Immunochemotherapy for Richter syndrome: current insights

References

• CampoEGhiaPMontserratEHarrisNChronic lymphocytic leukemia/Small lymphocytic leukemiaSwerdlowSCampoEHarrisNWHO classification of tumours of haematopoietic and lymphoid tissuesLyonIARC2017216220
   Google Scholar
• RichterMNGeneralized reticular cell sarcoma of lymph nodes associated with lymphatic leukemiaAm J Pathol19284428529219969796
   PubMedGoogle Scholar
• LortholaryPBoironMRipaultPLevyJPManusABernardJLeucé-mie lymphoide chronique secondairement associée à une réticulopathie maligne, syndrome de Richter [Chronic lymphoid leukemia secondarily associated with a malignant reticulopathy: Richter’s syndrome]Nouv Rev Fr Hematol19644621644 French14199493
   PubMedGoogle Scholar
• AgbayRLJainNLoghaviSMedeirosLJKhouryJDHistologic transformation of chronic lymphocytic leukemia/small lymphocytic lymphomaAm J Hematol201691101036104327414262
   PubMed Web of Science ®Google Scholar
• ReinigerLBödörCBognárARichter’s and prolymphocytic transformation of chronic lymphocytic leukemia are associated with high mRNA expression of activation-induced cytidine deaminase and aberrant somatic hypermutationLeukemia20062061089109516541139
   PubMed Web of Science ®Google Scholar
• ParikhSARabeKGCallTGDiffuse large B-cell Lymphoma (Richter syndrome) in patients with chronic lymphocytic leukaemia (CLL): a cohort study of newly diagnosed patientsBr J Haematol2013162677478223841899
   PubMed Web of Science ®Google Scholar
• RobertsAWDavidsMSPagelJMTargeting Bcl2 with venetoclax in relapsed chronic lymphocytic leukemiaN Engl J Med2016374431132226639348
   PubMed Web of Science ®Google Scholar
• LindenMACase study interpretation-New Orleans: case 4. Richter syndrome characterized by diffuse large B cell lymphoma in the context of prior chronic lymphocytic leukemia/small lymphocytic lymphomaCytometry B Clin Cytom201384535035323283841
   PubMed Web of Science ®Google Scholar
• CwynarskiKvan BiezenAde WreedeLAutologous and allogeneic stem-cell transplantation for transformed chronic lymphocytic leukemia (Richter’s syndrome): a retrospective analysis from the chronic lymphocytic leukemia Subcommittee of the chronic leukemia Working Party and lymphoma Working Party of the European Group for blood and marrow transplantationJ Clin Oncol201230182211221722547610
   PubMed Web of Science ®Google Scholar
• GinéEMartinezAVillamorNExpanded and highly active proliferation centers identify a histological subtype of chronic lymphocytic leukemia (“accelerated” chronic lymphocytic leukemia) with aggressive clinical behaviorHaematologica20109591526153320421272
   PubMed Web of Science ®Google Scholar
• SoilleuxEJWotherspoonAEyreTACliffordRCabesMSchuhAHDiagnostic dilemmas of high-grade transformation (Richter’s syndrome) of chronic lymphocytic leukaemia: results of the phase II National Cancer Research Institute CHOP-OR clinical trial specialist haematopathology central reviewHistopathology20166961066107627345622
   PubMed Web of Science ®Google Scholar
• MaoZQuintanilla-MartinezLRaffeldMIgVH mutational status and clonality analysis of Richter’s transformation: diffuse large B-cell lymphoma and Hodgkin lymphoma in association with B-cell chronic lymphocytic leukemia (B-CLL) represent 2 different pathways of disease evolutionAm J Surg Pathol200731101605161417895764
   PubMed Web of Science ®Google Scholar
• RossiDCerriMCapelloDBiological and clinical risk factors of chronic lymphocytic leukaemia transformation to Richter syndromeBr J Haematol2008142220221518492108
   PubMed Web of Science ®Google Scholar
• RossiDSpinaVForconiFMolecular history of Richter syndrome: origin from a cell already present at the time of chronic lymphocytic leukemia diagnosisInt J Cancer2012130123006301021796624
   PubMed Web of Science ®Google Scholar
• RossiDSpinaVDeambrogiCThe genetics of Richter syndrome reveals disease heterogeneity and predicts survival after transformationBlood2011117123391340121266718
   PubMed Web of Science ®Google Scholar
• CherepakhinVBairdSMMeisenholderGWKippsTJCommon clonal origin of chronic lymphocytic leukemia and high-grade lymphoma of Richter’s syndromeBlood19938210314131477693038
   PubMed Web of Science ®Google Scholar
• ChigrinovaERinaldiAKweeITwo main genetic pathways lead to the transformation of chronic lymphocytic leukemia to Richter syndromeBlood2013122152673268224004666
   PubMed Web of Science ®Google Scholar
• RossiDSpinaVGaidanoGBiology and treatment of Richter syndromeBlood2018131252761277229692342
   PubMed Web of Science ®Google Scholar
• FabbriGKhiabanianHHolmesABGenetic lesions associated with chronic lymphocytic leukemia transformation to Richter syndromeJ Exp Med2013210112273228824127483
   PubMed Web of Science ®Google Scholar
• RossiDBerraECerriMAberrant somatic hypermutation in transformation of follicular lymphoma and chronic lymphocytic leukemia to diffuse large B-cell lymphomaHaematologica200691101405140917018394
   PubMed Web of Science ®Google Scholar
• FabbriGRasiSRossiDAnalysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activationJ Exp Med201120871389140121670202
   PubMed Web of Science ®Google Scholar
• PuenteXSPinyolMQuesadaVWhole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemiaNature2011475735410110521642962
   PubMed Web of Science ®Google Scholar
• JamroziakKTadmorTRobakTPolliackARichter syndrome in chronic lymphocytic leukemia: updates on biology, clinical features and therapyLeuk Lymphoma20155671949195825356923
   PubMed Web of Science ®Google Scholar
• RinaldiAMensahAAKweeIPromoter methylation patterns in Richter syndrome affect stem-cell maintenance and cell cycle regulation and differ from de novo diffuse large B-cell lymphomaBr J Haematol2013163219420423961875
   PubMed Web of Science ®Google Scholar
• RossiDBruscagginASpinaVMutations of the SF3B1 splicing factor in chronic lymphocytic leukemia: association with progression and fludarabine-refractorinessBlood2011118266904690822039264
   PubMed Web of Science ®Google Scholar
• ScandurraMRossiDDeambrogiCGenomic profiling of Richter’s syndrome: recurrent lesions and differences with de novo diffuse large B-cell lymphomasHematol Oncol2010282626720014148
   PubMed Web of Science ®Google Scholar
• JamroziakKPułaBWalewskiJCurrent treatment of chronic lymphocytic leukemiaCurr Treat Options Oncol2017181528185174
   PubMed Web of Science ®Google Scholar
• AhnIEUnderbayevCAlbitarAClonal evolution leading to ibrutinib resistance in chronic lymphocytic leukemiaBlood2017129111469147928049639
   PubMed Web of Science ®Google Scholar
• BurgerJALandauDATaylor-WeinerAClonal evolution in patients with chronic lymphocytic leukaemia developing resistance to BTK inhibitionNat Commun2016711158927199251
   PubMed Web of Science ®Google Scholar
• GounariMNtoufaSApollonioBExcessive antigen reactivity may underlie the clinical aggressiveness of chronic lymphocytic leukemia stereotyped subset #8Blood2015125233580358725900981
   PubMed Web of Science ®Google Scholar
• GhiottoFFaisFValettoARemarkably similar antigen receptors among a subset of patients with chronic lymphocytic leukemiaJ Clin Invest200411371008101615057307
   PubMed Web of Science ®Google Scholar
• RossiDSpinaVCerriMStereotyped B-cell receptor is an independent risk factor of chronic lymphocytic leukemia transformation to Richter syndromeClin Cancer Res200915134415442219509140
   PubMed Web of Science ®Google Scholar
• RossiDRasiSSpinaVIntegrated mutational and cytogenetic analysis identifies new prognostic subgroups in chronic lymphocytic leukemiaBlood201312181403141223243274
   PubMed Web of Science ®Google Scholar
• AthanasiadouAStamatopoulosKGaitatziMStavroyianniNFassasAAnagnostopoulosARecurrent cytogenetic findings in subsets of patients with chronic lymphocytic leukemia expressing IgG-switched stereotyped immunoglobulinsHaematologica200893347347418310544
   PubMed Web of Science ®Google Scholar
• BehdadAGriffinBChenYHPD-1 is highly expressed by neoplastic B-cells in Richter transformationBr J Haematol Epub2018720
   Web of Science ®Google Scholar
• HeRDingWViswanathaDSPD-1 expression in chronic lymphocytic Leukemia/Small lymphocytic lymphoma (CLL/SLL) and large B-cell Richter transformation (DLBCL-RT): a characteristic feature of DLBCL-RT and potential surrogate marker for clonal relatednessAm J Surg Pathol201842784385429762141
   PubMed Web of Science ®Google Scholar
• FranciscoLMSagePTSharpeAHThe PD-1 pathway in tolerance and autoimmunityImmunol Rev2010236121924220636820
   PubMed Web of Science ®Google Scholar
• SolhMRaiKRPetersonBLThe impact of initial fludarabine therapy on transformation to Richter syndrome or prolymphocytic leukemia in patients with chronic lymphocytic leukemia: analysis of An intergroup trial (CALGB 9011)Leuk Lymphoma201354225225422897733
   PubMed Web of Science ®Google Scholar
• RossiDRichter syndrome and fludarabine: a controversial relationshipLeuk Lymphoma201354221321422897730
   PubMed Web of Science ®Google Scholar
• O’BrienSMKantarjianHMThomasDAAlemtuzumab as treatment for residual disease after chemotherapy in patients with chronic lymphocytic leukemiaCancer200398122657266314669286
   PubMed Web of Science ®Google Scholar
• KarlssonCNorinSKimbyEAlemtuzumab as first-line therapy for B-cell chronic lymphocytic leukemia: long-term follow-up of clinical effects, infectious complications and risk of Richter transformationLeukemia200620122204220717051245
   PubMed Web of Science ®Google Scholar
• LepretreSAurranTMahéBExcess mortality after treatment with fludarabine and cyclophosphamide in combination with alemtuzumab in previously untreated patients with chronic lymphocytic leukemia in a randomized phase 3 trialBlood2012119225104511022337714
   PubMed Web of Science ®Google Scholar
• JainPThompsonPAKeatingMLong-term outcomes for patients with chronic lymphocytic leukemia who discontinue ibrutinibCancer2017123122268227328171709
   PubMed Web of Science ®Google Scholar
• MaddocksKJRuppertASLozanskiGEtiology of ibrutinib therapy discontinuation and outcomes in patients with chronic lymphocytic leukemiaJAMA Oncol201511808726182309
   PubMed Web of Science ®Google Scholar
• FarooquiMZValdezJMartyrSIbrutinib for previously untreated and relapsed or refractory chronic lymphocytic leukaemia with TP53 aberrations: a phase 2, single-arm trialLancet Oncol201516216917625555420
   PubMed Web of Science ®Google Scholar
• MatoARNabhanCBarrPMOutcomes of CLL patients treated with sequential kinase inhibitor therapy: a real world experienceBlood2016128182199220527601462
   PubMed Web of Science ®Google Scholar
• Iskierka-JażdżewskaEHusMGiannopoulosKEfficacy and toxicity of compassionate ibrutinib use in relapsed/refractory chronic lymphocytic leukemia in Poland: analysis of the Polish adult leukemia group (PALG)Leuk Lymphoma201758102485248828278701
   PubMed Web of Science ®Google Scholar
• BarrientosJCCoutreSDe VosSLong-term follow-up of a phase Ib trial of idelalisib (IDELA) in combination with chemoimmunotherapy (CIT) in patients (PTS) with relapsed/refractory (R/R) CLL including PTS with del17p/TP53 mutationJ Clin Oncol20153315 Suppl70117011
   Web of Science ®Google Scholar
• PułaBBudziszewskaBKRybkaJComparable efficacy of idelalisib plus rituximab and ibrutinib in relapsed/refractory chronic lymphocytic leukemia: a retrospective case matched study of the Polish adult leukemia group (PALG)Anticancer Res20183853025303029715135
   PubMed Web of Science ®Google Scholar
• ByrdJCBrownJRO’BrienSIbrutinib versus ofatumumab in previously treated chronic lymphoid leukemiaN Engl J Med2014371321322324881631
   PubMed Web of Science ®Google Scholar
• BurgerJATedeschiABarrPMIbrutinib as initial therapy for patients with chronic lymphocytic leukemiaN Engl J Med2015373252425243726639149
   PubMed Web of Science ®Google Scholar
• Chanan-KhanACramerPDemirkanFIbrutinib combined with bendamustine and rituximab compared with placebo, bendamustine, and rituximab for previously treated chronic lymphocytic leukaemia or small lymphocytic lymphoma (Helios): a randomised, double-blind, phase 3 studyLancet Oncol201617220021126655421
   PubMed Web of Science ®Google Scholar
• FurmanRRSharmanJPCoutreSEIdelalisib and rituximab in relapsed chronic lymphocytic leukemiaN Engl J Med201437011997100724450857
   PubMed Web of Science ®Google Scholar
• JamroziakKSzymczykAHusMHodgkin’s variant of Richter’s transformation during ibrutinib therapy in a series of CLL patients; the Polish adult leukemia Group report (PALG)Eur J Haematol2018100438939129243346
   PubMed Web of Science ®Google Scholar
• GlaveySQuinnJMcCloyMEmergence of Bruton’s tyrosine kinase-negative Hodgkin lymphoma during ibrutinib treatment of chronic lymphocytic leukaemiaEur J Haematol201799437838028561533
   PubMed Web of Science ®Google Scholar
• SachanasSPangalisGAMoschogiannisMHodgkin lymphoma transformation of chronic lymphocytic leukemia under ibrutinib therapy: chance association or therapy-related?Anticancer Res20173763277328028551676
   PubMed Web of Science ®Google Scholar
• TsimberidouAMO’BrienSKhouriIClinical outcomes and prognostic factors in patients with Richter’s syndrome treated with chemotherapy or chemoimmunotherapy with or without stem-cell transplantationJ Clin Oncol200624152343235116710033
   PubMed Web of Science ®Google Scholar
• RossiDLobetti BodoniCGenuardiETelomere length is an independent predictor of survival, treatment requirement and Richter’s syndrome transformation in chronic lymphocytic leukemiaLeukemia20092361062107219340005
   PubMed Web of Science ®Google Scholar
• KadriSLeeJFitzpatrickCClonal evolution underlying leukemia progression and Richter transformation in patients with ibrutinib-relapsed CLLBlood Adv201711271572729296715
   PubMed Web of Science ®Google Scholar
• MillerCRRuppertASHeeremaNANear-tetraploidy is associated with Richter transformation in chronic lymphocytic leukemia patients receiving ibrutinibBlood Adv20171191584158829296799
   PubMed Web of Science ®Google Scholar
• BalattiVTomaselloLRassentiLZmiR-125a and miR-34a expression predicts Richter syndrome in chronic lymphocytic leukemia patientsBlood2018132202179218230242085
   PubMed Web of Science ®Google Scholar
• OmotiCEOmotiAERichter syndrome: a review of clinical, ocular, neurological and other manifestationsBr J Haematol2008142570971618492119
   PubMed Web of Science ®Google Scholar
• RobertsonLEPughWO’BrienSRichter’s syndrome: a report on 39 patientsJ Clin Oncol19931110198519898410123
   PubMed Web of Science ®Google Scholar
• WoronieckaRRymkiewiczGGrygalewiczBCytogenetic and flow cytometry evaluation of Richter syndrome reveals MYC, CDKN2A, IgH alterations with loss of CD52, CD62L and increase of CD71 antigen expression as the most frequent recurrent abnormalitiesAm J Clin Pathol20151431253525511139
   PubMed Web of Science ®Google Scholar
• PapajíkTMyslivečekMUrbanováR2-[18F]fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography examination in patients with chronic lymphocytic leukemia may reveal Richter transformationLeuk Lymphoma201455231431923656196
   PubMed Web of Science ®Google Scholar
• NiemannCUPolliackAHutchingsMSuspected Richter transformation: positron emission tomography/computed tomography tells us who should have a biopsy and whereLeuk Lymphoma201455223323423915194
   PubMed Web of Science ®Google Scholar
• BruzziJFMacapinlacHTsimberidouAMDetection of Richter’s transformation of chronic lymphocytic leukemia by PET/CTJ Nucl Med20064781267127316883004
   PubMed Web of Science ®Google Scholar
• RobakTMalignanciesSSecond malignancies and Richter’s syndrome in patients with chronic lymphocytic leukemiaHematology200495–638740015763979
   PubMedGoogle Scholar
• RobakTBlonskiJZGora-TyborJSecond malignancies and Richter’s syndrome in patients with chronic lymphocytic leukaemia treated with cladribineEur J Cancer200440338338914746857
   PubMed Web of Science ®Google Scholar
• TravisLBCurtisREHankeyBFFraumeniJFSecond cancers in patients with chronic lymphocytic leukemiaJ Natl Cancer Inst19928418142214271512794
   PubMed Web of Science ®Google Scholar
• MatoARWierdaWGDavidsMSAnalysis of PET-CT to identify Richter’s transformation in 167 patients with disease progression following kinase inhibitor therapyBlood2017130Suppl 1834834
   Google Scholar
• ParikhSAKayNEShanafeltTDHow we treat Richter syndromeBlood2014123111647165724421328
   PubMed Web of Science ®Google Scholar
• YunSVinceletteNDAbrahamIPuvvadaSAnwerFOutcome comparison of allogeneic versus autologous stem cell transplantation in transformed low-grade lymphoid malignancies: a systematic review and pooled analysis of comparative studiesActa Haematol2016136424425527802434
   PubMed Web of Science ®Google Scholar
• DingWLaplantBRCallTGPembrolizumab in patients with CLL and Richter transformation or with relapsed CLLBlood2017129263419342728424162
   PubMed Web of Science ®Google Scholar
• VisentinAImbergamoSScomazzonEBCR kinase inhibitors, idelalisib and ibrutinib, are active and effective in Richter syndromeBr J Haematol Epub201875
   Web of Science ®Google Scholar
• WoyachJAHow I manage ibrutinib-refractory chronic lymphocytic leukemiaBlood2017129101270127428096090
   PubMed Web of Science ®Google Scholar
• LangerbeinsPBuschRAnheierNPoor efficacy and tolerability of R-CHOP in relapsed/refractory chronic lymphocytic leukemia and Richter transformationAm J Hematol20148912E239E24325196783
   PubMed Web of Science ®Google Scholar
• EyreTACliffordRBloorANCRI phase II study of CHOP in combination with ofatumumab in induction and maintenance in newly diagnosed Richter syndromeBr J Haematol20161751435427378086
   PubMed Web of Science ®Google Scholar
• RogersKAHuangYRuppertASA single-institution retrospective cohort study of first-line R-EPOCH chemoimmunotherapy for Richter syndrome demonstrating complex chronic lymphocytic leukaemia karyotype as an adverse prognostic factorBr J Haematol2018180225926629193006
   PubMed Web of Science ®Google Scholar
• TsimberidouAMKantarjianHMCortesJFractionated cyclophosphamide, vincristine, liposomal daunorubicin, and dexamethasone plus rituximab and granulocyte-macrophage-colony stimulating factor (GM-CSF) alternating with methotrexate and cytarabine plus rituximab and GM-CSF in patients with Richter syndrome or fludarabine-refractory chronic lymphocytic leukemiaCancer20039771711172012655528
   PubMed Web of Science ®Google Scholar
• TsimberidouAMWierdaWGWenSPhase I-II clinical trial of oxaliplatin, fludarabine, cytarabine, and rituximab therapy in aggressive relapsed/refractory chronic lymphocytic leukemia or Richter syndromeClin Lymphoma Myeloma Leuk201313556857423810245
   PubMed Web of Science ®Google Scholar
• TsimberidouAMWierdaWGPlunkettWPhase I-II study of oxaliplatin, fludarabine, cytarabine, and rituximab combination therapy in patients with Richter’s syndrome or fludarabine-refractory chronic lymphocytic leukemiaJ Clin Oncol200826219620318182662
   PubMed Web of Science ®Google Scholar
• DurotEMichalletASLeprêtreSLeQHLeblondVDelmerAPlatinum and high-dose cytarabine-based regimens are efficient in ultra high/high-risk chronic lymphocytic leukemia and Richter’s syndrome: results of a French retrospective multicenter studyEur J Haematol201595216016725359318
   PubMed Web of Science ®Google Scholar
• TsangMShanafeltTDCallTGThe efficacy of ibrutinib in the treatment of Richter syndromeBlood2015125101676167825745187
   PubMed Web of Science ®Google Scholar
• HillmenPSchuhAEyreTAAcalabrutinib monotherapy in patients with Richter transformation from the phase 1/2 ACE-CL-001 clinical studyBlood201612822606027222478
   PubMed Web of Science ®Google Scholar
• DavidsMSRobertsAWSeymourJFPhase I first-in-human study of venetoclax in patients with relapsed or refractory non-Hodgkin lymphomaJ Clin Oncol201735882683328095146
   PubMed Web of Science ®Google Scholar
• RogersKAHuangYDotsonEUse of PD-1 (PDCD1) inhibitors for the treatment of Richter syndrome: experience at a single academic centreBr J Haematol Epub2018720
   Google Scholar
• KuruvillaJByrdJCFlynnJMThe Oral Selective Inhibitor of Nuclear Export (SINE) selinexor (KPT-330) demonstrates broad and durable clinical activity in relapsed /refractory Non Hodgkin’s Lymphoma (NHL)Blood201412421396396
   Web of Science ®Google Scholar
• AlderuccioJPMackridesNChapmanJRVegaFLossosISRapid complete response to blinatumomab as a successful bridge to allogeneic stem cell transplantation in a case of refractory Richter syndromeLeuk Lymphoma Epub2018510
   Web of Science ®Google Scholar
• EvansABurackRRothbergPGPorterDEvolution to Plasmablastic Lymphoma (PBL) after CAR-T Cell Therapy in a Case of SLL/CLL with Richter’s TransformationBlood20141242156605660
   Web of Science ®Google Scholar
• ChavezJCLockeFLCAR T cell therapy for B-cell lymphomasBest Pract Res Clin Haematol201831213514629909914
   PubMed Web of Science ®Google Scholar
• LockeFLNeelapuSSBartlettNLPhase 1 results of ZUMA-1: a multicenter study of KTE-C19 anti-CD19 CAR T cell therapy in refractory aggressive lymphomaMol Ther201725128529528129122
   PubMed Web of Science ®Google Scholar
• TsimberidouAMO’BrienSKantarjianHMHodgkin transformation of chronic lymphocytic leukemia: the M. D. Anderson Cancer Center experienceCancer200610761294130216902984
   PubMed Web of Science ®Google Scholar
• BrecherMBanksPMHodgkin’s disease variant of Richter’s syndrome. Report of eight casesAm J Clin Pathol19909333333391689938
   PubMed Web of Science ®Google Scholar
• TadmorTShvidelLGoldschmidtNHodgkin’s variant of Richter transformation in chronic lymphocytic leukemia; a retrospective study from the Israeli CLL Study GroupAnticancer Res201434278579024511013
   PubMed Web of Science ®Google Scholar
• JamroziakKGrzybowska-IzydorczykOJesionek-KupnickaDGora-TyborJRobakTPoor prognosis of Hodgkin variant of Richter transformation in chronic lymphocytic leukemia treated with cladribineBr J Haematol2012158228628822500554
   PubMed Web of Science ®Google Scholar
• BockornyBCodreanuIDasanuCAHodgkin lymphoma as Richter transformation in chronic lymphocytic leukaemia: a retrospective analysis of world literatureBr J Haematol20121561506622017478
   PubMed Web of Science ®Google Scholar
• ParikhSAHabermannTMChaffeeKGHodgkin transformation of chronic lymphocytic leukemia: Incidence, outcomes, and comparison to de novo Hodgkin lymphomaAm J Hematol201590433433825581025
   PubMed Web of Science ®Google Scholar
• MauroFRGalieniPTedeschiAFactors predicting survival in chronic lymphocytic leukemia patients developing Richter syndrome transformation into Hodgkin lymphomaAm J Hematol201792652953528295527
   PubMed Web of Science ®Google Scholar