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Review

Severe bronchial asthma in children: a review of novel biomarkers used as predictors of the disease

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Pages 11-18 | Published online: 15 Jan 2018

References

  • MartinezFDVercelliDAsthmaLancet20133821360137224041942
  • BierbaumSHeinzmannAThe genetics of bronchial asthma in childrenRespir Med20071011369137517353123
  • World Health OrganizationAsthma2017 Available from: http://www.who.int/mediacentre/factsheets/fs307/en/index.htmlAccessed March 7, 2017
  • OzdemirCCeyhanBYaziDNon-atopic asthma in children is related to maternal bronchial hyper-reactivityPediatr Allergy Immunol20081924825418397409
  • LemanskeRFBusseWWAsthma: clinical expression and molecular mechanismsJ Allergy Clin Immunol2010125S95S10220176271
  • ChiapporiADe FerrariLFolliCMauriPRiccioAMCanonicaGWBiomarkers and severe asthma: a critical appraisalClin Mol Allergy2015132026430389
  • WalshLJWongCACooperSGuhanARPringleMTattersfieldAEMorbidity from asthma in relation to regular treatment: a community based studyThorax19995429630010092689
  • ChungKFWenzelSEBrozekJLInternational ERS/ATS guidelines on definition, evaluation and treatment of severe asthmaEur Respir J20144334337324337046
  • American Thoracic SocietyProceedings of the ATS workshop on refractory asthma: current understanding, recommendations, and unanswered questionsAm J Respir Crit Care Med20001622341235111112161
  • ArronJRIzuharaKAsthma biomarkers: what constitutes a ‘gold standard’?Thorax20157010510725432945
  • HaldarPPavordIDShawDECluster analysis and clinical asthma phenotypesAm J Respir Crit Care Med200817821822418480428
  • MirandaCBusackerABalzarSTrudeauJWenzelSEDistinguishing severe asthma phenotypes: role of age at onset and eosinophilic inflammationJ Allergy Clin Immunol200411310110814713914
  • WenzelSEBalzarSAmplefordEIL4Rα mutations are associated with asthma exacerbations and mast cell/IgE expressionAm J Respir Crit Care Med200717557057617170387
  • LiXHowardTDZhengSLGenome-wide association study of asthma identifies RAD50-IL13 and HLA-DR/DQ regionsJ Allergy Clin Immunol201012532833520159242
  • HaselkornTZeigerRSChippsBERecent asthma exacerbations predict future exacerbations in children with severe or difficult-to-treat asthmaJ Allergy Clin Immunol200912492192719895984
  • WoodruffPGModrekBChoyDFT-helper type 2-driven inflammation defines major subphenotypes of asthmaAm J Respir Crit Care Med200918038839519483109
  • WangFHeXYBainesKJDifferentiating inflammatory phenotypes in adults and children with acute asthmaEur Resp J201138567574
  • CampoPRodríguezFSánchez-GarcíaSPhenotypes and endotypes of uncontrolled severe asthma: new treatmentsJ Investig Allergol Clin Immunol2013237688
  • MooreWCMeyersDAWenzelSEIdentification of asthma phenotypes using cluster analysis in the severe asthma research programAm J Respir Crit Care Med201018131532319892860
  • WenzelSEBusseWWSevere asthma: lessons from the Severe Asthma Research ProgramJ Allerg Clin Immunol20071191421
  • ZisslerUMEsser-von BierenJJakwerthCAChakerAMSchmidt-WeberCBCurrent and future biomarkers in allergic asthmaAllergy20167147549426706728
  • JatakanonAUasufCMaziakWLimSChungKFBarnesPJNeutrophilic inflammation in severe persistent asthmaAm J Respir Crit Care Med19991601532153910556116
  • GibsonPGSimpsonJLSaltosNHeterogeneity of airway inflammation in persistent asthma: evidence of neutrophilic inflammation and increased sputum interleukin-8Chest20011191329133611348936
  • SchleimerRPGlucocorticoids suppress inflammation but spare innate immune responses in airway epitheliumProc Am Thorac Soc2004122223016113438
  • BarnesPJAdcockIMGlucocorticoid resistance in inflammatory diseasesLancet20093731905191719482216
  • BoldoghIBacsiAChoudhuryBKDharajiyaNAlamRHazraTKROS generated by pollen NADPH oxidase provide a signal that augments antigen-induced allergic airway inflammationJ Clin Invest20051152169217916075057
  • SimsGPRoweDCRietdijkSTHerbstRCoyleAJHMGB1 and RAGE in inflammation and cancerAnnu Rev Immunol20102836738820192808
  • Gómez-GaviroMDomínguez-LuisMCanchadoJExpression and regulation of the metalloproteinase ADAM-8 during human neutrophil pathophysiological activation and its catalytic activity on L-selectin sheddingJ Immunol20071788053806317548643
  • OreoKMGibsonPGSimpsonJLWoodLGMcDonaldVMBainesKJSputum ADAM-8 expression in increased in severe asthma and COPDClin Exp Allergy201344342352
  • ConroyDMWilliamsTJEotaxin and the attraction of eosinophils to the asthmatic lungRespir Res2001215015611686879
  • KimCKKitaHCallawayZThe roles of a Th2 cytokine and CC chemokine in children with stable asthma: potential implication in eosinophil degranulationPediatr Allergy Immunol201021e697e70420444156
  • ZietowskiZTomasiek-LozowskaMMSkiepkoRZietowskaEBodzenta-LukaszykAEotaxin-1 in exhaled breath condensate of stable and unstable asthma patientsRespir Res20101111020704746
  • WenzelSSevere asthma in adultsAm J Resp Crit Care Med200517214916015849323
  • BalzarSChuHWStrandMWenzelSRelationship of small airway chymase-positive mast cells and lung function in severe asthmaAm J Respir Crit Care Med200517143143915563633
  • KotaruCSchoonoverKJTrudeauJBRegional fibroblast heterogeneity in the lung: implications for remodelingAm J Respir Crit Care Med20061731208121516543551
  • StaudtVBothurEKleinMInterferon-regulating factor 4 is essential for the developmental program of T helper 9 cellsImmunity20103319220220674401
  • JiangLDiazPTBestTMStumpfJNHeFZuoLMolecular characterization of redox mechanisms in allergic asthmaAnn Allergy Asthma Immunol201411313714224986036
  • HoffmanSMTullyJELahueKGGenetic ablation of glutaredoxin-1 causes enhanced resolution of airways hyperresponsiveness and mucus metaplasia in mice with allergic airways diseaseAm J Physiol Lung Cell Mol Physiol2012303L528L53822752969
  • IdzkoMPitchfordSPageCRole of platelets in allergic airway inflammationJ Allergy Clin Immunol20151351416142326051948
  • RossallMRCaddenPAMolphySDPlumbJSinghDRepeatability of induced sputum measurements in moderate to severe asthmaRespir Med20141081566156825195138
  • NairPGagaMZervasESafety and efficacy of a CXCR2 antagonist in patients with severe asthma and sputum neutrophils: a randomized, placebo-controlled clinical trialClin Exp Allergy2012421097110322702508
  • TakTHilveringBTesselaarKKoendermanLSimilar activation state of neutrophils in sputum of asthma patients irrespective of sputum eosinophiliaClin Exp Immunol201518220421226148992
  • MannBSChungKFBlood neutrophil activation markers in severe asthma: lack of inhibition by prednisolone therapyRespir Res200675916600024
  • SimpsonJLGrissellTVDouwesJScottRJBoyleMJGibsonPGInnate immune activation in neutrophilic asthma and bronchiectasisThorax20076221121816844729
  • NairPGagaMZervasESafety and efficacy of a CXCR2 antagonist in patients with severe asthma and sputum neutrophils: a randomized, placebo-controlled clinical trialClin Exp Allergy2012421097110322702508
  • KrugNTschernigTErpenbeckVJHohlfeldJMKöhlJComplement factors C3a and C5a are increased in bronchoalveolar lavage fluid after segmental allergen provocation in subjects with asthmaAm J Respir Crit Care Med20011641841184311734433
  • BraunRKFoersterMWorkalemahuGHaefnerDKroegelCWalkerCDifferential regulation of aminopeptidase N (CD13) by transendothelial migration and cytokines on human eosinophilsExp Lung Res200329597712554354
  • BatesMELiuLYEsnaultSExpression of interleukin-5-and granulocyte macrophage-colony-stimulating factor-responsive genes in blood and airway eosinophilsAm J Respir Cell Mol Biol20043073674314630612
  • JohanssonMWHanSTGundersonKABusseWWJarjourNNMosherDFPlatelet activation, P-selectin, and eosinophil β1-integrin activation in asthmaAm J Respir Crit Care Med201218549850722227382
  • KantersDten HoveWLuijkBExpression of activated FcγRII discriminates between multiple granulocyte priming phenotypes in peripheral blood of allergic asthmatic subjectsJ Allergy Clin Immunol20071201073108117697704
  • JohanssonMWActivation states of blood eosinophils in asthmaClin Exp Allergy20144448249824552191
  • GaoPGibsonPGBainesKJAnti-inflammatory deficiencies in neutrophilic asthma: reduced galectin-3 and IL-1RA/IL1βRespir Res201516525616863
  • TornhamreSEhnhageAKölbeckKGEdeniusCLindgrenJAUncoupled regulation of leukotriene C4 synthase in platelets from aspirin-intolerant asthmatics and healthy volunteers after aspirin treatmentClin Exp Allergy2002321566157312569976
  • ZietkowskiZBodzenta-LukaszykATomasiakMMSkiepkoRMroczkoBSzmitkowskiMChanges in RANTES and β-thromboglobulin after intensive exercise in patients with allergic asthmaInt Arch Allergy Immunol2009148314018716401
  • KnauerKALichtensteinLMAdkinsonNFJrFishJEPlatelet activation during antigen-induced airway reactions in asthmatic subjectsN Engl J Med1981304140414077231463
  • DürkTDuerschmiedDMüllerTProduction of serotonin by tryptophan hydroxylase 1 and release via platelets contribute to allergic airway inflammationAm J Respir Crit Care Med201318747648523328530
  • WadsworthSSinDDorscheidDClinical update on the use of biomarkers of airway inflammation in the management of asthmaJ Asthma Allergy20114778621792321
  • EltboliOBrightlingCEEosinophils as diagnostic tools in chronic lung diseaseExpert Rev Respir Med201373342
  • SzeflerSJWenzelSBrownRAsthma outcomes: biomarkersJ Allergy Clin Immunol2012129923
  • PavordIDKornSHowarthPMepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trialLancet201238065165922901886
  • HarropCAGoreRBEvansCMThorntonDJHerrickSETGF-β2 decreases baseline and IL-13-stimulated mucin production by primary human bronchial epithelial cellsExp Lung Res201339394723249391
  • ShimodaTObaseYKishikawaRIwanagaTSerum high-sensitivity C-reactive protein can be an airway inflammation predictor in bronchial asthmaAllergy Asthma Proc201536e23e2825715235
  • KatoMYamadaYMaruyamaKHayashiYSerum eosinophil cationic protein and 27 cytokines/chemokines in acute exacerbation of childhood asthmaInt Arch Allergy Immunol2010152626620523065
  • WrightAKMistryVRichardsonMToll-like receptor 9 dependent interferon-α release is impaired in severe asthma but is not associated with exacerbation frequencyImmunobiology201522085986425662572
  • PenninoDBhavsarPKEffnerRIL-22 suppresses IFN-γ-mediated lung inflammation in asthmatic patientsJ Allergy Clin Immunol201313156257023174657
  • ThomasPSHeywoodGEffects of inhaled tumour necrosis factor alpha in subjects with mild asthmaThorax20025777477812200521
  • BoonpiyathadSPornsuriyasakPBuranapraditkunSKlaewsongkramJInterleukin-2 levels in exhaled breath condensates, asthma severity, and asthma control in non-allergic asthmaAllergy Asthma Proc201334e35e4123998235
  • BelliniAMariniMABianchettiLBarczykMSchmidtMMattoliSInterleukin (IL)-4, IL-13, and IL-17A differentially affect the profibrotic and proinflammatory functions of fibrocytes from asthmatic patientsMucosal Immunol2012514014922189956
  • RovinaNDimaEBakakosPLow interleukin (IL)-18 levels in sputum supernatants of patients with severe refractory asthmaRespir Med201510958058725840484
  • BoboleaIBarrancoPDel PozoVSputum periostin in patients with different severe asthma phenotypesAllergy20157054054625631525
  • KanemitsuYItoINiimiAOsteopontin and periostin are associated with a 20-year decline of pulmonary function in patients with asthmaAm J Respir Crit Care Med201419047247425127307
  • DesaiDGuptaSSiddiquiSSputum mediator profiling and relationship to airway wall geometry imaging in severe asthmaRespir Res2013141723398985
  • BoulayMEPrincePDeschesnesFChakirJBouletLPMetalloproteinase-9 in induced sputum correlates with the severity of the late allergen-induced asthmatic responseRespiration20047121622415133340
  • CataldoDDGuedersMMunautCMatrix metalloproteinases and tissue inhibitors of matrix metalloproteinases mRNA transcripts in the bronchial secretions of asthmaticsLab Invest20048441842414968124
  • HanZXuJZhongNExpression of matrix metalloproteinases MMP-9 within the airways in asthmaRespir Med20039756356712735676
  • KarakocGBYukselenAYilmazMAltintasDUKendirliSGExhaled breath condensate MMP-9 level and its relationship with asthma severity and interleukin-4/10 levels in childrenAnn Allergy Asthma Immunol201210830030422541398
  • IsgroMBianchettiLMariniMABelliniASchmidtMMattoliSThe C-C motif chemokine ligands CCL5, CCL11, and CCL24 induce the migration of circulating fibrocytes from patients with severe asthmaMucosal Immunol2013671872723149666
  • JiaGEricksonRWChoyDFPeriostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patientsJ Allergy Clin Immunol201213064765422857879
  • KanemitsuYMatsumotoHIzuharaKIncreased periostin associates with greater airflow limitation in patients receiving inhaled corticosteroidsJ Allergy Clin Immunol201313230531223791506
  • ParulekarADMustafaAAHananiaNAPeriostin, a novel biomarker of Th2-driven asthmaCurr Opin Pulm Med201420606524247042
  • TakayamaGArimaKKanajiTPeriostin: a novel component of sub-epithelial fibrosis of bronchial asthma downstream of IL-4 and IL-13 signalsJ Allergy Clin Immunol20061189810416815144
  • SidhuSSYuanSInnesALRoles of epithelial cell-derived periostin in TFG-β activation, collagen production, and collagen gel elasticity in asthmaProc Natl Acad Sci U S A2010107141701417520660732
  • YuyamaNDaviesDEAkaiwaMAnalysis of novel disease-related genes in bronchial asthmaCytokine20021928729612421571
  • ConwaySJIzuharaKKudoYThe role of periostin in tissue remodeling across health and diseaseCell Mol Life Sci2014711279128824146092
  • MasuokaMShiraishiHOhtaSPeriostin promotes chronic allergic inflammation in response to Th2 cytokinesJ Clin Invest20121222590260022684102
  • MatsumotoHSerum periostin: a novel biomarker for asthma managementAllergol Int20146315316024759559
  • BainesKJSimpsonJLWoodLGSputum gene expression signature of 6 biomarkers discriminates asthma inflammatory phenotypesJ Allergy Clin Immunol2014133997100724582314
  • SamitasKZervasEVittorakisSOsteopontin expression and relation to disease severity in human asthmaEur Respir J20113733134120562127
  • TorregoAHewMOatesTSukkarMChungKFExpression and activation of TGF-β isoforms in acute allergen induced remodeling in asthmaThorax20076230731317251317
  • AsaiKKanazawaHKamoiHShiraishiSHirataKYoshikawaJIncreased levels of vascular endothelial growth factor in induced sputum in asthmatic patientsClin Exp Allergy20033359559912752587
  • KonradsenJRJamesANordlundBThe chitinase-like protein YKL-40: a possible biomarker of inflammation and airway remodeling in severe pediatric asthmaJ Allergy Clin Immunol201313232833523628340
  • ButlerWTStructural and functional domains of osteopontinAnn N Y Acad Sci19957606117785926
  • KohAda SilvaAPBansalAKRole of osteopontin in neutrophil functionImmunology200712246647517680800
  • KonradsenJRJamesANordlundBThe chitinase-like protein YKL-40: a possible biomarker of inflammation and airway remodeling in severe pediatric asthmaJ Allergy Clin Immunol201313232833523628340
  • OberCTanZSunYEffect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung functionN Engl J Med20083581682169118403759
  • DentAGSutedjaTGZimmermanPVExhaled breath analysis for lung cancerJ Thorac Dis20135540550
  • HorváthIHuntJBarnesPJExhaled breath condensate: methodological recommendations and unresolved questionsEur Respir J20052652354816135737
  • KazaniSPlanagumaAOnoEBoniniMZahidMMarigowdaGExhaled breath condensate eicosanoid levels associate with asthma and its severityJ Allergy Clin Immunol201313254755323608729
  • WuDZhouJBiHCCL-11 as a potential diagnostic marker for asthma?J Asthma20145184785424796647
  • LaneCKnightDBurgessSEpithelial inducible nitric oxide synthase activity is the major determinant of nitric oxide concentration in exhaled breathThorax20045975776015333851
  • DweikRABoggsPBErzurumSCAn official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applicationsAm J Respir Crit Care Med201118460615
  • YangSParkJLeeYKKimHHahnYSAssociation of longitudinal fractional exhaled nitric oxide measurements with asthma control in atopic childrenRespir Med201510957257925840483
  • GemiciogluBMusellimBDoganIGuvenKFractional exhaled nitric oxide (FeNo) in different asthma phenotypesAllergy Rhinol20145157161
  • SippelJMHoldenWETillesSAExhaled nitric oxide levels correlate with measures of disease control in asthmaJ Allergy Clin Immunol200010664565011031334
  • HamidQGross pathology and histopathology of asthmaJ Allergy Clin Immunol200311143143212589370