References
- Biomarkers and surrogate endpoints: Preferred definitions and conceptual frameworkClin Pharmacol Ther2001693899511240971
- MaiselABiomarkers in heart failure. Does prognostic utility translate to clinical futility?J Am Coll Cardiol200750111061106317825715
- ChangCLRobinsonSCMillsGDBiochemical markers of cardiac dysfunction predict mortality in acute exacerbations of COPDThoraxApril 72011 [Epub ahead of print]
- WenzelSEAsthma: defining of the persistent adult phenotypesLancet2006368953780481316935691
- AdcockIMItoKSteroid resistance in asthma: a major problem requiring novel solutions or a non-issue?Curr Opin Pharmacol20044325726215140417
- LaitinenAAltrajaAKampeMLindenMVirtanenILaitinenLATenascin is increased in airway basement membrane of asthmatics and decreased by an inhaled steroidAm J Respir Crit Care Med19971563 Pt 19519589310019
- HirstSJAirway smooth muscle as a target in asthmaClin Exp Allergy200030 Suppl 1545910849477
- HolgateSTDaviesDELackiePMWilsonSJPuddicombeSMLordanJLEpithelial-mesenchymal interactions in the pathogenesis of asthmaJ Allergy Clin Immunol20001052 Pt 119320410669837
- HackettTLKnightDAThe role of epithelial injury and repair in the origins of asthmaCurr Opin Allergy Clin Immunol200771636817218813
- BarnesPJThe role of inflammation and anti-inflammatory medication in asthmaRespir Med200296 Suppl AS9S1511858564
- MalmstromKPelkonenASMalmbergLPLung function, airway remodelling and inflammation in symptomatic infants: outcome at 3 yearsThorax201166215716221199817
- SontJKHanJvan KriekenJMRelationship between the inflammatory infiltrate in bronchial biopsy specimens and clinical severity of asthma in patients treated with inhaled steroidsThorax19965154965028711677
- GreenRHBrightlingCEWoltmannGParkerDWardlawAJPavordIDAnalysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroidsThorax2002571087587912324674
- ReddelHKTaylorDRBatemanEDAn official American Thoracic Society/European Respiratory Society statement: asthma control and exacerbations: standardizing endpoints for clinical asthma trials and clinical practiceAm J Respir Crit Care Med20091801599919535666
- KulkarniNSHollinsFSutcliffeAEosinophil protein in airway macrophages: a novel biomarker of eosinophilic inflammation in patients with asthmaJ Allergy Clin Immunol2010126161.e369.e320639010
- WatanabeTAsaiKFujimotoHTanakaHKanazawaHHirataKIncreased levels of HMGB-1 and endogenous secretory RAGE in induced sputum from asthmatic patientsRespir Med2011105451952521041074
- D’AmicoAPennazzaGSantonicoMAn investigation on electronic nose diagnosis of lung cancerLung Cancer201068217017619959252
- PayneDNAdcockIMWilsonNMOatesTScallanMBushARelationship between exhaled nitric oxide and mucosal eosinophilic inflammation in children with difficult asthma, after treatment with oral prednisoloneAm J Respir Crit Care Med20011648 Pt 11376138111704581
- SchleichFNSeidelLSeleJExhaled nitric oxide thresholds associated with a sputum eosinophil count ≥3% in a cohort of unselected patients with asthmaThorax201065121039104420671307
- JiangJMalaviaNSureshVGeorgeSCNitric oxide gas phase release in human small airway epithelial cellsRespir Res200910319152703
- TaylorDRNitric oxide as a clinical guide for asthma managementJ Allergy Clin Immunol2006117225926216461124
- OlinACRosengrenAThelleDSLissnerLBakeBTorenKHeight, age, and atopy are associated with fraction of exhaled nitric oxide in a large adult general population sampleChest200613051319132517099006
- SmithADCowanJOBrassettKPExhaled nitric oxide: a predictor of steroid responseAm J Respir Crit Care Med2005172445345915901605
- PijnenburgMWHofhuisWHopWCDe JongsteJCExhaled nitric oxide predicts asthma relapse in children with clinical asthma remissionThorax200560321521815741438
- KostikasKPapaioannouAITanouKExhaled NO and exhaled breath condensate pH in the evaluation of asthma controlRespir Med2011105452653221051211
- PetskyHLCatesCJLiAKynastonJATurnerCChangABTailored interventions based on exhaled nitric oxide versus clinical symptoms for asthma in children and adultsCochrane Database Syst Rev20094CD00634019821360
- HolzOMagnussenHCutoff values for FENO-guided asthma managementAm J Respir Crit Care Med2009180328128219633157
- PearceNPekkanenJBeasleyRHow much asthma is really attributable to atopy?Thorax199954326827210325905
- HervasDMilanJMGardeJDifferences in exhaled nitric oxide in atopic childrenAllergol Immunopathol (Madr)200836633133519150032
- ChanEYNgDKChanCHMeasuring FENO in asthma: coexisting allergic rhinitis and severity of atopy as confounding factorsAm J Respir Crit Care Med2009180328119633158
- BanovcinPJesenakMMichnovaZFactors attributable to the level of exhaled nitric oxide in asthmatic childrenEur J Med Res200914 Suppl 491320156716
- ScottMRazaAKarmausWInfluence of atopy and asthma on exhaled nitric oxide in an unselected birth cohort studyThorax201065325826220335297
- RouhosAKainuAKarjalainenJAtopic sensitization to common allergens without symptoms or signs of airway disorders does not increase exhaled nitric oxideClin Respir J20082314114820298322
- CordeiroDRudolphusASnoeyEBraunstahlGJUtility of nitric oxide for the diagnosis of asthma in an allergy clinic populationAllergy Asthma Proc201132211912621439165
- GessnerCRechnerBHammerschmidtSAngiogenic markers in breath condensate identify non-small cell lung cancerLung Cancer201068217718419647334
- BloemenKVan Den HeuvelRGovartsEA new approach to study exhaled proteins as potential biomarkers for asthmaClin Exp Allergy201141334635621105917
- HoffmeyerFRaulf-HeimsothMBruningTExhaled breath condensate and airway inflammationCurr Opin Allergy Clin Immunol200991162219532089
- LessardATurcotteHCormierYBouletLPObesity and asthma: a specific phenotype?Chest2008134231732318641097
- SinDDMillerBEDuvoixASerum PARC/CCL-18 concentrations and health outcomes in chronic obstructive pulmonary diseaseAm J Respir Crit Care Med201118391187119221216880
- WedzichaJASeemungalTAMacCallumPKAcute exacerbations of chronic obstructive pulmonary disease are accompanied by elevations of plasma fibrinogen and serum IL-6 levelsThromb Haemost200084221021510959691
- LowhagenOWeverAMLusuardiMThe inflammatory marker serum eosinophil cationic protein (ECP) compared with PEF as a tool to decide inhaled corticosteroid dose in asthmatic patientsRespir Med20029629510111862965
- DosanjhAGamstAPhillipsonJBroughtonAElevated serum eosinophil cationic protein levels in cystic fibrosis, pediatric asthma, and bronchiolitisPediatr Asthma Allergy Immunol1996104169173
- LessardASt-LaurentJTurcotteHBouletLPLeptin and adiponectin in obese and non-obese subjects with asthmaBiomarkers201116327127321247368
- BergCMThelleDSRosengrenALissnerLTorenKOlinACDecreased fraction of exhaled nitric oxide in obese subjects with asthma symptoms: data from the population study INTERGENE/ADONIXChest201113951109111621183611
- KimSHKimTHLeeJSAdiposity, adipokines, and exhaled nitric oxide in healthy adults without asthmaJ Asthma201148217718221222563
- SekiyaTYamadaHYamaguchiMIncreased levels of a TH2-type CC chemokine thymus and activation-regulated chemokine (TARC) in serum and induced sputum of asthmaticsAllergy200257217317711929424
- LeungTFWongCKChanIHIpWKLamCWWongGWPlasma concentration of thymus and activation-regulated chemokine is elevated in childhood asthmaJ Allergy Clin Immunol2002110340440912209086
- ChuppGLLeeCGJarjourNA chitinase-like protein in the lung and circulation of patients with severe asthmaN Engl J Med2007357202016202718003958
- HartlDLeeCGDa SilvaCAChuppGLEliasJANovel biomarkers in asthma: chemokines and chitinase-like proteinsCurr Opin Allergy Clin Immunol200991606619532094
- WadsworthSJAtsutaRMcIntyreJOHackettTLSingheraGKDorscheidDRIL-13 and TH2 cytokine exposure triggers matrix metalloproteinase 7-mediated Fas ligand cleavage from bronchial epithelial cellsJ Allergy Clin Immunol2010126236637420624652
- GoswamiSAngkasekwinaiPShanMDivergent functions for airway epithelial matrix metalloproteinase 7 and retinoic acid in experimental asthmaNat Immunol200910549650319329997
- StephanVZimmermannAKuhrJUrbanekRDetermination of N-methylhistamine in urine as an indicator of histamine release in immediate allergic reactionsJ Allergy Clin Immunol199086 6 Pt 18628681702126
- TakeiSShimagoAIwashitaMKumamotoTKamuroKMiyataKUrinary N-methylhistamine in asthmatic children receiving azelastine hydrochlorideAnn Allergy Asthma Immunol19977854924969164363
- SaudeEJSkappakCDRegushSMetabolomic profiling of asthma: diagnostic utility of urine nuclear magnetic resonance spectroscopyJ Allergy Clin Immunol2011127375776421377043