Small-Airway Function Variables in Spirometry, Fractional Exhaled Nitric Oxide, and Circulating Eosinophils Predicted Airway Hyperresponsiveness in Patients with Mild Asthma

References

• Lipworth B, Manoharan A, Anderson W. Unlocking the quiet zone: the small airway asthma phenotype. Lancet Respir Med. 2014;2(6):497–506. doi:10.1016/S2213-2600(14)70103-1
   PubMed Web of Science ®Google Scholar
• Coates AL, Wanger J, Cockcroft DW, et al. ERS technical standard on bronchial challenge testing: general considerations and performance of methacholine challenge tests. Eur Respir J. 2017;49(5):1–17.
   Web of Science ®Google Scholar
• Dusser D, Montani D, Chanez P, et al. Mild asthma: an expert review on epidemiology, clinical characteristics and treatment recommendations. Allergy. 2007;62(6):591–604. doi:10.1111/j.1398-9995.2007.01394.x
   PubMed Web of Science ®Google Scholar
• Bao W, Zhang X, Lv C, et al. The value of fractional exhaled nitric oxide and forced mid-expiratory flow as predictive markers of bronchial hyperresponsiveness in adults with chronic cough. J Allergy Clin Immunol Pract. 2018;6(4):1313–1320. doi:10.1016/j.jaip.2017.09.026
   PubMed Web of Science ®Google Scholar
• Drewek R, Garber E, Stanclik S, Simpson P, Nugent M, Gershan W. The FEF25-75 and its decline as a predictor of methacholine responsiveness in children. J Asthma. 2009;46(4):375–381. doi:10.1080/02770900802492079
   PubMed Web of Science ®Google Scholar
• van der Wiel E, Postma DS, van der Molen T, Schiphof-Godart L, Ten Hacken NH, van den Berge M. Effects of small airway dysfunction on the clinical expression of asthma: a focus on asthma symptoms and bronchial hyper-responsiveness. Allergy. 2014;69(12):1681–1688. doi:10.1111/all.12510
   PubMed Web of Science ®Google Scholar
• Shi Y, Aledia AS, Galant SP, George SC. Peripheral airway impairment measured by oscillometry predicts loss of asthma control in children. J Allergy Clin Immunol. 2013;131(3):718–723. doi:10.1016/j.jaci.2012.09.022
   PubMed Web of Science ®Google Scholar
• Manoharan A, von Wilamowitz-moellendorff A, Morrison A, Lipworth BJ. Effects of formoterol or salmeterol on impulse oscillometry in patients with persistent asthma. J Allergy Clin Immunol. 2016;137(3):727–33.e1. doi:10.1016/j.jaci.2015.06.012
   Web of Science ®Google Scholar
• Arıkoglu T, Unlu A, Yıldırım DD, Kuyucu S. The airway hyperresponsiveness to methacholine may be predicted by impulse oscillometry and plethysmography in children with well-controlled asthma. J Asthma. 2018;55(11):1166–1173. doi:10.1080/02770903.2017.1407337
   PubMed Web of Science ®Google Scholar
• Ekström S, Hallberg J, Kull I, et al. Body mass index status and peripheral airway obstruction in school-age children: a population-based cohort study. Thorax. 2018;73(6):538–545. doi:10.1136/thoraxjnl-2017-210716
   PubMed Web of Science ®Google Scholar
• Dweik RA, Boggs PB, Erzurum SC, et al. An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications. Am J Respir Crit Care Med. 2011;184(5):602–615. doi:10.1164/rccm.9120-11ST
   PubMed Web of Science ®Google Scholar
• Madan K, Hadda V, Khilnani GC, Guleria R. Isolated reduction of the FEV3/FVC ratio as an indicator of mild airflow obstruction. Chest. 2014;145(3):662. doi:10.1378/chest.13-2435
   Web of Science ®Google Scholar
• Piorunek T, Kostrzewska M, Stelmach-Mardas M, et al. Small airway obstruction in chronic obstructive pulmonary disease: potential parameters for early detection. Adv Exp Med Biol. 2017;980:75–82.
   PubMed Web of Science ®Google Scholar
• Morris ZQ, Coz A, Starosta D. An isolated reduction of the FEV3/FVC ratio is an indicator of mild lung injury. Chest. 2013;144(4):1117–1123. doi:10.1378/chest.12-2816
   Web of Science ®Google Scholar
• Miller MR, Hankinson J, Brusasco V, et al. ATS/ERS Task Force. Standardisation of spirometry. Eur Respir J. 2005;26:319–338. doi:10.1183/09031936.05.00034805
   PubMed Web of Science ®Google Scholar
• Coates AL, Wanger J, Cockcroft DW, et al. ERS technical standard on bronchial challenge testing: general considerations and performance of methacholine challenge tests. Eur Respir J. 2017;49(5):1601526.
   PubMed Web of Science ®Google Scholar
• Wagner EM, Liu MC, Weinmann GG, Permutt S, Bleecker ER. Peripheral lung resistance in normal and asthmatic subjects. Am Rev Respir Dis. 1990;141(3):584–588. doi:10.1164/ajrccm/141.3.584
   Web of Science ®Google Scholar
• DeLong ER, DeLong DM, Clarke-Pearson DL. Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics. 1988;44(3):837–845. doi:10.2307/2531595
   PubMed Web of Science ®Google Scholar
• Altman DG, Bland JM. Diagnostic tests 2: predictive values. BMJ. 1994;309(6947):102. doi:10.1136/bmj.309.6947.102
   PubMed Web of Science ®Google Scholar
• Youden WJ. Index for rating diagnostic tests. Cancer. 1950;3(1):32–35. doi:10.1002/1097-0142(1950)3:1<32::AID-CNCR2820030106>3.0.CO;2-3
   PubMed Web of Science ®Google Scholar
• Thornbury JR, Fryback DG, Edwards W. Likelihood ratios as a measure of the diagnostic usefulness of excretory urogram information. Radiology. 1975;114(3):561–565. doi:10.1148/114.3.561
   Web of Science ®Google Scholar
• Hung J, Chaitman BR, Lam J, et al. A logistic regression analysis of multiple noninvasive tests for the prediction of the presence and extent of coronary artery disease in men. Am Heart J. 1985;110(2):460–469. doi:10.1016/0002-8703(85)90170-X
   Web of Science ®Google Scholar
• Castro M, Corren J, Pavord ID, et al. Dupilumab efficacy and safety in moderate-to-severe uncontrolled asthma. N Engl J Med. 2018;378(26):2486–2496. doi:10.1056/NEJMoa1804092
   PubMed Web of Science ®Google Scholar
• Sadeghi-Hashjin G, Folkerts G, Henricks PA, et al. Peroxynitrite induces airway hyperresponsiveness in guinea pigs in vitro and in vivo. Am J Respir Crit Care Med. 1996;153(5):1697–1701. doi:10.1164/ajrccm.153.5.8630623
   PubMed Web of Science ®Google Scholar
• Jatakanon A, Lim S, Kharitonov SA, Chung KF, Barnes PJ. Correlation between exhaled nitric oxide, sputum eosinophils, and methacholine responsiveness in patients with mild asthma. Thorax. 1998;53(2):91–95. doi:10.1136/thx.53.2.91
   PubMed Web of Science ®Google Scholar
• Song WJ, Kim HJ, Shim JS, et al. Diagnostic accuracy of fractional exhaled nitric oxide measurement in predicting cough-variant asthma and eosinophilic bronchitis in adults with chronic cough: a systematic review and meta-analysis. J Allergy Clin Immunol. 2017;140(3):701–709. doi:10.1016/j.jaci.2016.11.037
   PubMed Web of Science ®Google Scholar
• Chatkin JM, Ansarin K, Silkoff PE, et al. Exhaled nitric oxide as a noninvasive assessment of chronic cough. Am J Respir Crit Care Med. 1999;159(6):1810–1813. doi:10.1164/ajrccm.159.6.9809047
   PubMed Web of Science ®Google Scholar
• Schleich FN, Asandei R, Manise M, Sele J, Seidel L, Is LR. FENO50 useful diagnostic tool in suspected asthma? Int J Clin Pract. 2012;66(2):158–165. doi:10.1111/j.1742-1241.2011.02840.x
   PubMed Web of Science ®Google Scholar
• Schneider A, Schwarzbach J, Faderl B, Welker L, Karsch-Völk M, Jörres RA. FENO measurement and sputum analysis for diagnosing asthma in clinical practice. Respir Med. 2013;107(2):209–216. doi:10.1016/j.rmed.2012.10.003
   PubMed Web of Science ®Google Scholar
• Cirillo I, Klersy C, Marseglia GL, et al. Role of FEF25%-75% as a predictor of bronchial hyperreactivity in allergic patients. Ann Allergy Asthma Immunol. 2006;96(5):692–700. doi:10.1016/S1081-1206(10)61067-8
   PubMed Web of Science ®Google Scholar
• He L, Wei M, Luo J, et al. Re-evaluation of the diagnostic value of fractional exhaled nitric oxide & its impact in patients with asthma. Indian J Med Res. 2018;148(4):441–448. doi:10.4103/ijmr.IJMR_1478_16
   Web of Science ®Google Scholar
• Feng-Jia C, Xin-Yan H, Geng-Peng L, Yang-Li L, Can-Mao X. Validity of fractional exhaled nitric oxide and small airway function indices in diagnosis of cough-variant asthma. J Asthma. 2018;55(7):750–755. doi:10.1080/02770903.2017.1366509
   PubMed Web of Science ®Google Scholar
• Pellegrino R, Viegi G, Brusasco V, et al. Interpretative strategies for lung function tests. Eur Respir J. 2005;26(5):948–968. doi:10.1183/09031936.05.00035205
   PubMed Web of Science ®Google Scholar
• Lee H, Chang B, Kim K, et al. Clinical Utility of additional measurement of total lung capacity in diagnosing obstructive lung disease in subjects with restrictive pattern of spirometry. Respir Care. 2016;61(4):475–482. doi:10.4187/respcare.04222
   Web of Science ®Google Scholar
• Forno E, Han YY, Mullen J, Celedón JC. Overweight, obesity, and lung function in children and adults-a meta-analysis. J Allergy Clin Immunol Pract. 2018;6(2):570–581.e10. doi:10.1016/j.jaip.2017.07.010
   PubMed Web of Science ®Google Scholar
• Marotta A, Klinnert MD, Price MR, Larsen GL, Liu AH. Impulse oscillometry provides an effective measure of lung dysfunction in 4-year-old children at risk for persistent asthma. J Allergy Clin Immunol. 2003;112(2):317–322. doi:10.1067/mai.2003.1627
   PubMed Web of Science ®Google Scholar
• Heijkenskjöld Rentzhog C, Janson C, Berglund L, et al. Overall and peripheral lung function assessment by spirometry and forced oscillation technique in relation to asthma diagnosis and control. Clin Exp Allergy. 2017;47(12):1546–1554. doi:10.1111/cea.13035
   PubMed Web of Science ®Google Scholar
• Farr RS, Kopetzky MT, Spector SL, Hurewitz DS. Asthma without wheezing. Chest. 1973;63(Suppl):64S–68S. doi:10.1378/chest.63.4_Supplement.64S
   Google Scholar
• Global Initiative for Asthma. 2020 GINA Report, Global Strategy for Asthma Management and Prevention. Available at: https://ginasthma.org/gina-reports/. 2020.
   Google Scholar
• Taniguchi H, Furuse H, Nakanishi Y, et al. Bronchial biopsy and reactivity in patients with chest tightness relieved with bronchodilator. J Asthma. 2017;54(5):479–487. doi:10.1080/02770903.2016.1236940
   PubMed Web of Science ®Google Scholar
• Shen H, Hua W, Wang P, Li W. A new phenotype of asthma: chest tightness as the sole presenting manifestation. Ann Allergy Asthma Immunol. 2013;111:226–227. doi:10.1016/j.anai.2013.06.016
   Web of Science ®Google Scholar
• Taniguchi H, Kanbara K, Hoshino K, Izumi S. Chest pain relieved with a bronchodilator or other asthma drugs. Allergol Int. 2009;58(3):421–427. doi:10.2332/allergolint.08-OA-0084
   PubMedGoogle Scholar