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REVIEW

Diagnosis and Management of Allergic Rhinitis in Asthmatic Children

, ORCID Icon, , , ORCID Icon, , & ORCID Icon show all
Pages 45-57 | Received 01 Sep 2022, Accepted 19 Dec 2022, Published online: 05 Jan 2023

References

  • Liva GA, Karatzanis AD, Prokopakis EP. Review of rhinitis: classification, types, pathophysiology. J Clin Med. 2021;10(14):3183. doi:10.3390/jcm10143183
  • Papadopoulos NG, Guibas GV. Rhinitis Subtypes, Endotypes, and Definitions. Vol. 36, Immunology and Allergy Clinics of North America. W.B. Saunders; 2016:215–233.
  • Skoner DP. Allergic rhinitis: definition, epidemiology, pathophysiology, detection, and diagnosis. J Allergy Clin Immunol. 2001;108(1 Suppl):S2–8. doi:10.1067/mai.2001.115569
  • Marple BF. Allergic rhinitis and inflammatory airway disease: interactions within the unified airspace. Am J Rhinol Allergy. 2010;24:249–254. doi:10.2500/ajra.2010.24.3499
  • Bousquet J, Schünemann HJ, Togias A, et al. Next-generation Allergic Rhinitis and Its Impact on Asthma (ARIA) guidelines for allergic rhinitis based on Grading of Recommendations Assessment, Development and Evaluation (GRADE) and real-world evidence. J Allergy Clin Immunol. 2020;145(1):70–80.e3. doi:10.1016/j.jaci.2019.06.049
  • Sin B, Togias A. Pathophysiology of allergic and nonallergic rhinitis. In: Proceedings of the American Thoracic Society; 2011:106–114.
  • Bentley A, Jacobson M, Cumberworth V, et al. Immunohistology of the nasal mucosa in seasonal allergic rhinitis: increases in activated eosinophils and epithelial mast cells. J Allergy Clin Immunol. 1992;89(4):877–883. doi:10.1016/0091-6749(92)90444-7
  • Cingi C, Gevaert P, Mösges R, et al. Multi-morbidities of allergic rhinitis in adults: European Academy of Allergy and Clinical Immunology Task Force report. Clin Transl Allergy. 2017;7:17. doi:10.1186/s13601-017-0153-z
  • Pawankar R. The WAO white book on allergy. 2013.
  • Meltzer EO, Blaiss MS, Naclerio RM, et al. Burden of allergic rhinitis: allergies in America, Latin America, and Asia-Pacific adult surveys. Allergy Asthma Proc. 2012;33(Suppl 1):S113–41. doi:10.2500/aap.2012.33.3603
  • Tiotiu A, Novakova P, Baiardini I, et al. Manifesto on united airways diseases (UAD): an Interasma (global asthma association–GAA) document. J Asthma. 2022;59(4):639–654. doi:10.1080/02770903.2021.1879130
  • Craig TJ, Sherkat A, Safaee S. Congestion and sleep impairment in allergic rhinitis. Curr Allergy Asthma Rep. 2010;10(2):113–121. doi:10.1007/s11882-010-0091-5
  • Meltzer EO. Allergic rhinitis. Burden of illness, quality of life, comorbidities, and control. Immunol Allergy Clin North Am. 2016;36(2):235–248. doi:10.1016/j.iac.2015.12.002
  • Staevska MT, Mandajieva MA, Dimitrov VD. Rhinitis and sleep apnea. Curr Allergy Asthma Rep. 2004;4(3):193–199. doi:10.1007/s11882-004-0026-0
  • Lin SY, Melvin TAN, Boss EF, Ishman SL. The association between allergic rhinitis and sleep-disordered breathing in children: a systematic review. Int Forum Allergy Rhinol. 2013;3(6):504–509. doi:10.1002/alr.21123
  • Meltzer EO, Blaiss MS, Derebery MJ, et al. Burden of allergic rhinitis: results from the Pediatric Allergies in America survey. J Allergy Clin Immunol. 2009;124(3):S43–70. doi:10.1016/j.jaci.2009.05.013
  • Wang J, Xiao D, Chen H, Hu J. Cumulative evidence for association of rhinitis and depression. Allergy Asthma Clin Immunol. 2021;17(1):111. doi:10.1186/s13223-021-00615-5
  • Dowlati Y, Herrmann N, Swardfager W, et al. A meta-analysis of cytokines in major depression. Biol Psychiatry. 2010;67(5):446–457. doi:10.1016/j.biopsych.2009.09.033
  • Asher MI, Keil U, Anderson HR, et al. International Study of Asthma and Allergies in Childhood (ISAAC): rationale and methods. Eur Respir J. 1995;8(3):483–491. doi:10.1183/09031936.95.08030483
  • Asher MI, Montefort S, Björkstén B, et al.; ISAAC Phase Three Study Group. Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys. Lancet. 2006;368(9537):733–743. doi:10.1016/S0140-6736(06)69283-0
  • Licari A, Ciprandi G, Marseglia A, et al. Current recommendations and emerging options for the treatment of allergic rhinitis. Expert Rev Clin Immunol. 2014;10(10):1337–1347. doi:10.1586/1744666X.2014.955476
  • Bousquet J, Khaltaev N, Cruz AA, et al.; World Health Organization; GA(2)LEN; AllerGen. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen). Allergy. 2008;63(Suppl 86):8–160. doi:10.1111/j.1398-9995.2007.01620.x
  • Cruz AA, Popov T, Pawankar R, et al.; ARIA Initiative Scientific Committee. Common characteristics of upper and lower airways in rhinitis and asthma: ARIA update, in collaboration with GA(2)LEN. Allergy. 2007;62(Suppl 84):1–41. doi:10.1111/j.1398-9995.2007.01551.x
  • Brozek JL, Bousquet J, Baena-Cagnani CE, et al. Allergic rhinitis and its impact on asthma (ARIA) guidelines: 2010 revision. J Allergy Clin Immunol. 2010;126:466–476. doi:10.1016/j.jaci.2010.06.047
  • Asher MI, Stewart AW, Wong G, et al.; ISAAC Phase Three Study Group. Changes over time in the relationship between symptoms of asthma, rhinoconjunctivitis and eczema: a global perspective from the International Study of Asthma and Allergies in Childhood (ISAAC). Allergol Immunopathol. 2012;40(5):267–274. doi:10.1016/j.aller.2011.11.004
  • Tosca MA, Pistorio A, Silvestri M, et al; “ControL’Asma” Study Group. The comparison between children and adolescents with asthma provided by the real-world “ControL’Asma” study. J Asthma. 2022;59(8):1531–1536. doi:10.1080/02770903.2021.1941089
  • Gough H, Grabenhenrich L, Reich A, et al. Allergic multimorbidity of asthma, rhinitis and eczema over 20 years in the German birth cohort MAS. Pediatr Allergy Immunol. 2015;26:431–437. doi:10.1111/pai.12410
  • Cibella F, Cuttitta G, La Grutta S, et al. Proportional Venn diagram and determinants of allergic respiratory diseases in Italian adolescents. Pediatr Allergy Immunol. 2011;22(1 Pt 1):60–68. doi:10.1111/j.1399-3038.2010.01097.x
  • Pinart M, Benet M, Annesi-Maesano I, et al. Comorbidity of eczema, rhinitis, and asthma in IgE-sensitised and non-IgE-sensitised children in MeDALL: a population-based cohort study. Lancet Respir Med. 2014;2(2):131–140. doi:10.1016/S2213-2600(13)70277-7
  • Stern J, Chen M, Fagnano M, et al. Allergic rhinitis comorbidity on asthma outcomes in city school children. J Asthma. 2022;1–7. doi:10.1080/02770903.2022.2043363
  • Tiotiu A, Plavec D, Novakova S, et al. Current opinions for the management of asthma associated with ear, nose and throat comorbidities. Eur Respir Rev. 2018;27(150):180056. doi:10.1183/16000617.0056-2018
  • Tohidinik HR, Mallah N, Takkouche B. History of allergic rhinitis and risk of asthma; a systematic review and meta-analysis. World Allergy Organ J. 2019;12(10):100069. doi:10.1016/j.waojou.2019.100069
  • Iyer A, Athavale A. Nasal airway resistance and latent lower airway involvement in allergic rhinitis. J Assoc Physicians India. 2020;68(3):43–47.
  • Chakir J, Laviolette M, Boutet M, Laliberté R, Dubé J, Boulet LP. Lower airways remodeling in nonasthmatic subjects with allergic rhinitis. Lab Invest. 1996;75(5):735–744.
  • Shturman-Ellstein R, Zeballos RJ, Buckley JM, Souhrada JF. The beneficial effect of nasal breathing on exercise-induced bronchoconstriction. Am Rev Respir Dis. 1978;118(1):65–73. doi:10.1164/arrd.1978.118.1.65
  • van Cauwenberge P, Sys L, de Belder T, Watelet JB. Anatomy and physiology of the nose and the paranasal sinuses. Immunol Allergy Clin North Am. 2004;24(1):1–17. doi:10.1016/S0889-8561(03)00107-3
  • Liu Y, Sha J, Meng C, Zhu D. Mechanism of lower airway hyperresponsiveness induced by allergic rhinitis. J Immunol Res. 2022;2022:1–8.
  • Frigas E, Gleich GJ. The eosinophil and the pathophysiology of asthma. J Allergy Clin Immunol. 1986;77(4):527–537. doi:10.1016/0091-6749(86)90341-6
  • Flavahan NA, Slifman NR, Gleich GJ, Vanhoutte PM. Human eosinophil major basic protein causes hyperreactivity of respiratory smooth muscle. Role of the epithelium. Am Rev Respir Dis. 1988;138(3):685–688. doi:10.1164/ajrccm/138.3.685
  • Laitinen LA, Heino M, Laitinen A, Kava T, Haahtela T. Damage of the airway epithelium and bronchial reactivity in patients with asthma. Am Rev Respir Dis. 1985;131(4):599–606. doi:10.1164/arrd.1985.131.4.599
  • Sedgwick JB, Calhoun WJ, Gleich GJ, et al. Immediate and late airway response of allergic rhinitis patients to segmental antigen challenge. Characterization of eosinophil and mast cell mediators. Am Rev Respir Dis. 1991;144(6):1274–1281. doi:10.1164/ajrccm/144.6.1274
  • Bui DS, Lodge CJ, Burgess JA, et al. Childhood predictors of lung function trajectories and future COPD risk: a prospective cohort study from the first to the sixth decade of life. Lancet Respir Med. 2018;6(7):535–544. doi:10.1016/S2213-2600(18)30100-0
  • de Groot EP, Nijkamp A, Duiverman EJ, Brand PLP. Allergic rhinitis is associated with poor asthma control in children with asthma. Thorax. 2012;67(7):582–587. doi:10.1136/thoraxjnl-2011-201168
  • Belhassen M, Demoly P, Bloch-Morot E, et al. Costs of perennial allergic rhinitis and allergic asthma increase with severity and poor disease control. Allergy. 2017;72(6):948–958. doi:10.1111/all.13098
  • Gaugris S, Sazonov-Kocevar V, Thomas M. Burden of concomitant allergic rhinitis in adults with asthma. J Asthma. 2006;43(1):1–7. doi:10.1080/02770900500446823
  • Greiner AN, Hellings PW, Rotiroti G, Scadding GK. Allergic rhinitis. Lancet. 2011;378(9809):2112–2122. doi:10.1016/S0140-6736(11)60130-X
  • Kim JY, Lee S, Suh DI, et al. Distinct endotypes of pediatric rhinitis based on cluster analysis. Allergy Asthma Immunol Res. 2022;14(6):730–741. doi:10.4168/aair.2022.14.6.730
  • Shin SH, Ye MK, Park J, Geum S-Y. Immunopathologic role of eosinophils in eosinophilic chronic rhinosinusitis. Int J Mol Sci. 2022;23(21):13313. doi:10.3390/ijms232113313
  • Bousquet J, Sousa-Pinto B, Anto JM, et al. Identification by cluster analysis of patients with asthma and nasal symptoms using the MASK-air® mHealth app. Pulmonology. 2022;S2531-0437(22)00252–5. doi:10.1016/j.pulmoe.2022.10.005
  • Scadding GK, Smith PK, Blaiss M, et al. Allergic rhinitis in childhood and the new EUFOREA algorithm. Front Allergy. 2021;2:706589. doi:10.3389/falgy.2021.706589
  • Doulaptsi M, Aoi N, Kawauchi H, et al. Differentiating rhinitis in the paediatric population by giving focus on medical history and clinical examination. Med Sci. 2019;7(3):38–52.
  • Campbell RG. Risks and management of long-term corticosteroid use in chronic rhinosinusitis. Curr Opin Otolaryngol Head Neck Surg. 2018;26(1):1–7. doi:10.1097/MOO.0000000000000421
  • Roberts G, Xatzipsalti M, Borrego LM, et al. Paediatric rhinitis: position paper of the European Academy of Allergy and Clinical Immunology. Allergy. 2013;68(9):1102–1116. doi:10.1111/all.12235
  • Zhang B, Ma L. Transverse nasal creases. N Engl J Med. 2021;385(24):2281. doi:10.1056/NEJMicm2111716
  • Fokkens WJ, Lund VJ, Hopkins C, et al. European position paper on rhinosinusitis and nasal polyps 2020. Rhinology. 2020;29:1–464.
  • Testera-Montes A, Jurado R, Salas M, et al. Diagnostic tools in allergic rhinitis. Front Allergy. 2021;2:721851. doi:10.3389/falgy.2021.721851
  • Breiteneder H, Peng YQ, Agache I, et al. Biomarkers for diagnosis and prediction of therapy responses in allergic diseases and asthma. Allergy. 2020;75(12):3039–3068. doi:10.1111/all.14582
  • Mastrorilli C, Posa D, Cipriani F, Caffarelli C. Asthma and allergic rhinitis in childhood: what’s new. Pediatr Allergy Immunol. 2016;27(8):795–803. doi:10.1111/pai.12681
  • Hellings PW, Klimek L, Cingi C, et al. Non-allergic rhinitis: position paper of the European Academy of Allergy and Clinical Immunology. Allergy. 2017;72:1657–1665. doi:10.1111/all.13200
  • Papadopoulos NG, Aggelides X, Stamataki S, et al. New concepts in pediatric rhinitis. Pediatr Allergy Immunol. 2021;32(4):635–646. doi:10.1111/pai.13454
  • Colavita L, Catalano N, Sposito G, et al. Local allergic rhinitis in pediatric patients: is IgE dosage in nasal lavage fluid a useful diagnostic method in children? Int J Mol Cell Med. 2017;6(3):174–182. doi:10.22088/acadpub.BUMS.6.3.174
  • Poddighe D, Gelardi M, Licari A, Del Giudice MM, Marseglia GL. Non-allergic rhinitis in children: epidemiological aspects, pathological features, diagnostic methodology and clinical management. World J Methodol. 2016;6(4):200–213. doi:10.5662/wjm.v6.i4.200
  • Schuler CF, Montejo JM. Allergic rhinitis in children and adolescents. Immunol Allergy Clin North Am. 2021;41(4):613–625. doi:10.1016/j.iac.2021.07.010
  • Schenkel EJ. Paediatric issues relating to the pharmacotherapy of allergic rhinitis. Expert Opin Pharmacother. 2000;1(7):1289–1306. doi:10.1517/14656566.1.7.1289
  • Abdullah B, Latiff AHA, Manuel AM, et al. Pharmacological management of allergic rhinitis: a consensus statement from the Malaysian Society of Allergy and Immunology. J Asthma Allergy. 2022;15:983–1003. doi:10.2147/JAA.S374346
  • Khattiyawittayakun L, Seresirikachorn K, Chitsuthipakorn W, Kanjanawasee D, Snidvongs K. Effects of double-dose intranasal corticosteroid for allergic rhinitis: a systematic review and meta-analysis. Int Forum Allergy Rhinol. 2019;9(1):72–78. doi:10.1002/alr.22204
  • Jang TY, Kim YH. Recent updates on the systemic and local safety of intranasal steroids. Curr Drug Metab. 2016;17(10):992–996. doi:10.2174/1389200218666161123123516
  • William Kelly H, Sternberg AL, Lescher R, et al.; CAMP Research Group. Effect of inhaled glucocorticoids in childhood on adult height. N Engl J Med. 2012;367(10):904–912. doi:10.1056/NEJMoa1203229
  • Du K, Qing H, Zheng M, Wang X, Zhang L. Intranasal antihistamines is superior to oral H1 antihistamines as an add-on therapy to intranasal corticosteroids for treating allergic rhinitis. Ann Allergy Asthma Immunol. 2020;125(5):589–596.e3. doi:10.1016/j.anai.2020.06.038
  • Vervloet D, Charpin D, Desfougeres JL. Intranasal fluticasone once daily compared with once-daily cetirizine in the treatment of seasonal allergic rhinitis: results of a multicentre, double-blind study. Clin Drug Investig. 1997;13(6):291–298. doi:10.2165/00044011-199713060-00001
  • Deckx L, de Sutter AI, Guo L, et al. Nasal decongestants in monotherapy for the common cold. Cochrane Database Syst Rev. 2016;10:CD009612. doi:10.1002/14651858.CD009612.pub2
  • Krishnamoorthy M, Mohd Noor N, Mat Lazim N, et al. Efficacy of montelukast in allergic rhinitis treatment: a systematic review and meta-analysis. Drugs. 2020;80:1831–1851. doi:10.1007/s40265-020-01406-9
  • Gazi U, Bahceciler NN. Immune mechanisms induced by sublingual immunotherapy in allergic respiratory diseases. Clin Exp Immunol. 2022;2022:uxac075.
  • Zhang Y, Lan F, Zhang L. Update on pathomechanisms and treatments in allergic rhinitis. Allergy. 2022;77:3309–3319. doi:10.1111/all.15454
  • Djuric-Filipovic I, Caminati M, Filipovic D, Salvottini C, Zivkovic Z. Effects of specific allergen immunotherapy on biological markers and clinical parameters in asthmatic children: a controlled-real life study. Clin Mol Allergy. 2017;15(1):7. doi:10.1186/s12948-017-0064-5
  • Liu W, Zeng Q, He C, et al. Compliance, efficacy, and safety of subcutaneous and sublingual immunotherapy in children with allergic rhinitis. Pediatr Allergy Immunol. 2021;32:86–91. doi:10.1111/pai.13332
  • Epstein TG, Liss GM, Murphy-Berendts K, Bernstein DI. AAAAI/ACAAI surveil- lance study of subcutaneous immunotherapy, years 2008–2012: an update on fatal and nonfatal systemic allergic reactions. J Allergy Clin Immunol Pract. 2014;2:161–167.e3. doi:10.1016/j.jaip.2014.01.004
  • Caminati M, Dama AR, Djuric I, et al. Incidence and risk factors for subcutaneous immunotherapy anaphylaxis: the optimization of safety. Expert Rev Clin Immunol. 2015;11(2):233–245. doi:10.1586/1744666X.2015.988143
  • Senna G, Caminati M, Canonica GW. Safety and tolerability of sublingual immunotherapy in clinical trials and real life. Curr Opin Allergy Clin Immunol. 2013;13(6):656–662. doi:10.1097/ACI.0000000000000007
  • Đurić-filipović I, Caminati M, Kostić G, Filipović Đ, Živković Z. Allergen specific sublingual immunotherapy in children with asthma and allergic rhinitis. World J Pediatr. 2016;12(3):283–290. doi:10.1007/s12519-016-0022-1
  • Roberts G, Pfaar O, Akdis CA, et al. EAACI guidelines on allergen immunotherapy: allergic rhinoconjunctivitis. Allergy. 2018;73:765–798. doi:10.1111/all.13317
  • Panganiban CM, Tam JS. Considerations in allergen immunotherapy for allergic asthma in pediatric patients under 4 years of age. Ann Allergy Asthma Immunol. 2021;126:314–315. doi:10.1016/j.anai.2021.02.007
  • Pajno GB, Caminiti L, Crisafulli G, et al. Adherence to sublingual immunotherapy in preschool children. Pediatr Allergy Immunol. 2012;23:688–689. doi:10.1111/j.1399-3038.2012.01317.x
  • Dhami S, Nurmatov U, Arasi S, et al. Allergen immunotherapy for allergic rhinoconjunctivitis: a systematic review and meta-analysis. Allergy. 2017;72:1597–1631.
  • Meltzer EO, Wallace D, Friedman HS, et al. Meta-analyses of the efficacy of pharmacotherapies and sublingual allergy immunotherapy tablets for allergic rhinitis in adults and children. Rhinology. 2021. doi:10.4193/Rhin21.054
  • Fritzsching B, Contoli M, Porsbjerg C, et al. Long-term real-world effectiveness of allergy immunotherapy in patients with allergic rhinitis and asthma: results from the REACT study, a retrospective cohort study. Lancet Reg Health Eur. 2021;13. doi:10.1016/j.lanepe.2021.100275
  • Calderón MA, Bacharier LB. Controversies in allergy: a pro/con review of sublingual allergen immunotherapy and allergic asthma. J Allergy Clin Immunol Pract. 2021;9:1818–1825. doi:10.1016/j.jaip.2021.02.029
  • Zielen S, Devillier P, Heinrich J, et al. Sublingual immunotherapy provides long-term relief in allergic rhinitis and reduces the risk of asthma: a retrospective, real-world database analysis. Allergy. 2018;73:165–177. doi:10.1111/all.13213
  • Durham SR, Emminger W, Kapp A, et al. Long-term clinical efficacy in grass pollen-induced rhinoconjunctivitis after treatment with SQ-standardized grass allergy immunotherapy tablet. J Allergy Clin Immunol. 2010;125:131–138.e7. doi:10.1016/j.jaci.2009.10.035
  • Halken S, Larenas-Linnemann D, Roberts G, et al. EAACI guidelines on allergen immunotherapy: prevention of allergy. Pediatr Allergy Immunol. 2017;28:728–745. doi:10.1111/pai.12807
  • Agache I, Lau S, Akdis CA, et al. EAACI guidelines on allergen immunotherapy: house dust mite-driven allergic asthma. Allergy. 2019;74:855–873. doi:10.1111/all.13749
  • Global initiative for asthma. Available from: https://ginasthma.org/. Accessed December 28, 2022.
  • de Vos G, Viswanathan S, Pichardo Y, et al. A randomized trial of subcutaneous allergy immunotherapy in inner-city children with asthma less than 4 years of age. Ann Allergy Asthma Immunol. 2021;126:367–377.e5. doi:10.1016/j.anai.2020.12.016