Ultraconservative, Fertility Sparing Treatment of Bilateral Borderline Ovarian Tumors: A Case Report of a 26-Year-Old, 0-Gravida with an Endometrioid Borderline Ovarian Tumor of the Right Ovary and a Sero-Mucinous Borderline Ovarian Tumor of the Left Ovary and a Review of the Literature

References

• Jia S, Zhang J, Liang Z, et al. Safety and fertility outcomes after the conservative treatment of endometrioid borderline ovarian tumours. BMC Cancer. 2018;18(1):1160. doi:10.1186/s12885-018-5091-1
   Web of Science ®Google Scholar
• Cadron I, Leunen K, Van Gorp T, Amant F, Neven P, Vergote I. Management of borderline ovarian neoplasms. J Clin Oncol off J Am Soc Clin Oncol. 2007;25(20):2928–2937. doi:10.1200/JCO.2007.10.8076
   Web of Science ®Google Scholar
• Morris CR, Liu L, Rodriguez AO, Cress RD, Snipes K. Epidemiologic features of borderline ovarian tumors in California: a population-based study. Cancer Causes Control. 2013;24(4):665–674. doi:10.1007/s10552-013-0145-9
   Web of Science ®Google Scholar
• Skírnisdóttir I, Garmo H, Wilander E, Holmberg L. Borderline ovarian tumors in Sweden 1960–2005: trends in incidence and age at diagnosis compared to ovarian cancer. Int J Cancer. 2008;123(8):1897–1901. doi:10.1002/ijc.23724
   Web of Science ®Google Scholar
• Masciangelo R, Bosisio C, Donnez J, Amorim CA, Dolmans -M-M. Safety of ovarian tissue transplantation in patients with borderline ovarian tumors. Hum Reprod Oxf Engl. 2018;33(2):212–219. doi:10.1093/humrep/dex352
   Web of Science ®Google Scholar
• Zanetta G, Rota S, Chiari S, Bonazzi C, Bratina G, Mangioni C. Behavior of borderline tumors with particular interest to persistence, recurrence, and progression to invasive carcinoma: a prospective study. J Clin Oncol off J Am Soc Clin Oncol. 2001;19(10):2658–2664. doi:10.1200/JCO.2001.19.10.2658
   PubMed Web of Science ®Google Scholar
• Donnez J. Safety of conservative management and fertility outcome in women with borderline tumors of the ovary. Fertil Steril. 2003;79(5):1216–1221. doi:10.1016/S0015-0282(03)00160-2
   Web of Science ®Google Scholar
• Harter P, Gershenson D, Lhomme C, et al. Gynecologic Cancer InterGroup (GCIG) consensus review for ovarian tumors of low malignant potential (borderline ovarian tumors). Int J Gynecol Cancer off J Int Gynecol Cancer Soc. 2014;24(9 Suppl 3):S5–8. doi:10.1097/IGC.0000000000000282
   Web of Science ®Google Scholar
• Morice P. Borderline tumours of the ovary and fertility. Eur J Cancer. 2006;42(2):149–158. doi:10.1016/j.ejca.2005.07.029
   Web of Science ®Google Scholar
• Kurman RJ, Trimble CL. The behavior of serous tumors of low malignant potential: are they ever malignant? Int J Gynecol Pathol off J Int Soc Gynecol Pathol. 1993;12(2):120–127. doi:10.1097/00004347-199304000-00006
   Web of Science ®Google Scholar
• Casey AC, Bell DA, Lage JM, Fuller AF, Nikrui N, Rice LW. Epithelial ovarian tumors of borderline malignancy: long-term follow-up. Gynecol Oncol. 1993;50(3):316–322. doi:10.1006/gyno.1993.1218
   Web of Science ®Google Scholar
• Chevrot A, Pouget N, Bats A-S, et al. Fertility and prognosis of borderline ovarian tumor after conservative management: results of the multicentric OPTIBOT study by the GINECO & TMRG group. Gynecol Oncol. 2020;157(1):29–35. doi:10.1016/j.ygyno.2019.12.046
   Web of Science ®Google Scholar
• Delle Marchette M, Ceppi L, Andreano A, et al. Oncologic and fertility impact of surgical approach for borderline ovarian tumours treated with fertility sparing surgery. Eur J Cancer. 2019;111:61–68. doi:10.1016/j.ejca.2019.01.021
   Web of Science ®Google Scholar
• Mangili G, Somigliana E, Giorgione V, et al. Fertility preservation in women with borderline ovarian tumours. Cancer Treat Rev. 2016;49:13–24. doi:10.1016/j.ctrv.2016.06.010
   PubMed Web of Science ®Google Scholar
• Morice P, Uzan C, Fauvet R, Gouy S, Duvillard P, Darai E. Borderline ovarian tumour: pathological diagnostic dilemma and risk factors for invasive or lethal recurrence. Lancet Oncol. 2012;13(3):e103–115. doi:10.1016/S1470-2045(11)70288-1
   PubMed Web of Science ®Google Scholar
• Daraï E, Fauvet R, Uzan C, Gouy S, Duvillard P, Morice P. Fertility and borderline ovarian tumor: a systematic review of conservative management, risk of recurrence and alternative options. Hum Reprod Update. 2013;19(2):151–166. doi:10.1093/humupd/dms047
   PubMed Web of Science ®Google Scholar
• Chen R-F, Li J, Zhu -T-T, Yu H-L LX. Fertility-sparing surgery for young patients with borderline ovarian tumors (BOTs): single institution experience. J Ovarian Res. 2016;9:16. doi:10.1186/s13048-016-0226-y
   Web of Science ®Google Scholar
• Vasconcelos I, de Sousa Mendes M. Conservative surgery in ovarian borderline tumours: a meta-analysis with emphasis on recurrence risk. Eur J Cancer. 2015;51(5):620–631. doi:10.1016/j.ejca.2015.01.004
   PubMed Web of Science ®Google Scholar
• Uzan C, Kane A, Rey A, Gouy S, Duvillard P, Morice P. Outcomes after conservative treatment of advanced-stage serous borderline tumors of the ovary. Ann Oncol off J Eur Soc Med Oncol. 2010;21(1):55–60. doi:10.1093/annonc/mdp267
   Web of Science ®Google Scholar
• Du Bois A, Ewald-Riegler N, de Gregorio N, et al. Borderline tumours of the ovary: a cohort study of the Arbeitsgmeinschaft Gynäkologische Onkologie (AGO) study group. Eur J Cancer. 2013;49(8):1905–1914. doi:10.1016/j.ejca.2013.01.035
   PubMed Web of Science ®Google Scholar
• Nakagawa E, Abiko K, Kido A, et al. Four cases of endometrioid borderline ovarian tumour: case reports and literature review. BJR Case Rep. 2018;4(1):20170062. doi:10.1259/bjrcr.20170062
   Web of Science ®Google Scholar
• Ellenson LH, Carinelli SG, Cho KR, et al. Endometrioid tumours. In:Kurman RJ, International Agency for Research on Cancer, World Health Organization, editor. WHO Classification of Tumours of Female Reproductive Organs. 4th. International Agency for Research on Cancer; 2014
   Google Scholar
• Yüksel D, Çakır C, Kimyon Cömert G, et al. Uncommon borderline ovarian tumours: a clinicopathologic study of seventeen patients. J Turk Ger Gynecol Assoc. 2019;20(4):224–230. doi:10.4274/jtgga.galenos.2018.2018.0098
   Web of Science ®Google Scholar
• Hussin H, Ghani F. Ovarian endometrioid borderline tumor arising from an endometriotic cyst. J Interdiscip Histopathol. 2017;1. doi:10.5455/jihp.20161231122553.
   Google Scholar
• Uzan C, Berretta R, Rolla M, et al. Management and prognosis of endometrioid borderline tumors of the ovary. Surg Oncol. 2012;21(3):178–184. doi:10.1016/j.suronc.2012.02.002
   Web of Science ®Google Scholar
• Snyder RR, Norris HJ, Tavassoli F. Endometrioid proliferative and low malignant potential tumors of the ovary. A clinicopathologic study of 46 cases. Am J Surg Pathol. 1988;12(9):661–671. doi:10.1097/00000478-198809000-00002
   Web of Science ®Google Scholar
• Jia S-Z, Zhang -J-J, Yang -J-J, Xiang Y, Liang Z, Leng J-H. Risk of synchronous endometrial disorders in women with endometrioid borderline tumors of the ovary. J Ovarian Res. 2018;11(1):30. doi:10.1186/s13048-018-0405-0
   Web of Science ®Google Scholar
• Bell KA, Kurman RJ. A clinicopathologic analysis of atypical proliferative (borderline) tumors and well-differentiated endometrioid adenocarcinomas of the ovary. Am J Surg Pathol. 2000;24(11):1465–1479. doi:10.1097/00000478-200011000-00002
   Web of Science ®Google Scholar
• Zhang W, Jia S, Xiang Y, Yang J, Jia C, Leng J. Comparative study of endometrioid borderline ovarian tumor with and without endometriosis. J Ovarian Res. 2018;11(1):67. doi:10.1186/s13048-018-0440-x
   Web of Science ®Google Scholar
• Palomba S, Falbo A, Del Negro S, et al. Ultra-conservative fertility-sparing strategy for bilateral borderline ovarian tumours: an 11-year follow-up. Hum Reprod Oxf Engl. 2010;25(8):1966–1972. doi:10.1093/humrep/deq159
   Web of Science ®Google Scholar
• Uzan C, Muller E, Kane A, et al. Prognostic factors for recurrence after conservative treatment in a series of 119 patients with stage I serous borderline tumors of the ovary. Ann Oncol off J Eur Soc Med Oncol. 2014;25(1):166–171. doi:10.1093/annonc/mdt430
   PubMed Web of Science ®Google Scholar
• Trillsch F, Mahner S, Woelber L, et al. Age-dependent differences in borderline ovarian tumours (BOT) regarding clinical characteristics and outcome: results from a sub-analysis of the Arbeitsgemeinschaft Gynaekologische Onkologie (AGO) ROBOT study. Ann Oncol off J Eur Soc Med Oncol. 2014;25(7):1320–1327. doi:10.1093/annonc/mdu119
   PubMed Web of Science ®Google Scholar
• Ouldamer L, Bendifallah S, Nikpayam M, et al. Improving the clinical management of women with borderline tumours: a recurrence risk scoring system from a French multicentre study. BJOG Int J Obstet Gynaecol. 2017;124(6):937–944. doi:10.1111/1471-0528.14577
   Web of Science ®Google Scholar
• Roth LM, Emerson RE, Ulbright TM. Ovarian endometrioid tumors of low malignant potential: a clinicopathologic study of 30 cases with comparison to well-differentiated endometrioid adenocarcinoma. Am J Surg Pathol. 2003;27(9):1253–1259. doi:10.1097/00000478-200309000-00009
   Web of Science ®Google Scholar