Systemic Thrombolysis for Isolated Splenic Vein Thrombosis Secondary to Oral Contraceptives: A Case Report

References

• Valeriani E, Riva N, Di Nisio M, Ageno W. Splanchnic vein thrombosis: current perspectives. Vasc Health Risk Manag. 2019;15:449–461. doi:10.2147/VHRM.S197732
   PubMed Web of Science ®Google Scholar
• Galante A, De Gottardi A. Portal vein thrombosis: an overview of current treatment options. Acta Gastroenterol Belg. 2021;84(2):327–332. doi:10.51821/84.2.327
   PubMed Web of Science ®Google Scholar
• Senzolo M, Garcia-Tsao G, Garcia-Pagan JC. Current knowledge and management of portal vein thrombosis in cirrhosis. J Hepatol. 2021;75(2):442–453. doi:10.1016/j.jhep.2021.04.029
   PubMed Web of Science ®Google Scholar
• Moossa AR, Gadd MA. Isolated splenic vein thrombosis. World J Surg. 1985;9(3):384–390. doi:10.1007/BF01655272
   PubMed Web of Science ®Google Scholar
• Zafar M, Heslop-Harrison W, Loterh L, Ofuafor K. Splenic vein thrombosis: a case series of consequential chronic pancreatitis and sequential myeloproliferative disorder. Cureus. 2022;14(6):e25924. doi:10.7759/cureus.25924
   PubMed Web of Science ®Google Scholar
• Akhondi H, Ganjali S, Nagalli S. Splanchnic venous thrombosis. StatPearls; 2023.
   Google Scholar
• Sutton JP, Yarborough DY, Richards JT. Isolated splenic vein occlusion. Review of literature and report of an additional case. Arch Surg. 1970;100(5):623–626. doi:10.1001/archsurg.1970.01340230089024
   PubMedGoogle Scholar
• Khan AH, O’Reilly CJ, Avakian VA, Lucina PA. Splenic vein thrombosis: an unusual case of gastric bleeding. Angiology. 1977;28(10):725–727. doi:10.1177/000331977702801010
   PubMed Web of Science ®Google Scholar
• Bunt TJ, Hackler MT, Greene FL. Isolated splenic vein thrombosis: the curable variceal hemorrhage. South Med J. 1983;76(7):936–938. doi:10.1097/00007611-198307000-00036
   PubMed Web of Science ®Google Scholar
• Roder OC. Splenic vein thrombosis with bleeding gastroesophageal varices. Reports of two splenectomized cases and review of the literature. Acta Chir Scand. 1984;150(3):265–268.
   PubMedGoogle Scholar
• Madsen MS. Splenic vein obstruction: a cause of upper gastrointestinal bleeding. Acta Chir Scand. 1986;152:393–395.
   PubMedGoogle Scholar
• Singh K, Zargar SA, Bhasin D, Malik AK, Nagi B, Bose SM. Isolated splenic vein thrombosis with natural shunt caused by jejunal tuberculosis. Trop Gastroenterol. 1990;11(1):39–43.
   PubMedGoogle Scholar
• Perisic-Savic M, Colovic R, Milosavljevic T, Ivanovic L. Splenic vein thrombosis. Diagnosed with Doppler ultrasonography. Hepatogastroenterology. 1991;38(6):557–560.
   PubMedGoogle Scholar
• Moller S, Bech K, Bendtsen F. Segmental ”portal hypertension”. A rare cause of severe tractable variceal bleeding. Ugeskr Laeger. 1997;159(17):2563–2565.
   PubMedGoogle Scholar
• Tsuchida S, Ku Y, Fukumoto T, Tominaga M, Iwasaki T, Kuroda Y. Isolated gastric varices resulting from iatrogenic splenic vein occlusion: report of a case. Surg Today. 2003;33(7):542–544. doi:10.1007/s10595-002-2519-7
   PubMed Web of Science ®Google Scholar
• Koklu S, Koksal A, Yolcu OF, et al. Isolated splenic vein thrombosis: an unusual cause and review of the literature. Can J Gastroenterol. 2004;18(3):173–174. doi:10.1155/2004/801576
   PubMed Web of Science ®Google Scholar
• Joya Seijo MD, Del Valle Loarte P, Marco Martinez J, Herrera Merino N, Agud Aparicio JL. Sinistral portal hypertension with bleeding gastric varices as initial manifestation of renal-cell carcinoma. An Med Interna. 2004;21(6):283–284. doi:10.4321/s0212-71992004000600006
   PubMedGoogle Scholar
• Bilski RA, Szczepanik AB. Isolated splenic vein thrombosis. Wiad Lek. 2004;57(11–12):697–698.
   PubMedGoogle Scholar
• Yamaguchi T, Takahashi H, Kagawa R, et al. Nonfunctioning pancreatic endocrine tumor presenting with hemorrhage from isolated gastric varices. Am Surg. 2005;71(12):1027–1030. doi:10.1177/000313480507101208
   PubMed Web of Science ®Google Scholar
• Hiraiwa K, Morozumi K, Miyazaki H, et al. Isolated splenic vein thrombosis secondary to splenic metastasis: a case report. World J Gastroenterol. 2006;12(40):6561–6563. doi:10.3748/wjg.v12.i40.6561
   PubMed Web of Science ®Google Scholar
• Liu CH, Tsai FC, Liang PC, Lee CZ, Yang PM. Splenic vein thrombosis and Klebsiella pneumoniae septicemia after endoscopic gastric variceal obturation therapy with N-butyl-2-cyanoacrylate. Gastrointest Endosc. 2006;63(2):336–338. doi:10.1016/j.gie.2005.08.025
   PubMed Web of Science ®Google Scholar
• Hariharan D, Singhal R, Kinra S, Chilton A. Post traumatic intra thoracic spleen presenting with upper GI bleed!--a case report. BMC Gastroenterol. 2006;6(1):38. doi:10.1186/1471-230X-6-38
   PubMedGoogle Scholar
• Allen LM, Behrens G, Patel NH, Ferral H. Splenic artery embolization and balloon occlusion retrograde alcohol embolization in a patient with bleeding gastric varices. Semin Intervent Radiol. 2007;24(1):53–57. doi:10.1055/s-2007-971186
   PubMedGoogle Scholar
• Guler N, Yapici O, Erdem D, Ogur G, Ozatli D, Bakir T. Acute complete splenic infarction in a patient with Hirschsprung’s disease and literature review of complete splenic infarction. Pathophysiol Haemost Thromb. 2008;36(2):102–104. doi:10.1159/000173730
   PubMedGoogle Scholar
• Tzur I, Almoznino-Sarafian D, Dotan E, et al. Splenic vein thrombosis following abdominal compression and vibration: a case report. Angiology. 2008;59(4):514–516. doi:10.1177/0003319707305403
   PubMed Web of Science ®Google Scholar
• Nomura T, Keira N, Urakabe Y, et al. Fatal splenic laceration in a young woman caused by idiopathic isolated splenic vein thrombosis. Intern Med. 2009;48(11):907–910. doi:10.2169/internalmedicine.48.1843
   PubMed Web of Science ®Google Scholar
• Karagiannis G, Anagnostara A, Samaras V, Mylona S. Isolated splenic vein thrombosis. JBR-BTR. 2012;95(2):105. doi:10.5334/jbr-btr.192
   PubMedGoogle Scholar
• Chen BC, Wang HH, Lin YC, Shih YL, Chang WK, Hsieh TY. Isolated gastric variceal bleeding caused by splenic lymphoma-associated splenic vein occlusion. World J Gastroenterol. 2013;19(40):6939–6942. doi:10.3748/wjg.v19.i40.6939
   PubMed Web of Science ®Google Scholar
• Jain D, Verma K, Jain P. Disseminated tuberculosis causing isolated splenic vein thrombosis and multiple splenic abscesses. Oxf Med Case Rep. 2014;2014(6):107–109. doi:10.1093/omcr/omu042
   PubMedGoogle Scholar
• Koksal AS, Kalkan IH, Torun S, Yuksel M, Okten RS, Kayacetin E. Isolated splenic vein thrombosis and splenic infarct due to external compression of enlarged lymph nodes in a patient with lymphoma. Indian J Cancer. 2014;51(4):586. doi:10.4103/0019-509X.175293
   PubMed Web of Science ®Google Scholar
• Kiani MA, Forouzan A, Masoumi K, et al. Isolated splenic vein thrombosis: 8-year-old boy with massive upper gastrointestinal bleeding and hypersplenism. Case Rep Pediatr. 2015;2015:480507. doi:10.1155/2015/480507
   PubMedGoogle Scholar
• Parekh R, Walia S, Zalawadia A, Siddiqui Y. A rare case of splenic lymphoma in a patient with polymyositis manifesting as gastric variceal bleeding. Clin J Gastroenterol. 2015;8(2):92–96. doi:10.1007/s12328-015-0561-3
   PubMedGoogle Scholar
• Lenhart A, Fernandez-Castillo J, Mullins K, Salgia R. A rare case of gastric variceal hemorrhage secondary to infiltrative B-cell lymphoma. Case Rep Gastroenterol. 2016;10(3):518–524. doi:10.1159/000445184
   PubMedGoogle Scholar
• Franco-Aviles L, Hernandez-Rocha FI, Mercado U, Malvido-Torres CG. Segmental portal hypertension with splenic vein thrombosis caused by pancreatitis. Rev Med Inst Mex Seguro Soc. 2017;55(6):788–790.
   PubMedGoogle Scholar
• Lupascu-Ursulescu C, Trofin AM, Zabara M, et al. Bleeding from isolated gastric varices as complication of a mucinous cystic neoplasm of the pancreas: a case report. Medicine. 2017;96(47):e8775. doi:10.1097/MD.0000000000008775
   PubMed Web of Science ®Google Scholar
• Salazar-Mejia CE, Hernandez-Barajas D, Llerena-Hernandez E, et al. Testicular cancer presenting as gastric variceal hemorrhage. Case Rep Gastrointest Med. 2017;2017:4510387. doi:10.1155/2017/4510387
   PubMedGoogle Scholar
• Patel H, Bhandari P, Kumar K, Makker J, Chandrala C. Isolated gastric varices due to essential thrombocytosis related to splenic vein thrombosis: a challenge to uncover the concealed diagnosis. Cureus. 2019;11(11):e6068. doi:10.7759/cureus.6068
   PubMed Web of Science ®Google Scholar
• Hayashi H, Shimizu A, Motoyama H, et al. Left-sided portal hypertension caused by idiopathic splenic vein stenosis improved by splenectomy: a case report. Surg Case Rep. 2020;6(1):148. doi:10.1186/s40792-020-00912-y
   PubMed Web of Science ®Google Scholar
• Park CG, Lee YN, Kim WY. Desmoid type fibromatosis of the distal pancreas: a case report. Ann Hepatobiliary Pancreat Surg. 2021;25(2):276–282. doi:10.14701/ahbps.2021.25.2.276
   PubMedGoogle Scholar
• Sikana AM, Thamrin H. Splenic vein thrombosis in cirrhosis of the liver: a rare case. Ann Med Surg. 2022;81:104439. doi:10.1016/j.amsu.2022.104439
   PubMed Web of Science ®Google Scholar
• Capraro S, Acquazzino M, Drake M, Dike CR. Successful treatment of splenic vein thrombosis secondary to acute pancreatitis with oral anticoagulants: a pediatric case series. Am J Case Rep. 2022;23:e937599. doi:10.12659/AJCR.937599
   PubMedGoogle Scholar
• Fussel LM, Muller-Wille R, Dinkhauser P, Schauer W, Hofer H. Treatment of colonic varices and gastrointestinal bleeding by recanalization and stenting of splenic-vein-thrombosis: a case report and literature review. World J Gastroenterol. 2023;29(24):3922–3931. doi:10.3748/wjg.v29.i24.3922
   PubMed Web of Science ®Google Scholar
• Pak J, Lee S, Lee HN, Hyun D, Park SJ, Cho Y. Isolated gastric varix bleeding caused by splenic vein obstruction: two case reports. J Korean Soc Radiol. 2023;84(1):291–297. doi:10.3348/jksr.2022.0059
   PubMedGoogle Scholar
• Garcia Soria A, Brotons Brotons A, Girona Torres E, et al. Gastric variceal bleeding as a form of presentation of pancreatic neuroendocrine tumor. Rev Esp Enferm Dig. 2023. doi:10.17235/reed.2023.9757/2023
   PubMed Web of Science ®Google Scholar
• Khialani D, Rosendaal F, Vlieg AVH. Hormonal contraceptives and the risk of venous thrombosis. Semin Thromb Hemost. 2020;46(8):865–871. doi:10.1055/s-0040-1715793
   PubMedGoogle Scholar
• Abou-Ismail MY, Citla Sridhar D, Nayak L. Estrogen and thrombosis: a bench to bedside review. Thromb Res. 2020;192:40–51. doi:10.1016/j.thromres.2020.05.008
   PubMed Web of Science ®Google Scholar
• Gialeraki A, Valsami S, Pittaras T, Panayiotakopoulos G, Politou M. Oral contraceptives and HRT risk of thrombosis. Clin Appl Thromb Hemost. 2018;24(2):217–225. doi:10.1177/1076029616683802
   PubMed Web of Science ®Google Scholar
• Morimont L, Haguet H, Dogne JM, Gaspard U, Douxfils J. Combined oral contraceptives and venous thromboembolism: review and perspective to mitigate the risk. Front Endocrinol. 2021;12:769187. doi:10.3389/fendo.2021.769187
   PubMed Web of Science ®Google Scholar
• Zhao JW, Cui XH, Zhao WY, et al. Acute mesenteric ischemia secondary to oral contraceptive-induced portomesenteric and splenic vein thrombosis: a case report. World J Clin Cases. 2022;10(29):10629–10637. doi:10.12998/wjcc.v10.i29.10629
   PubMed Web of Science ®Google Scholar
• Zhang Q, Jin Y, Li X, et al. Plasminogen activator inhibitor-1 (PAI-1) 4G/5G promoter polymorphisms and risk of venous thromboembolism - a meta-analysis and systematic review. Vasa. 2020;49(2):141–146. doi:10.1024/0301-1526/a000839
   PubMed Web of Science ®Google Scholar
• Grubic N, Stegnar M, Peternel P, Kaider A, Binder BR. A novel G/A and the 4G/5G polymorphism within the promoter of the plasminogen activator inhibitor-1 gene in patients with deep vein thrombosis. Thromb Res. 1996;84(6):431–443. doi:10.1016/S0049-3848(96)00211-3
   PubMed Web of Science ®Google Scholar
• Prabhudesai A, Shetty S, Ghosh K, Kulkarni B. Investigation of Plasminogen Activator Inhibitor-1 (PAI-1) 4G/5G promoter polymorphism in Indian venous thrombosis patients: a case-control study. Eur J Haematol. 2017;99(3):249–254. doi:10.1111/ejh.12912
   PubMed Web of Science ®Google Scholar
• Kollabathula A, Sharma S, Kumar N, et al. Plasminogen activator inhibitor-1 4G/5G promoter polymorphism in adults with splanchnic vein thrombosis: a case-control study. Indian J Hematol Blood Transfus. 2022;38(1):169–172. doi:10.1007/s12288-021-01454-5
   PubMed Web of Science ®Google Scholar
• Balta G, Altay C, Gurgey A. PAI-1 gene 4G/5G genotype: a risk factor for thrombosis in vessels of internal organs. Am J Hematol. 2002;71(2):89–93. doi:10.1002/ajh.10192
   PubMed Web of Science ®Google Scholar
• Meltzer ME, Lisman T, Doggen CJ, de Groot PG, Rosendaal FR, Bounameaux H. Synergistic effects of hypofibrinolysis and genetic and acquired risk factors on the risk of a first venous thrombosis. PLoS Med. 2008;5(5):e97. doi:10.1371/journal.pmed.0050097
   PubMed Web of Science ®Google Scholar
• Lenicek Krleza J, Jakovljevic G, Bronic A, et al. Contraception-related deep venous thrombosis and pulmonary embolism in a 17-Year-old girl heterozygous for factor V Leiden, prothrombin G20210A mutation, MTHFR C677T and homozygous for PAI-1 mutation: report of a family with multiple genetic risk factors and review of the literature. Pathophysiol Haemost Thromb. 2010;37(1):24–29. doi:10.1159/000319051
   PubMedGoogle Scholar
• Qi X, Zhang C, Han G, et al. Prevalence of the JAK2V617F mutation in Chinese patients with Budd-Chiari syndrome and portal vein thrombosis: a prospective study. J Gastroenterol Hepatol. 2012;27(6):1036–1043. doi:10.1111/j.1440-1746.2011.07040.x
   PubMed Web of Science ®Google Scholar
• Zheng J, Han M, Chen J, Deng MM, Luo G. Predictive value of D-dimer and fibrinogen degradation product for splanchnic vein thrombosis in patients with severe acute pancreatitis: a single-center retrospective study. Scand J Gastroenterol. 2023;58(10):1–7.
   PubMed Web of Science ®Google Scholar
• Lee HK, Park SJ, Yi BH, Yeon EK, Kim JH, Hong HS. Portal vein thrombosis: CT features. Abdom Imaging. 2008;33(1):72–79. doi:10.1007/s00261-007-9200-x
   PubMedGoogle Scholar
• Abbitt PL. Portal vein thrombosis: imaging features and associated etiologies. Curr Probl Diagn Radiol. 1992;21(4):115–147. doi:10.1016/0363-0188(92)90036-F
   PubMedGoogle Scholar
• Sturm L, Bettinger D, Klinger C, et al. Validation of color Doppler ultrasound and computed tomography in the radiologic assessment of non-malignant acute splanchnic vein thrombosis. PLoS One. 2021;16(12):e0261499. doi:10.1371/journal.pone.0261499
   PubMed Web of Science ®Google Scholar
• Sherman CB, Behr S, Dodge JL, Roberts JP, Yao FY, Mehta N. Distinguishing tumor from bland portal vein thrombus in liver transplant candidates with hepatocellular carcinoma: the A-VENA criteria. Liver Transpl. 2019;25(2):207–216. doi:10.1002/lt.25345
   PubMed Web of Science ®Google Scholar
• Sogaard KK, Farkas DK, Pedersen L, Sorensen HT. Splanchnic venous thrombosis is a marker of cancer and a prognostic factor for cancer survival. Blood. 2015;126(8):957–963. doi:10.1182/blood-2015-03-631119
   PubMed Web of Science ®Google Scholar
• Thatipelli MR, McBane RD, Hodge DO, Wysokinski WE. Survival and recurrence in patients with splanchnic vein thromboses. Clin Gastroenterol Hepatol. 2010;8(2):200–205. doi:10.1016/j.cgh.2009.09.019
   PubMed Web of Science ®Google Scholar
• de Franchis R, Bosch J, Garcia-Tsao G, Reiberger T, Ripoll C. Baveno VIIF. baveno VII - renewing consensus in portal hypertension. J Hepatol. 2022;76(4):959–974. doi:10.1016/j.jhep.2021.12.022
   PubMed Web of Science ®Google Scholar
• Northup PG, Garcia-Pagan JC, Garcia-Tsao G, et al. Vascular liver disorders, portal vein thrombosis, and procedural bleeding in patients with liver disease: 2020 practice guidance by the American Association for the study of liver diseases. Hepatology. 2021;73(1):366–413. doi:10.1002/hep.31646
   PubMed Web of Science ®Google Scholar
• Valeriani E, Di Nisio M, Riva N, et al. Anticoagulant therapy for splanchnic vein thrombosis: a systematic review and meta-analysis. Blood. 2021;137(9):1233–1240. doi:10.1182/blood.2020006827
   PubMed Web of Science ®Google Scholar
• Wang L, Guo X, Xu X, et al. Anticoagulation favors thrombus recanalization and survival in patients with liver cirrhosis and portal vein thrombosis: results of a meta-analysis. Adv Ther. 2021;38(1):495–520. doi:10.1007/s12325-020-01550-4
   PubMed Web of Science ®Google Scholar
• Ageno W, Beyer Westendorf J, Contino L, et al. Rivaroxaban for the treatment of noncirrhotic splanchnic vein thrombosis: an interventional prospective cohort study. Blood Adv. 2022;6(12):3569–3578. doi:10.1182/bloodadvances.2022007397
   PubMed Web of Science ®Google Scholar
• Naymagon L, Tremblay D, Zubizarreta N, et al. The efficacy and safety of direct oral anticoagulants in noncirrhotic portal vein thrombosis. Blood Adv. 2020;4(4):655–666. doi:10.1182/bloodadvances.2019001310
   PubMed Web of Science ®Google Scholar
• Zhang Z, Gao L, Liu Z, et al. Catheter-directed thrombolysis versus systemic anticoagulation in the treatment of symptomatic splanchnic venous thrombosis secondary to acute pancreatitis: a retrospective cohort study. BMC Surg. 2023;23(1):199. doi:10.1186/s12893-023-02046-y
   PubMed Web of Science ®Google Scholar
• Cheng Q, Tree K. Systematic review of thrombolysis therapy in the management of non-cirrhosis-related portal vein thrombosis. J Gastrointest Surg. 2021;25(6):1579–1590. doi:10.1007/s11605-020-04624-4
   PubMed Web of Science ®Google Scholar
• Liu K, Li WD, Du XL, Li CL, Li XQ. Comparison of systemic thrombolysis versus indirect thrombolysis via the superior mesenteric artery in patients with acute portal vein thrombosis. Ann Vasc Surg. 2017;39:264–269. doi:10.1016/j.avsg.2016.06.029
   PubMed Web of Science ®Google Scholar
• Gao F, Wang L, Pan J, et al. Efficacy and safety of thrombolytic therapy for portal venous system thrombosis: a systematic review and meta-analysis. J Intern Med. 2023;293(2):212–227. doi:10.1111/joim.13575
   PubMed Web of Science ®Google Scholar