New Perspectives in the Management of Mild to Moderate Asthma in Children

References

• Global Initiative for Asthma (GINA). Global strategy for asthma management and prevention (Updated 2020). Available from: www.ginasthma.org. Accessed March 10, 2021.
   Google Scholar
• National Asthma Education and Prevention Program. Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma. Bethesda, Maryland: National Heart, Lung, and Blood Institute, National Institutes of Health; 2007.
   Google Scholar
• Fitzpatrick AM, Bacharier LB, Jackson DJ, et al. Heterogeneity of mild to moderate persistent asthma in children: confirmation by latent class analysis and association with 1-year outcomes. J Allergy Clin Immunol Pract. 2020;8(8):2617–2627. doi:10.1016/j.jaip.2020.02.032
   PubMed Web of Science ®Google Scholar
• Howrylak JA, Fuhlbrigge AL, Strunk RC, Zeiger RS, Weiss ST, Raby BA; Childhood Asthma Management Program Research Group. Classification of childhood asthma phenotypes and long-term clinical responses to inhaled anti-inflammatory medications. J Allergy Clin Immunol. 2014;133(5):1289–300, 1300.e1-12. doi:10.1016/j.jaci.2014.02.006
   Web of Science ®Google Scholar
• Rodriguez-Martinez CE, Sossa-Briceño MP, Castro-Rodriguez JA. Predictors of response to medications for asthma in pediatric patients: a systematic review of the literature. Pediatr Pulmonol. 2020;55(6):1320–1331. doi:10.1002/ppul.24782
   PubMed Web of Science ®Google Scholar
• Dusser D, Montani D, Chanez P, et al. Mild asthma: an expert review on epidemiology, clinical characteristics and treatment recommendations. Allergy. 2007;62(6):591–604. doi:10.1111/j.1398-9995.2007.01394.x
   PubMed Web of Science ®Google Scholar
• Papadopoulos NG, Čustović A, Cabana MD, et al. Pediatric asthma: an unmet need for more effective, focused treatments. Pediatr Allergy Immunol. 2019;30(1):7–16. doi:10.1111/pai.12990
   Web of Science ®Google Scholar
• FDA. FDA Requires Boxed Warning About Serious Mental Health Side Effects for Asthma and Allergy Drug Montelukast (Singulair); Advises Restricting Use for Allergic Rhinitis. FDA; 2020.
   Google Scholar
• Global Initiative for Asthma (GINA). Global strategy for asthma management and prevention (Updated 2019). Avaliable from: www.ginasthma.org. Accessed March 10, 2021.
   Google Scholar
• A report from the National Asthma Education and Prevention Program Coordinating Committee Expert Panel Working Group. 2020 Focused Updates to The Asthma Management Guidelines. National Heart, Lung, and Blood Institute, National Institutes of Health; 2020 Available from: www.nhlbi.nih.gov. Accessed March 10, 2021.
   Google Scholar
• Suissa S, Ernst P, Benayoun S, Baltzan M, Cai B. Low-dose inhaled corticosteroids and the prevention of death from asthma. N Engl J Med. 2000;343(5):332–336. doi:10.1056/NEJM200008033430504
   PubMed Web of Science ®Google Scholar
• Suissa S, Ernst P, Kezouh A. Regular use of inhaled corticosteroids and the long term prevention of hospitalisation for asthma. Thorax. 2002;57(10):880–884. doi:10.1136/thorax.57.10.880
   PubMed Web of Science ®Google Scholar
• Reddel HK, Ampon RD, Sawyer SM, Peters MJ. Risks associated with managing asthma without a preventer: urgent healthcare, poor asthma control and over-the-counter reliever use in a cross-sectional population survey. BMJ Open. 2017;7(9):e016688. doi:10.1136/bmjopen-2017-016688
   PubMed Web of Science ®Google Scholar
• O’Byrne PM, FitzGerald JM, Bateman ED, et al. Inhaled Combined Budesonide-Formoterol as Needed in Mild Asthma. N Engl J Med. 2018;378(20):1865–1876. doi:10.1056/NEJMoa1715274
   PubMed Web of Science ®Google Scholar
• Bateman ED, Reddel HK, O’Byrne PM, et al. As-Needed Budesonide-Formoterol versus Maintenance Budesonide in Mild Asthma. N Engl J Med. 2018;378(20):1877–1887. doi:10.1056/NEJMoa1715275
   PubMed Web of Science ®Google Scholar
• Martinez FD, Chinchilli VM, Morgan WJ, et al. Use of beclomethasone dipropionate as rescue treatment for children with mild persistent asthma (TREXA): a randomised, double-blind, placebo-controlled trial. Lancet. 2011;377(9766):650–657. doi:10.1016/S0140-6736(10)62145-9
   PubMed Web of Science ®Google Scholar
• Sumino K, Bacharier LB, Taylor J, et al. A pragmatic trial of symptom-based inhaled corticosteroid use in African-American Children with Mild Asthma. J Allergy Clin Immunol Pract. 2020;8(1):176–185.e2. doi:10.1016/j.jaip.2019.06.030
   PubMed Web of Science ®Google Scholar
• Bacharier LB, Phillips BR, Zeiger RS, et al. Episodic use of an inhaled corticosteroid or leukotriene receptor antagonist in preschool children with moderate-to-severe intermittent wheezing. J Allergy Clin Immunol. 2008;122(6):1127–35.e8. doi:10.1016/j.jaci.2008.09.029
   PubMed Web of Science ®Google Scholar
• Ducharme FM, Lemire C, Noya FJ, et al. Preemptive use of high-dose fluticasone for virus-induced wheezing in young children. N Engl J Med. 2009;360(4):339–353. doi:10.1056/NEJMoa0808907
   PubMed Web of Science ®Google Scholar
• Svedmyr J, Nyberg E, Thunqvist P, Asbrink-Nilsson E, Hedlin G. Prophylactic intermittent treatment with inhaled corticosteroids of asthma exacerbations due to airway infections in toddlers. Acta Paediatr. 1999;88(1):42–47. doi:10.1111/j.1651-2227.1999.tb01266.x
   Web of Science ®Google Scholar
• Pauwels RA, Pedersen S, Busse WW, et al. Early intervention with budesonide in mild persistent asthma: a randomised, double-blind trial. Lancet. 2003;361(9363):1071–1076. doi:10.1016/S0140-6736(03)12891-7
   PubMed Web of Science ®Google Scholar
• Kaiser SV, Huynh T, Bacharier LB, et al. Preventing exacerbations in preschoolers with recurrent wheeze: a meta-analysis. Pediatrics. 2016;137(6):e20154496. doi:10.1542/peds.2015-4496
   PubMed Web of Science ®Google Scholar
• Bitsko MJ, Everhart RS, Rubin BK. The adolescent with asthma. Paediatr Respir Rev. 2014;15(2):146–153. doi:10.1016/j.prrv.2013.07.003
   PubMed Web of Science ®Google Scholar
• Jorup C, Lythgoe D, Bisgaard H. Budesonide/formoterol maintenance and reliever therapy in adolescent patients with asthma. Eur Respir J. 2018;51(1):1701688. doi:10.1183/13993003.01688-2017
   PubMed Web of Science ®Google Scholar
• O’Byrne PM, Bisgaard H, Godard PP, et al. Budesonide/formoterol combination therapy as both maintenance and reliever medication in asthma. Am J Respir Crit Care Med. 2005;171(2):129–136. doi:10.1164/rccm.200407-884OC
   PubMed Web of Science ®Google Scholar
• Papi A, Corradi M, Pigeon-Francisco C, et al. Beclometasone-formoterol as maintenance and reliever treatment in patients with asthma: a double-blind, randomised controlled trial. Lancet Respir Med. 2013;1(1):23–31. doi:10.1016/S2213-2600(13)70012-2
   PubMed Web of Science ®Google Scholar
• Cates CJ, Karner C. Combination formoterol and budesonide as maintenance and reliever therapy versus current best practice (including inhaled steroid maintenance), for chronic asthma in adults and children. Cochrane Database Syst Rev. 2013;4:CD007313.
   Google Scholar
• Rabe KF, Pizzichini E, Stallberg B, et al. Budesonide/formoterol in a single inhaler for maintenance and relief in mild-to-moderate asthma: a randomized, double-blind trial. Chest. 2006;129(2):246–256. doi:10.1378/chest.129.2.246
   PubMed Web of Science ®Google Scholar
• Scicchitano R, Aalbers R, Ukena D, et al. Efficacy and safety of budesonide/formoterol single inhaler therapy versus a higher dose of budesonide in moderate to severe asthma. Curr Med Res Opin. 2004;20(9):1403–1418. doi:10.1185/030079904X2051
   PubMed Web of Science ®Google Scholar
• Bisgaard H, Le Roux P, Bjamer D, Dymek A, Vermeulen JH, Hultquist C. Budesonide/formoterol maintenance plus reliever therapy: a new strategy in pediatric asthma. Chest. 2006;130(6):1733–1743. doi:10.1378/chest.130.6.1733
   PubMed Web of Science ®Google Scholar
• Stempel DA, Szefler SJ, Pedersen S, et al. Safety of Adding Salmeterol to Fluticasone Propionate in Children with Asthma. N Engl J Med. 2016;375(9):840–849. doi:10.1056/NEJMoa1606356
   PubMed Web of Science ®Google Scholar
• Hatziagorou E, Kouroukli E, Galogavrou M, et al. Efficacy and safety of the combination fluticasone propionate plus salmeterol in asthmatic preschoolers: an observational study. J Asthma. 2019;56(6):573–580. doi:10.1080/02770903.2018.1474923
   PubMed Web of Science ®Google Scholar
• Yoshihara S, Tsubaki T, Ikeda M, et al. The efficacy and safety of fluticasone/salmeterol compared to fluticasone in children younger than four years of age. Pediatr Allergy Immunol. 2019;30(2):195–203. doi:10.1111/pai.13010
   Web of Science ®Google Scholar