Advanced search
Publication Cover
Journal of Asthma and Allergy Volume 13, 2020 - Issue
Submit an article Journal homepage
108
Views
2
CrossRef citations to date
0
Altmetric
Original Research

Design of an Optimally-Diagnostic Skin Test for Diagnosis of Sensitivity to Eight Allergens: A First-in-Human Study of Dose Escalation and Simultaneous Administration in Chinese Subjects

Xiaoyi Ning1 Center of Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0002-7909-7997
ORCID Icon,
Yun Kuang1 Center of Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of China
,
Shuwei Zhao2 Center of Clinical Medical Trial, Medical University General Hospital, Tianjin, People’s Republic of China
,
Wenjing Hou2 Center of Clinical Medical Trial, Medical University General Hospital, Tianjin, People’s Republic of China
,
Guoping Yang1 Center of Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of China;3 Research Center for Drug Clinical Evaluation of Central South University, Changsha, Hunan, People’s Republic of China;4 Department of Pharmacy, The Third Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0001-5930-586X
ORCID Icon,
Xuerui Zhu5 Department of clinical research and development, Zhejiang Wolwo Biopharmaceuticals, Deqing, Zhejiang, People’s Republic of China
,
Ruiling Liu6 Department of Allergy, Medical University General Hospital, Tianjin, People’s Republic of ChinaCorrespondence[email protected]
&
Jie Huang1 Center of Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of ChinaCorrespondence[email protected]
 show all
Pages 471-481 | Published online: 13 Oct 2020

References

  • Anto JM, Bousquet J, Akdis M, et al. Mechanisms of the development of allergy (MeDALL): introducing novel concepts in allergy phenotypes. J Allergy Clin Immunol. 2017;139(2):388–399. doi:10.1016/j.jaci.2016.12.94028183433
  • Valenta R, Karaulov A, Niederberger V, et al. Molecular aspects of allergens and allergy. Adv Immunol. 2018;138:195–256.29731005
  • Larche M, Akdis CA, Valenta R. Immunological mechanisms of allergen-specific immunotherapy. Nat Rev Immunol. 2006;6(10):761–771. doi:10.1038/nri193416998509
  • Bousquet J, Heinzerling L, Bachert C, et al. Practical guide to skin prick tests in allergy to aeroallergens. Allergy. 2012;67(1):18–24.22050279
  • Bernstein IL, Li JT, Bernstein DI, et al. Allergy diagnostic testing: an updated practice parameter. Ann Allergy Asthma Immunol. 2008;100(3 Suppl 3):S1–148.
  • Frati F, Incorvaia C, Cavaliere C, et al. The skin prick test. J Biol Regul Homeost Agents. 2018;32(1 Suppl. 1):19–24.
  • Ansotegui IJ, Melioli G, Canonica GW, et al. IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper. World Allergy Organ J. 2020;13(2):100080. doi:10.1016/j.waojou.2019.10008032128023
  • Rueff F, Bergmann KC, Brockow K, et al. [Skin tests for diagnostics of allergic immediate-type reactions. Guideline of the German society for allergology and clinical immunology]. Pneumologie. 2011;65(8):484–495.21830178
  • Kleine-Tebbe J, Matricardi PM, Hamilton RG. Allergy work-up including component-resolved diagnosis: how to make allergen-specific immunotherapy more specific. Immunol Allergy Clin North Am. 2016;36(1):191–203. doi:10.1016/j.iac.2015.08.01226617235
  • Klimek L, Hoffmann HJ, Renz H, et al. Diagnostic test allergens used for in vivo diagnosis of allergic diseases are at risk: a European perspective. Allergy. 2015;70(10):1329–1331. doi:10.1111/all.1267626105127
  • van Kampen V, de Blay F, Folletti I, et al. EAACI position paper: skin prick testing in the diagnosis of occupational type I allergies. Allergy. 2013;68(5):580–584. doi:10.1111/all.1212023409759
  • Slater JE, Menzies SL, Bridgewater J, et al. The US Food and Drug Administration review of the safety and effectiveness of nonstandardized allergen extracts. J Allergy Clin Immunol. 2012;129(4):1014–1019. doi:10.1016/j.jaci.2012.01.06622341039
  • Bousquet PJ, Chinn S, Janson C, et al. Geographical variation in the prevalence of positive skin tests to environmental aeroallergens in the European community respiratory health survey I. Allergy. 2007;62(3):301–309. doi:10.1111/j.1398-9995.2006.01293.x17298348
  • Wheeler AW, Jessberger B, Drachenberg KJ, Rakoski J. Design of an optimally-diagnostic skin test solution for diagnosis of sensitivity to timothy grass (Phleum pratense) pollen. Clin Exp Allergy. 1996;26(8):897–902. doi:10.1111/j.1365-2222.1996.tb00624.x8877154
  • Heinzerling L, Mari A, Bergmann KC, et al. The skin prick test – European standards. Clin Transl Allergy. 2013;3(1):3. doi:10.1186/2045-7022-3-323369181
  • Wagner N, Rudert M. Sensitivity and specificity of standardised allergen extracts in skin prick test for diagnoses of IgE-mediated respiratory allergies. Clin Transl Allergy. 2019;9(1):8. doi:10.1186/s13601-019-0248-930820315
  • Szeinbach SL, Barnes JH, Sullivan TJ, Williams PB. Precision and accuracy of commercial laboratories’ ability to classify positive and/or negative allergen-specific IgE results. Ann Allergy Asthma Immunol. 2001;86(4):373–381. doi:10.1016/S1081-1206(10)62481-711345278
  • Williams PB, Barnes JH, Szeinbach SL, Sullivan TJ. Analytic precision and accuracy of commercial immunoassays for specific IgE: establishing a standard. J Allergy Clin Immunol. 2000;105(6):1221–1230. doi:10.1067/mai.2000.10521910856158
  • Sander I, Fleischer C, Meurer U, Bruning T, Raulf-Heimsoth M. Allergen content of grass pollen preparations for skin prick testing and sublingual immunotherapy. Allergy. 2009;64(10):1486–1492. doi:10.1111/j.1398-9995.2009.02040.x19385952
  • van der Valk JP, Gerth van Wijk R, Hoorn E, et al. Measurement and interpretation of skin prick test results. Clin Transl Allergy. 2015;6(1):8. doi:10.1186/s13601-016-0092-026909142
  • Alvarez-Cuesta E, Bousquet J, Canonica GW, et al. Standards for practical allergen-specific immunotherapy. Allergy. 2006;61(Suppl s82):1–20. doi:10.1111/j.1398-9995.2006.01219_1.x

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.