The Extent of Antibiotic Dispensing in Self-Medication Encounters in Sudan: A Simulated Patient Study Focusing on Cefixime Sale

References

• World Health Organization. Antimicrobial Resistance: Global Report on Surveillance. World Health Organization; 2014. Available from: https://apps.who.int/iris/handle/10665/112642. Accessed July 13, 2023.
   Google Scholar
• Mathers C, Fat DM, Boerma JT. The Global Burden of Disease: 2004 Update. World Health Organization; 2008. Available from: https://www.who.int/healthinfo/global_burden_disease/2004_report_update/en/. Accessed July 20, 2023.
   Google Scholar
• Muhie OA. Antibiotic use and resistance pattern in Ethiopia: systematic review and meta-analysis. Int J Microbiol. 2019;1(2489063):56.
   Google Scholar
• Yimenu DK, Emam A, Elemineh E, Atalay W. Assessment of Antibiotic Prescribing Patterns at Outpatient Pharmacy Using World Health Organization Prescribing Indicators. J Prim Care Community. Health. 2019;10:2150132719886942.
   Web of Science ®Google Scholar
• Abdelaziz AI, Tawfik AG, Rabie KA, et al. Quality of Community Pharmacy Practice in Antibiotic Self-Medication Encounters: a Simulated Patient Study in Upper Egypt. Antibiotics. 2019;8(2):35. doi:10.3390/antibiotics8020035
   Web of Science ®Google Scholar
• Awad AI, Eltayeb IB, Capps PA. Self-medication practices in Khartoum State, Sudan. Eur J Clin Pharmacol. 2006;62(4):317–324. doi:10.1007/s00228-006-0107-1
   PubMed Web of Science ®Google Scholar
• Grigoryan L, Monnet DL, Haaijer-Ruskamp FM, Bonten MJ, Lundborg S, Verheij TJ. Self-medication with antibiotics in Europe: a case for action. Curr Drug Saf. 2010;5(4):329–332. doi:10.2174/157488610792246046
   PubMedGoogle Scholar
• Lescure D, Paget J, Schellevis F, van Dijk L. Determinants of Self-Medication With Antibiotics in European and Anglo-Saxon Countries: a Systematic Review of the Literature. Front Public Health. 2018;6(370). doi:10.3389/fpubh.2018.00370
   PubMedGoogle Scholar
• Auta A, Hadi MA, Oga E, et al. Global access to antibiotics without prescription in community pharmacies: a systematic review and meta-analysis. J Infect. 2019;78(1):8–18. doi:10.1016/j.jinf.2018.07.001
   PubMed Web of Science ®Google Scholar
• Arumugham VB, Gujarathi R, Cascella M. Third-Generation Cephalosporins. Treasure Island (FL): StatPearls Publishing; 2023. Available from: https://www.ncbi.nlm.nih.gov/books/NBK549881/. Accessed 16 May 2023.
   Google Scholar
• Adam D. Overview of the clinical features of cefixime. Chemotherapy. 1998;1:1–5. doi:10.1159/000048455
   Google Scholar
• Shigi Y, Matsumoto Y, Kaizu M, Fujishita Y, Kojo H. Mechanism of action of the new orally active cephalosporin FK027. J Antibiot. 1984;37(7):790–796. doi:10.7164/antibiotics.37.790
   PubMed Web of Science ®Google Scholar
• Ntizala AB, Mulume TY, Runyeruka BL, Kishabongo AS. Antibiotic Dispensing Practices in Community Pharmacies: a Major Health Concern in the Eastern Democratic Republic of Congo. J Pharm Res Int. 2020;32(14):33–44. doi:10.9734/jpri/2020/v32i1430603
   Web of Science ®Google Scholar
• Bianco A, Licata F, Trovato A, Napolitano F, Pavia M. Antibiotic-Dispensing Practice in Community Pharmacies: results of a Cross-Sectional Study in Italy. Antimicrob Agents Chemother. 2021;65(6):2729. doi:10.1128/AAC.02729-20
   Web of Science ®Google Scholar
• Seiberth JM, Moritz K, Kücükay N, Schiek S, Bertsche T. What is the attitude towards and the current practice of information exchange during self-medication counselling in German community pharmacies? An assessment through self-report and non-participant observation. PLoS One. 2020;15(10):e0240672. doi:10.1371/journal.pone.0240672
   PubMed Web of Science ®Google Scholar
• Zawahir S, Lekamwasam S, Aslani P. Community pharmacy staff’s response to symptoms of common infections: a pseudo-patient study. Antimicrob Resist Infect Control. 2019;8(1):60. doi:10.1186/s13756-019-0510-x
   PubMed Web of Science ®Google Scholar
• Bennadi D. Self-medication: a current challenge. J Basic Clin Pharm. 2014;5(1):19–23. doi:10.4103/0976-0105.128253
   Google Scholar
• Al-Mohamadi A, Badr A, Bin Mahfouz L, Samargandi D, Al Ahdal A. Dispensing medications without prescription at Saudi community pharmacy: extent and perception. Saudi Pharm J. 2013;21(1):13–18. doi:10.1016/j.jsps.2011.11.003
   PubMed Web of Science ®Google Scholar
• Saleem Z, Hassali MA, Godman B, et al. Sale of WHO AWaRe groups antibiotics without a prescription in Pakistan: a simulated client study. J Pharm Policy Pract. 2020;13(26):020–00233. doi:10.1186/s40545-020-00233-3
   PubMedGoogle Scholar
• Björnsdottir I, Granas AG, Bradley A, Norris P. A systematic review of the use of simulated patient methodology in pharmacy practice research from 2006 to 2016. Int J Pharm Pract. 2020;28(1):13–25. doi:10.1111/ijpp.12570
   PubMed Web of Science ®Google Scholar
• Abdelrahman Hussain M A, Osman Mohamed A, Sandel Abkar A, Siddig Mohamed F, Knowledge KEH. Attitude and Practice of Community Pharmacists in Relation to Dispensing Antibiotics Without Prescription in Sudan: a Cross-sectional Study. Integr Pharm Res Pract. 2022;11:107–116. doi:10.2147/IPRP.S363079
   PubMed Web of Science ®Google Scholar
• Salim AM, Elgizoli B. Exploring the reasons why pharmacists dispense antibiotics without prescriptions in Khartoum state, Sudan. Int J Pharm Pract. 2017;25(1):59–65. doi:10.1111/ijpp.12317
   PubMed Web of Science ®Google Scholar
• Hussain MA, Mohamed AO, Abdelkarim OA, et al. Prevalence and Predictors of Antibiotic Self-Medication in Sudan: a Descriptive Cross-Sectional Study. Antibiotics. 2023;12(3):612. doi:10.3390/antibiotics12030612
   Google Scholar
• Vandenbroucke JP, von Elm E, Altman DG, et al. Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): explanation and elaboration. Ann Intern Med. 2007;147(8):W163–94. doi:10.7326/0003-4819-147-8-200710160-00010-w1
   PubMed Web of Science ®Google Scholar
• Bouter S, van Weel-Baumgarten E, Bolhuis S. Construction and validation of the Nijmegen Evaluation of the Simulated Patient (NESP): assessing simulated patients’ ability to role-play and provide feedback to students. Acad Med. 2013;88(2):253–259. doi:10.1097/ACM.0b013e31827c0856
   PubMed Web of Science ®Google Scholar
• Czajkowski K, Broś-Konopielko M, Teliga-Czajkowska J. Urinary tract infection in women. Prz Menopauzalny. 2021;20(1):40–47. doi:10.5114/pm.2021.105382
   PubMedGoogle Scholar
• Nepal A, Hendrie D, Robinson S, Selvey LA. Survey of the pattern of antibiotic dispensing in private pharmacies in Nepal. BMJ Open. 2019;9(10):2019–032422. doi:10.1136/bmjopen-2019-032422
   Web of Science ®Google Scholar
• Llor C, Cots JM. The sale of antibiotics without prescription in pharmacies in Catalonia, Spain. Clin Infect Dis. 2009;48(10):1345–1349. doi:10.1086/598183
   PubMed Web of Science ®Google Scholar
• Bahta M, Tesfamariam S, Weldemariam DG, et al. Dispensing of antibiotics without prescription and associated factors in drug retail outlets of Eritrea: a simulated client method. PLoS One. 2020;15(1):e0228013. doi:10.1371/journal.pone.0228013
   PubMed Web of Science ®Google Scholar
• Mokwele RN, Schellack N, Bronkhorst E, Brink AJ, Schweickerdt L, Godman B. Using mystery shoppers to determine practices pertaining to antibiotic dispensing without a prescription among community pharmacies in South Africa - a pilot survey. JAC-Antimicrobial Resist. 2022;4(1):1–10. doi:10.1093/jacamr/dlab196
   Google Scholar
• Al-Faham Z, Habboub G, Takriti F. The sale of antibiotics without prescription in pharmacies in Damascus, Syria. J Infect Dev Ctries. 2011;5(5):396–399. doi:10.3855/jidc.1248
   PubMed Web of Science ®Google Scholar
• Erku DA, Mekuria AB, Surur AS, Gebresillassie BM. Extent of dispensing prescription-only medications without a prescription in community drug retail outlets in Addis Ababa, Ethiopia: a simulated-patient study. Drug Healthc Patient Saf. 2016;8:65–70. doi:10.2147/DHPS.S106948
   PubMedGoogle Scholar
• Yaacoub SG, Lahoud NA, Francis NJ, et al. Antibiotic prescribing rate in Lebanese community pharmacies: a nationwide patient-simulated study of acute bacterial rhinosinusitis. J Epidemiol Glob Health. 2019;9(1):44–49. doi:10.2991/jegh.k.190305.001
   PubMed Web of Science ®Google Scholar
• Al-Tannir M, Altannir Y, Altannir M, AlFayyad I. Community pharmacy sales of non-prescribed antibiotics in Riyadh, Saudi Arabia: a simulated patient study. Int J Clin Pharm. 2020;42(2):341–346. doi:10.1007/s11096-020-01033-0
   PubMed Web of Science ®Google Scholar
• Nyazema N, Viberg N, Khoza S, et al. Low sale of antibiotics without prescription: a cross-sectional study in Zimbabwean private pharmacies. J Antimicrob Chemother. 2007;59(4):718–726. doi:10.1093/jac/dkm013
   PubMed Web of Science ®Google Scholar
• Yaacoub SG, Koyess V, Lahoud N, et al. Antibiotic prescribing for acute uncomplicated cystitis in Lebanese community pharmacies using a simulated patient. Pharm Pract (Granada). 2019;17(4):1–8. doi:10.18549/PharmPract.2019.4.1604
   Web of Science ®Google Scholar
• Shet A, Sundaresan S, Forsberg BC. Pharmacy-based dispensing of antimicrobial agents without prescription in India: appropriateness and cost burden in the private sector. Antimicrob Resist Infect Control. 2015;4(1):1–7. doi:10.1186/s13756-015-0098-8
   PubMedGoogle Scholar
• Zawahir S, Lekamwasam S, Aslani P. Antibiotic dispensing practice in community pharmacies: a simulated client study. Res Soc Adm Pharm. 2019;15(5):584–590. doi:10.1016/j.sapharm.2018.07.019
   PubMed Web of Science ®Google Scholar
• Chang J, Xu S, Zhu S, et al. Articles Assessment of non-prescription antibiotic dispensing at community pharmacies in China with simulated clients: a mixed cross-sectional and longitudinal study. Lancet Infect Dis. 2019;3099(19):1–10. doi:10.1016/S1473-3099(19)30324-X
   Google Scholar
• Moja L, Huttner B. Selection and Use of Essential Medicines. In: Raviglione MCB, Tediosi F, Villa S, Casamitjana N, Plasència A, editors. Global Health Essentials. Cham: Springer International Publishing; 2023:321–325.
   Google Scholar
• Malik UR, Chang J, Hashmi F, et al. A simulated client exploration of nonprescription dispensing of antibiotics at drugstores for pediatric acute diarrhea and upper respiratory infection in Lahore, Pakistan. Infect Drug Resist. 2021;14:1129–1140. doi:10.2147/IDR.S301812
   PubMed Web of Science ®Google Scholar
• Parienti J, Cattoir V, Thibon P, Lebouvier G, Verdon R, Daubin C. Hospital-wide modification of fluoroquinolone policy and meticillin-resistant Staphylococcus aureus rates: a 10-year interrupted time-series analysis. J Hosp Infect. 2011;78(2):118–122. doi:10.1016/j.jhin.2011.03.008
   PubMed Web of Science ®Google Scholar
• Wilcox MH, Chalmers JD, Nord CE, Freeman J, Bouza E. Role of cephalosporins in the era of Clostridium difficile infection. J Antimicrob Chemother. 2017;72(1):1–18. doi:10.1093/jac/dkw385
   PubMed Web of Science ®Google Scholar
• Onanuga A, T TC. Multidrug-resistant intestinal Staphylococcus aureus among self-medicated healthy adults in Amassoma, South-South, Nigeria. J Heal Popul Nutr. 2011;29(5):446–453.
   PubMed Web of Science ®Google Scholar
• Chaudhary MK, Ghyanshyam P, Mahendra G, Ramesh G, Subash G. Efficacy of cefixime in the treatment of urinary tract infection. World J Pharm Pharm Sci. 2015;4(4):987–994.
   Google Scholar
• Allen VG, Mitterni L, Seah C, et al. Neisseria gonorrhoeae treatment failure and susceptibility to cefixime in Toronto, Canada. JAMA. 2013;309(2):163–170. doi:10.1001/jama.2012.176575
   PubMed Web of Science ®Google Scholar
• Abdellatif O, Ali AN, Mohamed IA. Evaluation of the Antibiotic Resistance Pattern at the Medical Services Administration Hospital in Khartoum, Sudan, 2021. J Res Appl Sci Biotechnol. 2022;1(4):50–56. doi:10.55544/jrasb.1.4.6
   Google Scholar
• Moglad EH. Antibiotics Profile, Prevalence of Extended-Spectrum Beta-Lactamase (ESBL), and Multidrug-Resistant Enterobacteriaceae from Different Clinical Samples in Khartoum State, Sudan. Int J Microbiol. 2020;2020:8898430. doi:10.1155/2020/8898430
   PubMed Web of Science ®Google Scholar
• Salim AMA, Hamed FHM. Exploring health insurance services in Sudan from the perspectives of insurers. SAGE Open Med. 2018;6:2050312117752298. doi:10.1177/2050312117752298
   Web of Science ®Google Scholar
• Bahta M, Weldemariam DG, Tesfamariam S, Tesfamariam EH, Russom M. Determinants of dispensing antibiotics without prescription in Eritrea: a mixed-method qualitative study on pharmacy professionals’ perspective. BMJ Open. 2021;11(8):e049000. doi:10.1136/bmjopen-2021-049000
   PubMed Web of Science ®Google Scholar
• Marković-Peković V, Grubiša N, Burger J, Bojanić L, Godman B. Initiatives to Reduce Nonprescription Sales and Dispensing of Antibiotics: findings and Implications. J Res Pharm Pract. 2017;6(2):120–125. doi:10.4103/jrpp.JRPP_17_12
   PubMed Web of Science ®Google Scholar
• Mukokinya MMA, Opanga S, Oluka M, Godman B. Dispensing of Antimicrobials in Kenya: a Cross-sectional Pilot Study and Its Implications. J Res Pharm Pract. 2018;7(2):77–82. doi:10.4103/jrpp.JRPP_17_88
   PubMed Web of Science ®Google Scholar
• Mohamed SSE, Mahmoud AA, Ali AA. Sudanese community pharmacy practice and its readiness for change to patient care. Int J Pharm Pract. 2015;23(4):266–273. doi:10.1111/ijpp.12156
   PubMedGoogle Scholar
• Mohamed SS, Mahmoud AA, Ali AA. The role of Sudanese community pharmacists in patients’ self-care. Int J Clin Pharm. 2014;36(2):412–419. doi:10.1007/s11096-013-9911-8
   PubMed Web of Science ®Google Scholar
• Napolitano F, Izzo MT, Di Giuseppe G, Angelillo IF. Public knowledge, attitudes, and experience regarding the use of antibiotics in Italy. PLoS One. 2013;8(12):e84177. doi:10.1371/journal.pone.0084177
   PubMed Web of Science ®Google Scholar
• Abdelrahman Hussain M, Osman Mohamed A, Sandel Abkar A, Siddig Mohamed F, Knowledge KEH. Attitude and Practice of Community Pharmacists in Relation to Dispensing Antibiotics Without Prescription in Sudan: a Cross-sectional Study. Integr Pharm Res Pract. 2022;11:107–116.
   PubMed Web of Science ®Google Scholar