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Original Research

Effect of ultramicronized-palmitoylethanolamide and co-micronized palmitoylethanolamide/polydatin on chronic pelvic pain and quality of life in endometriosis patients: An open-label pilot study

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Pages 443-449 | Published online: 12 Aug 2019

References

  • Angioni S. New insights on endometriosis. Minerva Ginecol. 2017;69(5):438–439.28545294
  • Pontis A, Arena I, Angioni S. Umbilical endometriosis primary site without pelvic endometriosis and previous surgery: a case report. G Ital Ostet E Ginecol. 2014;36(2):336–338.
  • Angioni S, Cela V, Sedda F, et al. Focusing on surgery results in infertile patients with deep endometriosis. Gynecol Endocrinol Off J Int Soc Gynecol Endocrinol. 2015;31(8):595–598. doi:10.3109/09513590.2015.1062868
  • Locci R, Nisolle M, Angioni S, Foidart J-M, Munaut C. Expression of the gamma 2 chain of laminin-332 in eutopic and ectopic endometrium of patients with endometriosis. Reprod Biol Endocrinol. 2013;11:94. doi:10.1186/1477-7827-11-9424070183
  • Bourdel N, Alves J, Pickering G, Ramilo I, Roman H, Canis M. Systematic review of endometriosis pain assessment: how to choose a scale? Hum Reprod Update. 2015;21(1):136–152. doi:10.1093/humupd/dmu04625180023
  • Melis I, Agus M, Pluchino N, et al. Alexithymia in women with deep endometriosis? A pilot study. J Endometr Pelvic Pain Disord. 2014;6(1):26–33.
  • Melis I, Litta P, Nappi L, Agus M, Melis GB, Angioni S. Sexual function in women with deep endometriosis: correlation with quality of life, intensity of pain, depression, anxiety, and body image. Int J Sex Health. 2015;27(2). doi:10.1080/19317611.2014.952394
  • Angioni S, Cofelice V, Sedda F, et al. Progestins for symptomatic endometriosis: results of clinical studies. Curr Drug Ther. 2015;10:2. doi:10.2174/157488551002151222160051
  • Mereu L, Florio P, Carri G, Pontis A, Petraglia F, Mencaglia L. Clinical outcomes associated with surgical treatment of endometrioma coupled with resection of the posterior broad ligament. Int J Gynaecol Obstet Off Organ Int Fed Gynaecol Obstet. 2012;116(1):57–60. doi:10.1016/j.ijgo.2011.08.017
  • Angioni S, Peiretti M, Zirone M, et al. Laparoscopic excision of posterior vaginal fornix in the treatment of patients with deep endometriosis without rectum involvement: surgical treatment and long-term follow-up. Hum Reprod Oxf Engl. 2006;21(6):1629–1634. doi:10.1093/humrep/del006
  • Angioni S, Pontis A, Cela V, Sedda F, Genazzani AD, Nappi L. Surgical technique of endometrioma excision impacts on the ovarian reserve. Single-port access laparoscopy versus multiport access laparoscopy: a case control study. Gynecol Endocrinol Off J Int Soc Gynecol Endocrinol. 2015;31(6):454–457. doi:10.3109/09513590.2015.1017812
  • Angioni S, Nappi L, Pontis A, et al. Dienogest. A possible conservative approach in bladder endometriosis. Results of a pilot study. Gynecol Endocrinol Off J Int Soc Gynecol Endocrinol. 2015;31(5):406–408. doi:10.3109/09513590.2015.1006617
  • Alessandro P, Luigi N, Felice S, Maria PA, Benedetto MG, Stefano A. Research development of a new GnRH antagonist (Elagolix) for the treatment of endometriosis: a review of the literature. Arch Gynecol Obstet. 2017;295(4):827–832. doi:10.1007/s00404-017-4328-628255765
  • Uchiide I, Ihara T, Sugamata M. Pathological evaluation of the rat endometriosis model. Fertil Steril. 2002;78(4):782–786. doi:10.1016/S0015-0282(02)03327-712372457
  • Kirchhoff D, Kaulfuss S, Fuhrmann U, Maurer M, Zollner TM. Mast cells in endometriosis: guilty or innocent bystanders? Expert Opin Ther Targets. 2012;16(3):237–241. doi:10.1517/14728222.2012.66141522332753
  • Kempuraj D, Papadopoulou N, Stanford EJ, et al. Increased numbers of activated mast cells in endometriosis lesions positive for corticotropin-releasing hormone and urocortin. Am J Reprod Immunol N Y N 1989. 2004;52(4):267–275.
  • Anaf V, Chapron C, El Nakadi I, De Moor V, Simonart T, Noël J-C. Pain, mast cells, and nerves in peritoneal, ovarian, and deep infiltrating endometriosis. Fertil Steril. 2006;86(5):1336–1343. doi:10.1016/j.fertnstert.2006.03.05717007852
  • Tsuda M, Masuda T, Tozaki-Saitoh H, Inoue K. Microglial regulation of neuropathic pain. J Pharmacol Sci. 2013;121(2):89–94. doi:10.1254/jphs.12R14CP23337437
  • Skaper SD, Facci L. Mast cell-glia axis in neuroinflammation and therapeutic potential of the anandamide congener palmitoylethanolamide. Philos Trans R Soc Lond B Biol Sci. 2012;367(1607):3312–3325. doi:10.1098/rstb.2011.039123108549
  • Oral E, Olive DL, Arici A. The peritoneal environment in endometriosis. Hum Reprod Update. 1996;2(5):385–398. doi:10.1093/humupd/2.5.38515717438
  • Graziottin A, Skaper SD, Fusco M. Mast cells in chronic inflammation, pelvic pain and depression in women. Gynecol Endocrinol Off J Int Soc Gynecol Endocrinol. 2014;30(7):472–477. doi:10.3109/09513590.2014.911280
  • Cerrato S, Brazis P, Della Valle MF, Miolo A, Puigdemont A. Effects of palmitoylethanolamide on immunologically induced histamine, PGD2 and TNFalpha release from canine skin mast cells. Vet Immunol Immunopathol. 2010;133(1):9–15. doi:10.1016/j.vetimm.2009.06.01119625089
  • Bettoni I, Comelli F, Colombo A, Bonfanti P, Costa B. Non-neuronal cell modulation relieves neuropathic pain: efficacy of the endogenous lipid palmitoylethanolamide. CNS Neurol Disord Drug Targets. 2013;12(1):34–44. doi:10.2174/187152731131201000823394519
  • Jackson LW, Schisterman EF, Dey-Rao R, Browne R, Armstrong D. Oxidative stress and endometriosis. Hum Reprod Oxf Engl. 2005;20(7):2014–2020. doi:10.1093/humrep/dei001
  • Bertelli AA, Ferrara F, Diana G, et al. Resveratrol, a natural stilbene in grapes and wine, enhances intraphagocytosis in human promonocytes: a co-factor in antiinflammatory and anticancer chemopreventive activity. Int J Tissue React. 1999;21(4):93–104.10761539
  • Indraccolo U, Barbieri F. Effect of palmitoylethanolamide-polydatin combination on chronic pelvic pain associated with endometriosis: preliminary observations. Eur J Obstet Gynecol Reprod Biol. 2010;150(1):76–79. doi:10.1016/j.ejogrb.2010.01.00820176435
  • Impellizzeri D, Bruschetta G, Cordaro M, et al. Micronized/ultramicronized palmitoylethanolamide displays superior oral efficacy compared to nonmicronized palmitoylethanolamide in a rat model of inflammatory pain. J Neuroinflammation. 2014;11(1):136. doi:10.1186/s12974-014-0139-x25164769
  • Petrosino S, Cordaro M, Verde R, et al. Oral ultramicronized palmitoylethanolamide: plasma and tissue levels and spinal anti-hyperalgesic effect. Front Pharmacol. 2018;9:249. doi:10.3389/fphar.2018.0024929615912
  • Iuvone T, Affaitati G, De Filippis D, et al. Ultramicronized palmitoylethanolamide reduces viscerovisceral hyperalgesia in a rat model of endometriosis plus ureteral calculosis: role of mast cells. Pain. 2016;157(1):80–91. doi:10.1097/j.pain.000000000000047325974242
  • Di Paola R, Fusco R, Gugliandolo E, et al. Co-micronized palmitoylethanolamide/polydatin treatment causes endometriotic lesion regression in a rodent model of surgically induced endometriosis. Front Pharmacol. 2016;7:382. doi:10.3389/fphar.2016.0032327790149
  • Giugliano E, Cagnazzo E, Soave I, Lo Monte G, Wenger JM, Marci R. The adjuvant use of N-palmitoylethanolamine and transpolydatin in the treatment of endometriotic pain. Eur J Obstet Gynecol Reprod Biol. 2013;168(2):209–213. doi:10.1016/j.ejogrb.2013.01.00923415738
  • Cobellis L, Castaldi MA, Giordano V, et al. Effectiveness of the association micronized N-Palmitoylethanolamine (PEA)-transpolydatin in the treatment of chronic pelvic pain related to endometriosis after laparoscopic assessment: a pilot study. Eur J Obstet Gynecol Reprod Biol. 2011;158(1):82–86. doi:10.1016/j.ejogrb.2011.04.01121601979
  • Di Francesco A, Pizzagallo D. Use of micronized palmitoylethanolamide and trans-polydatin in chronic pelvic pain associated with endometriosis. An open-label study. G Ital Ostet E Ginecol. 2014;XXXVI(2):353–358.
  • Dell’Anna A, De Marzi CA. Mast cells and microglia: new therapeutic targets for the treatment of endometriosis-associated symptomatology. Giorn It Ost Gin. 2017;2017;39(4): 193-201.
  • Price DD, McGrath PA, Rafii A, Buckingham B. The validation of visual analogue scales as ratio scale measures for chronic and experimental pain. Pain. 1983;17(1):45–56. doi:10.1016/0304-3959(83)90126-46226917
  • Apolone G, Mosconi P. The Italian SF-36 health survey: translation, validation and norming. J Clin Epidemiol. 1998;51(11):1025–1036. doi:10.1016/S0895-4356(98)00094-89817120
  • Hays RD, Sherbourne CD, Mazel RM. The RAND 36-item health survey 1.0. Health Econ. 1993;2(3):217–227. doi:10.1002/(ISSN)1099-10508275167
  • Derogatis LR, Cleary PA. Confirmation of the dimensional structure of the scl‐90: A study in construct validation. J Clin Psychol. 1977;33(4):981–989. doi:10.1002/(ISSN)1097-4679
  • Skaper SD, Facci L, Fusco M, et al. Palmitoylethanolamide, a naturally occurring disease-modifying agent in neuropathic pain. Inflammopharmacology. 2014;22(2):79–94. doi:10.1007/s10787-013-0191-724178954
  • Sommariva M, Schievano C, Saleh O. Micronized palmitoylethanolamide reduces bladder chronic pelvic pain due to different etiologies and improves bladder functions. Pelviperineology. 2017;36:92–96.
  • Petrosino S, Iuvone T, Di Marzo V. N-palmitoyl-ethanolamine: biochemistry and new therapeutic opportunities. Biochimie. 2010;92(6):724–727. doi:10.1016/j.biochi.2010.01.00620096327
  • Steiner J, Walter M, Gos T, et al. Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: evidence for an immune-modulated glutamatergic neurotransmission? J Neuroinflammation. 10 agosto, 2011;8:94. doi:10.1186/1742-2094-8-7221831269
  • Wium-Andersen MK, Ørsted DD, Nielsen SF, Nordestgaard BG. Elevated C-reactive protein levels, psychological distress, and depression in 73, 131 individuals. JAMA Psychiatry. 2013;70(2):176–184. doi:10.1001/2013.jamapsychiatry.10223266538
  • Nasyrova RF, Sotnikova LS, Baystrukova NV, et al. Psychoimmune interactions in women of reproductive age with endometriosis. Bull Exp Biol Med. 2011;152(1):93–97. doi:10.1007/s10517-011-1463-022803050
  • Nelissen S, Lemmens E, Geurts N, et al. The role of mast cells in neuroinflammation. Acta Neuropathol (Berl). 2013;125(5):637–650. doi:10.1007/s00401-013-1092-y23404369
  • Hendriksen E, van Bergeijk D, Oosting RS, Redegeld FA. Mast cells in neuroinflammation and brain disorders. Neurosci Biobehav Rev. 2017;79:119–133. doi:10.1016/j.neubiorev.2017.05.00128499503