127
Views
0
CrossRef citations to date
0
Altmetric
REVIEW

Targeted siRNA Therapy for Psoriasis: Translating Preclinical Potential into Clinical Treatments

ORCID Icon, , , , , , , , , , , , , & show all
Pages 259-271 | Received 25 Jan 2024, Accepted 07 May 2024, Published online: 16 May 2024

References

  • Michalek IM, Loring B, John SM. A systematic review of worldwide epidemiology of psoriasis. J Eur Cad Dermatol VenereoAl. 2017;31(2):205–212. doi:10.1111/jdv.13854
  • Ghoreschi K, Balato A, Enerbäck C, et al. Therapeutics targeting the IL-23 and IL-17 pathway in psoriasis. Lancet. 2021;397(10275):754–766. doi:10.1016/S0140-6736(21)00184-7
  • Griffiths CE, Barker JN. Pathogenesis and clinical features of psoriasis. Lancet. 2007;370(9583):263–271. doi:10.1016/S0140-6736(07)61128-3
  • Shen Q, Liu R, Tan S, et al. Advances in pathogenesis and nanoparticles (NPs)-mediated treatment of psoriasis. Front Immunol. 2022;13:1089262. doi:10.3389/fimmu.2022.1089262
  • Yiu ZZ, Griffiths CE. Interleukin 17-A inhibition in the treatment of psoriasis. Expert Rev Clin Immunol. 2016;12(1):1–4. doi:10.1586/1744666X.2016.1112739
  • D’Souza LS, Payette MJ. Estimated cost efficacy of systemic treatments that are approved by the US Food and Drug Administration for the treatment of moderate to severe psoriasis. J Am Acad Dermatol. 2015;72(4):589–598. doi:10.1016/j.jaad.2014.11.028
  • Galloway JB, Hyrich KL, Mercer LK, et al. Anti-TNF therapy is associated with an increased risk of serious infections in patients with rheumatoid arthritis especially in the first 6 months of treatment: updated results from the British Society for Rheumatology Biologics Register with special emphasis on risks in the elderly. Rheumatology. 2011;50(1):124–131. doi:10.1093/rheumatology/keq242
  • Carmona-Rocha E, Rusiñol L, Puig L. New and emerging oral/topical small-molecule treatments for psoriasis. Pharmaceutics. 2024;16(2):239. doi:10.3390/pharmaceutics16020239
  • Lee WR, Lin YK, Alalaiwe A, et al. Fractional laser-mediated siRNA delivery for mitigating psoriasis-like lesions via IL-6 silencing. Mol Ther Nucleic Acids. 2020;19:240–251. doi:10.1016/j.omtn.2019.11.013
  • Saw PE, Song EW. siRNA therapeutics: a clinical reality. Sci China Life Sci. 2020;63(4):485–500. doi:10.1007/s11427-018-9438-y
  • Lamb YN. Inclisiran: first Approval [published correction appears in Drugs. 2021 Jun;81(9):1129]. Drugs. 2021;81(3):389–395. doi:10.1007/s40265-021-01473-6
  • Zhu L, Luo J, Ren K. Nucleic acid-based artificial nanocarriers for gene therapy. J Mater Chem B. 2023;11(2):261–279. doi:10.1039/D2TB01179D
  • Ni X, Lai Y. Keratinocyte: a trigger or an executor of psoriasis? J Leukoc Biol. 2020;108(2):485–491. doi:10.1002/JLB.5MR0120-439R
  • Xu N, Brodin P, Wei T, et al. MiR-125b, a microRNA downregulated in psoriasis, modulates keratinocyte proliferation by targeting FGFR2. J Invest Dermatol. 2011;131(7):1521–1529. doi:10.1038/jid.2011.55
  • Hampton PJ, Jans R, Flockhart RJ, et al. Lithium regulates keratinocyte proliferation via glycogen synthase kinase 3 and NFAT2 (Nuclear Factor of Activated T Cells 2). J Cell Physiol. 2012;227(4):1529–1537. doi:10.1002/jcp.22872
  • Song Y, Chen L, Li Y, et al. Knockdown of TRAF3IP2 suppresses the expression of VEGFA and the proliferation of keratinocytes and vascular endothelial cells. Heliyon. 2019;5(5):e01642. doi:10.1016/j.heliyon.2019.e01642
  • Szegedi K, Sonkoly E, Nagy N, et al. The anti-apoptotic protein G1P3 is overexpressed in psoriasis and regulated by the non-coding RNA, PRINS. Exp Dermatol. 2010;19(3):269–278. doi:10.1111/j.1600-0625.2010.01066.x
  • Gao Y, Yi X, Ding Y. Combined transcriptomic analysis revealed AKR1B10 played an important role in psoriasis through the dysregulated lipid pathway and overproliferation of keratinocyte. Biomed Res Int. 2017;2017:8717369. doi:10.1155/2017/8717369
  • Zieba BA, Henry L, Lacroix M, et al. The proteasome maturation protein POMP increases proteasome assembly and activity in psoriatic lesional skin. J Dermatol Sci. 2017;88(1):10–19. doi:10.1016/j.jdermsci.2017.04.009
  • Fang Y, C E, Wu S, et al. Circ-IGF1R plays a significant role in psoriasis via regulation of a miR-194-5p/CDK1 axis. Cytotechnology. 2021;73(6):775–785. doi:10.1007/s10616-021-00496-x
  • Liu XB, Li F, Li YQ, et al. Pituitary tumor transforming gene PTTG2 induces psoriasis by regulating vimentin and E-cadherin expression. Int J Clin Exp Pathol. 2015;8(9):10887–10893.
  • Gao J, Chen F, Hua M, et al. Knockdown of lncRNA MIR31HG inhibits cell proliferation in human HaCaT keratinocytes. Biol Res. 2018;51(1):30. doi:10.1186/s40659-018-0181-8
  • Umegaki-Arao N, Tamai K, Nimura K, et al. Karyopherin alpha2 is essential for rRNA transcription and protein synthesis in proliferative keratinocytes. PLoS One. 2013;8(10):e76416. doi:10.1371/journal.pone.0076416
  • Liao Y, Su Y, Wu R, et al. Overexpression of Wilms tumor 1 promotes IL-1β expression by upregulating histone acetylation in keratinocytes. Int Immunopharmacol. 2021;96:107793. doi:10.1016/j.intimp.2021.107793
  • Kong Y, Wu R, Zhang S, et al. Wilms’ tumor 1-associating protein contributes to psoriasis by promoting keratinocytes proliferation via regulating cyclinA2 and CDK2. Int Immunopharmacol. 2020;88:106918. doi:10.1016/j.intimp.2020.106918
  • Adamo P, Ladomery MR. The oncogene ERG: a key factor in prostate cancer. Oncogene. 2016;35(4):403–414. doi:10.1038/onc.2015.109
  • Kristl J, Slanc P, Krasna M, et al. Calcipotriol affects keratinocyte proliferation by decreasing expression of early growth response-1 and polo-like kinase-2. Pharm Res. 2008;25(3):521–529. doi:10.1007/s11095-007-9388-z
  • Chen JG, Fan HY, Wang T, et al. Silencing KRT16 inhibits keratinocyte proliferation and VEGF secretion in psoriasis via inhibition of ERK signaling pathway. Kaohsiung J Med Sci. 2019;35(5):284–296. doi:10.1002/kjm2.12034
  • Chang T, Sun L, Wang Y, et al. Inhibition of keratin 17 expression with antisense and RNAi strategies: exploring novel therapy for psoriasis. Exp Dermatol. 2011;20(7):555–560. doi:10.1111/j.1600-0625.2010.01235.x
  • Yang L, Fan X, Cui T, et al. Nrf2 Promotes Keratinocyte Proliferation in Psoriasis through Up-Regulation of Keratin 6, Keratin 16, and Keratin 17. J Invest Dermatol. 2017;137(10):2168–2176. doi:10.1016/j.jid.2017.05.015
  • Dallaglio K, Marconi A, Truzzi F, et al. E-FABP induces differentiation in normal human keratinocytes and modulates the differentiation process in psoriatic keratinocytes in vitro. Exp Dermatol. 2013;22(4):255–261. doi:10.1111/exd.12111
  • Luo Y, Pang B, Hao J, et al. Keratin 17 covalently binds to alpha-enolase and exacerbates proliferation of keratinocytes in psoriasis. Int J Biol Sci. 2023;19(11):3395–3411. doi:10.7150/ijbs.83141
  • Yu J, Zhao Q, Wang X, et al. Pathogenesis, multi-omics research, and clinical treatment of psoriasis. J Autoimmun. 2022;133:102916. doi:10.1016/j.jaut.2022.102916
  • Zhou X, Chen Y, Cui L, et al. Advances in the pathogenesis of psoriasis: from keratinocyte perspective. Cell Death Dis. 2022;13(1):81. doi:10.1038/s41419-022-04523-3
  • Ran L-W, Wang H, Lan D, et al. Effect of RNA interference targeting STAT3 gene combined with ultrasonic irradiation and SonoVue microbubbles on proliferation and apoptosis in keratinocytes of psoriatic lesions. Chin Med J. 2018;131(17):2097–2104. doi:10.4103/0366-6999.239297
  • Qin X, Chen C, Zhang Y, et al. Acitretin modulates HaCaT cells proliferation through STAT1- and STAT3-dependent signaling. Saudi Pharm J. 2017;25(4):620–624. doi:10.1016/j.jsps.2017.04.034
  • Huang W, Zheng X, Huang Q, et al. Protein Kinase CK2 promotes proliferation, abnormal differentiation, and proinflammatory cytokine production of keratinocytes via regulation of STAT3 and Akt pathways in psoriasis. Am J Pathol. 2023;193(5):567–578. doi:10.1016/j.ajpath.2023.01.016
  • Lerman G, Volman E, Sidi Y, et al. Small-interfering RNA targeted at antiapoptotic mRNA increases keratinocyte sensitivity to apoptosis. Br J Dermatol. 2011;164(5):947–956. doi:10.1111/j.1365-2133.2010.10191.x
  • Tonel G, Conrad C. Interplay between keratinocytes and immune cells--recent insights into psoriasis pathogenesis. Int J Biochem Cell Biol. 2009;41(5):963–968. doi:10.1016/j.biocel.2008.10.022
  • Zhu H, Hou L, Liu J, et al. MiR-217 is down-regulated in psoriasis and promotes keratinocyte differentiation via targeting GRHL2. Biochem Biophys Res Commun. 2016;471(1):169–176. doi:10.1016/j.bbrc.2016.01.157
  • Jeon S, Song J, Lee D, et al. Inhibition of sphingosine 1-phosphate lyase activates human keratinocyte differentiation and attenuates psoriasis in mice. J Lipid Res. 2020;61(1):20–32. doi:10.1194/jlr.RA119000254
  • Hong JH, Youm JK, Kwon MJ, et al. K6PC-5, a direct activator of sphingosine kinase 1, promotes epidermal differentiation through intracellular Ca2+ signaling. J Invest Dermatol. 2008;128(9):2166–2178. doi:10.1038/jid.2008.66
  • Xu D, Wang J. Downregulation of cathepsin B reduces proliferation and inflammatory response and facilitates differentiation in human HaCaT keratinocytes, ameliorating IL-17A and SAA-induced psoriasis-like lesion. Inflammation. 2021;44(5):2006–2017. doi:10.1007/s10753-021-01477-0
  • Lian N, Chen Y, Chen S, et al. Gasdermin D-mediated keratinocyte pyroptosis as a key step in psoriasis pathogenesis. Cell Death Dis. 2023;14(9):595. doi:10.1038/s41419-023-06094-3
  • Yamamoto T. Angiogenic and inflammatory properties of psoriatic arthritis. ISRN Dermatol. 2013;2013:630620. doi:10.1155/2013/630620
  • Patel AB, Tsilioni I, Weng Z, et al. TNF stimulates IL-6, CXCL 8 and VEGF secretion from human keratinocytes via activation of mTOR, inhibited by tetramethoxyluteolin. Exp Dermatol. 2018;27(2):135–143. doi:10.1111/exd.13461
  • Benhadou F, Glitzner E, Brisebarre A, et al. Epidermal autonomous VEGFA/Flt1/Nrp1 functions mediate psoriasis-like disease. Sci Adv. 2020;6(2):eaax5849. doi:10.1126/sciadv.aax5849
  • Nicchia GP, Stigliano C, Sparaneo A, et al. Inhibition of aquaporin-1 dependent angiogenesis impairs tumour growth in a mouse model of melanoma. J Mol Med. 2013;91(5):613–623. doi:10.1007/s00109-012-0977-x
  • Zhang J, Ma WY. Nerve growth factor regulates the expression of vascular endothelial growth factor in human HaCaT keratinocytes via PI3K/mTOR pathway. Genet Mol Res. 2014;13(4):9324–9335. doi:10.4238/2014.January.24.14
  • Niu X, Han Q, Li X, et al. EDIL3 influenced the αvβ3-FAK/MEK/ERK axis of endothelial cells in psoriasis. J Cell Mol Med. 2022;26(20):5202–5212. doi:10.1111/jcmm.17544
  • Ghosh D, Ganguly T, Chatterjee R. Emerging roles of non-coding RNAs in psoriasis pathogenesis. Funct Integr Genomics. 2023;23(2):129. doi:10.1007/s10142-023-01057-5
  • Grän F, Kerstan A, Serfling E, et al. Current developments in the immunology of psoriasis. Yale J Biol Med. 2020;93(1):97–110. doi:10.1038/jid.2012.339
  • Ding Y, Gong P, Jiang J, et al. Mesenchymal stem/stromal cells primed by inflammatory cytokines alleviate psoriasis-like inflammation via the TSG-6-neutrophil axis. Cell Death Dis. 2022;13(11):996. doi:10.1038/s41419-022-05445-w
  • Chen F, Wu S, Zhan J, et al. IL-22-induced ubiquitin-specific protease 15 promotes proliferation and inflammation of keratinocytes through stabilization of squamous cell carcinoma antigen 2. J Invest Dermatol. 2024;144(1):63–72.e4. doi:10.1016/j.jid.2023.07.006
  • Xiao CY, Zhu ZL, Zhang C, et al. Small interfering RNA targeting of keratin 17 reduces inflammation in imiquimod-induced psoriasis-like dermatitis. Chin Med J. 2020;133(24):2910–2918. doi:10.1097/CM9.0000000000001197
  • Bertelsen T, Ljungberg C, Boye Kjellerup R, et al. IL-17F regulates psoriasis-associated genes through IκBζ. Exp Dermatol. 2017;26(3):234–241. doi:10.1111/exd.13182
  • Bertelsen T, Iversen L, Johansen C. The human IL-17A/F heterodimer regulates psoriasis-associated genes through IκBζ. Exp Dermatol. 2018;27(9):1048–1052. doi:10.1111/exd.13722
  • Johansen C, Mose M, Ommen P, et al. IκBζ is a key driver in the development of psoriasis. Proc Natl Acad Sci U S A. 2015;112(43):E5825–E5833. doi:10.1073/pnas.1509971112
  • Wang A, Wei J, Lu C, et al. Genistein suppresses psoriasis-related inflammation through a STAT3-NF-κB-dependent mechanism in keratinocytes. Int Immunopharmacol. 2019;69:270–278. doi:10.1016/j.intimp.2019.01.054
  • Fan T, Wang S, Yu L, et al. Treating psoriasis by targeting its susceptibility gene Rel. Clin Immunol. 2016;165:47–54. doi:10.1016/j.clim.2016.03.009
  • Gao Y, Lu J, Bao X, et al. Inhibition of phospholipases suppresses progression of psoriasis through modulation of inflammation. Exp Biol Med. 2021;246(11):1253–1262. doi:10.1177/1535370221993424
  • Xiang X, Tu C, Li Q, et al. Oxymatrine ameliorates imiquimod-induced psoriasis pruritus and inflammation through inhibiting Heat Shock Protein 90 and Heat Shock Protein 60 expression in keratinocytes. Toxicol Appl Pharmacol. 2020;405:115209. doi:10.1016/j.taap.2020.115209
  • Hsieh WL, Huang YH, Wang TM, et al. IFI27, a novel epidermal growth factor-stabilized protein, is functionally involved in proliferation and cell cycling of human epidermal keratinocytes. Cell Prolif. 2015;48(2):187–197. doi:10.1111/cpr.12168
  • Deng Y, Chen J, Zhao Y, et al. Transdermal Delivery of siRNA through Microneedle Array. Sci Rep. 2016;6(1):21422. doi:10.1038/srep21422
  • Dharamdasani V, Mandal A, Qi QM, et al. Topical delivery of siRNA into skin using ionic liquids. J Control Release. 2020;323:475–482. doi:10.1016/j.jconrel.2020.04.038
  • Mandal A, Kumbhojkar N, Reilly C, et al. Treatment of psoriasis with NFKBIZ siRNA using topical ionic liquid formulations. Sci Adv. 2020;6(30):eabb6049. doi:10.1126/sciadv.abb6049
  • Hsu T, Mitragotri S. Delivery of siRNA and other macromolecules into skin and cells using a peptide enhancer. Proc Natl Acad Sci U S A. 2011;108(38):15816–15821. doi:10.1073/pnas.1016152108
  • Desmet E, Van Gele M, Grine L, Remaut K, Lambert J. Towards the development of a RNAi-based topical treatment for psoriasis: proof-of-concept in a 3D psoriasis skin model. Exp Dermatol. 2018;27(5):463–469. doi:10.1111/exd.13414
  • Feng AP, He YM, Liu XX, et al. Expression of USP15, TβR-I and Smad7 in psoriasis. J Huazhong Univ Sci Technolog Med Sci. 2014;34(3):415–419. doi:10.1007/s11596-014-1293-1
  • Vaher H, Kivihall A, Runnel T, et al. SERPINB2 and miR-146a/b are coordinately regulated and act in the suppression of psoriasis-associated inflammatory responses in keratinocytes. Exp Dermatol. 2020;29(1):51–60. doi:10.1111/exd.14049
  • Rooney P, Connolly M, Gao W, et al. Notch-1 mediates endothelial cell activation and invasion in psoriasis. Exp Dermatol. 2014;23(2):113–118. doi:10.1111/exd.12306
  • Ji X, Chen H, Xie L, et al. The study of GSDMB in pathogenesis of psoriasis vulgaris. PLoS One. 2023;18(1):e0279908. doi:10.1371/journal.pone.0279908
  • Li R, Wang J, Wang X, et al. Increased βTrCP are associated with imiquimod-induced psoriasis-like skin inflammation in mice via NF-κB signaling pathway. Gene. 2016;592(1):164–171. doi:10.1016/j.gene.2016.07.066
  • Kaikai S, Yuchen S, Lili J, Zhengtao W. Critical role of c-Jun N-terminal kinase in regulating bFGF-induced angiogenesis in vitro. J Biochem. 2011;150(2):189–197. doi:10.1093/jb/mvr060
  • Ezure T, Amano S. Stanniocalcin-1 mediates negative regulatory action of epidermal layer on expression of matrix-related genes in dermal fibroblasts. Biofactors. 2019;45(6):944–949. doi:10.1002/biof.1547
  • Qiu X, Zheng L, Liu X, et al. ULK1 inhibition as a targeted therapeutic strategy for psoriasis by regulating keratinocytes and their crosstalk with neutrophils. Front Immunol. 2021;12:714274. doi:10.3389/fimmu.2021.714274
  • Xu M, Zhang Y, Cheng H, et al. Transcription factor 7-like 1 dysregulates keratinocyte differentiation through upregulating lipocalin 2. Cell Death Discov. 2016;2(1):16028. doi:10.1038/cddiscovery.2016.28
  • Vegfors J, Ekman AK, Stoll SW, Bivik Eding C, Enerbäck C. Psoriasin (S100A7) promotes stress-induced angiogenesis. Br J Dermatol. 2016;175(6):1263–1273. doi:10.1111/bjd.14718
  • Wang H, Ran LW, Hui K, et al. Survivin 和PI3K、AKT在寻常型银屑病皮损角质形成细胞中的表达及其相关性 [Expressions of survivin, PI3K and AKT in keratinocytes in skin lesions and their pathogenic role in psoriasis vulgaris]. Nan Fang Yi Ke Da Xue Xue Bao. 2017;37(11):1512–1516. Chinese. doi:10.3969/j.issn.1673-4254.2017.11.14
  • Tu C, Wang S, Hu X, et al. Lipopolysaccharide induces TREM-1-dependent HIF-1α expression in human keratinocyte cell line. Cell Biol Int. 2016;40(12):1357–1365. doi:10.1002/cbin.10693
  • Koegel H, von Tobel L, Schäfer M, et al. Loss of serum response factor in keratinocytes results in hyperproliferative skin disease in mice. J Clin Invest. 2009;119(4):899–910. doi:10.1172/JCI37771
  • Gargalionis AN, Malakou LS, Adamopoulos C, et al. Polycystin-1 downregulation induces ERK-dependent mTOR pathway activation in a cellular model of psoriasis. Biochim Biophys Acta Mol Basis Dis. 2018;1864(10):3468–3476. doi:10.1016/j.bbadis.2018.07.036
  • Tian R, Li Y, Yao X. PGRN Suppresses Inflammation and Promotes Autophagy in Keratinocytes Through the Wnt/β-Catenin Signaling Pathway. Inflammation. 2016;39(4):1387–1394. doi:10.1007/s10753-016-0370-y
  • Shan Y, Zhao J, Wei K, et al. A comprehensive review of Tripterygium wilfordii hook. f. in the treatment of rheumatic and autoimmune diseases: bioactive compounds, mechanisms of action, and future directions. Front Pharmacol. 2023;14:1282610. doi:10.3389/fphar.2023.1282610
  • Camela E, Potestio L, Fabbrocini G, Pallotta S, Megna M. The holistic approach to psoriasis patients with comorbidities: the role of investigational drugs. Expert Opin Investig Drugs. 2023;32(6):537–552. doi:10.1080/13543784.2023.2219387