Recent Developments In Bronchial Thermoplasty For Severe Asthma

References

• Hekking -P-PW, Wener RR, Amelink M, Zwinderman AH, Bouvy ML, Bel EH. The prevalence of severe refractory asthma. J Allergy Clin Immunol. 2015;135(4):896–902. doi:10.1016/j.jaci.2014.08.04225441637
   PubMed Web of Science ®Google Scholar
• Chung KF, Wenzel SE, Brozek JL, et al. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J. 2014;43(2):343–373. doi:10.1183/09031936.0020201324337046
   PubMed Web of Science ®Google Scholar
• Sweeney J, Patterson CC, Menzies-Gow A, et al. Comorbidity in severe asthma requiring systemic corticosteroid therapy: cross-sectional data from the Optimum Patient Care Research Database and the British Thoracic Difficult Asthma Registry. Thorax. 2016;71(4):339–346. doi:10.1136/thoraxjnl-2015-20763026819354
   PubMed Web of Science ®Google Scholar
• O’Neill S, Sweeney J, Patterson CC, et al. The cost of treating severe refractory asthma in the UK: an economic analysis from the British Thoracic Society Difficult Asthma Registry. Thorax. 2015;70(4):376–378. doi:10.1136/thoraxjnl-2013-20411424917087
   PubMed Web of Science ®Google Scholar
• Chen W, Marra CA, Lynd LD, FitzGerald JM, Zafari Z, Sadatsafavi M. The natural history of severe asthma and influences of early risk factors: a population-based cohort study. Thorax. 2016;71(3):267–275. doi:10.1136/thoraxjnl-2015-20753026732738
   PubMed Web of Science ®Google Scholar
• McDonald VM, Fingleton J, Agusti A, et al. Treatable traits: a new paradigm for 21st century management of chronic airway diseases: treatable traits down under international workshop report. Eur Respir J. 2019;53(5):1802058. doi:10.1183/13993003.02058-201830846468
   PubMed Web of Science ®Google Scholar
• Global Initiative for Asthma (GINA). Diagnosis and management of difficult-to-treat and severe asthma in adolescent and adult patients Web site. Available from: http://www.ginasthma.org/ Published 2019 Accessed 910, 2019.
   Google Scholar
• Cox PG, Miller J, Mitzner W, Leff AR. Radiofrequency ablation of airway smooth muscle for sustained treatment of asthma: preliminary investigations. Eur Respir J. 2004;24(4):659–663. doi:10.1183/09031936.04.0005460415459147
   PubMed Web of Science ®Google Scholar
• Torrego A, Solà I, Munoz A, et al. Bronchial thermoplasty for moderate or severe persistent asthma in adults. Cochrane Database Syst Rev. 2014;(3):Art. No.: CD009910. doi:10.1002/14651858.CD009910.pub2
   PubMed Web of Science ®Google Scholar
• Thomson NC, Bicknell S, Chaudhuri R. Bronchial thermoplasty for severe asthma. Curr Opin Allergy Clin Immunol. 2012;12(3):241–248. doi:10.1097/ACI.0b013e32835335ca22475996
   PubMed Web of Science ®Google Scholar
• Dombret M-C, Alagha K, Philippe Boulet L, et al. Bronchial thermoplasty: a new therapeutic option for the treatment of severe, uncontrolled asthma in adults. Eur Respir Rev. 2014;23(134):510–518. doi:10.1183/09059180.0000511425445950
   PubMedGoogle Scholar
• Mainardi AS, Castro M, Chupp G. Bronchial thermoplasty. Clin Chest Med. 2019;40(1):193–207. doi:10.1016/j.ccm.2018.10.01530691712
   PubMed Web of Science ®Google Scholar
• Tan LD, Yoneda KY, Louie S, Hogarth DK, Castro M. Bronchial thermoplasty: a decade of experience: state of the art. J Allergy Clin Immunol in Pract. 2019;7(1):71–80. doi:10.1016/j.jaip.2018.08.01730193939
   PubMed Web of Science ®Google Scholar
• Cox G, Thomson NC, Rubin AS, et al. Asthma control during the year after bronchial thermoplasty. N Eng J Med. 2007;356(13):1327–1337. doi:10.1056/NEJMoa064707
   PubMed Web of Science ®Google Scholar
• Pavord ID, Cox G, Thomson NC, et al. Safety and efficacy of bronchial thermoplasty in symptomatic, severe asthma. Am J Respir Crit Care Med. 2007;176(12):1185–1191. doi:10.1164/rccm.200704-571OC17901415
   PubMed Web of Science ®Google Scholar
• Castro M, Rubin AS, Laviolette M, et al. Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma: a multicenter, randomized, double-blind, sham-controlled clinical trial. Am J Respir Crit Care Med. 2010;181(2):116–124. doi:10.1164/rccm.200903-0354OC19815809
   PubMed Web of Science ®Google Scholar
• D’Anci KE, Lynch MP, Leas BF, et al. Effectiveness and safety of bronchial thermoplasty in management of asthma. Comparative Effectiveness Review No. 202. Available from: www.effectivehealthcare.ahrq.gov/reports/final.cfm Published 2017 Accessed 910, 2019.
   Google Scholar
• Wu Q, Xing Y, Zhou X, Wang D. Meta-analysis of the efficacy and safety of bronchial thermoplasty in patients with moderate-to-severe persistent asthma. J Int Med Res. 2011;39(1):10–22. doi:10.1177/14732300110390010221672303
   PubMed Web of Science ®Google Scholar
• Thomson NC, Rubin A, Niven R, et al. Long term (5 Year) safety of bronchial thermoplasty: Asthma Intervention Research (AIR) trial. BMC Pulm Med. 2011;11(1):8. doi:10.1186/1471-2466-11-821314924
   PubMed Web of Science ®Google Scholar
• Pavord ID, Thomson NC, Niven RM, et al. Safety of bronchial thermoplasty in patients with severe refractory asthma. Ann Allergy Asthma Immunol. 2013;111(5):402–407. doi:10.1016/j.anai.2013.05.00224125149
   PubMed Web of Science ®Google Scholar
• Wechsler ME, Laviolette M, Rubin AS, et al. Bronchial thermoplasty: long-term safety and effectiveness in patients with severe persistent asthma. J Allergy Clin Immunol. 2013;132:1295–1302. doi:10.1016/j.jaci.2013.08.00923998657
   PubMed Web of Science ®Google Scholar
• Zhou JP, Feng Y, Wang Q, Zhou LN, Wan HY, Li QY. Long-term efficacy and safety of bronchial thermoplasty in patients with moderate-to-severe persistent asthma: a systemic review and meta-analysis. J Asthma. 2016;53(1):94–100. doi:10.3109/02770903.2015.106542426383773
   PubMed Web of Science ®Google Scholar
• U.S. National Institutes of Health. U.S. National Institutes of Health. Available from: https://clinicaltrials.gov/ Published 2019 Accessed 910, 2019.
   Google Scholar
• Chaudhuri R, Rubin A, Fiterman J, et al. Ten-year follow-up of subjects who received bronchial thermoplasty (BT) in 3 randomized controlled studies (BT10+). Eur Respir Soc Congr. 2019 Madrid.
   Google Scholar
• Iyer VN, Lim KG. Bronchial thermoplasty: reappraising the evidence (or lack thereof). Chest. 2014;146(1):17–21. doi:10.1378/chest.14-053625010960
   PubMed Web of Science ®Google Scholar
• Castro M, Cox G, Wechsler ME, Niven RM. Bronchial thermoplasty: ready for prime time – the evidence is there! Chest. 2015;147(2):e73–e74. doi:10.1378/chest.14-229625522284
   PubMed Web of Science ®Google Scholar
• British Guideline on the Management of Asthma. 2019 Available from: www.brit-thoracic.org.uk/quality-improvement/guidelines/asthma/Published Accessed 910, 2019.
   Google Scholar
• Trivedi A, Pavord ID, Castro M. Bronchial thermoplasty and biological therapy as targeted treatments for severe uncontrolled asthma. Lancet Respir Med. 2016;4(7):585–592. doi:10.1016/S2213-2600(16)30018-227230825
   PubMed Web of Science ®Google Scholar
• Blaiss MS, Castro M, Chipps BE, Zitt M, Panettieri RA Jr., Foggs MB. Guiding principles for use of newer biologics and bronchial thermoplasty for patients with severe asthma. Ann Allergy Asthma Immunol. 2017;119(6):533–540. doi:10.1016/j.anai.2017.09.05829103801
   PubMed Web of Science ®Google Scholar
• Bonta PI, Chanez P, Annema JT, Shah PL, Niven R. Bronchial thermoplasty in severe asthma: best practice recommendations from an expert panel. Respiration. 2018;95(5):289–300. doi:10.1159/00048829129669351
   PubMed Web of Science ®Google Scholar
• Bicknell S, Chaudhuri R, Lee N, et al. Effectiveness of bronchial thermoplasty in severe asthma in ‘real life’ patients compared with those recruited to clinical trials in the same centre. Therap Adv Respir Dis. 2015;9(6):267–271. doi:10.1177/175346581560133226307767
   PubMed Web of Science ®Google Scholar
• Thomson NC. Bronchial thermoplasty as a treatment for severe asthma: controversies, progress and uncertainties. Exp Rev Respir Med. 2018;12(4):269–282. doi:10.1080/17476348.2018.1444991
   PubMed Web of Science ®Google Scholar
• Chupp G, Laviolette M, Cohn L, et al. Long-term outcomes of bronchial thermoplasty in subjects with severe asthma: a comparison of 3-year follow-up results from two prospective multicentre studies. Eur Respir J. 2017;50:2. doi:10.1183/13993003.00017-2017
   Web of Science ®Google Scholar
• Burn J, Sims AJ, Patrick H, Heaney LG, Niven RM. Efficacy and safety of bronchial thermoplasty in clinical practice: a prospective, longitudinal, cohort study using evidence from the UK Severe Asthma Registry. BMJ Open. 2019;9(6):e026742. doi:10.1136/bmjopen-2018-026742
   PubMed Web of Science ®Google Scholar
• Langton D, Ing A, Fielding D, et al. Safety and effectiveness of bronchial thermoplasty when FEV1 less than 50%. Chest. 2019; S0012-3692(19)33753–5 Epub ahead of print. doi:10.1016/j.chest.2019.08.2193
   Web of Science ®Google Scholar
• U.S. Food and Drug Administration. Alair bronchial thermoplasty system: Alair catheter and Alair RF controller; 2010 Available from: https://www.accessdata.fda.gov/cdrh_docs/pdf8/p080032a.pdf Accessed 910, 2019.
   Google Scholar
• Niven R, Aubier M, Bonta P, Puente-Maestu L, Facciolongo N, Ryan D. European consensus meeting/statement on bronchial thermoplasty who? Where? How? Respir Med. 2019;150:161–164. doi:10.1016/j.rmed.2019.02.02030961945
   PubMed Web of Science ®Google Scholar
• Hall CS, Castro M. Predicting response to bronchial thermoplasty in patients with severe uncontrolled asthma: an elusive goal. Respirology. 2019;24(1):11–12. doi:10.1111/resp.2019.24.issue-130324712
   PubMed Web of Science ®Google Scholar
• Sierra M, Fernandez-Bussy S, Mehta H, et al. Bronchial thermoplasty in severe uncontrolled asthma with different phenotypes. Chest. 2017;152(4, Supplement):A29. doi:10.1016/j.chest.2017.08.059
   Web of Science ®Google Scholar
• Yamamura K, Hara J, Ohkura N, et al. Increased cough receptor sensitivity to capsaicin predicts a positive bronchial thermoplasty response: a single-center retrospective study. J Bronchology Interv Pulmonol. 2019;26(2):137–141. doi:10.1097/LBR.000000000000057730829895
   PubMed Web of Science ®Google Scholar
• Langton D, Ing A, Fielding D, Wang W, Plummer V, Thien F. Bronchodilator responsiveness as a predictor of success for bronchial thermoplasty. Respirology. 2019;24(1):63–67. doi:10.1111/resp.2019.24.issue-130063104
   PubMed Web of Science ®Google Scholar
• d’Hooghe JNS, Goorsenberg AWM, Ten Hacken NHT, et al. Airway smooth muscle reduction after bronchial thermoplasty in severe asthma correlates with FEV1. Clin Exp Allergy. 2019;49(4):541–544. doi:10.1111/cea.1336530723963
   PubMed Web of Science ®Google Scholar
• Pretolani M, Bergqvist A, Thabut G, et al. Effectiveness of bronchial thermoplasty in patients with severe refractory asthma: clinical and histopathological correlations. J Allergy Clin Immunol. 2017;139(4):1176–1185. doi:10.1016/j.jaci.2016.08.00927609656
   PubMed Web of Science ®Google Scholar
• Langton D, Sha J, Ing A, Fielding D, Thien F, Plummer V. Bronchial thermoplasty: activations predict response. Respir Res. 2017;18(1):134. doi:10.1186/s12931-017-0617-728676053
   PubMed Web of Science ®Google Scholar
• Donovan GM, Elliot JG, Boser SR, Green FHY, James AL, Noble PB. Patient-specific targeted bronchial thermoplasty: predictions of improved outcomes with structure-guided treatment. J Appl Physiol. 2019;126(3):599–606. doi:10.1152/japplphysiol.00951.201830676870
   PubMed Web of Science ®Google Scholar
• Kirby M, Ohtani K, Lopez Lisbona RM, et al. Bronchial thermoplasty in asthma: 2-year follow-up using optical coherence tomography. Eur Respir J. 2015;46(3):859–862. doi:10.1183/09031936.0001681526022958
   PubMed Web of Science ®Google Scholar
• Feroldi F, Willemse J, Davidoiu V, et al. In vivo multifunctional optical coherence tomography at the periphery of the lungs. Biomed Opt Express. 2019;10(6):3070–3091. doi:10.1364/BOE.10.00307031259075
   PubMed Web of Science ®Google Scholar
• Zanon M, Strieder DL, Rubin AS, et al. Use of MDCT to assess the results of bronchial thermoplasty. AJR Am J Roentgenol. 2017;209(4):752–756. doi:10.2214/AJR.17.1802728796545
   PubMed Web of Science ®Google Scholar
• Bicknell S, Chaudhuri R, Thomson NC. How to: bronchial thermoplasty in asthma. Breathe. 2014;10(1):48–59. doi:10.1183/20734735.007813
   Google Scholar
• Eisenmann S, Schütte W, Funke F, Oezkan F, Islam S, Darwiche K. Bronchial thermoplasty including the middle lobe bronchus significantly improves lung function and quality of life in patients suffering from severe asthma. Lung. 2019;197(4):493–499. doi:10.1007/s00408-019-00240-531134337
   PubMed Web of Science ®Google Scholar
• Hall C, Quirk JD, Goss CW, et al. Targeted bronchial thermoplasty guided by 129Xe MRI. Am J Respir Crit Care Med. 2019;A7355–A7355.
   Google Scholar
• Langton D, Gaffney N, Wang WC, Thien F, Plummer V. Utility of a thin bronchoscope in facilitating bronchial thermoplasty. J Asthma Allergy. 2018;11:261–266. doi:10.2147/JAA.S17935930410372
   PubMed Web of Science ®Google Scholar
• Langton D, Sha J, Ing A, Fielding D, Wood E. Bronchial thermoplasty in severe asthma in Australia. Intern Med J. 2017;47(5):536–541. doi:10.1111/imj.1337228101900
   PubMed Web of Science ®Google Scholar
• Chakir J, Haj-Salem I, Gras D, et al. Effects of bronchial thermoplasty on airway smooth muscle and collagen deposition in asthma. Annals ATS. 2015;12(11):1612–1618.
   Google Scholar
• Salem IH, Boulet L-P, Biardel S, et al. Long-term effects of bronchial thermoplasty on airway smooth muscle and reticular basement membrane thickness in severe asthma. Annals ATS. 2016;13(8):1426–1428. doi:10.1513/AnnalsATS.201603-182LE
   Web of Science ®Google Scholar
• Madsen H, Henriksen DP, Backer V, Siersted HC, Bjerring N, Ulrik CS. Efficacy of bronchial thermoplasty in patients with severe asthma. J Asthma. 2019;1–7. Epub ahead of print. doi:10.1080/02770903.2019.1678636
   Web of Science ®Google Scholar
• O’Reilly A, Browne I, Watchorn D, Egan JJ, Lane S. The efficacy and safety of bronchial thermoplasty in severe persistent asthma on extended follow-up. QJM. 2017;111(3):155–159. doi:10.1093/qjmed/hcx221
   Web of Science ®Google Scholar
• Iikura M, Hojo M, Nagano N, et al. Bronchial thermoplasty for severe uncontrolled asthma in Japan. Allergol Internat. 2017;67(2):273–275. doi:10.1016/j.alit.2017.07.006
   Web of Science ®Google Scholar
• Kang J, Cho YS, Choi D-K, et al. Bronchial thermoplasty in patients with severe uncontrolled asthma: first Korean cases. J Korean Med Sci. 2019;34:15. doi:10.3346/jkms.2019.34.e120
   Web of Science ®Google Scholar
• Puente-Maestu L, Llanos Flores M, Benedetti P, et al. Effectiveness and safety of bronchial thermoplasty in severe asthma in clinical practice in Spain. Biomedicine Hub. 2018;3(3):1–9. doi:10.1159/000492075
   Google Scholar
• Burn J, Sims AJ, Keltie K, et al. Procedural and short-term safety of bronchial thermoplasty in clinical practice: evidence from a national registry and Hospital Episode Statistics. J Asthma. 2017;54(8):872–879. doi:10.1080/02770903.2016.126365227905828
   PubMed Web of Science ®Google Scholar
• Doeing DC, Mahajan AK, White SR, Naureckas ET, Krishnan JA, Hogarth DK. Safety and feasibility of bronchial thermoplasty in asthma patients with very severe fixed airflow obstruction: a case series. J Asthma. 2013;50:215–218. doi:10.3109/02770903.2012.75199723252954
   PubMed Web of Science ®Google Scholar
• Kanaan R, Strange C, Hogarth K, et al. Bronchial thermoplasty is effective and relatively safe in high risk asthma patients. Am J Respir Crit Care Med. 2017;195:A4690. doi:10.1164/rccm.201701-0150WS
   Web of Science ®Google Scholar
• Chupp GL, Kline JN, Khatri SB, et al. Long-term efficacy and safety of bronchial thermoplasty (BT): 4 year follow-up results from a large scale prospective study. Am J Respir Crit Care Med. 2019;A2683–A2683.
   Web of Science ®Google Scholar
• Torrego A, Herth F, Munoz AM, et al. Bronchial thermoplasty global registry: one year results. Eur Respir J. 2018;52(suppl 62):OA1921.
   Google Scholar
• Langton D, Wang W, Thien F, Plummer V. The acute effects of bronchial thermoplasty on FEV1. Respir Med. 2018;137:147–151. doi:10.1016/j.rmed.2018.03.00329605199
   PubMed Web of Science ®Google Scholar
• Debray M-P, Dombret M-C, Pretolani M, et al. Early computed tomography modifications following bronchial thermoplasty in patients with severe asthma. Eur Respir J. 2017;49:3. doi:10.1183/13993003.01565-2016
   Web of Science ®Google Scholar
• d’Hooghe JNS, van den Berk IAH, Annema JT, Bonta PI. Acute radiological abnormalities after bronchial thermoplasty: a prospective cohort trial. Respiration. 2017;94(3):258–262. doi:10.1159/00047758628675890
   PubMed Web of Science ®Google Scholar
• Qiu M, Lai Z, Wei S, et al. Bronchiectasis after bronchial thermoplasty. J Thorac Dis. 2018;10(10): E721–E726. doi:10.21037/jtd.2018.09.116
   Web of Science ®Google Scholar
• Funatsu A, Kobayashi K, Iikura M, Ishii S, Izumi S, Sugiyama H. A case of pulmonary cyst and pneumothorax after bronchial thermoplasty. Respirol Case Rep. 2018;6(2):e00286.29321930
   PubMed Web of Science ®Google Scholar
• Facciolongo N, Menzella F, Lusuardi M, et al. Recurrent lung atelectasis from fibrin plugs as a very early complication of bronchial thermoplasty: a case report. Multidiscipl Respir Med. 2015;10(1):9. doi:10.1186/s40248-015-0002-7
   Google Scholar
• Menzella F, Lusuardi M, Galeone C, Montanari G, Cavazza A, Facciolongo N. Heat-induced necrosis after bronchial thermoplasty: a new concern? Allergy Asthma Clin Immunol. 2018;14(1):25. doi:10.1186/s13223-018-0252-y29983718
   PubMed Web of Science ®Google Scholar
• d’Hooghe JNS, Ten Hacken NH, Weersink EJM, Sterk PJ, Annema JT, Bonta PI. Emerging understanding of the mechanism of action of bronchial thermoplasty in asthma. Pharmacol Therapeut. 2018;181:101–107. doi:10.1016/j.pharmthera.2017.07.015
   PubMed Web of Science ®Google Scholar
• Donovan GM, Elliot JG, Green FHY, James AL, Noble PB. Unraveling a clinical paradox: why does bronchial thermoplasty work in asthma? Am J Respir Cell Mol Biol. 2018;59(3):355–362. doi:10.1165/rcmb.2018-0011OC29668295
   PubMed Web of Science ®Google Scholar
• James AL, Elliot JG, Jones RL, et al. Airway smooth muscle hypertrophy and hyperplasia in asthma. Am J Respir Crit Care Med. 2012;185(10):1058–1064. doi:10.1164/rccm.201110-1849OC22403800
   PubMed Web of Science ®Google Scholar
• Pepe C, Foley S, Shannon J, et al. Differences in airway remodeling between subjects with severe and moderate asthma. J Allergy Clin Immunol. 2005;116(3):544–549. doi:10.1016/j.jaci.2005.06.01116159622
   PubMed Web of Science ®Google Scholar
• Zuyderduyn S, Sukkar MB, Fust A, Dhaliwal S, Burgess JK. Treating asthma means treating airway smooth muscle cells. Eur Resp J. 2008;32(2):265–274. doi:10.1183/09031936.00051407
   PubMed Web of Science ®Google Scholar
• Elliot JG, Noble PB, Mauad T, et al. Inflammation-dependent and independent airway remodelling in asthma. Respirology. 2018;23(12):1138–1145. doi:10.1111/resp.2018.23.issue-1229943875
   PubMed Web of Science ®Google Scholar
• Danek CJ, Lombard CM, Dungworth DL, et al. Reduction in airway hyperresponsiveness to methacholine by the application of RF energy in dogs. J Appl Physiol. 2004;97(5):1946–1953. doi:10.1152/japplphysiol.01282.200315258133
   PubMed Web of Science ®Google Scholar
• Miller JD, Cox G, Vincic L, Lombard CM, Loomas BE, Danek CJ. A prospective feasibility study of bronchial thermoplasty in the human airway. Chest. 2005;127(6):1999–2006. doi:10.1378/chest.127.6.199915947312
   PubMed Web of Science ®Google Scholar
• Gordon I, Husain A, Charbeneau J, Krishnan J, Hogarth D. Endobronchial biopsy: a guide for asthma therapy selection in the era of bronchial thermoplasty. J Asthma. 2013;50(6):634–641. doi:10.3109/02770903.2013.79423923621125
   PubMed Web of Science ®Google Scholar
• Denner DR, Doeing DC, Hogarth DK, Dugan K, Naureckas ET, White SR. Airway inflammation after bronchial thermoplasty for severe asthma. Annals Am Thor Soc. 2015;12(9):1302–1309. doi:10.1513/AnnalsATS.201502-082OC
   PubMed Web of Science ®Google Scholar
• Ichikawa T, Panariti A, Audusseau S, et al. Effect of bronchial thermoplasty on structural changes and inflammatory mediators in the airways of subjects with severe asthma. Respir Med. 2019;150:165–172. doi:10.1016/j.rmed.2019.03.00530961946
   PubMed Web of Science ®Google Scholar
• Russell R, Aubier M, Pretolani M, et al. Bronchial thermoplasty leads to rapid and persistent improvements in airway remodeling. Eur Respir Soc Congr. 2019 Madrid.
   Google Scholar
• Langton D, Sloan G, Banks C, Bennetts K, Plummer V, Thien F. Bronchial thermoplasty increases airway volume measured by functional respiratory imaging. Respir Res. 2019;20(1):157. doi:10.1186/s12931-019-1132-931311604
   PubMed Web of Science ®Google Scholar
• Konietzke P, Weinheimer O, Wielpütz MO, et al. Quantitative CT detects changes in airway dimensions and air-trapping after bronchial thermoplasty for severe asthma. Eur J Radiol. 2018;107:33–38. doi:10.1016/j.ejrad.2018.08.00730292270
   PubMed Web of Science ®Google Scholar
• Chernyavsky IL, Russell RJ, Saunders RM, et al. In vitro, in silico and in vivo study challenges the impact of bronchial thermoplasty on acute airway smooth muscle mass loss. Eur Respir J. 2018;51:5. doi:10.1183/13993003.01680-2017
   Web of Science ®Google Scholar
• Dyrda P, Tazzeo T, DoHarris L, et al. Acute response of airway muscle to extreme temperature includes disruption of actin-myosin interaction. Am J Respir Cell Mol Biol. 2011;44(2):213–221. doi:10.1165/rcmb.2009-0259OC20395634
   PubMed Web of Science ®Google Scholar
• Salem IH, Gras D, Joubert P, et al. Persistent reduction of mucin production after bronchial thermoplasty in severe asthma. Am J Respir Crit Care Med. 2019;199(4):536–538. doi:10.1164/rccm.201811-2064LE30540915
   PubMed Web of Science ®Google Scholar
• Sun Q, Fang L, Roth M, et al. Bronchial thermoplasty decreases airway remodelling by blocking epithelium-derived heat shock protein 60 (HSP60) secretion and protein arginine methyltransferase 1 (PRMT1) in fibroblasts. Eur Respir J. 2019; 1900300 Epub ahead of print. doi:10.1183/13993003.00300-201931467116
   PubMed Web of Science ®Google Scholar
• Facciolongo N, Di Stefano A, Pietrini V, et al. Nerve ablation after bronchial thermoplasty and sustained improvement in severe asthma. BMC Pulm Med. 2018;18(1):29. doi:10.1186/s12890-017-0554-829422039
   PubMed Web of Science ®Google Scholar
• Ryan DM, Fowler SJ, Niven RM. Reduction in peripheral blood eosinophil counts after bronchial thermoplasty. J Allergy Clin Immunol. 2016;138(1):308–310.e302. doi:10.1016/j.jaci.2015.11.04426953157
   PubMed Web of Science ®Google Scholar
• Liao S-Y, Linderholm AL, Yoneda KY, Kenyon NJ, Harper RW. Airway transcriptomic profiling after bronchial thermoplasty. ERJ Open Res. 2019;5(1):00123–02018. doi:10.1183/23120541.00123-201830792984
   PubMedGoogle Scholar
• Contoli M, Santus P, Papi A. Small airway disease in asthma: pathophysiological and diagnostic considerations. Curr Opin Pulm Med. 2015;21(1):68–73. doi:10.1097/MCP.000000000000012225415403
   PubMed Web of Science ®Google Scholar
• Chanez P, Pahus L, Charriot J, Bourdin A. Severe asthma treated by bronchial thermoplasty: a success not due to the small airways? Respirology. 2019;24(5):402–403. doi:10.1111/resp.2019.24.issue-530694006
   PubMed Web of Science ®Google Scholar
• Boulet L-P, Laviolette M. Acute effects of bronchial thermoplasty: a matter of concern or an indicator of possible benefit to small airways? Eur Respir J. 2017;49(3):1700029. doi:10.1183/13993003.00029-201728298407
   PubMed Web of Science ®Google Scholar
• Langton D, Ing A, Bennetts K, et al. Bronchial thermoplasty reduces gas trapping in severe asthma. BMC Pulm Med. 2018;18(1):155. doi:10.1186/s12890-018-0721-630249234
   PubMed Web of Science ®Google Scholar
• Langton D, Ing A, Sha J, et al. Measuring the effects of bronchial thermoplasty using oscillometry. Respirology. 2019;24(5):431–436. doi:10.1111/resp.2019.24.issue-530419608
   PubMed Web of Science ®Google Scholar
• Thomen RP, Sheshadri A, Quirk JD, et al. Regional ventilation changes in severe asthma after bronchial thermoplasty with (3)He MR imaging and CT. Radiology. 2015;274(1):250–259. doi:10.1148/radiol.1414008025144646
   PubMed Web of Science ®Google Scholar
• Luc F, Prieur E, Whitmore GA, Gibson PG, Vandemheen KL, Aaron SD. “Placebo effects” in clinical trials evaluating patients with uncontrolled persistent asthma. Annals ATS. 2019;16(9):1124–1130. doi:10.1513/AnnalsATS.201901-071OC
   Web of Science ®Google Scholar
• Redberg RF. Sham controls in medical device trials. N Eng J Med. 2014;371(10):892–893. doi:10.1056/NEJMp1406388
   PubMed Web of Science ®Google Scholar
• Nguyen HV, Bose S, Mital S, et al. Is bronchial thermoplasty cost-effective as treatment for problematic asthma patients? Singapore’s perspective on a global model. Respirology. 2017;22(6):1102–1109. doi:10.1111/resp.2017.22.issue-628370985
   PubMed Web of Science ®Google Scholar
• Zein JG, Menegay MC, Singer ME, et al. Cost effectiveness of bronchial thermoplasty in patients with severe uncontrolled asthma. J Asthma. 2015;1–7.
   Web of Science ®Google Scholar
• Zafari Z, Sadatsafavi M, Marra CA, Chen W, FitzGerald JM. Cost-effectiveness of bronchial thermoplasty, omalizumab, and standard therapy for moderate-to-severe allergic asthma. PLoS One. 2016;11(1):e0146003. doi:10.1371/journal.pone.014600326751790
   PubMed Web of Science ®Google Scholar
• Niven RM, Simmonds MR, Cangelosi MJ, Tilden DP, Cottrell S, Shargill NS. Indirect comparison of bronchial thermoplasty versus omalizumab for uncontrolled severe asthma. J Asthma. 2017;55(4):443–451. doi:10.1080/02770903.2017.133778928708944
   PubMed Web of Science ®Google Scholar
• Oberle AJ, Mathur P. Precision medicine in asthma: the role of bronchial thermoplasty. Curr Opin Pulm Med. 2017;23(3):254–260. doi:10.1097/MCP.000000000000037228319473
   PubMed Web of Science ®Google Scholar
• Humbert M, Beasley R, Ayres J, et al. Benefits of omalizumab as add-on therapy in patients with severe persistent asthma who are inadequately controlled despite best available therapy (GINA 2002 step 4 treatment): INNOVATE. Allergy. 2005;60(3):309–316. doi:10.1111/all.2005.60.issue-315679715
   PubMed Web of Science ®Google Scholar
• Hanania NA, Alpan O, Hamilos DL, et al. Omalizumab in severe allergic asthma inadequately controlled with standard therapy. Ann Intern Med. 2011;154(9):573–582. doi:10.7326/0003-4819-154-9-201105030-0000221536936
   PubMed Web of Science ®Google Scholar
• Siddiqui S, Denlinger LC, Fowler SJ, et al. Unmet needs in severe asthma subtyping and precision medicine trials. Bridging clinical and patient perspectives. Am J Respir Crit Care Med. 2019;199(7):823–829. doi:10.1164/rccm.201809-1817PP30726120
   PubMed Web of Science ®Google Scholar
• Han X, Zhang S, Zhao W, et al. A successful bronchial thermoplasty procedure in a “very severe” asthma patient with rare complications: a case report. J Asthma. 2019;56(9):1004–1007. doi:10.1080/02770903.2018.150999230285511
   PubMed Web of Science ®Google Scholar