The hygiene hypothesis: current perspectives and future therapies

References

• No authors listedWorldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC. The International Study of Asthma and Allergies in Childhood (ISAAC) Steering CommitteeLancet19983519111122512329643741
   PubMed Web of Science ®Google Scholar
• AnandanCNurmatovUvan SchayckOCSheikhAIs the prevalence of asthma declining? Systematic review of epidemiological studiesAllergy201065215216719912154
   PubMed Web of Science ®Google Scholar
• OkadaHKuhnCFeilletHBachJFThe ‘hygiene hypothesis’ for autoimmune and allergic diseases: an updateClin Exp Immunol201016011920415844
   PubMed Web of Science ®Google Scholar
• BrooksCPearceNDouwesJThe hygiene hypothesis in allergy and asthma: an updateCurr Opin Allergy Clin Immunol2013131707723103806
   PubMed Web of Science ®Google Scholar
• GreenwoodBMPolyarthritis in Western Nigeria. I. Rheumatoid arthritisAnn Rheum Dis19692854884964186678
   PubMed Web of Science ®Google Scholar
• GreenwoodBMHerrickEMVollerASuppression of autoimmune disease in NZB and (NZB x NZW) F1 hybrid mice by infection with malariaNature197022652422662675437516
   PubMed Web of Science ®Google Scholar
• GerrardJWGeddesCARegginPLGerrardCDHorneSSerum IgE levels in white and metis communities in SaskatchewanAnn Allergy197637291100987744
   PubMedGoogle Scholar
• StrachanDPHay fever, hygiene, and household sizeBMJ19892996710125912602513902
   PubMed Web of Science ®Google Scholar
• StrachanDPTaylorEMCarpenterRGFamily structure, neonatal infection, and hay fever in adolescenceArch Dis Child19967454224268669958
   PubMed Web of Science ®Google Scholar
• OwnbyDRJohnsonCCPetersonELExposure to dogs and cats in the first year of life and risk of allergic sensitization at 6 to 7 years of ageJAMA2002288896397212190366
   PubMed Web of Science ®Google Scholar
• BennCSMelbyeMWohlfahrtJBjörksténBAabyPCohort study of sibling effect, infectious diseases, and risk of atopic dermatitis during first 18 months of lifeBMJ20043287450122315121716
   PubMed Web of Science ®Google Scholar
• MatricardiPMRosminiFRiondinoSExposure to foodborne and orofecal microbes versus airborne viruses in relation to atopy and allergic asthma: epidemiological studyBMJ2000320723241241710669445
   PubMed Web of Science ®Google Scholar
• EgeMJMayerMNormandACGABRIELA Transregio 22 Study GroupExposure to environmental microorganisms and childhood asthmaN Engl J Med2011364870170921345099
   PubMed Web of Science ®Google Scholar
• MosmannTRCherwinskiHBondMWGiedlinMACoffmanRLTwo types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteinsJ Immunol19861367234823572419430
   PubMed Web of Science ®Google Scholar
• BosnjakBStelzmuellerBErbKJEpsteinMMTreatment of allergic asthma: modulation of Th2 cells and their responsesRespir Res20111211421867534
   PubMed Web of Science ®Google Scholar
• HuangLKriegAMEllerNScottDEInduction and regulation of Th1-inducing cytokines by bacterial DNA, lipopolysaccharide, and heat-inactivated bacteriaInfect Immun199967126257626310569735
   PubMed Web of Science ®Google Scholar
• OrissTBMcCarthySAMorelBFCampanaMAMorelPACrossregulation between T helper cell (Th)1 and Th2: inhibition of Th2 proliferation by IFN-gamma involves interference with IL-1J Immunol19971588366636729103429
   PubMed Web of Science ®Google Scholar
• MaizelsRMMcSorleyHJSmythDJHelminths in the hygiene hypothesis: sooner or later?Clin Exp Immunol20141771384624749722
   PubMed Web of Science ®Google Scholar
• O’SheaJJPaulWEMechanisms underlying lineage commitment and plasticity of helper CD4+ T cellsScience201032759691098110220185720
   PubMed Web of Science ®Google Scholar
• LloydCMSaglaniST cells in asthma: influences of genetics, environment, and T-cell plasticityJ Allergy Clin Immunol2013131512671274 quiz 127523541326
   PubMed Web of Science ®Google Scholar
• HolgateSTInnate and adaptive immune responses in asthmaNat Med201218567368322561831
   PubMed Web of Science ®Google Scholar
• RookGAAdamsVHuntJPalmerRMartinelliRBrunetLRMycobacteria and other environmental organisms as immunomodulators for immunoregulatory disordersSpringer Semin Immunopathol2004253–423725515007629
   PubMed Web of Science ®Google Scholar
• NoverrMCHuffnagleGBThe ‘microflora hypothesis’ of allergic diseasesClin Exp Allergy200535121511152016393316
   PubMed Web of Science ®Google Scholar
• RookGABrunetLRMicrobes, immunoregulation, and the gutGut200554331732015710972
   PubMed Web of Science ®Google Scholar
• van den BiggelaarAHvan ReeRRodriguesLCDecreased atopy in children infected with Schistosoma haematobium: a role for parasite-induced interleukin-10Lancet200035692431723172711095260
   PubMed Web of Science ®Google Scholar
• WilsonMSTaylorMDBalicAFinneyCAMLambJRMaizelsRMSuppression of allergic airway inflammation by helminth-induced regulatory T cellsJ Exp Med200520291199121216275759
   PubMed Web of Science ®Google Scholar
• KitagakiKBusingaTRRacilaDElliottDEWeinstockJVKlineJNIntestinal helminths protect in a murine model of asthmaJ Immunol200617731628163516849471
   PubMed Web of Science ®Google Scholar
• ManganNEFallonRESmithPvan RooijenNMcKenzieANFallonPGHelminth infection protects mice from anaphylaxis via IL-10-producing B cellsJ Immunol2004173106346635615528374
   PubMed Web of Science ®Google Scholar
• LiuQSundarKMishraPKHelminth infection can reduce insulitis and type 1 diabetes through CD25- and IL-10-independent mechanismsInfect Immun200977125347535819752032
   PubMed Web of Science ®Google Scholar
• MishraPKPatelNWuWBleichDGauseWCPrevention of type 1 diabetes through infection with an intestinal nematode parasite requires IL-10 in the absence of a Th2-type responseMucosal Immunol20136229730822806101
   PubMed Web of Science ®Google Scholar
• HübnerMPStockerJTMitreEInhibition of type 1 diabetes in filaria-infected non-obese diabetic mice is associated with a T helper type 2 shift and induction of FoxP3+ regulatory T cellsImmunology2009127451252219016910
   PubMed Web of Science ®Google Scholar
• HübnerMPShiYTorreroMNHelminth protection against autoimmune diabetes in nonobese diabetic mice is independent of a type 2 immune shift and requires TGF-betaJ Immunol2012188255956822174447
   PubMed Web of Science ®Google Scholar
• McSorleyHJMaizelsRMHelminth infections and host immune regulationClin Microbiol Rev201225458560823034321
   PubMed Web of Science ®Google Scholar
• O’haraAMShanahanFThe gut flora as a forgotten organEmbo Reports20067768869316819463
   PubMed Web of Science ®Google Scholar
• PollardMSharonNResponses of the Peyer’s patches in germ-free mice to antigenic stimulationInfect Immun1970219610016557807
   PubMedGoogle Scholar
• RoundJLMazmanianSKThe gut microbiota shapes intestinal immune responses during health and diseaseNat Rev Immunol20099531332319343057
   PubMed Web of Science ®Google Scholar
• FagundesCTAmaralFAVieiraATTransient TLR activation restores inflammatory response and ability to control pulmonary bacterial infection in germfree miceJ Immunol201218831411142022210917
   PubMed Web of Science ®Google Scholar
• InagakiHSuzukiTNomotoKYoshikaiYIncreased susceptibility to primary infection with Listeria monocytogenes in germfree mice may be due to lack of accumulation of L-selectin+ CD44+ T cells in sites of inflammationInfect Immun1996648328032878757865
   PubMed Web of Science ®Google Scholar
• YiPLiLThe germfree murine animal: an important animal model for research on the relationship between gut microbiota and the hostVet Microbiol20121571–21722079217
   PubMed Web of Science ®Google Scholar
• CashHLWhithamCVBehrendtCLHooperLVSymbiotic bacteria direct expression of an intestinal bactericidal lectinScience200631357901126113016931762
   PubMed Web of Science ®Google Scholar
• LindénSKFlorinTHMcGuckinMAMucin dynamics in intestinal bacterial infectionPLoS One2008312e395219088856
   PubMed Web of Science ®Google Scholar
• Rakoff-NahoumSPaglinoJEslami-VarzanehFEdbergSMedzhitovRRecognition of commensal microflora by toll-like receptors is required for intestinal homeostasisCell2004118222924115260992
   PubMed Web of Science ®Google Scholar
• CordingSFleissnerDHeimesaatMMCommensal microbiota drive proliferation of conventional and Foxp3(+) regulatory CD4(+) T cells in mesenteric lymph nodes and Peyer’s patchesEur J Microbiol Immunol (Bp)20133111024265914
   PubMedGoogle Scholar
• ShawMHKamadaNKimYGNúñezGMicrobiota-induced IL-1beta, but not IL-6, is critical for the development of steady-state TH17 cells in the intestineJ Exp Med2012209225125822291094
   PubMed Web of Science ®Google Scholar
• AtarashiKTanoueTShimaTInduction of colonic regulatory T cells by indigenous Clostridium speciesScience2011331601533734121205640
   PubMed Web of Science ®Google Scholar
• MarcobalABarbozaMFroehlichJWConsumption of human milk oligosaccharides by gut-related microbesJ Agric Food Chem20105895334534020394371
   PubMed Web of Science ®Google Scholar
• TrompetteAGollwitzerESYadavaKGut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesisNat Med201420215916624390308
   PubMed Web of Science ®Google Scholar
• WongJMde SouzaRKendallCWEmamAJenkinsDJColonic health: fermentation and short chain fatty acidsJ Clin Gastroenterol200640323524316633129
   PubMed Web of Science ®Google Scholar
• ParkJKimMKangSGShort-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR-S6K pathwayMucosal Immunol201581809324917457
   PubMed Web of Science ®Google Scholar
• SmithPMHowittMRPanikovNThe microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasisScience2013341614556957323828891
   PubMed Web of Science ®Google Scholar
• AbrahamssonTRJakobssonHEAnderssonAFBjörksténBEngstrandLJenmalmMCLow gut microbiota diversity in early infancy precedes asthma at school ageClin Exp Allergy201444684285024330256
   PubMed Web of Science ®Google Scholar
• AzadMBKonyaTGuttmanDSCHILD Study InvestigatorsInfant gut microbiota and food sensitization: associations in the first year of lifeClin Exp Allergy201545363264325599982
   PubMed Web of Science ®Google Scholar
• Hoskin-ParrLTeyhanABlockerAHendersonAJAntibiotic exposure in the first two years of life and development of asthma and other allergic diseases by 7.5 yr: a dose-dependent relationshipPediatr Allergy Immunol201324876277124299467
   PubMed Web of Science ®Google Scholar
• KummelingIStelmaFFDagneliePCEarly life exposure to antibiotics and the subsequent development of eczema, wheeze, and allergic sensitization in the first 2 years of life: the KOALA Birth Cohort StudyPediatrics20071191e225e23117200248
   PubMed Web of Science ®Google Scholar
• JakobssonHEAbrahamssonTRJenmalmMCDecreased gut microbiota diversity, delayed Bacteroidetes colonisation and reduced Th1 responses in infants delivered by caesarean sectionGut201463455956623926244
   PubMed Web of Science ®Google Scholar
• PendersJThijsCVinkCFactors influencing the composition of the intestinal microbiota in early infancyPediatrics2006118251152116882802
   PubMed Web of Science ®Google Scholar
• ArslanogluSMoroGESchmittJTandoiLRizzardiSBoehmGEarly dietary intervention with a mixture of prebiotic oligosaccharides reduces the incidence of allergic manifestations and infections during the first two years of lifeJ Nutr200813861091109518492839
   PubMed Web of Science ®Google Scholar
• PendersJGerholdKStobberinghEEEstablishment of the intestinal microbiota and its role for atopic dermatitis in early childhoodJ Allergy Clin Immunol20131323601607.e823900058
   PubMed Web of Science ®Google Scholar
• MulloolyJPSchulerRBarrettMMaherJEVaccines, antibiotics, and atopyPharmacoepidemiol Drug Saf200716327528816794993
   PubMed Web of Science ®Google Scholar
• OrtqvistAKLundholmCKielerHAntibiotics in fetal and early life and subsequent childhood asthma: nationwide population based study with sibling analysisBMJ2014349g697925432937
   PubMed Web of Science ®Google Scholar
• SearsMRGreeneJMWillanARLong-term relation between breastfeeding and development of atopy and asthma in children and young adults: a longitudinal studyLancet2002360933790190712354471
   PubMed Web of Science ®Google Scholar
• AlmqvistCCnattingiusSLichtensteinPLundholmCThe impact of birth mode of delivery on childhood asthma and allergic diseases – a sibling studyClin Exp Allergy20124291369137622925323
   PubMed Web of Science ®Google Scholar
• MaitraASherriffAStrachanDHendersonJTeamASMode of delivery is not associated with asthma or atopy in childhoodClin Exp Allergy20043491349135515347366
   PubMed Web of Science ®Google Scholar
• KramerMSMatushLVanilovichIPromotion of Breastfeeding Intervention Trial (PROBIT) Study GroupEffect of prolonged and exclusive breast feeding on risk of allergy and asthma: cluster randomised trialBMJ2007335762481517855282
   PubMed Web of Science ®Google Scholar
• ForsythePInmanMDBienenstockJOral treatment with live Lactobacillus reuteri inhibits the allergic airway response in miceAm J Respir Crit Care Med2007175656156917204726
   PubMed Web of Science ®Google Scholar
• SchabussovaIHufnaglKWildCDistinctive anti-allergy properties of two probiotic bacterial strains in a mouse model of allergic poly-sensitizationVaccine201129101981199021216308
   PubMed Web of Science ®Google Scholar
• LyonsAO’MahonyDO’BrienFBacterial strain-specific induction of Foxp3+ T regulatory cells is protective in murine allergy modelsClin Exp Allergy201040581181920067483
   PubMed Web of Science ®Google Scholar
• OlszakTAnDZeissigSMicrobial exposure during early life has persistent effects on natural killer T cell functionScience2012336608048949322442383
   PubMed Web of Science ®Google Scholar
• ArnoldICDehzadNReuterSHelicobacter pylori infection prevents allergic asthma in mouse models through the induction of regulatory T cellsJ Clin Invest201112183088309321737881
   PubMed Web of Science ®Google Scholar
• RussellSLGoldMJWillingBPThorsonLMcNagnyKMFinlayBBPerinatal antibiotic treatment affects murine microbiota, immune responses and allergic asthmaGut Microbes20134215816423333861
   PubMed Web of Science ®Google Scholar
• RussellSLGoldMJReynoldsLAPerinatal antibiotic-induced shifts in gut microbiota have differential effects on inflammatory lung diseasesJ Allergy Clin Immunol2015135110010925145536
   PubMed Web of Science ®Google Scholar
• ArrietaMCStiemsmaLTAmenyogbeNBrownEMFinlayBThe intestinal microbiome in early life: health and diseaseFront Immunol2014542725250028
   PubMed Web of Science ®Google Scholar
• MolodeckyNASoonISRabiDMIncreasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic reviewGastroenterol201214214654.e42 quiz e30
   PubMed Web of Science ®Google Scholar
• SellonRKTonkonogySSchultzMResident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient miceInfect Immun19986611522452319784526
   PubMed Web of Science ®Google Scholar
• MadsenKLDoyleJSTaverniniMMJewellLDRennieRPFedorakRNAntibiotic therapy attenuates colitis in interleukin 10 gene-deficient miceGastroenterol2000118610941105
   PubMed Web of Science ®Google Scholar
• BamiasGMariniMMoskalukCADown-regulation of intestinal lymphocyte activation and Th1 cytokine production by antibiotic therapy in a murine model of Crohn’s diseaseJ Immunol200216995308531412391251
   PubMed Web of Science ®Google Scholar
• HoentjenFHarmsenHJBraatHAntibiotics with a selective aerobic or anaerobic spectrum have different therapeutic activities in various regions of the colon in interleukin 10 gene deficient miceGut200352121721172714633949
   PubMed Web of Science ®Google Scholar
• ShawSYBlanchardJFBernsteinCNAssociation between the use of antibiotics and new diagnoses of Crohn’s disease and ulcerative colitisAm J Gastroenterol2011106122133214221912437
   PubMed Web of Science ®Google Scholar
• HviidASvanströmHFrischMAntibiotic use and inflammatory bowel diseases in childhoodGut2011601495420966024
   PubMed Web of Science ®Google Scholar
• ShawSYBlanchardJFBernsteinCNAssociation between the use of antibiotics in the first year of life and pediatric inflammatory bowel diseaseAm J Gastroenterol2010105122687269220940708
   PubMed Web of Science ®Google Scholar
• KoidoSOhkusaTKajiuraTLong-term alteration of intestinal microbiota in patients with ulcerative colitis by antibiotic combination therapyPLoS One201491e8670224489770
   PubMed Web of Science ®Google Scholar
• RogierEWFrantzALBrunoMESecretory antibodies in breast milk promote long-term intestinal homeostasis by regulating the gut microbiota and host gene expressionProc Natl Acad Sci U S A201411183074307924569806
   PubMed Web of Science ®Google Scholar
• BarclayARRussellRKWilsonMLGilmourWHSatsangiJWilsonDCSystematic review: the role of breastfeeding in the development of pediatric inflammatory bowel diseaseJ Pediatr2009155342142619464699
   PubMed Web of Science ®Google Scholar
• KarvonenMViik-KajanderMMoltchanovaELibmanILaPorteRTuomilehtoJIncidence of childhood type 1 diabetes worldwide. Diabetes Mondiale (DiaMond) Project GroupDiabetes Care200023101516152611023146
   PubMed Web of Science ®Google Scholar
• DIAMOND Project GroupIncidence and trends of childhood Type 1 diabetes worldwide 1990–1999Diabet Med200623885786616911623
   PubMed Web of Science ®Google Scholar
• D’AngeliMAMerzonEValbuenaLFTirschwellDParisCAMuellerBAEnvironmental factors associated with childhood-onset type 1 diabetes mellitus: an exploration of the hygiene and overload hypothesesArch Pediatr Adolesc Med2010164873273820679164
   PubMedGoogle Scholar
• VirtanenSMTakkinenHMNwaruBIMicrobial exposure in infancy and subsequent appearance of type 1 diabetes mellitus-associated autoantibodies: a cohort studyJAMA Pediatr2014168875576324957949
   PubMed Web of Science ®Google Scholar
• BrugmanSVisserJTJHillebrandsJLBosNARozingJProlonged exclusive breastfeeding reduces autoimmune diabetes incidence and increases regulatory T-cell frequency in bio-breeding diabetes-prone ratsDiabetes Metab Res Rev200925438038719334008
   PubMed Web of Science ®Google Scholar
• CardwellCRSteneLCJonerGCaesarean section is associated with an increased risk of childhood-onset type 1 diabetes mellitus: a meta-analysis of observational studiesDiabetologia200851572673518292986
   PubMed Web of Science ®Google Scholar
• BonifacioEWarnckeKWinklerCWallnerMZieglerAGCesarean section and interferon-induced helicase gene polymorphisms combine to increase childhood type 1 diabetes riskDiabetes201160123300330622110093
   PubMed Web of Science ®Google Scholar
• Mejía-LeónMEPetrosinoJFAjamiNJDomínguez-BelloMGde la BarcaAMFecal microbiota imbalance in Mexican children with type 1 diabetesSci Rep20144381424448554
   PubMed Web of Science ®Google Scholar
• ValladaresRSankarDLiNLactobacillus johnsonii N6.2 mitigates the development of type 1 diabetes in BB-DP ratsPLoS One201055e1050720463897
   PubMed Web of Science ®Google Scholar
• WenLLeyREVolchkovPYInnate immunity and intestinal microbiota in the development of Type 1 diabetesNature200845572161109111318806780
   PubMed Web of Science ®Google Scholar
• KriegelMASefikEHillJAWuHJBenoistCMathisDNaturally transmitted segmented filamentous bacteria segregate with diabetes protection in nonobese diabetic miceProc Natl Acad Sci U S A201110828115481155321709219
   PubMed Web of Science ®Google Scholar
• HaraNAlkananiAKIrDPrevention of virus-induced type 1 diabetes with antibiotic therapyJ Immunol201218983805381422988033
   PubMed Web of Science ®Google Scholar
• HviidASvanströmHAntibiotic use and type 1 diabetes in childhoodAm J Epidemiol200916991079108419318617
   PubMed Web of Science ®Google Scholar
• ApiwattanakulNThomasPGIversonARMcCullersJAChronic helminth infections impair pneumococcal vaccine responsesVaccine201432425405541025131738
   PubMed Web of Science ®Google Scholar
• BobatSDarbyMMrdjenDNatural and vaccine-mediated immunity to Salmonella typhimurium is impaired by the helminth Nippostrongylus brasiliensisPLoS Negl Trop Dis2014812e334125474738
   PubMed Web of Science ®Google Scholar
• CooperPJEspinelIParedesWGuderianRHNutmanTBImpaired tetanus-specific cellular and humoral responses following tetanus vaccination in human onchocerciasis: a possible role for interleukin-10J Infect Dis19981784113311389806045
   PubMed Web of Science ®Google Scholar
• CooperPJChicoMSandovalCHuman infection with Ascaris lumbricoides is associated with suppression of the interleukin-2 response to recombinant cholera toxin B subunit following vaccination with the live oral cholera vaccine CVD 103-HgRInfect Immun20016931574158011179329
   PubMed Web of Science ®Google Scholar
• SabinEAAraujoMICarvalhoEMPearceEJImpairment of tetanus toxoid-specific Th1-like immune responses in humans infected with Schistosoma mansoniJ Infect Dis199617312692728537675
   PubMed Web of Science ®Google Scholar
• FlemingJOWeinstockJVClinical trials of helminth therapy in autoimmune diseases: rationale and findingsParasite Immunol201537627729225600983
   PubMed Web of Science ®Google Scholar
• SummersRWElliottDEUrbanJFJrThompsonRWeinstockJVTrichuris suis therapy in Crohn’s diseaseGut2005541879015591509
   PubMed Web of Science ®Google Scholar
• SandbornWJElliottDEWeinstockJRandomised clinical trial: the safety and tolerability of Trichuris suis ova in patients with Crohn’s diseaseAliment Pharmacol Ther201338325526323730956
   PubMed Web of Science ®Google Scholar
• CroeseJO’NeilJMassonJA proof of concept study establishing Necator americanus in Crohn’s patients and reservoir donorsGut200655113613716344586
   PubMed Web of Science ®Google Scholar
• SummersRWElliottDEQadirKUrbanJFJrThompsonRWeinstockJVTrichuris suis seems to be safe and possibly effective in the treatment of inflammatory bowel diseaseAm J Gastroenterol20039892034204114499784
   PubMed Web of Science ®Google Scholar
• FearyJVennABrownASafety of hookworm infection in individuals with measurable airway responsiveness: a randomized placebo-controlled feasibility studyClin Exp Allergy20093971060106819400893
   PubMed Web of Science ®Google Scholar
• SummersRWElliottDEUrbanJFJrThompsonRAWeinstockJVTrichuris suis therapy for active ulcerative colitis: a randomized controlled trialGastroenterol20051284825832
   PubMed Web of Science ®Google Scholar
• HewitsonJPGraingerJRMaizelsRMHelminth immunoregulation: the role of parasite secreted proteins in modulating host immunityMol Biochem Parasitol2009167111119406170
   PubMed Web of Science ®Google Scholar
• McSorleyHJO’GormanMTBlairNSutherlandTEFilbeyKJMaizelsRMSuppression of type 2 immunity and allergic airway inflammation by secreted products of the helminth Heligmosomoides polygyrusEur J Immunol201242102667268222706967
   PubMed Web of Science ®Google Scholar
• McSorleyHJBlairNFSmithKAMcKenzieANMaizelsRMBlockade of IL-33 release and suppression of type 2 innate lymphoid cell responses by helminth secreted products in airway allergyMucosal Immunol2014751068107824496315
   PubMed Web of Science ®Google Scholar
• RuyssersNEDe WinterBYDe ManJGTherapeutic potential of helminth soluble proteins in TNBS-induced colitis in miceInflamm Bowel Dis200915449150019023900
   PubMed Web of Science ®Google Scholar
• CançadoGGFiuzaJAde PaivaNCHookworm products ameliorate dextran sodium sulfate-induced colitis in BALB/c miceInflamm Bowel Dis201117112275228621290484
   PubMed Web of Science ®Google Scholar
• SchnoellerCRauschSPillaiSA helminth immunomodulator reduces allergic and inflammatory responses by induction of IL-10-producing macrophagesJ Immunol200818064265427218322239
   PubMed Web of Science ®Google Scholar
• FerreiraISmythDGazeSHookworm excretory/secretory products induce interleukin-4 (IL-4)+ IL-10+ CD4+ T cell responses and suppress pathology in a mouse model of colitisInfect Immun20138162104211123545299
   PubMed Web of Science ®Google Scholar
• ZacconePFehérváriZJonesFMSchistosoma mansoni antigens modulate the activity of the innate immune response and prevent onset of type 1 diabetesEur J Immunol20033351439144912731071
   PubMed Web of Science ®Google Scholar
• CulleyFJBrownAConroyDMSabroeIPritchardDIWilliamsTJEotaxin is specifically cleaved by hookworm metalloproteases preventing its action in vitro and in vivoJ Immunol2000165116447645311086084
   PubMed Web of Science ®Google Scholar
• GraingerJRSmithKAHewitsonJPHelminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF- β pathwayJ Exp Med2010207112331234120876311
   PubMed Web of Science ®Google Scholar
• RauschSHeldJFischerASmall intestinal nematode infection of mice is associated with increased enterobacterial loads alongside the intestinal tractPLoS One201389e7402624040152
   PubMed Web of Science ®Google Scholar
• ReynoldsLASmithKAFilbeyKJCommensal-pathogen interactions in the intestinal tract: lactobacilli promote infection with, and are promoted by, helminth parasitesGut Microbes20145452253225144609
   PubMed Web of Science ®Google Scholar
• WalkSTBlumAMEwingSAWeinstockJVYoungVBAlteration of the murine gut microbiota during infection with the parasitic helminth Heligmosomoides polygyrusInflamm Bowel Dis201016111841184920848461
   PubMed Web of Science ®Google Scholar
• SchultzMVeltkampCDielemanLALactobacillus plantarum 299V in the treatment and prevention of spontaneous colitis in interleukin-10-deficient miceInflamm Bowel Dis200282718011854603
   PubMed Web of Science ®Google Scholar
• Nanda KumarNSBalamuruganRJayakanthanKPulimoodAPugazhendhiSRamakrishnaBSProbiotic administration alters the gut flora and attenuates colitis in mice administered dextran sodium sulfateJ Gastroenterol Hepatol200823121834183919120873
   PubMed Web of Science ®Google Scholar
• CalcinaroFDionisiSMarinaroMOral probiotic administration induces interleukin-10 production and prevents spontaneous autoimmune diabetes in the non-obese diabetic mouseDiabetologia20054881565157515986236
   PubMed Web of Science ®Google Scholar
• DuanFFLiuJHMarchJCEngineered commensal bacteria reprogram intestinal cells into glucose-responsive insulin-secreting cells for the treatment of diabetesDiabetes20156451794180325626737
   PubMed Web of Science ®Google Scholar
• TangMLPonsonbyALOrsiniFAdministration of a probiotic with peanut oral immunotherapy: a randomized trialJ Allergy Clin Immunol20151353737744.e825592987
   PubMed Web of Science ®Google Scholar
• RosenfeldtVBenfeldtENielsenSDEffect of probiotic Lactobacillus strains in children with atopic dermatitisJ Allergy Clin Immunol2003111238939512589361
   PubMed Web of Science ®Google Scholar
• OlivaSDi NardoGFerrariFRandomised clinical trial: the effectiveness of Lactobacillus reuteri ATCC 55730 rectal enema in children with active distal ulcerative colitisAliment Pharmacol Ther201235332733422150569
   PubMed Web of Science ®Google Scholar
• KruisWFricPPokrotnieksJMaintaining remission of ulcerative colitis with the probiotic Escherichia coli Nissle 1917 is as effective as with standard mesalazineGut200453111617162315479682
   PubMed Web of Science ®Google Scholar
• AbrahamssonTRJakobssonTBjörksténBOldaeusGJenmalmMCNo effect of probiotics on respiratory allergies: a seven-year follow-up of a randomized controlled trial in infancyPediatr Allergy Immunol201324655656123902407
   PubMed Web of Science ®Google Scholar
• BoyleRJBath-HextallFJLeonardi-BeeJMurrellDFTangMLProbiotics for the treatment of eczema: a systematic reviewClin Exp Allergy20093981117112719573037
   PubMed Web of Science ®Google Scholar
• FeigheryLMSmithPO’MahonyLFallonPGBraydenDJEffects of Lactobacillus salivarius 433118 on intestinal inflammation, immunity status and in vitro colon function in two mouse models of inflammatory bowel diseaseDig Dis Sci20085392495250618157694
   PubMed Web of Science ®Google Scholar
• CummingsJHMacfarlaneGTEnglystHNPrebiotic digestion and fermentationAm J Clin Nutr2001732 Suppl415S420S11157351
   PubMed Web of Science ®Google Scholar
• VosAPvan EschBCStahlBDietary supplementation with specific oligosaccharide mixtures decreases parameters of allergic asthma in miceInt Immunopharmacol20077121582158717920536
   PubMed Web of Science ®Google Scholar
• KolevaPTValchevaRSSunXGänzleMGDielemanLAInulin and fructo-oligosaccharides have divergent effects on colitis and commensal microbiota in HLA-B27 transgenic ratsBr J Nutr201210891633164322243836
   PubMed Web of Science ®Google Scholar
• BenjaminJLHedinCRKoutsoumpasARandomised, double-blind, placebo-controlled trial of fructo-oligosaccharides in active Crohn’s diseaseGut201160792392921262918
   PubMed Web of Science ®Google Scholar
• de KivitSSaelandEKraneveldADGalectin-9 induced by dietary synbiotics is involved in suppression of allergic symptoms in mice and humansAllergy201267334335222229637
   PubMed Web of Science ®Google Scholar
• van der AaLBHeymansHSvan AalderenWMSynbad Study GroupEffect of a new synbiotic mixture on atopic dermatitis in infants: a randomized-controlled trialClin Exp Allergy201040579580420184604
   PubMed Web of Science ®Google Scholar
• van der AaLBvan AalderenWMHeymansHSSynbad Study GroupSynbiotics prevent asthma-like symptoms in infants with atopic dermatitisAllergy201166217017720560907
   PubMed Web of Science ®Google Scholar
• FurrieEMacfarlaneSKennedyASynbiotic therapy (Bifidobacterium longum/Synergy 1) initiates resolution of inflammation in patients with active ulcerative colitis: a randomised controlled pilot trialGut200554224224915647189
   PubMed Web of Science ®Google Scholar
• LueKHSunHLLuKHA trial of adding Lactobacillus johnsonii EM1 to levocetirizine for treatment of perennial allergic rhinitis in children aged 7–12 yearsInt J Pediatr Otorhinolaryngol2012767994100122513081
   PubMed Web of Science ®Google Scholar
• XiaoJZKondoSYanagisawaNClinical efficacy of probiotic Bifidobacterium longum for the treatment of symptoms of Japanese cedar pollen allergy in subjects evaluated in an environmental exposure unitAllergol Int2007561677517259812
   PubMedGoogle Scholar