IgE-Mediated Systemic Anaphylaxis And Its Association With Gene Polymorphisms Of ACE, Angiotensinogen And Chymase

References

• Terr AI. Anaphylaxis. Clin Rev Allergy. 1985;3:3–23.3884127
   PubMedGoogle Scholar
• Mullins RJ, Wainstein BK, Barnes EH, Liew WK, Campbell DE. Increases in anaphylaxis fatalities in Australia from 1997–2013. Clin Exp Allergy. 2016;46:1099–1110. doi:10.1111/cea.1274827144664
   PubMed Web of Science ®Google Scholar
• Tejeclor A, Lonson MA, Moromoro M, Mugica Garcia MV. Epidemiology of anaphylaxis. Clin Exp Allergy. 2014;45:1027–1039.
   Web of Science ®Google Scholar
• Sheikh A, Alves B. Age, sex, geographical and socio-economic variations in admissions for anaphylaxis: analysis of four years of English hospital data. Clin Exp All. 2001;31:1571–1576. doi:10.1046/j.1365-2222.2001.01203.x
   PubMed Web of Science ®Google Scholar
• Bjornsson I, Graffeo LS. Improving diagnostic accuracy of anaphylaxis in acute care setting. West J Emerg Med. 2010;11(5):456–461.21293765
   PubMedGoogle Scholar
• Lee J, Vadas P. Anaphylaxis: mechanisms and management. Clin Exp Allergy. 2011;41:923–938. doi:10.1111/j.1365-2222.2011.03779.x21668816
   PubMed Web of Science ®Google Scholar
• Pumphrey R, Stanworth SJ. The clinical spectrum of anaphylaxis in north-west England. Clin Exp All. 1996;26(12):1364–1370. doi:10.1111/j.1365-2222.1996.tb00537.x
   Web of Science ®Google Scholar
• Pumphrey RS. Lessons for management of anaphylaxis from a study of fatal reactions. Clin Exp Allergy. 2000;30:1144–1150. doi:10.1046/j.1365-2222.2000.00864.x10931122
   PubMed Web of Science ®Google Scholar
• Kajiwara N, Sasaki T, Bradding P. Activation of human mast cells through the platelet-activating factor receptor. J Allergy Clin Immunol. 2010;125:1136–1137. doi:10.1016/j.jaci.2010.01.056
   Web of Science ®Google Scholar
• Finkleman FD, Rothenburg ME, Brandt EB, Morris SC, Strait RT. Molecular mechanisms of anaphylaxis; lessons from studies with murine models. J Allergy Clin Immunol. 2005;115:449–457. doi:10.1016/j.jaci.2004.12.112515753886
   PubMed Web of Science ®Google Scholar
• Umsasunthar T, Leonardi-Bel J, Hodes M, et al. Incidence of fatal food anaphylaxis in people with food allergy: a systematic review and meta-analysis. Clin Exp Allergy. 2013;43:1333–1341. doi:10.1111/cea.1221124118190
   PubMed Web of Science ®Google Scholar
• Lieberman P, Simons FER. Anaphylaxis and cardiovascular disease: therapeutic dilemmas. Clin Exp Allergy. 2015;45:1288–1295. doi:10.1111/cea.1252025711241
   PubMed Web of Science ®Google Scholar
• Rutkowski K, Dua S, Nasser S. Anaphylaxis: current state of knowledge for the modern physician. Postgrad Med J. 2012;88:458–464. doi:10.1136/postgradmedj-2011-13063422467837
   PubMed Web of Science ®Google Scholar
• Berlin MC. Pathogenesis of IgE mediated food allergy. Clin Exp Allergy. 2015;45:1483–1496. doi:10.1111/cea.1259826215729
   PubMed Web of Science ®Google Scholar
• Braganza SC, Acworth JP, McKinnon DRL, Peake JE, Brown AFT. Paediatric emergency department anaphylaxis: different patterns from Adults. Arch Dis Child. 2006;91:159–163. doi:10.1136/adc.2004.06991416308410
   PubMed Web of Science ®Google Scholar
• Macdougall CF, Cart AJ, Clover AF. How dangerous is food allergy in childhood? The incidence of severe and fatal allergic reactions across UK and Ireland. Arch Dis Child. 2002;86:236–237. doi:10.1136/adc.86.4.23611919093
   PubMed Web of Science ®Google Scholar
• Smith PK, Hourihane JO, Lieberman P. Risk multipliers for severe food anaphylaxis. World Allergy Organ J. 2005;8:30. doi:10.1186/s40413-015-0081-0
   Web of Science ®Google Scholar
• Gupta R, Sheikh A, Strachan DP. Time trends in allergic disorders in the UK. Thorax. 2007;62:91–96. doi:10.1136/thx.2004.03884416950836
   PubMed Web of Science ®Google Scholar
• Vetander M, Protudjer JLP, Liija G, et al. Anaphylaxis to foods in a population of adolescents: incidence, characteristics and associated risks. Clin Exp Allergy. 2016;46:1575–1587. doi:10.1111/cea.1284227790764
   PubMed Web of Science ®Google Scholar
• Delage C, Irey NS. Anaphylactic deaths: a Clinicopathologic study of 43 cases. J Forensic Sci. 1972;17:525–540. doi:10.1520/JFS10141J4618279
   PubMedGoogle Scholar
• Greenberger PA, Rotskoff BD, Lifschultz B. Fatal anaphylaxis: post-mortem findings and associated comorbid diseases. Ann Allergy Asthma Immunol. 2007;98:252–257. doi:10.1016/S1081-1206(10)60714-417378256
   PubMed Web of Science ®Google Scholar
• Stumpf JL, Shehab N, Patel AC. Safety of ACE-inhibitors in patients with insect venom allergies. Am Pharmacother. 2006;40:699–703. doi:10.1345/aph.1G295
   PubMed Web of Science ®Google Scholar
• Slade CA, Douglass JA. Changing practice: no need to stop ACE inhibitors for venom immunotherapy. Clin Exp Allergy. 2014;44:617–619. doi:10.1111/cea.1229524734926
   PubMed Web of Science ®Google Scholar
• Londe S. Blood pressure in children under office conditions. Clin Paediatr. 1966;5(2):71–78. doi:10.1177/000992286600500204
   Web of Science ®Google Scholar
• Strufald MW, Silva EMK, France MC, Puccini RF. Blood pressure levels in childhood:-probing the relative importance of birthweight and current size. Eur J Pediatr. 2009;168:619–625. doi:10.1007/s00431-008-0813-z18830709
   PubMed Web of Science ®Google Scholar
• Strufaldi MW, Silva EM, Franco MC, Puccini RF. Blood pressure in childhood: probing the relative importance of birth weight and current size. Eur J Pediatr. 2009;168:619–625. doi:10.1007/s00431-008-0813-z18830709
   PubMed Web of Science ®Google Scholar
• Pipkin FB, Smales OR, O’Callaghan MJ. Renin and angiotensin levels in children. Arch Dis Child. 1981;56:298–302. doi:10.1136/adc.56.4.2987018406
   PubMed Web of Science ®Google Scholar
• Vlajinac H, Miljus D, Adanja B, Marinkovic J, Sipetic S, Kovec N. Blood pressure levels in 7 to 14 year old Belgrade children. J Human Hypertens. 2003;17:761–765. doi:10.1038/sj.jhh.100161814578915
   PubMed Web of Science ®Google Scholar
• VanAcker KJ, Scharpe SL, Depreltere JR, Neels HM. Renin-angiotensin-aldosterone system in the healthy infant and child. Kidney Int. 1979;16:196–203. doi:10.1038/ki.1979.121513506
   PubMed Web of Science ®Google Scholar
• Silva AC, Diniz JS, Filho AR, Santos RAS. The renin angiotensin system in childhood hypertension: selective increase of angiotensin (1-7) in essential hypertension. J Pediatr. 2004;145:93–98. doi:10.1016/j.jpeds.2004.03.05515238914
   PubMed Web of Science ®Google Scholar
• Fiselier TJW, Lunen P, Monnens L, Van Munster JM, Peer P. Levels of renin, angiotensin-I and 2, ACE and aldosterone in infancy and childhood. Eur J Pediat. 1983;141:3–7. doi:10.1007/BF00445660
   PubMed Web of Science ®Google Scholar
• Sassard A, Incent M, Francois R, Cier JF. Plasma renin activity in normal subjects from infancy to puberty. J Clin Endocrinol Metab. 1975;40:524–525. doi:10.1210/jcem-40-3-5241117060
   PubMed Web of Science ®Google Scholar
• Dillon MJ, Ryness JM. Plasma renin activity and aldosterone concentration in children. Bmj. 1975;4:316–319. doi:10.1136/bmj.4.5992.3161192047
   PubMed Web of Science ®Google Scholar
• Slalker HP, Holland NH, Kotchen JM, Kotchen TA. Plasma renin activity in healthy children.The. J Pediatr. 1976;89:256–258. doi:10.1016/S0022-3476(76)80460-X940018
   PubMed Web of Science ®Google Scholar
• Kruger C, Rauh M, Dorr HG. Immunoreactive renin concentrations in healthy children from birth to adolescence. Clin Chimica Acta. 1998;274:15–27. doi:10.1016/S0009-8981(98)00044-8
   Web of Science ®Google Scholar
• Beneteau-Burnat B, Baudin B, Morgant G, Baumann FCH, Gilboudeau J. Serum angiotensin-converting enzyme in healthy and sarcoidotic children: comparison with the reference intervals for adults. Clin Chem. 1990;36:344–348.2154343
   PubMed Web of Science ®Google Scholar
• Gallagher PE, Li P, Lenhart MC, Brosnihan KB. Estrogen regulation of angiotensin-converting enzyme mRNA. Hypertension. 1999;33:323–328. doi:10.1161/01.hyp.33.1.3239931124
   PubMed Web of Science ®Google Scholar
• Fogo A, Yoshido Y, Yared A, Ichikawa I. Important of angiogenic action of angiotensin II in the glomerular growth of maturing kidneys. Kidney Int. 1990;38:1068–1074. doi:10.1038/ki.1990.3142074650
   PubMed Web of Science ®Google Scholar
• Franco MC, Casarini DE, Carneiro-Ramos MS, Sawaya AL, Barreto-Chaves MLM, Sesso R. Circulating renin-angiotensin system and catecholamine’s in childhood: is there a role for birthweight? Clin Sci. 2008;114:375–380. doi:10.1042/CS2007028417953515
   PubMed Web of Science ®Google Scholar
• Sippell WG, Dorr HG, Bidlingmaier F, Knorr D. Plasma levels of aldosterone, cortisone, 11-deoxycorticosterone, progesterone, 17-hydroxyprogerone, cortisol during infancy and childhood. Pediatr Res. 1980;14:39–46. doi:10.1203/00006450-198001000-000107360520
   PubMed Web of Science ®Google Scholar
• Howard PJ, Ambrosuis WT, Tewksbury DA, Wagner MA, Zhou L, Hanna MP. Serum Angiotensinogen concentration in relation to gonadal hormones, body size and genotype in growing young people. Hypertension. 1998;32:875–879. doi:10.1161/01.hyp.32.5.8759822447
   PubMed Web of Science ®Google Scholar
• Giacchetti G, Faloia E, Mariniello B, et al. Over expression of the renin angiotensin system in human visceral adipose tissue in normal and overweight subjects. Am J Hypertension. 2002;15(5):381–388. doi:10.1016/S0895-7061(02)02257-4
   PubMed Web of Science ®Google Scholar
• Staessen JA, Ginocchio B, Wang JG, et al. Genetic variability in the renin-angiotensin system: prevalence of alleles and genotypes. J Cardiovasc Risk. 1997;4:401–422.9865673
   PubMedGoogle Scholar
• Herman K, Ring J. The renin angiotensin system and hymenoptera venom anaphylaxis. Clin Exp Allergy. 1993;23(9):762–769. doi:10.1111/j.1365-2222.1993.tb00364.x10779307
   PubMed Web of Science ®Google Scholar
• Herman K, Ring J. Hymenoptera venom anaphylaxis: may decrease levels of angiotensin peptides play a role? Clin Exp All. 1990;20(5):569–570. doi:10.1111/j.1365-2222.1990.tb03151.x
   Web of Science ®Google Scholar
• Summers CW, Pumphrey RS, Woods CN, Mcdowell G, Pemberton PW, Arkwright PD. Factors predicting anaphylaxis to peanuts and tree nuts in patients referred to a specialist centre. J Allergy Clin Immunol. 2008;121(3):632–638. doi:10.1016/j.jaci.2007.12.00318207562
   PubMed Web of Science ®Google Scholar
• Niedoszytko M, Ratajska M, Jassem E. AGT(M235T), ACE(I/D,I/I,D/D) polymorphism in patients with insect venom allergy preliminary results. Allergy. 2007;62(suppl 83):111. doi:10.1111/j.1398-9995.2007.01456.x
   Web of Science ®Google Scholar
• Mueller UR. Clinical Presentation and Pathogenesis in Venom Allergy. Stuggart: Gustav Fischer; 1990:35–60.
   Google Scholar
• Varney VA, Warner A, Ghosh A, Nicholas A, Sumar N. IgE-mediated anaphylaxis to foods, venom, and drugs; influence of serum angiotensin converting enzyme levels and genotype. 2012 J Allergy. 9 article ID 258145.
   Google Scholar
• Dimitropoulou C, Chatterjee A, McCloud L, Yetik-Anacak G, Catravas JD. Angiotensin, Bradykinin and the Endothelium. Hypertension. 2006;176:255–294.
   Google Scholar
• Persson K, Safholm ACE, Andersson RGG, Ahlner J. GTN-induced angiotensin-converting enzyme (ACE) inhibition in healthy volunteers is dependent on ACE genotype. J Physiol Pharmacol. 2005;83:1117–1122. doi:10.1139/y05-118
   Web of Science ®Google Scholar
• Reyes-Engel A, Morcillo L, Aranda FJ, et al. Influence of Gender and Genetic Variability on Plasma Angiotensin Peptides. J Renin Aldosterone Angiotensin Sys. 2006;7(2):92–97. doi:10.3317/jraas.2006.015
   Web of Science ®Google Scholar
• Jan Danser AH, Deinum J, Osterop APRM, Admiral PJJ, Schalekamp M. Angiotensin I to angiotensin II conversion in the human forearm and leg: effects of angiotensin converting enzyme gene insertion/deletion polymorphisms. Hypertension. 1999;17:1867–1872. doi:10.1097/00004872-199917121-00014
   Web of Science ®Google Scholar
• Van Dijik MA, Kroon K, Kamper AM, Boomsma F, Danser AHJ, Chang PC. The angiotensin-converting enzyme gene polymorphism and responses to angiotensin and bradykinin in the human foreman. J Cardiovascular Pharmacol. 2000;35(30):484–490. doi:10.1097/00005344-200003000-00020
   Web of Science ®Google Scholar
• Woods D, Sanders J, Jones A, et al. The serum angiotensin-converting enzyme and angiotensin II response to altered posture and acute exercise, and the influence of ACE genotype. Eur J Appl Physiol. 2004;91:342–348. doi:10.1007/s00421-003-0993-114595564
   PubMed Web of Science ®Google Scholar
• Zee RYL, Schrader AP, Morris BJ. Effect of angiotensin-converting enzyme genotype on the renin-angiotensin components in hypertensives. Clin Chimica Acta. 1996;252:33–39. doi:10.1016/0009-8981(96)06310-3
   Web of Science ®Google Scholar
• Sumino H, Ichikawa S, Kanda T, et al. Hormone replacement therapy in postmenopausal women with essential hypertension increases circulating plasma levels of bradykinin. Ajh. 1999;12:1044–1047. doi:10.1016/s0895-7061(99)00094-110560792
   PubMed Web of Science ®Google Scholar
• Vliagoftis H, Dimitriadou V, Boucher W, et al. Estradiol augments while tamoxifen inhibits rat mast cell secretion. Int Arch Allergy Immunol. 1992;98:398–409. doi:10.1159/0002362171384869
   PubMed Web of Science ®Google Scholar
• Tsuda M, Iwai M, Li J-M, et al. Inhibitory effects of AT1 receptor blocker, olmesartan and estrogen on atherosclerosis via anti-oxidative stress. Hypertension. 2005;45:545–551. doi:10.1161/01.HYP.0000157409.88971.fc15723967
   PubMed Web of Science ®Google Scholar
• Chikhladze NM, Samedova KF, Sudomoina MA, et al. Comparative genetic analysis of different forms of low-renin arterial hypertension. Mol Biol. 2008;42:521–530. doi:10.1134/S0026893308040067
   Web of Science ®Google Scholar
• Stein U, Grob W. Rapid detection of the hypertension associated Met234 toThr allele of the human angiotensinogen gene. Hum Mol Genet. 1993;2(5):609–610. doi:10.1093/hmg/2.5.6098518804
   PubMed Web of Science ®Google Scholar
• Nalogowska K, Glosnicka BI, Lacka MJ, et al. Angiotensin-2 type-1 receptor A1166c polymorphism is associated with increased risk of pregnancy associated hypertension. Med Sci Monit. 2000;6(3):523–529.11208365
   PubMedGoogle Scholar
• Pfeufer A, Osterziel KJ, Urata H, et al. Angiotensin-converting enzyme and heart Chymase gene polymorphisms in hypertrophic cardiomyopathy. Am J Cardiol. 1996;78:362–364. doi:10.1016/S0002-9149(96)00296-28759823
   PubMed Web of Science ®Google Scholar
• Ortlepp JR, Metmkat J, Mevissen V, et al. Relation between the angiotensinogen (AGT) M235T gene polymorphism and blood pressure in a large homogenous study population. J Human Hypertens. 2003;17:555–559. doi:10.1038/sj.jhh.100158712874613
   PubMed Web of Science ®Google Scholar
• Holla L, Vasku A, Znojil V, Siskova L, Vache J. Association of 3 gene polymorphisms with atopic diseases. J Allergy Clin Immunol. 1999;103(4):702–708. doi:10.1016/s0091-6749(99)70246-010200023
   PubMed Web of Science ®Google Scholar
• Joong J, Hyun-ju K, Lee I-K, Chung HT, Lee JH. Association between polymorphisms of the angiotensin-converting enzyme and angiotensinogen genes and allergic rhinitis in a Korean population. Ann Otol Rhinol Laryngol. 2004;113:297–302. doi:10.1177/00034894041130040815112973
   PubMed Web of Science ®Google Scholar
• Li H, Du Z, Zhang L, et al. The relationship between angiotensinogen gene polymorphisms and essential hypertension in a northern Han Chinese population. Hypertension. 2014;65(5):614–619.
   Google Scholar
• Al-Hazzan A, Daoud MS, Ataya FS, Fouad D, Al-Jafari AA. Renin-angiotensin system gene polymorphisms among Saudi patients with coronary artery disease. J Biol Res. 2014;21(8):1–9.
   Google Scholar
• Ortlepp JR, Metrikat J, Mevissen V, et al. Relation between the angiotensinogen (AGT) M235T gene polymorphism and blood pressure in a large, homogenous study population. J Human Hypertens. 2003;17:555–559. doi:10.1038/sj.jhh.100158712874613
   PubMed Web of Science ®Google Scholar
• Glavnik N, Petrovic D. M235T polymorphisms of the angiotensinogen gene and insertion/deletion polymorphisms of the angiotensin-1 converting enzyme gene in essential arterial hypertension in Caucasians. Folia Biol. 2007;53(2):69–73.
   PubMed Web of Science ®Google Scholar
• Buraczynska M, Pijanowski Z, Spasiewicz D, et al. Renin-angiotensin system gene polymorphisms: assessment of the risk of coronary heart disease. Kardiol Pol. 2003;58(1):1–9.14502296
   PubMedGoogle Scholar
• Fernandez-Arcas N, Dieguez-lucena JL, Munoz-Moran E, et al. Both alleles of the M235T polymorphism of angiotensinogen gene can be a risk factor for myocardial infarction. Clin Genet. 2001;60:52–57. doi:10.1034/j.1399-0004.2001.600108.x11531970
   PubMed Web of Science ®Google Scholar
• Murugan M, Ramalingam K, Nazzuredin M, Rashed HA, Punamalai G. SNP’s and its correltion with hypertension: a comprehensive review. Dent Med Res. 2013;1:3–6.
   Google Scholar
• Sugiyama A, Kishikawa R, Honjo S, et al. Angiotensin-converting enzyme genotype is a risk for wheat-dependant exercise-induced anaphylaxis sensitized with hydrolysed wheat protein. Allergol Int. 2016;65:115–116. doi:10.1016/j.alit.2015.09.00326666484
   PubMed Web of Science ®Google Scholar
• Sethi AA, Nordesgaard BG, Agerholm-larsen B. Angiotensinogen polymorphisms and elevated blood pressure in the general population. The copenhagen city heart study. Hypertension. 2001;37:875–881. doi:10.1161/01.hyp.37.3.87511244011
   PubMed Web of Science ®Google Scholar
• Jimenez PM, Conde C, Casanegra A, Romero C, Tabares AH, Orias M. Association of ACE genotype and predominantly diastolic hypertension: a preliminary study. J RAA Sys. 2007;8(1):42–44.
   Google Scholar
• Miyazaki M, Takai S, Jin D, Muramatsu M. Pathological roles of angiotensin II produced by mast cell chymase and the effects of Chymase inhibition in animal models. Pharmacol Ther. 2006;112:668–676. doi:10.1016/j.pharmthera.2006.05.00816837049
   PubMed Web of Science ®Google Scholar
• Raymond WW, Su S, Makarova A, et al. α2-Macroglobulin capture allows detection of mast cell Chymase in serum and creates a reservoir of angiotensin II-generating activity. J Immunol. 2009;182:5770–5777. doi:10.4049/jimmunol.090012719380825
   PubMed Web of Science ®Google Scholar
• Fukani H, Okunishi H, Miyazaki M. Chymase: its pathophysiological roles and inhibitors. Curr Pharm Drugs. 1998;4:439–453.
   Web of Science ®Google Scholar
• Dell’talia LJ, Husain A. Dissecting the role of Chymase in angiotensin II formation and heart and blood vessels disease. Curr Opin Cardiol. 2002;17:374–379.12151872
   PubMed Web of Science ®Google Scholar
• Dell’italia LJ, Husain A. Dissecting the role of Chymase in angiotensin II formation and heart and blood vessel diseases. Curr Opin Cardiol. 2002;17:374–379.12151872
   PubMed Web of Science ®Google Scholar
• Mao XQ, Shirakawa T, Yoshikawa T, et al. Association between genetic variants of mast-cell chymase and eczema. Lancet. 1996;348:581–583. doi:10.1016/s0140-6736(95)10244-28774571
   PubMed Web of Science ®Google Scholar
• Welle M. Development, significance and heterogeneity of mast cells with particular regard to the mast cell specific proteases Chymase and tryptase. J Leucocyte Biol. 1997;61:233–245. doi:10.1002/jlb.61.3.233
   PubMed Web of Science ®Google Scholar
• Bacani C, Frishman WH. Chymase: a new pharmacological target in cardiovascular disease. Cardiol Rev. 2006;14(4):187–193. doi:10.1097/01.crd.0000195220.62533.c516788331
   PubMedGoogle Scholar
• Takai S, Jin D, Miyazaki M. New approaches to blockade of the renin-angiotensin-aldosterone system: chymase as an important target to prevent organ damage. J Pharmacol Sci. 2010;113:301–309. doi:10.1254/jphs.10r05fm20675958
   PubMed Web of Science ®Google Scholar
• Heuston S, Hyland NP. Chymase inhibition as a pharmacological target: a role in inflammatory and functional gastrointestinal disorders. Brit J Pharmacol. 2012;167:732–740. doi:10.1111/j.1476-5381.2012.02055.x22646261
   PubMed Web of Science ®Google Scholar
• Zhou X, Whitworth HS, E-Khedr M, et al. Mast cell chymase: a useful marker in anaphylaxis. J Allergy Clin Immunol. 2011;127(2): abstracts AB143 number 539. doi:10.1016/j.jaci.2011.01.057
   Web of Science ®Google Scholar
• He S, Walls AF. The induction of a prolonged increase in microvascular permeability by human mast cell chymase. Eur J Pharmacol. 1998;352:91–98. doi:10.1016/S0014-2999(98)00343-49718272
   PubMed Web of Science ®Google Scholar
• Ortlepp JR, Janssens U, Bleckmann F, et al. A chymase gene variant is associated with atherosclerosis in venous coronary bypass grafts. Coron Artery Dis. 2001;12:493–497.11696688
   PubMed Web of Science ®Google Scholar
• Ortlepp JR, Janssens U, Bleckmann F, et al. A chymase gene variant is associated with atherosclerosis in venous coronary artery bypass grafts. J Coronary Artery Dis. 2001;12:493–497. doi:10.1097/00019501-200109000-00008
   PubMed Web of Science ®Google Scholar
• Ahmad S, Varagic J, Groban L, et al. Angiotensin (1-12); A chymase mediated cellular angiotensin II substrate. Curr Hypertens Res. 2014;16:429–437. doi:10.1007/s11906-014-0429-9
   PubMed Web of Science ®Google Scholar
• Schwartz LB, Yunginger JW, Miller J, Bokhari R, Dull D. Time course of appearance and disappearance of human mast cell tryptase in the circulation after anaphylaxis. J Clin Invest. 1989;83:1551–1555. doi:10.1172/JCI1140512468689
   PubMed Web of Science ®Google Scholar
• Rubinstein I, Nadel JA, Graf PD, Caughey GH. Mast cell chymase potentiates histamine-induced wheal formation in the skin of ragweed-allergic dogs. J Clin Invest. 1990;86:555–559. doi:10.1172/JCI1147442384602
   PubMed Web of Science ®Google Scholar
• Saarinen JV, Harvima RJ, Naukkarinen A, Horsmanheimo M, Harvima IT. The release of histamine is associated with the inactivation of mast cell chymase during immediate allergic wheal reactions in the skin. Clin Exp Allergy. 2001;31:593–601. doi:10.1046/j.1365-2222.2001.01030.x11359428
   PubMed Web of Science ®Google Scholar
• Nisho H, Takai S, Miyazaki M, et al. Usefulness of serum mast cell-specific chymase levels for postmortem diagnosis of anaphylaxis. Int J Legal Med. 2005;119:331–334. doi:10.1007/s00414-005-0524-115735956
   PubMed Web of Science ®Google Scholar
• Wong CK, Ng SSM, Lun SWM, Cao J, Lam CWK. Signaling mechanisms regulating the activation of human eosinophils by mast-cell-derived Chymase; implications for mast-cell-eosinophil interaction in allergic inflammation. Immunology. 2009;126:579–587. doi:10.1111/j.1365-2567.2008.02916.x18771439
   PubMed Web of Science ®Google Scholar
• Caughey GH. Mast cell tryptases and chymases in inflammation and host defense. Immunol Rev. 2007;217:141–154. doi:10.1111/j.1600-065X.2007.00509.x17498057
   PubMed Web of Science ®Google Scholar
• Guilarte M, Sala-Cunill A, Luengo O, Labrador-Horrillo M, Cardona V. The mast cell contact and coagulation system connection in anaphylaxis. Front Immunol.2017;8:846.28798744
   PubMed Web of Science ®Google Scholar
• Proud D, Togias A, Nacleiro RM, Crush SA, Norman PS, Lichtenstein LM. Kinins are generated in vivo following airway challenge of allergic individuals with allergen. J Clin Invest. 1983;72(5):1678–1685. doi:10.1172/JCI1111276355183
   PubMed Web of Science ®Google Scholar
• Stone SF, Brown SG. Mediators released during human anaphylaxis. Curr Allergy Asthma Rev. 2012;12(1):33–41. doi:10.1007/s11882-011-0231-6
   Web of Science ®Google Scholar
• Caughey GH. Mast cell proteases as pharmacological targets. Eur J Pharmacol. 2016;778:44–55. doi:10.1016/j.ejphar.2015.04.04525958181
   PubMed Web of Science ®Google Scholar
• Imamura T, Dubin A, Moore W, Tanaka R, Travis J. Induction of vascular permeability enhancement by human tryptase : dependence on activation of prekallikrein and direct release of bradykinin from kininogens. Lab Invest. 1996;74(5):861–870.8642782
   PubMed Web of Science ®Google Scholar
• Weidinger S, Rummier L, Klopp N, et al. Association study of mast cell Chymase polymorphisms with atopy. Allergy. 2005;60(10):1256–1261. doi:10.1111/j.1398-9995.2005.00879.x16134991
   PubMed Web of Science ®Google Scholar
• Sharma S, Rajan UM, Kumar A, Soni A, Ghosh B. A novel (TG) n (GA) m repeat polymorphism 254bp downstream of the mast cell Chymase (CMA1) gene is associated with atopic asthma and total serum IgE levels. J Hum Genet. 2005;50(6):276–282. doi:10.1007/s10038-005-0252-x15924217
   PubMed Web of Science ®Google Scholar
• Hossny EM, Amr NH, Elsayed SB, Nasr RA, Ibraheim EM. Association of polymorphisms in the mast cell chymase gene promoter region (−1903 G/A) and (TG) n (GA) m repeat downstream of the gene with bronchial asthma in children. J Investing Allergol Clin Immunol. 2008;18(5):376–381.
   Web of Science ®Google Scholar
• Iwanaga T, McEuen A, Walls AF, et al. Polymorphisms of the mast cell Chymase(CMA1) promotor region: lack of association with asthma but association with serum total Immunoglobulin E levels in aduld atopic dermatitis. Clin Exp Allergy. 2004;34(7):1037–1042. doi:10.1111/j.1365-2222.2004.02000.x15248847
   PubMed Web of Science ®Google Scholar
• He S, Walls AF. The prolonged increase in microvascular permeability by human mast cells Chymase. Eur J Pharmacol. 1998;352:91–98. doi:10.1016/S0014-2999(98)00343-49718272
   PubMed Web of Science ®Google Scholar
• Orlowska-Baranowska E, Gora J, Baranowski R, et al. Association of the commeon genetic polymorphisms and haplotypes of the Chymase gene with left ventricular mass in male patients with symptomatic aortic stenosis. PLoS ONE. 2014;9(5):1–10.
   Web of Science ®Google Scholar
• Veerappan A, Reid AC, Estephan R, et al. Mast cell renin and a local renin-angiotensin system in the airway: role in bronchoconstriction. PNAS. 2008;105(4):1315–1320. doi:10.1073/pnas.070973910518202178
   PubMed Web of Science ®Google Scholar
• Renne T. The vascular side of plasma kallikrein. Blood. 2015;125(4):589–590. doi:10.1182/blood-2014-11-60901625614637
   PubMed Web of Science ®Google Scholar
• European Marketing Authorization website Date 24/8/2012 EU/1/07/405/001-010.
   Google Scholar
• Przybilla RF, Bilo B, Muller U, Aberer W. Predictors of severe systemic anaphylaxic reactions in patients with hymenoptera venom allergy. J Allergy Clin Immunol. 2009;124:1047–1054. doi:10.1016/j.jaci.2009.08.02719895993
   PubMed Web of Science ®Google Scholar
• Reber LL, Hernandez JD, Galli SJ. The pathophysiology of anaphylaxis. J Allergy Clin Immunol. 2007;140:335–348. doi:10.1016/j.jaci.2017.06.003
   Web of Science ®Google Scholar
• Fukuda Y, Kawashima H, Saito K, Inomata N, Matsui M, Nakanishi T. Effect of human plasma-type plateletactivating factor acetylhydrolase in two anaphylactic shock models. Eur J Pharmacol. 2000;390(1–2):203–207. doi:10.1016/S0014-2999(99)00920-610708725
   PubMed Web of Science ®Google Scholar
• Arimura A, Harada M. Differential effect of a PAF antagonist CV-3988 on active and passive anaphylactic shock in various mouse strains. Lipids. 1991;26(12):1386–1390. doi:10.1007/BF025365721819738
   PubMed Web of Science ®Google Scholar
• Vadas P, Gold M, Perelman B, et al. Platelet-activating factor, PAF acetylhydrolase, and severe anaphylaxis. N Engl J Med. 2008;358(1):28–35. doi:10.1056/NEJMoa07003018172172
   PubMed Web of Science ®Google Scholar
• Campbell DJ, Alexiou T, Xiao HD, et al. Effect of reduced angiotensin-converting enzyme gene expression and angiotensin-converting enzyme inhibition on angiotensin and bradykinin peptide levels in mice. Hypertension. 2004;43(4):854–859. doi:10.1161/01.HYP.0000119190.06968.f114769811
   PubMed Web of Science ®Google Scholar
• Gill P, Jindal NL, Jagdis A, Vadas P. Platelets in the immune response; Revisiting platelet activating factor in anaphylaxis. J Allergy Clin Immunol. 2015;135(6):1424–1432. doi:10.1016/j.jaci.2015.04.01926051949
   PubMed Web of Science ®Google Scholar
• Kajiwara N, Sasaki T, Braddind P, et al. 2010 Activation of human mast cells through the platelet-activating factor receptor. J Allergy Clin Immunology. 125(5):1137–1145.20392487
   PubMed Web of Science ®Google Scholar
• Pretorius M, Luther JM, Murphey LJ, Vaughan DE, Brown NJ. Angiotensin-converting enzyme inhibition increases basal vascular tissue plasminogen activator release in women but not in men. Arterioscler Thromb Vasc Biol. 2005;25(11):2435–2440. doi:10.1161/01.ATV.0000186185.13977.9416166566
   PubMed Web of Science ®Google Scholar
• Ortega T, Paul M, Ackermann A, Fern´andez-Alfonso MS, De Rojas RS, Gonz´alez C. Modulation of angiotensinconverting enzyme by nitric oxide. Br J Pharmacol. 1998;124(2):291–298. doi:10.1038/sj.bjp.07018369641545
   PubMed Web of Science ®Google Scholar
• Finkelman FD, Rothenberg ME, Brandt EB, Morris SC, Strait RT. Molecular mechanisms of anaphylaxis: lessons from studies with murine models. J Allergy Clin Imunol. 2005;115(3):449–457. doi:10.1016/j.jaci.2004.10.029
   PubMed Web of Science ®Google Scholar
• Hox V, Desai A, Bandara G, Gilfillan AM, Metcalfe DD, Olivera A. Estrogen increases the severity of anaphylaxis in female mice through enhanced endothelial nitric oxide synthase expression and nitric oxide production.J. Allergy Clin Immunol. 2015;135(3):729–736. doi:10.1016/j.jaci.2014.11.003
   Google Scholar
• Dimitropoulou C, Chatterjee A, McCloud L, Yetik-Anacak G, Catravas JD. Angiotensin, bradykinin and the endothelium. Handb Exp Pharmacol. 2006;(176):255–294.16999222
   PubMedGoogle Scholar
• Mombouli JV, Vanhoutte PM. Heterogeneity of endothelium-dependent vasodilator effects of angiotensinconverting enzyme inhibitors: role of bradykinin generation during ACE inhibition. J Cardiovasc Pharmacol. 1992;20(9):S74–S82. doi:10.1097/00005344-199200209-00014
   Web of Science ®Google Scholar
• Lowenstein CJ, Michel T. What’s in a name? eNOS and anaphylactic shock. Jci. 2006. doi:10.1172/JCI29406
   Google Scholar
• Castells M. Diagnosis and management of anaphylaxis in precision medicine. J Allergy Clin Immunol. 2017;140(2):321–333. doi:10.1016/j.jaci.2017.06.01228780940
   PubMed Web of Science ®Google Scholar
• Rajj L. Hypertension and cardiovascular risk factors: role of the angiotensin II-nitric oxide interaction. Hypertension. 2001;37(2):767–773. doi:10.1161/01.hyp.37.2.76711230371
   PubMed Web of Science ®Google Scholar
• Husain K, Hernandez W, Ansari RA, Ferder L. Inflammation, oxidative stress and renin angiotensin system in atherosclerosis. World J Boil Chem. 2015;6(3):209–217. doi:10.4331/wjbc.v6.i3.209
   PubMedGoogle Scholar
• Schmermund A, Lerman LO, Ritman EL, Rumberger JA. Cardiac production of Angiotensin II and its pharmacologic inhibition: effects on the coronary circulation. Mayo Clin Proc. 1999;74:503–513. doi:10.4065/74.5.50310319084
   PubMed Web of Science ®Google Scholar