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Review

The Role of Food Allergy in Eosinophilic Esophagitis

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Pages 679-688 | Published online: 15 Dec 2020

References

  • Sicherer SH, Sampson HA. Food allergy: a review and update on epidemiology, pathogenesis, diagnosis, prevention, and management. J Allergy Clin Immunol. 2018;141(1):41–58. doi:10.1016/j.jaci.2017.11.00329157945
  • Sampson HA. Food allergy: past, present and future. Allergol Int. 2016;65(4):363–369. doi:10.1016/j.alit.2016.08.00627613366
  • Cianferoni A. Non-IgE mediated food allergy. Curr Pediatr Rev. 2019.
  • Nowak-Wegrzyn A, Katz Y, Mehr SS, Koletzko S. Non-IgE-mediated gastrointestinal food allergy. J Allergy Clin Immunol. 2015;135(5):1114–1124. doi:10.1016/j.jaci.2015.03.02525956013
  • Furuta GT, Katzka DA, Ingelfinger JR. Eosinophilic esophagitis. N Engl J Med. 2015;373(17):1640–1648. doi:10.1056/NEJMra150286326488694
  • Hirano I, Chan ES, Rank MA, et al. AGA institute and the joint task force on allergy-immunology practice parameters clinical guidelines for the management of eosinophilic esophagitis. Ann Allergy Asthma Immunol. 2020;124(5):416–423. doi:10.1016/j.anai.2020.03.02032336462
  • Miehlke S. Clinical features of Eosinophilic esophagitis in children and adults. Best Pract Res Clin Gastroenterol. 2015;29(5):739–748. doi:10.1016/j.bpg.2015.09.00526552773
  • Spergel J, Aceves SS. Allergic components of eosinophilic esophagitis. J Allergy Clin Immunol. 2018;142(1):1–8. doi:10.1016/j.jaci.2018.05.00129980277
  • Spergel JM, Brown-Whitehorn TF, Cianferoni A, et al. Identification of causative foods in children with eosinophilic esophagitis treated with an elimination diet. J Allergy Clin Immunol. 2012;130(2):461–467e465. doi:10.1016/j.jaci.2012.05.02122743304
  • Kagalwalla AF, Shah A, Li BU, et al. Identification of specific foods responsible for inflammation in children with eosinophilic esophagitis successfully treated with empiric elimination diet. J Pediatr Gastroenterol Nutr. 2011;53(2):145–149. doi:10.1097/MPG.0b013e31821cf50321788754
  • Wilson JM, McGowan EC. Diagnosis and management of eosinophilic esophagitis. Immunol Allergy Clin North Am. 2018;38(1):125–139. doi:10.1016/j.iac.2017.09.01029132668
  • Hirano I. How i approach the management of eosinophilic esophagitis in adults. Am J Gastroenterol. 2017;112(2):197–199. doi:10.1038/ajg.2016.51527845336
  • Lucendo AJ, Molina-Infante J, Arias A, et al. Guidelines on eosinophilic esophagitis: evidence-based statements and recommendations for diagnosis and management in children and adults. United Eur Gastroenterol J. 2017;5(3):335–358.
  • Renz H, Allen KJ, Sicherer SH, et al. Food allergy. Nat Rev Dis Primers. 2018;4:17098.29300005
  • Tordesillas L, Berin MC, Sampson HA. Immunology of food allergy. Immunity. 2017;47(1):32–50. doi:10.1016/j.immuni.2017.07.00428723552
  • Eiwegger T, Hung L, San Diego KE, O’Mahony L, Upton J. Recent developments and highlights in food allergy. Allergy. 2019;74(12):2355–2367. doi:10.1111/all.1408231593325
  • Dobbins JW, Sheahan DG, Behar J. Eosinophilic gastroenteritis with esophageal involvement. Gastroenterology. 1977;72(6):1312–1316. doi:10.1016/S0016-5085(77)80034-6870380
  • Attwood SE, Smyrk TC, Demeester TR, Jones JB. Esophageal eosinophilia with dysphagia. A distinct clinicopathologic syndrome. Dig Dis Sci. 1993;38(1):109–116.8420741
  • Straumann A, Spichtin HP, Bernoulli R, Loosli J, Vogtlin J. Idiopathic eosinophilic esophagitis: a frequently overlooked disease with typical clinical aspects and discrete endoscopic findings. Schweiz Med Wochenschr. 1994;124(33):1419–1429.7939509
  • Dellon ES, Hirano I. Epidemiology and natural history of eosinophilic esophagitis. Gastroenterology. 2018;154(2):319–332e313. doi:10.1053/j.gastro.2017.06.06728774845
  • McGowan EC, Keller JP, Dellon ES, Peng R, Keet CA. Prevalence and geographic distribution of pediatric eosinophilic esophagitis in the 2012 US medicaid population. J Allergy Clin Immunol Pract. 2020;8(8):2796–2798.e4. doi:10.1016/j.jaip.2020.04.00932320795
  • Robson J, O’Gorman M, McClain A, et al. Incidence and prevalence of pediatric eosinophilic esophagitis in utah based on a 5-year population-based study. Clin Gastroenterol Hepatol. 2019;17(1):107–114e101. doi:10.1016/j.cgh.2018.06.02829935329
  • Mansoor E, Cooper GS. The 2010–2015 prevalence of eosinophilic esophagitis in the USA: a population-based study. Dig Dis Sci. 2016;61(10):2928–2934. doi:10.1007/s10620-016-4204-427250980
  • Nowak-Wegrzyn A, Ellis A, Castells M. Sex and allergic diseases. Ann Allergy Asthma Immunol. 2019;122(2):134–135. doi:10.1016/j.anai.2018.12.01030711034
  • Kottyan LC, Rothenberg ME. Genetics of eosinophilic esophagitis. Mucosal Immunol. 2017;10(3):580–588. doi:10.1038/mi.2017.428224995
  • Radano MC, Yuan Q, Katz A, et al. Cesarean section and antibiotic use found to be associated with eosinophilic esophagitis. J Allergy Clin Immunol Pract. 2014;2(4):475–477e471. doi:10.1016/j.jaip.2014.02.01825017541
  • Jensen ET, Kappelman MD, Kim HP, Ringel-Kulka T, Dellon ES. Early life exposures as risk factors for pediatric eosinophilic esophagitis. J Pediatr Gastroenterol Nutr. 2013;57(1):67–71. doi:10.1097/MPG.0b013e318290d15a23518485
  • Witmer CP, Susi A, Min SB, Nylund CM. Early infant risk factors for pediatric eosinophilic esophagitis. J Pediatr Gastroenterol Nutr. 2018;67(5):610–615. doi:10.1097/MPG.000000000000212330095574
  • Jensen ET, Dellon ES. Environmental factors and eosinophilic esophagitis. J Allergy Clin Immunol. 2018;142(1):32–40. doi:10.1016/j.jaci.2018.04.01529729305
  • Sorser SA, Barawi M, Hagglund K, Almojaned M, Lyons H. Eosinophilic esophagitis in children and adolescents: epidemiology, clinical presentation and seasonal variation. J Gastroenterol. 2013;48(1):81–85. doi:10.1007/s00535-012-0608-x22618806
  • O’Shea KM, Aceves SS, Dellon ES, et al. Pathophysiology of eosinophilic esophagitis. Gastroenterology. 2018;154(2):333–345. doi:10.1053/j.gastro.2017.06.06528757265
  • Hill DA, Grundmeier RW, Ramos M, Spergel JM. Eosinophilic esophagitis is a late manifestation of the allergic march. J Allergy Clin Immunol Pract. 2018;6(5):1528–1533. doi:10.1016/j.jaip.2018.05.01029954692
  • Anyane-Yeboa A, Wang W, Kavitt RT. The role of allergy testing in eosinophilic esophagitis. Gastroenterol Hepatol (N Y). 2018;14(8):463–469.30302061
  • Burks AW, Tang M, Sicherer S, et al. ICON: food allergy. J Allergy Clin Immunol. 2012;129(4):906–920. doi:10.1016/j.jaci.2012.02.00122365653
  • Kelly KJ, Lazenby AJ, Rowe PC, Yardley JH, Perman JA, Sampson HA. Eosinophilic esophagitis attributed to gastroesophageal reflux: improvement with an amino acid-based formula. Gastroenterology. 1995;109(5):1503–1512. doi:10.1016/0016-5085(95)90637-17557132
  • Peterson KA, Byrne KR, Vinson LA, et al. Elemental diet induces histologic response in adult eosinophilic esophagitis. Am J Gastroenterol. 2013;108(5):759–766. doi:10.1038/ajg.2012.46823381017
  • Arias A, Gonzalez-Cervera J, Tenias JM, Lucendo AJ. Efficacy of dietary interventions for inducing histologic remission in patients with eosinophilic esophagitis: a systematic review and meta-analysis. Gastroenterology. 2014;146(7):1639–1648. doi:10.1053/j.gastro.2014.02.00624534634
  • Molina-Infante J, Gonzalez-Cordero PL, Arias A, Lucendo AJ. Update on dietary therapy for eosinophilic esophagitis in children and adults. Expert Rev Gastroenterol Hepatol. 2017;11(2):115–123. doi:10.1080/17474124.2017.127132427998193
  • Warners MJ, Vlieg-Boerstra BJ, Verheij J, et al. Elemental diet decreases inflammation and improves symptoms in adult eosinophilic oesophagitis patients. Aliment Pharmacol Ther. 2017;45(6):777–787. doi:10.1111/apt.1395328112427
  • Erwin EA, Tripathi A, Ogbogu PU, et al. IgE antibody detection and component analysis in patients with eosinophilic esophagitis. J Allergy Clin Immunol Pract. 2015;3(6):896–904e893. doi:10.1016/j.jaip.2015.05.01526099818
  • Clayton F, Fang JC, Gleich GJ, et al. Eosinophilic esophagitis in adults is associated with IgG4 and not mediated by IgE. Gastroenterology. 2014;147(3):602–609. doi:10.1053/j.gastro.2014.05.03624907494
  • Schuyler AJ, Wilson JM, Tripathi A, et al. Specific IgG4 antibodies to cow’s milk proteins in pediatric patients with eosinophilic esophagitis. J Allergy Clin Immunol. 2018;142(1):139–148e112. doi:10.1016/j.jaci.2018.02.04929678750
  • Chehade M, Aceves SS. Food allergy and eosinophilic esophagitis. Curr Opin Allergy Clin Immunol. 2010;10(3):231–237. doi:10.1097/ACI.0b013e328338cbab20410819
  • Cianferoni A, Ruffner MA, Guzek R, et al. Elevated expression of activated TH2 cells and milk-specific TH2 cells in milk-induced eosinophilic esophagitis. Ann Allergy Asthma Immunol. 2018;120(2):177–183e172. doi:10.1016/j.anai.2017.11.00629289462
  • Hill DA, Dudley JW, Spergel JM. The prevalence of eosinophilic esophagitis in pediatric patients with IgE-mediated food allergy. J Allergy Clin Immunol Pract. 2017;5(2):369–375. doi:10.1016/j.jaip.2016.11.02028042003
  • Pelz BJ, Wechsler JB, Amsden K, et al. IgE-associated food allergy alters the presentation of paediatric eosinophilic esophagitis. Clin Exp Allergy. 2016;46(11):1431–1440. doi:10.1111/cea.1277627388929
  • Barbosa AC, Castro FM, Meireles PR, et al. Eosinophilic esophagitis: latent disease in patients with anaphylactic reaction to cow’s milk. J Allergy Clin Immunol Pract. 2017.
  • Wright BL, Fernandez-Becker NQ, Kambham N, et al. Baseline gastrointestinal eosinophilia is common in oral immunotherapy subjects with IgE-mediated peanut allergy. Front Immunol. 2018;9:2624. doi:10.3389/fimmu.2018.0262430524424
  • Maggadottir SM, Hill DA, Ruymann K, et al. Resolution of acute IgE-mediated allergy with development of eosinophilic esophagitis triggered by the same food. J Allergy Clin Immunol. 2014;133(5):1487–1489, 1489 e1481. doi:10.1016/j.jaci.2014.02.00424636092
  • Cafone J, Capucilli P, Hill DA, Spergel JM. Eosinophilic esophagitis during sublingual and oral allergen immunotherapy. Curr Opin Allergy Clin Immunol. 2019;19(4):350–357. doi:10.1097/ACI.000000000000053731058677
  • Lucendo AJ, Arias A, Tenias JM. Relation between eosinophilic esophagitis and oral immunotherapy for food allergy: a systematic review with meta-analysis. Ann Allergy Asthma Immunol. 2014;113(6):624–629. doi:10.1016/j.anai.2014.08.00425216976
  • Wright BL, Fernandez-Becker NQ, Kambham N, et al. Gastrointestinal eosinophil responses in a longitudinal, randomized trial of peanut oral immunotherapy. Clin Gastroenterol Hepatol. 2020. doi:10.1016/j.cgh.2020.05.019
  • Hoh RA, Joshi SA, Lee JY, et al. Origins and clonal convergence of gastrointestinal IgE+B cells in human peanut allergy. Sci Immunol. 2020;5(45):45. doi:10.1126/sciimmunol.aay4209
  • Tordesillas L, Goswami R, Benede S, et al. Skin exposure promotes a Th2-dependent sensitization to peanut allergens. J Clin Invest. 2014;124(11):4965–4975. doi:10.1172/JCI7566025295541
  • Walker MT, Green JE, Ferrie RP, Queener AM, Kaplan MH, Cook-Mills JM. Mechanism for initiation of food allergy: dependence on skin barrier mutations and environmental allergen costimulation. J Allergy Clin Immunol. 2018;141(5):1711–1725e1719. doi:10.1016/j.jaci.2018.02.00329454836
  • Galli SJ, Gaudenzio N, Tsai M. Mast cells in inflammation and disease: recent progress and ongoing concerns. Annu Rev Immunol. 2020;38(1):49–77. doi:10.1146/annurev-immunol-071719-09490332340580
  • Wechsler JB, Bryce PJ. Allergic mechanisms in eosinophilic esophagitis. Gastroenterol Clin North Am. 2014;43(2):281–296. doi:10.1016/j.gtc.2014.02.00624813516
  • Ravelli A, Villanacci V, Cadei M, Fuoti M, Gennati G, Salemme M. Dilated intercellular spaces in eosinophilic esophagitis. J Pediatr Gastroenterol Nutr. 2014;59(5):589–593. doi:10.1097/MPG.000000000000049125023586
  • Wright BL, Kulis M, Guo R, et al. Food-specific IgG4 is associated with eosinophilic esophagitis. J Allergy Clin Immunol. 2016;138(4):1190–1192e1193. doi:10.1016/j.jaci.2016.02.02427130859
  • Vicario M, Blanchard C, Stringer KF, et al. Local B cells and IgE production in the oesophageal mucosa in eosinophilic oesophagitis. Gut. 2010;59(1):12–20. doi:10.1136/gut.2009.17802019528036
  • Rosenberg CE, Mingler MK, Caldwell JM, et al. Esophageal IgG4 levels correlate with histopathologic and transcriptomic features in eosinophilic esophagitis. Allergy. 2018;73(9):1892–1901. doi:10.1111/all.1348629790577
  • Wilson JM, McNamara CA, Platts-Mills TAE. IgE, alpha-Gal and atherosclerosis. Aging (Albany NY). 2019;11(7):1900–1902. doi:10.18632/aging.10189430958794
  • Molina-Infante J, Arias A, Alcedo J, et al. Step-up empiric elimination diet for pediatric and adult eosinophilic esophagitis: the 2-4-6 study. J Allergy Clin Immunol. 2018;141(4):1365–1372. doi:10.1016/j.jaci.2017.08.03829074457
  • Spergel JM, Beausoleil JL, Mascarenhas M, Liacouras CA. The use of skin prick tests and patch tests to identify causative foods in eosinophilic esophagitis. J Allergy Clin Immunol. 2002;109(2):363–368. doi:10.1067/mai.2002.12145811842310
  • Kagalwalla AF, Sentongo TA, Ritz S, et al. Effect of six-food elimination diet on clinical and histologic outcomes in eosinophilic esophagitis. Clin Gastroenterol Hepatol. 2006;4(9):1097–1102. doi:10.1016/j.cgh.2006.05.02616860614
  • Zhan T, Ali A, Choi JG, et al. Model to determine the optimal dietary elimination strategy for treatment of eosinophilic esophagitis. Clin Gastroenterol Hepatol. 2018;16(11):1730–1737e1732. doi:10.1016/j.cgh.2018.04.01329730438
  • Platts-Mills TAE, Commins SP, Biedermann T, et al. On the cause and consequences of IgE to galactose-alpha-1,3-galactose: a report from the national institute of allergy and infectious diseases workshop on understanding IgE-mediated mammalian meat allergy. J Allergy Clin Immunol. 2020;145(4):1061–1071.32057766
  • Suaini NHA, Wang Y, Soriano VX, et al. Genetic determinants of paediatric food allergy: a systematic review. Allergy. 2019;74(9):1631–1648. doi:10.1111/all.1376730835860
  • Tham EH, Leung DY. Mechanisms by which atopic dermatitis predisposes to food allergy and the atopic march. Allergy Asthma Immunol Res. 2019;11(1):4–15. doi:10.4168/aair.2019.11.1.430479073
  • Hirota T, Nakayama T, Sato S, et al. Association study of childhood food allergy with genome-wide association studies-discovered loci of atopic dermatitis and eosinophilic esophagitis. J Allergy Clin Immunol. 2017;140(6):1713–1716. doi:10.1016/j.jaci.2017.05.03428629743
  • Platts-Mills TA. The allergy epidemics: 1870–2010. J Allergy Clin Immunol. 2015;136(1):3–13. doi:10.1016/j.jaci.2015.03.04826145982
  • Mitre E, Susi A, Kropp LE, Schwartz DJ, Gorman GH, Nylund CM. Association between use of acid-suppressive medications and antibiotics during infancy and allergic diseases in early childhood. JAMA Pediatr. 2018;172(6):e180315. doi:10.1001/jamapediatrics.2018.031529610864
  • Du Toit G, Sayre PH, Roberts G, et al. Effect of avoidance on peanut allergy after early peanut consumption. N Engl J Med. 2016;374(15):1435–1443. doi:10.1056/NEJMoa151420926942922
  • de Kroon MLA, Warners MJ, van Ampting MTJ, et al. The relationship of habitual diet with esophageal inflammation and integrity in eosinophilic esophagitis. Allergy. 2019;74(5):1005–1009. doi:10.1111/all.1369530515844
  • Phillips JT, Stahlhut RW, Looney RJ, Jarvinen KM. Food allergy, breastfeeding, and introduction of complementary foods in the New York old order mennonite community. Ann Allergy Asthma Immunol. 2020;124(3):292–294e292. doi:10.1016/j.anai.2019.12.01931923545
  • von Mutius E, Vercelli D. Farm living: effects on childhood asthma and allergy. Nat Rev Immunol. 2010;10(12):861–868. doi:10.1038/nri287121060319
  • Platts-Mills TA, Schuyler AJ, Erwin EA, Commins SP, Woodfolk JA. IgE in the diagnosis and treatment of allergic disease. J Allergy Clin Immunol. 2016;137(6):1662–1670. doi:10.1016/j.jaci.2016.04.01027264001
  • Aalberse RC, Stapel SO, Schuurman J, Rispens T. Immunoglobulin G4: an odd antibody. Clin Exp Allergy. 2009;39(4):469–477. doi:10.1111/j.1365-2222.2009.03207.x19222496
  • Aalberse RC, Platts-Mills TA, Rispens T. The developmental history of IgE and IgG4 antibodies in relation to atopy, eosinophilic esophagitis, and the modified TH2 response. Curr Allergy Asthma Rep. 2016;16(6):45. doi:10.1007/s11882-016-0621-x27221343
  • Pope AE, Stanzione N, Naini BV, et al. Esophageal IgG4: clinical, endoscopic, and histologic correlations in eosinophilic esophagitis. J Pediatr Gastroenterol Nutr. 2019;68(5):689–694. doi:10.1097/MPG.000000000000222730540707
  • Weidlich S, Nennstiel S, Jesinghaus M, et al. IgG4 is elevated in eosinophilic esophagitis but not in gastroesophageal reflux disease patients. J Clin Gastroenterol. 2020;54(1):43–49. doi:10.1097/MCG.000000000000115430614939
  • McGowan EC, Platts-Mills TAE, Wilson JM. Food allergy, eosinophilic esophagitis, and the enigma of IgG4. Ann Allergy Asthma Immunol. 2019;122(6):563–564. doi:10.1016/j.anai.2019.03.02430928417
  • Wilson JM, Platts-Mills TAE. Alpha-Gal and other recent findings that have informed our understanding of anaphylaxis. Ann Allergy Asthma Immunol. 2020;124(2):135–142. doi:10.1016/j.anai.2019.11.02431785367
  • Romagnani S. Immunologic influences on allergy and the TH1/TH2 balance. J Allergy Clin Immunol. 2004;113(3):395–400. doi:10.1016/j.jaci.2003.11.02514758340
  • Varricchi G, Harker J, Borriello F, Marone G, Durham SR, Shamji MH. T follicular helper (Tfh) cells in normal immune responses and in allergic disorders. Allergy. 2016;71(8):1086–1094. doi:10.1111/all.1287826970097
  • Gowthaman U, Chen JS, Eisenbarth SC. Regulation of IgE by T follicular helper cells. J Leukoc Biol. 2020;107(3):409–418. doi:10.1002/JLB.3RI1219-425R31965637
  • Noval Rivas M, Chatila TA. Regulatory T cells in allergic diseases. J Allergy Clin Immunol. 2016;138(3):639–652. doi:10.1016/j.jaci.2016.06.00327596705
  • Del Moral MG, Martinez-Naves E. The role of lipids in development of allergic responses. Immune Netw. 2017;17(3):133–143. doi:10.4110/in.2017.17.3.13328680374
  • Saidova A, Hershkop AM, Ponce M, Eiwegger T. Allergen-specific T cells in IgE-mediated food allergy. Arch Immunol Ther Exp (Warsz). 2018;66(3):161–170. doi:10.1007/s00005-017-0501-729256092
  • Wambre E, Bajzik V, DeLong JH, et al. A phenotypically and functionally distinct human TH2 cell subpopulation is associated with allergic disorders. Sci Transl Med. 2017;9(401):401. doi:10.1126/scitranslmed.aam9171
  • Mitson-Salazar A, Yin Y, Wansley DL, et al. Hematopoietic prostaglandin D synthase defines a proeosinophilic pathogenic effector human T(H)2 cell subpopulation with enhanced function. J Allergy Clin Immunol. 2016;137(3):907–918e909. doi:10.1016/j.jaci.2015.08.00726431580
  • Wen T, Aronow BJ, Rochman Y, et al. Single-cell RNA sequencing identifies inflammatory tissue T cells in eosinophilic esophagitis. J Clin Invest. 2019;129(5):2014–2028. doi:10.1172/JCI12591730958799
  • Mitson-Salazar A, Prussin C. Pathogenic effector Th2 cells in allergic eosinophilic inflammatory disease. Front Med (Lausanne). 2017;4:165. doi:10.3389/fmed.2017.0016529057225
  • Tantibhaedhyangkul U, Tatevian N, Gilger MA, Major AM, Davis CM. Increased esophageal regulatory T cells and eosinophil characteristics in children with eosinophilic esophagitis and gastroesophageal reflux disease. Ann Clin Lab Sci. 2009;39(2):99–107.19429794
  • Fuentebella J, Patel A, Nguyen T, et al. Increased number of regulatory T cells in children with eosinophilic esophagitis. J Pediatr Gastroenterol Nutr. 2010;51(3):283–289.20639775
  • Noval Rivas M, Burton OT, Wise P, et al. Regulatory T cell reprogramming toward a Th2-cell-like lineage impairs oral tolerance and promotes food allergy. Immunity. 2015;42(3):512–523. doi:10.1016/j.immuni.2015.02.00425769611
  • Frischmeyer-Guerrerio PA, Guerrerio AL, Oswald G, et al. TGFbeta receptor mutations impose a strong predisposition for human allergic disease. Sci Transl Med. 2013;5(195):195ra194. doi:10.1126/scitranslmed.3006448
  • Cohen SG. Food allergens: landmarks along a historic trail. J Allergy Clin Immunol. 2008;121(6):1521–1524, 1524 e1521. doi:10.1016/j.jaci.2008.04.02718539201
  • Wuthrich B. History of food allergy. Chem Immunol Allergy. 2014;100:109–119.24925391
  • Lambrecht BN, Hammad H. The immunology of the allergy epidemic and the hygiene hypothesis. Nat Immunol. 2017;18(10):1076–1083. doi:10.1038/ni.382928926539
  • Iweala OI, Nagler CR. The microbiome and food allergy. Annu Rev Immunol. 2019;37(1):377–403. doi:10.1146/annurev-immunol-042718-04162131026410
  • Wild CP. Complementing the genome with an “exposome”: the outstanding challenge of environmental exposure measurement in molecular epidemiology. Cancer Epidemiol Biomarkers Prev. 2005;14(8):1847–1850. doi:10.1158/1055-9965.EPI-05-045616103423
  • Renz H, Holt PG, Inouye M, Logan AC, Prescott SL, Sly PD. An exposome perspective: early-life events and immune development in a changing world. J Allergy Clin Immunol. 2017;140(1):24–40. doi:10.1016/j.jaci.2017.05.01528673401
  • Trumble BC, Finch CE. The exposome in human evolution: from dust to diesel. Q Rev Biol. 2019;94(4):333–394. doi:10.1086/70676832269391
  • May M, Abrams JA. Emerging insights into the esophageal microbiome. Curr Treat Options Gastroenterol. 2018;16(1):72–85. doi:10.1007/s11938-018-0171-529350339
  • Celebi Sozener Z, Cevhertas L, Nadeau K, Akdis M, Akdis CA. Environmental factors in epithelial barrier dysfunction. J Allergy Clin Immunol. 2020;145(6):1517–1528. doi:10.1016/j.jaci.2020.04.02432507229