Current Controversies and Future Prospects for Peanut Allergy Prevention, Diagnosis and Therapies

References

• Gupta RS, Springston EE, Warrier MR, et al. The prevalence, severity and distribution of childhood food allergy in the United States. Pediatrics. 2011;128:e9–e17. doi:10.1542/peds.2011-020421690110
   PubMed Web of Science ®Google Scholar
• Venter C, Maslin K, Patil V, et al. The prevalence, natural history and time trends of peanut allergy over the first 10 years of life in two cohorts born in the same geographical location 12 years apart. Pediatr Allergy Immunol. 2016;27:804–811. doi:10.1111/pai.2016.27.issue-827434312
   PubMed Web of Science ®Google Scholar
• Sicherer SH, Munoz-Furlong A, Sampson HA. Prevalence of peanut and tree nut allergy in the United States determined by means of a random digit dial telephone survey: a 5-year follow-up study. J Allergy Clin Immunol. 2003;112:1203–1207. doi:10.1016/S0091-6749(03)02026-814657884
   PubMed Web of Science ®Google Scholar
• Osborne NJ, Koplin JJ, Martin PE, et al. Prevalence of challenge-proven IgE-mediated food allergy using population-based sampling and predetermined challenge criteria in infants. J Allergy Clin Immunol. 2011;127:668–676. doi:10.1016/j.jaci.2011.01.03921377036
   PubMed Web of Science ®Google Scholar
• Basera W, Botha M, Gray CL, et al. The South African food sensitisation and food allergy population-based study of IgE-mediated food allergy: validity, safety, and acceptability. Ann Allergy Asthma Immunol. 2015;115:113–119. doi:10.1016/j.anai.2015.06.00326105048
   PubMed Web of Science ®Google Scholar
• Skolnick HS, Conover-Walker MK, Barnes C, et al. The natural history of peanut allergy. J Allergy Clin Immunol. 2001;107:367–374. doi:10.1067/mai.2001.11212911174206
   PubMed Web of Science ®Google Scholar
• Anna Nowak-Węgrzyn A, Albin E. Oral immunotherapy for food allergy. Curr Allergy Clin Immunol. 2016;29(2):90–99.
   Google Scholar
• Queeney E For children with peanut allergies, FDA experts recommend a new treatment. The New York times online. Available from: www.nytimes.com. Accessed 913, 2019.
   Google Scholar
• Chu DK, Wood RA, French A, et al. Oral immunotherapy for peanut allergy (PACE): a systemic review and meta-analysis of efficacy and safety. Lancet. 2019;3293(10187):2222–2232.
   Web of Science ®Google Scholar
• Available from: www.anaphylaxis.org.uk. Accessed 825, 2017.
   Google Scholar
• Gray CL, Levin ME. Food allergies-should we be going peanut-free in South African schools? Curr Allergy Clin Immunol. 2018;31:28–30.
   Web of Science ®Google Scholar
• Du Toit G, Roberts G, Sayre PH, et al. Randomized trial of peanut consumption in infants at risk for peanut allergy. N Eng J Med. 2015;372:803–813. doi:10.1056/NEJMoa1414850
   PubMed Web of Science ®Google Scholar
• Gray CL, Venter C, Emanuel S, Fleischer D. Peanut introduction and the prevention of peanut allergy: evidence and practical implications. Curr Allergy Clin Immunol. 2018;31:28–30.
   Web of Science ®Google Scholar
• du Toit G, Sayre PH, Roberts G, et al. Effect of avoidance on peanut allergy after early peanut consumption. N Engl J Med. 2016;374:1435–1443. doi:10.1056/NEJMoa151420926942922
   PubMed Web of Science ®Google Scholar
• Feeney M, du Toit G, Roberts G, et al. Impact of peanut consumption in the LEAP Study: feasibility, growth, and nutrition. J Allergy Clin Immunol. 2016;138:1108–1118. doi:10.1016/j.jaci.2016.04.01627297994
   PubMed Web of Science ®Google Scholar
• Koplin JJ, Peters RL, Dharmage SC, et al. Understanding the feasibility and implications of implementing early peanut introduction for prevention of peanut allergy. J Allergy Clin Immunol. 2016;138:1131–1141. doi:10.1016/j.jaci.2016.04.01127260320
   PubMed Web of Science ®Google Scholar
• Fleischer DM, Sicherer S, Greenhawt M, et al. Consensus communication on early peanut introduction and prevention of peanut allergy in high-risk infants. J Allergy Clin Immunol. 2015;136:258–261. doi:10.1016/j.jaci.2015.06.00126100082
   PubMed Web of Science ®Google Scholar
• Togias A, Cooper SF, Acebal ML, et al. Addendum guidelines for the prevention of peanut allergy in the United States: report of the National Institute of Allergy and Infectious Diseases-sponsored expert panel. J Allergy Clin Immunol. 2017;139:29–44. doi:10.1016/j.jaci.2016.10.01028065278
   PubMed Web of Science ®Google Scholar
• Shaker M, Stukus D, Chan ES, Fleischer DM, Spergel JM, Greenhawt M. “To screen or not to screen”: comparing the health and economic benefits of early peanut introduction strategies in five countries. Allergy. 2018;73:1707–1714. doi:10.1111/all.2018.73.issue-829601091
   PubMed Web of Science ®Google Scholar
• Perkin MR, Logan KL, Tseng A, et al. Randomized trial of introduction of allergenic foods in breast-fed infants. N Eng J Med. 2016;374:1733–1743. doi:10.1056/NEJMoa1514210
   PubMed Web of Science ®Google Scholar
• Perkin MR, Logan KL, Bahnson HT, et al. Efficacy of the Enquiring About Tolerance (EAT) study among infants at high risk of developing food allergy. J Allergy Clin Immunol. 2019;144:1606–1614. doi:10.1016/j.jaci.2019.06.04531812184
   PubMed Web of Science ®Google Scholar
• du Toit G, Katz Y, Sasieni P, et al. Early consumption of peanuts in infancy is associated with a low prevalence of peanut allergy. J Allergy Clin Immunol. 2008;122:984–991. doi:10.1016/j.jaci.2008.08.03919000582
   PubMed Web of Science ®Google Scholar
• Lack G, Fox D, Northstone K, Golding J. Factors associated with the development of peanut allergy in childhood. N Eng J Med. 2003;348:977–985. doi:10.1056/NEJMoa013536
   PubMed Web of Science ®Google Scholar
• Hourihane JOB, Kilburn SA, Dean P, Warner JO. Clinical characteristics of peanut allergy. Clin Exp Allergy. 1997;27:634–639. doi:10.1111/cea.1997.27.issue-69208183
   PubMed Web of Science ®Google Scholar
• Matsumoto K, Mori R, Miyazaki C, Ohya Y, Saito H. Are both early egg introduction and eczema treatment necessary for primary prevention of egg allergy? J Allergy Clin Immunol. 2018;141:1997–2001. doi:10.1016/j.jaci.2018.02.03329522845
   PubMed Web of Science ®Google Scholar
• Fox AT, Sasieni P, du Toit G, Syed H, Lack G. Household peanut consumption as a risk factor for the development of peanut allergy. J Allergy Clin Immunol. 2009;123:417–423. doi:10.1016/j.jaci.2008.12.01419203660
   PubMed Web of Science ®Google Scholar
• Brough HA, Liu AH, Sicherer S, et al. Atopic dermatitis increases the effect of exposure to peanut antigen in dust on peanut sensitization and likely peanut allergy. J Allergy Clin Immunol. 2015;135:164–170. doi:10.1016/j.jaci.2014.10.00725457149
   PubMed Web of Science ®Google Scholar
• Horimukai K, Morita K, Narita M, et al. Application of moisturizer to neonates prevents development of atopic dermatitis. J Allergy Clin Immunol. 2014;134:824–830. doi:10.1016/j.jaci.2014.07.06025282564
   PubMed Web of Science ®Google Scholar
• Simpson EL, Chalmers JR, Hanifin JM, et al. Emollient enhancement of the skin barrier from birth offers effective atopic dermatitis prevention. J Allergy Clin Immunol. 2014;134:818–823. doi:10.1016/j.jaci.2014.08.00525282563
   PubMed Web of Science ®Google Scholar
• Lowe AJ, Su JC, Allen KJ, et al. A randomised trial of a barrier lipid replacement strategy for the prevention of atopic dermatitis and allergic sensitisation: the PEBBLES pilot study. Br J Dermatol. 2018;178:e19–e21. doi:10.1111/bjd.1574728639306
   PubMed Web of Science ®Google Scholar
• Tsilochristou O, du Toit G, Sayre PH, et al. Association of Staphylococcus aureus colonization with food allergy occurs independently of eczema severity. J Allergy Clin Immunol. 2019;144:494–503. doi:10.1016/j.jaci.2019.04.02531160034
   PubMed Web of Science ®Google Scholar
• Fisher HR, Keet CA, Lack G, du Toit G.Preventing peanut allergy: where are we now? J Allergy Clin Immunol Pract. 2019;7:367–373. doi:10.1016/j.jaip.2018.11.00530717867
   PubMed Web of Science ®Google Scholar
• Soriano VX, Peters RL, Ponsonby AL, et al. Earlier ingestion of peanut after changes to infant feeding guidelines: the earlyNuts study. J Allergy Clin Immunol. 2019;144:1327–1335. doi:10.1016/j.jaci.2019.07.03231401287
   PubMed Web of Science ®Google Scholar
• Soares-Weiser K, Takwoingi Y, Panesar SS, et al. The diagnosis of food allergy: a systemic review and meta-analysis. Allergy. 2014;69:76–86. doi:10.1111/all.1233324329961
   PubMed Web of Science ®Google Scholar
• Sporik R, Hill DJ, Hosking CS. Specificity of allergen skin testing in predicting positive open food challenges to milk, egg and peanut in children. Clin Exp Allergy. 2000;30(11):1540–1546. doi:10.1046/j.1365-2222.2000.00928.x11069561
   PubMed Web of Science ®Google Scholar
• Peters RL, Allen KJ, Dharmage SC, et al. Skin prick test responses and allergen-specific IgE levels as predictors of peanut, egg and sesame allergy in children. J Allergy Clin Immunol. 2013;132:874–880. doi:10.1016/j.jaci.2013.05.03823891354
   PubMed Web of Science ®Google Scholar
• Sampson HA, Ho DG. Relationship between food-specific IgE concentrations and the risk of positive food challenges in children and adolescents. J Allergy Clin Immunol. 1997;100:444–451. doi:10.1016/S0091-6749(97)70133-79338535
   PubMed Web of Science ®Google Scholar
• Sampson HA. Utility of food-specific IgE concentrations in predicting symptomatic food allergy. J Allergy Clin Immunol. 2001;107:891–896. doi:10.1067/mai.2001.11470811344358
   PubMed Web of Science ®Google Scholar
• Peters RL, Allen KJ, Dharmage SC, et al. Natural history of peanut allergy and predictors of resolution in the first 4 years of life: a population-based assessment. J Allergy Clin Immunol. 2015;135:1257–1262. doi:10.1016/j.jaci.2015.01.00225725989
   PubMed Web of Science ®Google Scholar
• Gray CL, Levin ME, Du Toit G. Ethnic differences in peanut allergy patterns in South African children with atopic dermatitis. Pediatr Allergy Immunol. 2015;26(8):721–730. doi:10.1111/pai.1245926267015
   PubMed Web of Science ®Google Scholar
• Sastre J. Molecular diagnosis in allergy. J Brit Soc Allergy Clin Immunol. 2010;40(10):1442–1460. doi:10.1111/j.1365-2222.2010.03585.x
   Web of Science ®Google Scholar
• Borres MP, Ebisawa M, Eigenmann PA. Use of allergen components begins a new era in pediatric allergology. Ped Allergy Immunol. 2011;20:454–461. doi:10.1111/j.1399-3038.2011.01197.x
   Web of Science ®Google Scholar
• Krause S, Reese G, Randow S, et al. Lipid transfer protein (Ara h 9) as a new peanut allergen relevant for a Mediterranean allergic population. J Allergy Clin Immunol. 2009;124(4):771–778. doi:10.1016/j.jaci.2009.06.00819665774
   PubMed Web of Science ®Google Scholar
• Maeda Y, Ono E, Fukutomi Y, et al. Correlations between alder specific IgE and alder-related tree pollen specific IgE by RAST method. Allergol Int. 2008;57(1):79–81. doi:10.2332/allergolint.O-07-49618089941
   PubMedGoogle Scholar
• Van Rooyen C, van den Berg S. Advances in the laboratory diagnosis of food allergy. Curr Allergy Clin Immunol. 2016;29(2):77–82.
   Google Scholar
• Nicolaou N, Murray C, Belgrave D, et al. Quantification of specific IgE to whole peanut extract and peanut components in prediction of peanut allergy. J Allergy Clin Immunol. 2011;127(3):684–685. doi:10.1016/j.jaci.2010.12.01221272928
   PubMed Web of Science ®Google Scholar
• Codreanu F, Collignon O, Roitel O, et al. A novel immunoassay using recombinant allergens simplifies peanut allergy diagnosis. Int Arch Allergy Immunol. 2011;154(3):216–226. doi:10.1159/00032110820861643
   PubMed Web of Science ®Google Scholar
• Ebisawa M, Moverare R, Sato S, et al. Measurement of Arah1-,2-, and 3-specific antibodies is useful in diagnosis of peanut allergy in Japanese children. Pediatr Allergy Immunol. 2012;23(6):573–581. doi:10.1111/j.1399-3038.2012.01332.x22831547
   PubMed Web of Science ®Google Scholar
• Hong X, Caruso D, Kumar R, et al. IgE, but not IgG4, antibodies to Ara h 2 distinguish peanut allergy from asymptomatic peanut sensitization. Allergy. 2012;67(12):1538–1546. doi:10.1111/all.1204723094689
   PubMed Web of Science ®Google Scholar
• Gray CL, Levin ME, Du Toit G. Which test is best for diagnosing peanut allergy in South African children with atopic dermatitis. SAMJ. 2016;106(2):214–220. doi:10.7196/SAMJ.2016.v106i2.1012526821907
   PubMed Web of Science ®Google Scholar
• Klemans RJB, van Os-medendorp H, Blankestijn M, Bruijnzeel-Koomen CAFM, Knol EF, Knulst AC. Diagnostic accuracy of specific IgE to components in diagnosing peanut allergy; a systemic review. Clin Exp Allergy. 2015;45:720–730. doi:10.1111/cea.1241225226880
   PubMed Web of Science ®Google Scholar
• Flores Kim J, McCleary N, Nwaru BI, Stoddart A, Sheikh A. Diagnostic accuracy, risk assessment, and cost-effectiveness of component-resolved diagnostics for food allergy: a systemic review. Allergy. 2018;73:1609–1621. doi:10.1111/all.1339929319184
   PubMed Web of Science ®Google Scholar
• Santos AF, Douiri A, Becares N, et al. Basophil activation test discriminates between allergy and tolerance in peanut-sensitized children. J Allergy Clin Immunol. 2014;134:645–652. doi:10.1016/j.jaci.2014.04.03925065721
   PubMed Web of Science ®Google Scholar
• Glaumann S, Nopp A, Johansson SGO, Rudengren M, Borres MP, Nilsson C. Basophil allergen threshold sensitivity, CD-sens, IgE-sensitization and DBPCFC in peanut-sensitized children. Allergy. 2012;67:242–247. doi:10.1111/all.2012.67.issue-222126416
   PubMed Web of Science ®Google Scholar
• Santos AF, Couto-Francisco N, Becares N, Kwok M, Bahnson HT, Lack G. A novel human mast cell activation test for peanut allergy. J Allergy Clin Immunol. 2018;142:689–691. doi:10.1016/j.jaci.2018.03.01129731128
   PubMed Web of Science ®Google Scholar
• Bahri R, Custovic A, Korosec P, et al. Mast cell activation test in the diagnosis of allergic disease and anaphylaxis. J Allergy Clin Immunol. 2018;142:485–496. doi:10.1016/j.jaci.2018.01.04329518421
   PubMed Web of Science ®Google Scholar
• Larsen LF, Juel-Berg N, Hansen KS, et al. A comparative study on basophil activation test, histamine release assay, and passive sensitization histamine release assay in the diagnosis of peanut allergy. Allergy. 2017;73:137–144. doi:10.1111/all.1324328686296
   PubMed Web of Science ®Google Scholar
• Beyer KL, Ellman-Grunther L, Jarvinen KM, Wood RA, Hourihane J, Sampson HA. Measurement of peptide-specific IgE as an additional tool in identifying patients with clinical reactivity to peanuts. J Allergy Clin Immunol. 2003;112:202–207. doi:10.1067/mai.2003.162112847500
   PubMed Web of Science ®Google Scholar
• Vickery BP, Scurlock AM, Kulis M, et al. Sustained unresponsiveness to peanut in subjects who have completed peanut oral immunotherapy. J Allergy Clin Immunol. 2014;133:468–475. doi:10.1016/j.jaci.2013.11.00724361082
   PubMed Web of Science ®Google Scholar
• Nurmatov U, Devereux G, Worth A, Healy L, Sheikh A. Effectiveness and safety of orally administered immunotherapy for food allergies: a systematic review and meta-analysis. British J Nutrition. 2014;111:12–22. doi:10.1017/S0007114513002353
   PubMed Web of Science ®Google Scholar
• Nurmatov U, Venderbosch I, Devereux G, Simons FE, Sheikh A. Allergen-specific oral immunotherapy for peanut allergy. Cochrane Database Sys Rev. 2012;9:CD009014.
   Google Scholar
• Yee CS, Rachid R. The heterogeneity of oral immunotherapy clinical trials: implications and future directions. Curr Allergy Asthma Rep. 2016;16:25. doi:10.1007/s11882-016-0602-026922433
   PubMed Web of Science ®Google Scholar
• Vickery BP, Vereda A, Casale TB, et al.; PALISADE Group of Clinical Investigators. AR101 oral immunotherapy for peanut allergy. N Engl J Med. 2018;379:1991–2001.30449234
   PubMed Web of Science ®Google Scholar
• Vickery BP, Ebisawa M, Shreffler WG, Wood RA. Current and future treatment of peanut allergy. J Allergy Clin Immunol Pract. 2019;7:357–365. doi:10.1016/j.jaip.2018.11.04930717866
   PubMed Web of Science ®Google Scholar
• EH K, Yang L, Ping Y, et al. Long-term sublingual immunotherapy for peanut allergy in children: clinical and immunological evidence of desensitization. J Allergy Clin Immunol. 2019 e-published ahead of print.
   Web of Science ®Google Scholar
• Fleischer DM, Burks AW, Vickery BP, et al. Sublingual immunotherapy for peanut allergy: a randomized, double-blind, placebo-controlled multi-center trial. J Allergy Clin Immunol. 2013;131:119–127. doi:10.1016/j.jaci.2012.11.01123265698
   PubMed Web of Science ®Google Scholar
• Narisety SD, Frischmeyer-Guerrerio PA, Keet CA, et al. A randomized, double-blind, placebo-controlled pilot study of sublingual versus oral immunotherapy for the treatment of peanut allergy. J Allergy Clin Immunol. 2015;135:1275–1282. doi:10.1016/j.jaci.2014.11.00525528358
   PubMed Web of Science ®Google Scholar
• Burks AW, Wood RA, Jones SM, et al. Sublingual immunotherapy for peanut allergy: long-term follow-up of a randomized multicentre trial. J Allergy Clin Immunol. 2015;135:1240–1248. doi:10.1016/j.jaci.2014.12.191725656999
   PubMed Web of Science ®Google Scholar
• Mondoulet L, Dioszeghy V, Puteaux E, et al. Intact skin and not stripped skin is crucial for the safety and efficacy of peanut epicutaneous immunotherapy (EPIT) in mice. Clin Transl Allergy. 2012;2:22. doi:10.1186/2045-7022-2-2223140259
   PubMedGoogle Scholar
• Sampson HA, Shreffler WG, Yang WH, et al. Effect of varying doses of epicutaneous immunotherapy vs placebo on reaction to peanut protein exposure among patients with peanut sensitivity: a randomized clinical trial. JAMA. 2017;318:1798–1809. doi:10.1001/jama.2017.1659129136445
   PubMed Web of Science ®Google Scholar
• Fleisher DM, Sussman GL, Begin P. Effects of epicutaneous immunotherapy on inducing peanut desensitization in peanut-allergic children: topline Peanut Epicutaneous Immunotherapy Efficacy and Safety (PEPITES) randomized clinical trial results. J Allergy Clin Immunol. 2018;141:AB410. doi:10.1016/j.jaci.2017.12.967
   Google Scholar
• Semancik E, Sayej W. Oral immunotherapy for peanut allergy induces eosinophilic oesophagitis: three paediatric case reports. Pediatr Allergy Immunol. 2016;27(5):539–541. doi:10.1111/pai.1255426888330
   PubMed Web of Science ®Google Scholar
• Dua S, Ruiz-Garcia M, Bond S, et al. Effect of sleep deprivation and exercise on reaction threshold in adults with peanut allergy: A randomised, controlled study. J Allergy Clin Immunol. 2019. doi:10.1016/j.jaci.2019.06.038
   Web of Science ®Google Scholar
• Wasserman RL, Hague AR, Pence DM, et al. Real-world experience with peanut oral immunotherapy: lessons learned from 270 patients. J Allergy Clin Immunol Pract. 2019;7(2):418–426. doi:10.1016/j.jaip.2018.05.02329859333
   PubMed Web of Science ®Google Scholar
• Chinthrajah RS, Purington N, Andorf S, et al. Sustained outcomes in oral immunotherapy for peanut allergy (POISED Study): a large, randomised, double-blind, placebo-controlled, phase 2 study. Lancet. 2019;394:1437–1449. doi:10.1016/S0140-6736(19)31793-331522849
   PubMed Web of Science ®Google Scholar
• Santos AF, James LK, Kwok M, et al. Peanut oral immunotherapy induces blocking antibodies but does not change the functional characteristics of peanut-specific IgE. J Allergy Clin Immunol. 2019. doi:10.1016/j.jaci.2019.09.005
   Web of Science ®Google Scholar
• Wood RA, Chinthrajah S (Study chairs) Omalizumab as monotherapy and as adjunct therapy to multi-allergen OIT in food allergic participants (OUtMATCH Study). ClinicalTrials.gov, posted 3 2019.
   Google Scholar
• Koplin JJ, Perrett KP, Sampson HA. Diagnosing peanut allergy with fewer oral challenges. J Allergy Clin Immunol Pract. 2019;7(2):375–380. doi:10.1016/j.jaip.2018.11.01030581130
   PubMed Web of Science ®Google Scholar
• Vickery BP, Berglund JP, Burk CM, et al. Early oral immunotherapy in peanut-allergic preschool children is safe and highly effective. J Allergy Clin Immunol. 2017;139:173–181. doi:10.1016/j.jaci.2016.05.02727522159
   PubMed Web of Science ®Google Scholar
• Blumchen K, Trendelenburg V, Ahrens F, et al. Efficacy, safety, and quality of life in a multicentre, randomized, placebo controlled trial of low-dose peanut oral immunotherapy in children with peanut allergy. JACI Pract. 2019;7:479–491.
   Web of Science ®Google Scholar
• Nachshon L, Goldberg MR, Katz Y, et al. Long-term outcome of peanut oral immunotherapy -real-life experience. Pediatr Allergy Immunol. 2018;29:519–526. doi:10.1111/pai.1291429698554
   PubMed Web of Science ®Google Scholar
• Tang ML, Ponsonby AL, Orsini F, et al. Administration of a probiotic with peanut oral immunotherapy: a randomized trial. J Allergy Clin Immunol. 2015;135:737–744. doi:10.1016/j.jaci.2014.11.03425592987
   PubMed Web of Science ®Google Scholar
• Dunn Galvin A, McMahon S, Ponsoby AL, Hsiao KC, Tang MLK; PPOIT study team. The longitudinal impact of probiotic and peanut oral immunotherapy on health-related quality of life. Allergy. 2018;73:560–568. doi:10.1111/all.1333029052245
   PubMed Web of Science ®Google Scholar
• Leung DY, Sampson HA, Yunginger JW, et al. Effect of anti-IgE therapy in patients with peanut allergy. N Eng J Med. 2003;348:986–993. doi:10.1056/NEJMoa022613
   PubMed Web of Science ®Google Scholar
• Sampson HA, Leung DY, Burks AW, et al. A Phase II, randomized, double-blind, parallel-group, placebo-controlled oral food challenge trial of Xolair (omalizumab) in peanut allergy. J Allergy Clin Immunol. 2011;127:1309–1310. doi:10.1016/j.jaci.2011.01.05121397314
   PubMed Web of Science ®Google Scholar
• MacGinnitie AJ, Rachid R, Gragg H, et al. Omalizumab facilitates rapid oral desensitization for peanut allergy. J Allergy Clin Immunol. 2017;139:873–881. doi:10.1016/j.jaci.2016.08.01027609658
   PubMed Web of Science ®Google Scholar
• Lin C, Lee IT, Sampath V, et al. Combining anti-IgE with oral immunotherapy. Pediatr Allergy Immunol. 2017;28:619–627. doi:10.1111/pai.2017.28.issue-728782296
   PubMed Web of Science ®Google Scholar
• Patil SP, Wang J, Song Y, et al. Clinical safety of food allergy Herbal Formula-2 (FAHF-2) and inhibitory effect on basophils from patients with food allergy: extended Phase I study. J Allergy Clin Immunol. 2011;128:1259–1265. doi:10.1016/j.jaci.2011.06.01521794906
   PubMed Web of Science ®Google Scholar
• Wang J, Jones SM, Pongracic JA, et al. Safety, clinical, and immunological efficacy of a Chinese herbal medicine (Food Allergy Herbal Formula-2) for food allergy. J Allergy Clin Immunol. 2015;136:962–970. doi:10.1016/j.jaci.2015.04.02926044855
   PubMed Web of Science ®Google Scholar
• Various for Astella Pharma Inc. A study to evaluate safety, tolerability and immune response in adolescents allergic to peanut after receiving intradermal administration of ASP0892, a single multivalent peanut (Ara h1, h2, h3) lysosomal associated membrane protein DNA plasmid vaccine. ClinicalTrials.gov Identifier NCT03755713, 11 2018.
   Google Scholar
• Yu J. Methods for reducing allergenicity of peanuts and peanut derived products. J Food Sci Edu. 2016;1:1012–1020.
   Google Scholar
• Wang J, Fleischer DM. Should peanut be banned in schools? J Allergy Clin Immunol Pract. 2017;5:290–294. doi:10.1016/j.jaip.2017.01.00628283154
   PubMed Web of Science ®Google Scholar
• Stukus DR. Peanut-free schools: what does it really mean, and are they necessary? J Allergy Clin Immunol. 2017;140:391–392. doi:10.1016/j.jaci.2017.03.03728454741
   PubMed Web of Science ®Google Scholar
• Bartnikas LM, Huffaker MF, Sheehan WJ, et al. Impact of school peanut-free policies on epinephrine administration. J Allergy Clin Immunol. 2017;140:465–473. doi:10.1016/j.jaci.2017.01.04028347736
   PubMed Web of Science ®Google Scholar