD progression, health care costs and survival in diabetic predialysis CKD patientsNephron Clin Pract20091131c54c6119590235
   PubMedGoogle Scholar
• ThorpMLEastmanLSmithDHJohnsonESManaging the burden of chronic kidney diseaseDis Manag20069211512116620197
   PubMedGoogle Scholar
• SmithDHGullionCMNicholsGKeithDSBrownJBCost of medical care for chronic kidney disease and comorbidity among enrollees in a large HMO populationJ Am Soc Nephrol20041551300130615100370
   PubMed Web of Science ®Google Scholar
• TaylorTNSalinitriFDSatterhwaiteDWMedical care spending associated with chronic kidney disease by stage of disease [abstract PUK9]Value Health2011143A75
   Web of Science ®Google Scholar
• BrennerBMGoldszerRCHostetterTHGlomerular response to renal injuryContrib Nephrol19823348666749423
   PubMed Web of Science ®Google Scholar
• HostetterTHOlsonJLRennkeHGVenkatachalamMABrennerBMHyperfiltration in remnant nephrons: a potentially adverse response to renal ablationAm J Physiol19812411F85F937246778
   PubMed Web of Science ®Google Scholar
• BarbourSJErLDjurdjevOKarimMLevinADifferences in progression of CKD and mortality amongst Caucasian, Oriental Asian and South Asian CKD patientsNephrol Dial Transplant201025113663367220368302
   PubMed Web of Science ®Google Scholar
• DjamaliAKendziorskiCBrazyPCBeckerBNDisease progression and outcomes in chronic kidney disease and renal transplantationKidney Int20036451800180714531814
   PubMed Web of Science ®Google Scholar
• KuklaAAdullaMPascualJCKD stage-to-stage progression in native and transplant kidney diseaseNephrol Dial Transplant200823269370017881429
   PubMed Web of Science ®Google Scholar
• OrlandoLABelascoEJPatelUDMatcharDBThe chronic kidney disease model: a general purpose model of disease progression and treatmentBMC Med Inform Decis Mak2011114121679455
   PubMed Web of Science ®Google Scholar
• TangriNStevensLAGriffithJA predictive model for progression of chronic kidney disease to kidney failureJAMA2011305151553155921482743
   PubMed Web of Science ®Google Scholar
• TrivediHSPangMMCampbellASaabPSlowing the progression of chronic renal failure: economic benefits and patients’ perspectivesAm J Kidney Dis200239472172911920337
   PubMed Web of Science ®Google Scholar
• FeldmanHIAppelLJChertowGMChronic Renal Insufficiency Cohort (CRIC) Study InvestigatorsThe Chronic Renal Insufficiency Cohort (CRIC) Study: Design and MethodsJ Am Soc Nephrol2003147 Suppl 2S148S15312819321
   PubMed Web of Science ®Google Scholar
• ChinHJSongYRLeeJJModerately decreased renal function negatively affects the health-related quality of life among the elderly Korean population: a population-based studyNephrol Dial Transplant20082392810281718372390
   PubMed Web of Science ®Google Scholar
• GorodetskayaIZeniosSMcCullochCEHealth-related quality of life and estimates of utility in chronic kidney diseaseKidney Int20056862801280816316356
   PubMed Web of Science ®Google Scholar
• KrishnanAVKiernanMCNeurological complications of chronic kidney diseaseNat Rev Neurol200951054255119724248
   PubMed Web of Science ®Google Scholar
• MolstedSPrescottLHeafJEidemakIAssessment and clinical aspects of health-related quality of life in dialysis patients and patients with chronic kidney diseaseNephron Clin Pract20071061c24c3317409766
   PubMedGoogle Scholar
• MujaisSKStoryKBrouilletteJHealth-related quality of life in CKD Patients: correlates and evolution over timeClin J Am Soc Nephrol2009481293130119643926
   PubMed Web of Science ®Google Scholar
• NulsenRSYaqoobMMMahonAStoby-FieldsMKellyMVaragunamMPrevalence of cognitive impairment in patients attending pre-dialysis clinicJ Ren Care200834312112618786078
   PubMedGoogle Scholar
• PorterAFischerMJBrooksDQuality of life and psychosocial factors in African Americans with hypertensive chronic kidney diseaseTransl Res2012159141122153804
   PubMed Web of Science ®Google Scholar
• RichardsonMMSaris-BaglamaRNAnatchkovaMDPatient experience of chronic kidney disease (CKD): results of a focus group study [abstract 175]Am J Kidney Dis2007494B68
   Web of Science ®Google Scholar
• AlexanderMBradburyBDKewalramaniRBarlevAMohantySAGlobeDChronic kidney disease and US healthcare resource utilization in a nationally representative sampleAm J Nephrol200929547348219039210
   PubMed Web of Science ®Google Scholar
• MixTCSt PeterWLEbbenJHospitalization during advancing chronic kidney diseaseAm J Kidney Dis200342597298114582041
   PubMed Web of Science ®Google Scholar
• St PeterWLKhanSSEbbenJPPereiraBJCollinsAJChronic kidney disease: the distribution of health care dollarsKidney Int200466131332115200439
   PubMed Web of Science ®Google Scholar
• VekemanFYameogoNDLefebvrePBaileyRAMcKenzieRSPiechCTHealthcare costs associated with nephrology care in pre-dialysis chronic kidney disease patientsJ Med Econ201013467368021050062
   PubMedGoogle Scholar
• SchneiderKMO’DonnellBEDeanDPrevalence of multiple chronic conditions in the United States’ Medicare populationHealth Qual Life Outcomes200978219737412
   PubMed Web of Science ®Google Scholar
• AmediaCAJrManaging chronic kidney diseaseManag Care2003 Spec No812 discussion 17–2012751138
   PubMedGoogle Scholar
• USRDSCosts of chronic kidney disease2010 Annual Data Report Volume One: Atlas of Chronic Kidney Disease in the United States [cited February 17, 2012]Bethesda, MDNational Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases2010 Available from: http://www.usrds.org/2010/pdf/V1_09.pdfAccessed February 17, 2012
   Google Scholar
• SullivanSEmployer challenges with the chronic kidney disease populationJ Manag Care Pharm2007139 Suppl DS19S2118177215
   PubMed Web of Science ®Google Scholar
• PapatheofanisFBookhartBKMuserEPiechCTAn examination of productivity and resource utilization associated with epoetin alfa treatment in employees with predialysis chronic kidney diseaseJ Occup Environ Med200850558458918469628
   PubMed Web of Science ®Google Scholar
• HarshmanRNaimACarterJRichersonGNairKVEarly detection, screening, and management of chronic kidney disease among actively employed – an integrated population health management approach [abstract PUK20]Value Health2011143A78
   Web of Science ®Google Scholar
• De CosmoSLamacchiaORauseoACigarette smoking is associated with low glomerular filtration rate in male patients with type 2 diabetesDiabetes Care200629112467247017065686
   PubMed Web of Science ®Google Scholar
• KramerHTuttleKRLeeheyDObesity management in adults with CKDAm J Kidney Dis200953115116519101399
   PubMed Web of Science ®Google Scholar
• MafraDGuebre-EgziabherFFouqueDBody mass index, muscle and fat in chronic kidney disease: questions about survivalNephrol Dial Transplant20082382461246618390566
   PubMed Web of Science ®Google Scholar
• NavaneethanSDYehnertHMoustarahFSchreiberMJSchauerPRBeddhuSWeight loss interventions in chronic kidney disease: a systematic review and meta-analysisClin J Am Soc Nephrol20094101565157419808241
   PubMed Web of Science ®Google Scholar
• PoortmansJROuchinskyMGlomerular filtration rate and albumin excretion after maximal exercise in aging sedentary and active menJ Gerontol A Biol Sci Med Sci200661111181118517167160
   PubMed Web of Science ®Google Scholar
• TuttleKRSunwoldDKramerHCan comprehensive lifestyle change alter the course of chronic kidney disease?Semin Nephrol200929551252319751897
   PubMed Web of Science ®Google Scholar
• CabnessJMillerCFlowersKPromoting resilience in ESRD: evaluation of a group cognitive-behavioral intervention for patients on hemodialysisJ Nephrol Social Work2006253036
   Google Scholar
• HothKFChristensenAJEhlersSLRaichleKALawtonWJA longitudinal examination of social support, agreeableness and depressive symptoms in chronic kidney diseaseJ Behav Med2007301697617219057
   PubMed Web of Science ®Google Scholar
• Kidney Disease Outcomes Quality Initiative (K/DOQI) GroupK/DOQI clinical practice guidelines for management of dyslipidemias in patients with kidney diseaseAm J Kidney Dis200341:4Suppl 3IIVS191
   Google Scholar
• BrennerBMCooperMEde ZeeuwDRENAAL Study InvestigatorsEffects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathyN Engl J Med20013451286186911565518
   PubMed Web of Science ®Google Scholar
• Randomised placebo-controlled trial of effect of ramipril on decline in glomerular filtration rate and risk of terminal renal failure in proteinuric, non-diabetic nephropathyThe GISEN Group (Gruppo Italiano di Studi Epidemiologici in Nefrologia)Lancet19973499069185718639217756
   PubMed Web of Science ®Google Scholar
• LewisEJHunsickerLGBainRPRohdeRDThe effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. The Collaborative Study GroupN Engl J Med19933292014561462 Erratum in: N Engl J Med. 1993;330(2):1528413456
   PubMed Web of Science ®Google Scholar
• LewisEJHunsickerLGClarkeWRCollaborative Study GroupRenoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetesN Engl J Med20013451285186011565517
   PubMed Web of Science ®Google Scholar
• MaschioGAlbertiDJaninGEffect of the angiotensin-converting-enzyme inhibitor benazepril on the progression of chronic renal insufficiency. The Angiotensin-Converting-Enzyme Inhibition in Progressive Renal Insufficiency Study GroupN Engl J Med1996334159399458596594
   PubMed Web of Science ®Google Scholar
• RuggenentiPPernaAGherardiGRenoprotective properties of ACE-inhibition in non-diabetic nephropathies with non-nephrotic proteinuriaLancet1999354917635936410437863
   PubMed Web of Science ®Google Scholar
• ParvingHHAndersenARSmidtUMSvendsenPAEarly aggressive antihypertensive treatment reduces rate of decline in kidney function in diabetic nephropathyLancet198318335117511796133986
   PubMed Web of Science ®Google Scholar
• JafarTHStarkPCSchmidCHAIPRD Study GroupAngiotensin-converting enzyme inhibition and progression of renal disease. Proteinuria as a modifiable risk factor for the progression of non-diabetic renal diseaseKidney Int20016031131114011532109
   PubMed Web of Science ®Google Scholar
• AppelLJWrightJTJrGreeneTAfrican American Study of Kidney Disease and Hypertension Collaborative Research GroupLong-term effects of renin-angiotensin system-blocking therapy and a low blood pressure goal on progression of hypertensive chronic kidney disease in African AmericansArch Intern Med2008168883283918443258
   PubMedGoogle Scholar
• BaigentCLandrayMJReithCSHARP InvestigatorsThe effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomised placebo-controlled trialLancet201137797842181219221663949
   PubMed Web of Science ®Google Scholar
• The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitusThe Diabetes Control and Complications Trial Research GroupN Engl J Med1993329149779868366922
   PubMed Web of Science ®Google Scholar
• Writing Team for the Diabetes Control and Complications Trial/ Epidemiology of Diabetes Interventions and Complications Research GroupSustained effect of intensive treatment of type 1 diabetes mellitus on development and progression of diabetic nephropathy: the Epidemiology of Diabetes Interventions and Complications (EDIC) studyJAMA2003290162159216714570951
   PubMed Web of Science ®Google Scholar
• JenkinsAJLyonsTJZhengDDCCT/EDIC Research GroupLipoproteins in the DCCT/EDIC cohort: associations with diabetic nephropathyKidney Int200364381782812911531
   PubMed Web of Science ®Google Scholar
• LevinSRCoburnJWAbrairaCEffect of intensive glycemic control on microalbuminuria in type 2 diabetes. Veterans Affairs Cooperative Study on Glycemic Control and Complications in Type 2 Diabetes Feasibility Trial InvestigatorsDiabetes Care200023101478148511023140
   PubMed Web of Science ®Google Scholar
• HirschSAn update on proteinuric chronic kidney disease: the dual-goal approachCleve Clin J Med2008751070571318939386
   PubMed Web of Science ®Google Scholar
• VilayurEHarrisDCEmerging therapies for chronic kidney disease: what is their role?Nat Rev Nephrol20095737538319455178
   PubMed Web of Science ®Google Scholar
• AbbottPositive results from phase 2 study of atrasentan for treatment of diabetic kidney disease published in the Journal of the American Society of Nephrology [press release]Abbott Park, ILAbbott2011 [Mar 4]. Available from: http://www.abbott.com/news-media/press-releases/2011Mar04.htmAccessed February 17, 2012
   Google Scholar
• Reata PharmaceuticalsBardoxolone methyl [web page on the Internet]Irving, TXReata Pharmaceuticalsnd Available from: http://www.reatapharma.com/pip_rta402.aspAccessed February 17, 2012
   Google Scholar
• Mitsubishi Tanabe Pharma CorporationA study of AST-120 for evaluating prevention of progression in chronic kidney disease (EPPIC-1)ClinicalTrialsgov [website on the Internet]Bethseda, MDUS National Library of Medicine2007 [updated October 1, 2012]. Available from: http://clinicaltrials.gov/ct2/show/NCT00500682?term=ast-120&rank=7. NLM identifier: NCT00500682Accessed October 1, 2012
   Google Scholar
• AbbottA prospective, double-blind, placebo-controlled, multicenter study to evaluate efficacy and safety of atrasentan, including thoracic bioimpedance, in type 2 diabetic subjects with nephropathyClinicalTrials.gov [website on the Internet]Bethseda, MDUS National Library of Medicine2011 [updated August 11, 2012]. Available from: http://clinicaltrials.gov/ct2/show/NCT01399580?term=atrasentan+and+kidney+disease&rank=3. NLM identifier: NCT01399580Accessed October 1, 2012
   Google Scholar
• KurehaBusiness Report 2010TokyoKureha2010 Available from: http://www.kureha.co.jp/en/ir/pdf/br2010.pdfAccessed February 17, 2012
   Google Scholar
• Mitsubishi Tanabe Pharma CorporationA study of AST-120 for evaluating prevention of progression in chronic kidney disease including assessment of quality of life (EPPIC-2)ClinicalTrials.gov [website on the Internet]Bethseda, MDUS National Library of Medicine2007 [updated October 1, 2012]. Available from: http://clinicaltrials.gov/ct2/show/NCT00501046?term=AST-120&rank=8. NLM identifier: NCT00501046Accessed October 1, 2012
   Google Scholar
• Concert PharmaceuticalsCTP-499 – first-in-class treatment candidate for diabetic nephropathyTechnology [web page on the Internet]Lexington, MAConcert Pharmaceuticalsnd Available from: http://www.concertpharma.com/research/index.html#CTP499Accessed February 17, 2012
   Google Scholar
• Vitae PharmaceuticalsVTP-27999 programDirect inhibition of renin offers potentially better renal protection than current therapies for the 27 million people worldwide with chronic kidney disease (CKD) [web page on the Internet]Fort Washington, PAVitae Pharmaceuticalsnd Available from: http://www.vitaepharma.com/view.cfm/56/Chronic-Kidney-Disease-ReninAccessed February 17, 2012
   Google Scholar
• NovartisNovartis announces termination of ALTITUDE study with Rasilez^®/Tekturna^® in high-risk patients with diabetes and renal impairment [media release]BaselNovartis2011 [Dec 20]. Available from: http://www.novartis.com/newsroom/media-releases/en/2011/1572562.shtmlAccessed February 17, 2012
   Google Scholar
• TaalMWBrennerBMPredicting initiation and progression of chronic kidney disease: Developing renal risk scoresKidney Int200670101694170516969387
   PubMed Web of Science ®Google Scholar
• LeveyASEckardtKUTsukamotoYDefinition and classification of chronic kidney disease: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO)Kidney Int20056762089210015882252
   PubMed Web of Science ®Google Scholar