Oral calcitonin

References

• DeftosLJLeeMRPottsJTJrA radioimmunoassay for thyrocalcitoninProc Natl Acad Sci U S A19686012932994173038
   PubMed Web of Science ®Google Scholar
• HiltonJMDowtonMHoussamiSSextonPMIdentification of key components in the irreversibility of salmon calcitonin binding to calcitonin receptorsJ Endocrinol2000166121322610856900
   PubMed Web of Science ®Google Scholar
• ChambersTJMooreAThe sensitivity of isolated osteoclasts to morphological transformation by calcitoninJ Clin Endocrinol Metab19835748198246193136
   PubMed Web of Science ®Google Scholar
• SuzukiHNakamuraITakahashiNCalcitonin-induced changes in the cytoskeleton are mediated by a signal pathway associated with protein kinase A in osteoclastsEndocrinology199613711468546908895334
   PubMed Web of Science ®Google Scholar
• HenriksenKBay-JensenACChristiansenCKarsdalMAOral salmon calcitonin – pharmacology in osteoporosisExpert Opin Biol Ther201010111617162920932224
   PubMed Web of Science ®Google Scholar
• ShyuJFShihCTsengCYCalcitonin induces podosome disassembly and detachment of osteoclasts by modulating Pyk2 and Src activitiesBone20074051329134217321230
   PubMed Web of Science ®Google Scholar
• SextonPMFindlayDMMartinTJCalcitoninCurr Med Chem19996111067109310519914
   PubMed Web of Science ®Google Scholar
• IkegameMEjiriSOzawaHCalcitonin-induced change in serum calcium levels and its relationship to osteoclast morphology and number of calcitonin receptorsBone2004351273315207738
   PubMed Web of Science ®Google Scholar
• ChesnutCH3rdMajumdarSNewittDCEffects of salmon calcitonin on trabecular microarchitecture as determined by magnetic resonance imaging: results from the QUEST studyJ Bone Miner Res20052091548156116059627
   PubMed Web of Science ®Google Scholar
• JiangYZhaoJGeusensPFemoral neck trabecular microstructure in ovariectomized ewes treated with calcitonin: MRI microscopic evaluationJ Bone Miner Res200520112513015619678
   PubMed Web of Science ®Google Scholar
• HenriksenKNeutzsky-WulffAVBonewaldLFKarsdalMALocal communication on and within bone controls bone remodelingBone20094461026103319345750
   PubMed Web of Science ®Google Scholar
• KarsdalMAHenriksenKArnoldMChristiansenCCalcitonin: a drug of the past or for the future? Physiologic inhibition of bone resorption while sustaining osteoclast numbers improves bone qualityBio Drugs2008223137144
   Google Scholar
• SeemanEDelmasPDBone quality – the material and structural basis of bone strength and fragilityN Engl J Med2006354212250226116723616
   PubMed Web of Science ®Google Scholar
• MartinTJSeemanENew mechanisms and targets in the treatment of bone fragilityClin Sci (Lond)20071122779117155930
   PubMed Web of Science ®Google Scholar
• GrauerAReinelHHZieglerRRaueFNeutralizing antibodies against calcitoninHorm Metab Res19932594864888225203
   PubMed Web of Science ®Google Scholar
• GrauerAZieglerRRaueFClinical significance of antibodies against calcitoninExp Clin Endocrinol Diabetes199510363453518788305
   PubMed Web of Science ®Google Scholar
• SamuraAWadaSSudaSIitakaMKatayamaSCalcitonin receptor regulation and responsiveness to calcitonin in human osteoclast-like cells prepared in vitro using receptor activator of nuclear factor-kappaB ligand and macrophage colony-stimulating factorEndocrinology2000141103774378211014233
   PubMed Web of Science ®Google Scholar
• TekeoğluIAdakBBudancamanakMDemirelAEdizLComparison of cyclic and continuous calcitonin regimens in the treatment of postmenopausal osteoporosisRheumatol Int200526215716115660234
   PubMed Web of Science ®Google Scholar
• KaskaniELyritisGPKosmidisCEffect of intermittent administration of 200 IU intranasal salmon calcitonin and low doses of 1alpha(OH) vitamin D3 on bone mineral density of the lumbar spine and hip region and biochemical bone markers in women with postmenopausal osteoporosis: a pilot studyClin Rheumatol200524323223815647969
   PubMed Web of Science ®Google Scholar
• UshiroyamaTIkedaASakaiMHigashiyamaTUekiMEffects of the combined use of calcitonin and 1 alpha-hydroxycholecalciferol on vertebral bone loss and bone turnover in women with postmenopausal osteopenia and osteoporosis: a prospective study of long-term and continuous administration with low dose calcitoninMaturitas200140322923811731184
   PubMed Web of Science ®Google Scholar
• PeichlPRintelenBKumpanWBröllHIncrease of axial and appendicular trabecular and cortical bone density in established osteoporosis with intermittent nasal salmon calcitonin therapyGynecol Endocrinol199913171410368793
   PubMed Web of Science ®Google Scholar
• ChesnutCH3rdSilvermanSAndrianoKA randomized trial of nasal spray salmon calcitonin in postmenopausal women with established osteoporosis: the prevent recurrence of osteoporotic fractures study. PROOF Study GroupAm J Med2000109426727610996576
   PubMed Web of Science ®Google Scholar
• ByrjalsenILeemingDJQvistPChristiansenCKarsdalMABone turnover and bone collagen maturation in osteoporosis: effects of antiresorptive therapiesOsteoporos Int200819333934817846859
   PubMed Web of Science ®Google Scholar
• KarsdalMAByrjalsenILeemingDJDelmasPDChristiansenCThe effects of oral calcitonin on bone collagen maturation: implications for bone turnover and qualityOsteoporos Int20081991355136118385918
   PubMed Web of Science ®Google Scholar
• MacLeanCNewberrySMaglioneMSystematic review: comparative effectiveness of treatments to prevent fractures in men and women with low bone density or osteoporosisAnn Intern Med2008148319721318087050
   PubMed Web of Science ®Google Scholar
• CranneyATugwellPZytarukNMeta-analyses of therapies for postmenopausal osteoporosis. VI. Meta-analysis of calcitonin for the treatment of postmenopausal osteoporosisEndocr Rev200223454055112202469
   PubMed Web of Science ®Google Scholar
• OvergaardKHansenMADirksenKLChristiansenCRectal salmon calcitonin for the treatment of postmenopausal osteoporosisCalcif Tissue Int19925131841881422962
   PubMed Web of Science ®Google Scholar
• Leone-BayAMcInnesCWangNMicrosphere formation in a series of derivatized alpha-amino acids: properties, molecular modeling, and oral delivery of salmon calcitoninJ Med Chem19953821425742627473552
   PubMed Web of Science ®Google Scholar
• MalkovDAngeloRWangHZFlandersETangHGomez-OrellanaIOral delivery of insulin with the eligen technology: mechanistic studiesCurr Drug Deliv20052219119716305420
   PubMedGoogle Scholar
• MustataGDinhSMApproaches to oral drug delivery for challenging moleculesCrit Rev Ther Drug Carrier Syst200623211113516952274
   PubMed Web of Science ®Google Scholar
• KarsdalMAHenriksenKBay-JensenACLessons learned from the development of oral calcitonin: the first tablet formulation of a protein in phase III clinical trialsJ Clin Pharmacol201151446047120660294
   PubMed Web of Science ®Google Scholar
• BinkleyNBologneseMSidorowicz-BialynickaAA phase 3 trial of the efficacy and safety of oral recombinant calcitonin: The ORACAL trialJ Bone Miner Res3212012 [Epub ahead of print.]
   Web of Science ®Google Scholar
• ChinCMGutierrezMStillJGKosuticGPharmacokinetics of modified oral calcitonin product in healthy volunteersPharmacotherapy2004248994100115338848
   PubMed Web of Science ®Google Scholar
• MahatoRINarangASThomaLMillerDDEmerging trends in oral delivery of peptide and protein drugsCrit Rev Ther Drug Carrier Syst2003202–315321414584523
   PubMed Web of Science ®Google Scholar
• KarsdalMAByrjalsenIHenriksenKRiisBJChristiansenCInvestigations of inter- and intraindividual relationships between exposure to oral salmon calcitonin and a surrogate marker of pharmacodynamic efficacyEur J Clin Pharmacol2010661293719813008
   PubMed Web of Science ®Google Scholar
• KarsdalMAByrjalsenIRiisBJChristiansenCOptimizing bioavailability of oral administration of small peptides through pharmacokinetic and pharmacodynamic parameters: the effect of water and timing of meal intake on oral delivery of Salmon CalcitoninBMC Clin Pharmacol20088518782439
   PubMedGoogle Scholar
• QvistPChristgauSPedersenBJSchlemmerAChristiansenCCircadian variation in the serum concentration of C-terminal telo-peptide of type I collagen (serum CTx): effects of gender, age, menopausal status, posture, daylight, serum cortisol, and fastingBone2002311576112110413
   PubMed Web of Science ®Google Scholar
• BjarnasonNHHenriksenEEAlexandersenPChristgauSHenriksenDBChristiansenCMechanism of circadian variation in bone resorptionBone200230130731311792602
   PubMed Web of Science ®Google Scholar
• HenriksenDBAlexandersenPByrjalsenIReduction of nocturnal rise in bone resorption by subcutaneous GLP-2Bone200434114014714751571
   PubMed Web of Science ®Google Scholar
• KarsdalMAByrjalsenIRiisBJChristiansenCInvestigation of the diurnal variation in bone resorption for optimal drug delivery and efficacy in osteoporosis with oral calcitoninBMC Clin Pharmacol200881219055791
   PubMedGoogle Scholar
• TankóLBBaggerYZAlexandersenPSafety and efficacy of a novel salmon calcitonin (sCT) technology-based oral formulation in healthy postmenopausal women: acute and 3-month effects on biomarkers of bone turnoverJ Bone Miner Res20041991531153815312255
   PubMed Web of Science ®Google Scholar
• KarsdalMAAlexandersenPDamEBOral calcitonin demonstrated symptom-modifying efficacy and decreased cartilage volume loss: results of a 2-year phase 3 trial in patients with osteoarthritis of the kneeACR/ARPH Scientific meetingNov 2011Chicago Abstract presentation number L9
   Google Scholar
• RussoLALauETangHEfficacy and safety of oral salmon calcitonin in postmenopausal osteoporosis: randomized, double-blind, placebo-controlled trial. AbstractAmerican Society of Bone and Mineral Research annual meetingToronto, Canada2010
   Google Scholar
• MaricicMJOral calcitoninCurr Osteoporos Rep2012101808522281725
   PubMed Web of Science ®Google Scholar
• Emisphere: Salmon Calcitonin for Osteoarthritis and Osteoporosis [homepage on the Internet]Emisphere Technologies Inc Available from: http://www.emisphere.com/salmon_calcitonin.htmlAccessed May 11, 2012
   Google Scholar
• OfluogluDAkyuzGUnayOKayhanOThe effect of calcitonin on beta-endorphin levels in postmenopausal osteoporotic patients with back painClin Rheumatol2007261444916575494
   PubMed Web of Science ®Google Scholar
• LyritisGPTrovasGAnalgesic effects of calcitoninBone200230Suppl 571S74S12008162
   PubMed Web of Science ®Google Scholar
• AzriaMPossible mechanisms of the analgesic action of calcitoninBone200230Suppl 580S83S12008164
   PubMed Web of Science ®Google Scholar
• Knopp-SihotaJANewburn-CookCVHomikJCummingsGGVoaklanderDCalcitonin for treating acute and chronic pain of recent and remote osteoporotic vertebral compression fractures: a systematic review and meta-analysisOsteoporos Int2012231173821660557
   PubMed Web of Science ®Google Scholar
• Martinez-ZapataMJRoquéMAlonso-CoelloPCatalàECalcitonin for metastatic bone painCochrane Database Syst Rev20063CD00322316856000
   PubMedGoogle Scholar
• AltmanRDCollins-YudiskasBSynthetic human calcitonin in refractory Paget’s disease of boneArch Intern Med19871477130513083111398
   PubMedGoogle Scholar
• MirallesFSLopez-SorianoFPuigMMPerezDLopez-RodriguezFPostoperative analgesia induced by subarachnoid lidocaine plus calcitoninAnesth Analg19876676156183300423
   PubMed Web of Science ®Google Scholar
• ZieleniewskiWCalcitonin nasal spray for painful diabetic neuropathyLancet199033687124491974984
   PubMed Web of Science ®Google Scholar
• JaegerHMaierCCalcitonin in phantom limb pain: a double-blind studyPain199248121271738570
   PubMed Web of Science ®Google Scholar
• WaldburgerMMeierJLGobeletCThe frozen shoulder: diagnosis and treatment. Prospective study of 50 cases of adhesive capsulitisClin Rheumatol19921133643681281062
   PubMed Web of Science ®Google Scholar
• GobeletCWaldburgerMMeierJLThe effect of adding calcitonin to physical treatment on reflex sympathetic dystrophyPain19924821711751589234
   PubMed Web of Science ®Google Scholar
• KarsdalMALeemingDJDamEBShould subchondral bone turnover be targeted when treating osteoarthritis?Osteoarthritis Cartilage200816663864618362080
   PubMed Web of Science ®Google Scholar
• Kwan TatSLajeunesseDPelletierJPMartel-PelletierJTargeting subchondral bone for treating osteoarthritis: what is the evidence?Best Pract Res Clin Rheumatol2010241517020129200
   PubMed Web of Science ®Google Scholar
• HayamiTPickarskiMWesolowskiGAThe role of subchondral bone remodeling in osteoarthritis: reduction of cartilage degeneration and prevention of osteophyte formation by alendronate in the rat anterior cruciate ligament transection modelArthritis Rheum20045041193120615077302
   PubMed Web of Science ®Google Scholar
• SondergaardBCWulfHHenriksenKCalcitonin directly attenuates collagen type II degradation by inhibition of matrix metalloproteinase expression and activity in articular chondrocytesOsteoarthritis Cartilage200614875976816549372
   PubMed Web of Science ®Google Scholar
• SondergaardBCOestergaardSChristiansenCTankóLBKarsdalMAThe effect of oral calcitonin on cartilage turnover and surface erosion in an ovariectomized rat modelArthritis Rheum20075682674267817665432
   PubMed Web of Science ®Google Scholar
• SondergaardBCMadsenSHSegovia-SilvestreTInvestigation of the direct effects of salmon calcitonin on human osteoarthritic chondrocytesBMC Musculoskelet Disord2010116220367884
   PubMed Web of Science ®Google Scholar
• KarsdalMATankoLBRiisBJCalcitonin is involved in cartilage homeostasis: is calcitonin a treatment for OA?Osteoarthritis Cartilage200614761762416698291
   PubMed Web of Science ®Google Scholar
• KarsdalMASondergaardBCArnoldMChristiansenCCalcitonin affects both bone and cartilage: a dual action treatment for osteoarthritis?Ann N Y Acad Sci2007111718119518056043
   PubMed Web of Science ®Google Scholar
• KarsdalMAByrjalsenIHenriksenKThe effect of oral salmon calcitonin delivered with 5-CNAC on bone and cartilage degradation in osteoarthritic patients: a 14-day randomized studyOsteoarthritis Cartilage201018215015919747581
   PubMed Web of Science ®Google Scholar
• BaggerYZTankóLBAlexandersenPOral salmon calcitonin induced suppression of urinary collagen type II degradation in postmenopausal women: a new potential treatment of osteoarthritisBone200537342543016005273
   PubMed Web of Science ®Google Scholar
• ManicourtDHAzriaMMindeholmLThonarEJDevogelaerJPOral salmon calcitonin reduces Lequesne’s algofunctional index scores and decreases urinary and serum levels of biomarkers of joint metabolism in knee osteoarthritisArthritis Rheum200654103205321117009253
   PubMed Web of Science ®Google Scholar
• ManicourtDHAzriaMMindeholmLDevogelaerJPEfficacy of calcitonin therapy in patients with knee osteoarthritis: a clinical and biochemical preliminary studyOsteoarthritis Cartilage200513s88
   Google Scholar
• ManciniLPaul-ClarkMJRosignoliGCalcitonin and prednisolone display antagonistic actions on bone and have synergistic effects in experimental arthritisAm J Pathol200717031018102717322385
   PubMed Web of Science ®Google Scholar