The Patients’ Experience of Severe Asthma Add-On Pharmacotherapies: A Qualitative Descriptive Study

References

• Pavord ID, Beasley R, Agusti A, et al. After asthma: redefining airways diseases. Lancet. 2018;391(10118):350–400.
   PubMed Web of Science ®Google Scholar
• McDonald VM, Gibson PG. Exacerbations of severe asthma. Clin Exp Allergy. 2012;42(5):670–677. doi:10.1111/j.1365-2222.2012.03981.x
   PubMed Web of Science ®Google Scholar
• McDonald V, Kennington E, Hyland M. Understanding the experience of people living with severe asthma. In: Chung K, Gibson P, editors. Severe Asthma (ERS Monograph). Sheffield: European Respirtory Society; 2019.
   Google Scholar
• McDonald VM, Hiles SA, Godbout K, et al. Treatable traits can be identified in a severe asthma registry and predict future exacerbations. Respirology. 2019;24(1):37–47. doi:10.1111/resp.13389
   PubMed Web of Science ®Google Scholar
• Stubbs M, Clark V, McDonald V. Living well with severe asthma. Breathe. 2019;15(2):e40–e49. doi:10.1183/20734735.0165-2019
   Web of Science ®Google Scholar
• McDonald VM, Hiles SA, Jones KA, Clark VL, Yorke J. Health-related quality of life burden in severe asthma. Med J Austr. 2018;209(S2):S28–S233. doi:10.5694/mja18.00207
   PubMed Web of Science ®Google Scholar
• Eassey D, Reddel HK, Foster JM, et al. I’ve said I wish I was dead, you’d be better off without me”: a systematic review of people’s experiences of living with severe asthma. J Asthma. 2019;56(3):311–322. doi:10.1080/02770903.2018.1452034
   PubMed Web of Science ®Google Scholar
• Foster JM, McDonald VM, Guo M, Reddel HK. “I have lost in every facet of my life”: the hidden burden of severe asthma. Eur Respir J. 2017;50(3):1700765. doi:10.1183/13993003.00765-2017
   PubMed Web of Science ®Google Scholar
• Ten Brinke A, Sterk PJ, Masclee AA, et al. Risk factors of frequent exacerbations in difficult-to-treat asthma. Eur Respir J. 2005;26(5):812–818. doi:10.1183/09031936.05.00037905
   PubMed Web of Science ®Google Scholar
• Upham J, Lp C. Optimising treatment for severe asthma. Med J Austr. 2018;209(S2):S22–S27. doi:10.5694/mja18.00175
   Web of Science ®Google Scholar
• Fricker M, Heaney LG, Upham JW. Can biomarkers help us hit targets in difficult-to-treat asthma? Respirology. 2017;22(3):430–442. doi:10.1111/resp.13014
   Web of Science ®Google Scholar
• Pavord ID, Korn S, Howarth P, et al. Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial. Lancet. 2012;380(9842):651–659. doi:10.1016/S0140-6736(12)60988-X
   PubMed Web of Science ®Google Scholar
• Castro M, Zangrilli J, Wechsler ME, et al. Reslizumab for inadequately controlled asthma with elevated blood eosinophil counts: results from two multicentre, parallel, double-blind, randomised, placebo-controlled, Phase 3 trials. Lancet Respir Med. 2015;3(5):355–366. doi:10.1016/S2213-2600(15)00042-9
   PubMed Web of Science ®Google Scholar
• Niebauer K, Dewilde S, Fox-Rushby J, Revicki DA. Impact of omalizumab on quality-of-life outcomes in patients with moderate-to-severe allergic asthma. Ann Allergy Asthma Immunol. 2006;96(2):316–326. doi:10.1016/S1081-1206(10)61242-2
   Web of Science ®Google Scholar
• Hiles SA, McDonald VM, Guilhermino M, Brusselle GG, Gibson PG. Does maintenance azithromycin reduce asthma exacerbations? An individual participant data meta-analysis. Eur Respir J. 2019;54:1901381. doi:10.1183/13993003.01381-2019
   Web of Science ®Google Scholar
• Gibson PG, Yang IA, Upham JW, et al. Effect of azithromycin on asthma exacerbations and quality of life in adults with persistent uncontrolled asthma (AMAZES): a randomised, double-blind, placebo-controlled trial. Lancet. 2017;390(10095):659–668. doi:10.1016/S0140-6736(17)31281-3
   PubMed Web of Science ®Google Scholar
• Harvey E, Langton DL, Powell H, Gibson PG. Clinical response to mepolizumab in patients with severe eosinophilic asthma. Eur Respir J. 2019;54(suppl 63):PA541.
   Google Scholar
• Chung KF, Wenzel SE, Brozek JL, et al. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. European Respiratory Journal. 2014;43(2):343–373.
   Web of Science ®Google Scholar
• Juniper EF, Bousquet J, Abetz L, Bateman ED. Identifying ‘well-controlled’ and ‘not well-controlled’ asthma using the Asthma Control Questionnaire. Respir Med. 2006;100(4):616–621. doi:10.1016/j.rmed.2005.08.012
   PubMed Web of Science ®Google Scholar
• Hyland ME, Whalley B, Jones RC, Masoli M. A qualitative study of the impact of severe asthma and its treatment showing that treatment burden is neglected in existing asthma assessment scales. Qual Life Res. 2015;24(3):631–639. doi:10.1007/s11136-014-0801-x
   PubMed Web of Science ®Google Scholar
• Katsaounou P, Odemyr M, Spranger O, et al. Still Fighting for Breath: a patient survey of the challenges and impact of severe asthma. ERJ Open Res. 2018;4(4):00076–02018. doi:10.1183/23120541.00076-2018
   Google Scholar
• Lempp H, Hofmann D, Hatch SL, Scott DL. Patients’ views about treatment with combination therapy for Rheumatoid Arthritis: a comparative qualitative study. BMC Musculoskelet Disord. 2012;13(1):200. doi:10.1186/1471-2474-13-200
   Web of Science ®Google Scholar
• Marshall NJ, Wilson G, Lapworth K, Kay LJ. Patients’ perceptions of treatment with anti-TNF therapy for rheumatoid arthritis: a qualitative study. Rheumatology. 2004;43(8):1034–1038. doi:10.1093/rheumatology/keh237
   Web of Science ®Google Scholar
• Braun V, Clarke V. Using thematic analysis in psychology. Qual Res Psychol. 2006;3(2):77–101. doi:10.1191/1478088706qp063oa
   Google Scholar
• Juniper EF, Guyatt GH, Epstein RS, Ferrie PJ, Jaeschke R, Hiller TK. Evaluation of impairment of health related quality of life in asthma: development of a questionnaire for use in clinical trials. Thorax. 1992;47(2):76–83. doi:10.1136/thx.47.2.76
   PubMed Web of Science ®Google Scholar
• Clark V, Gibson P, McDonald V. What severe asthma treatment outcomes matter to patients? Respirology. 2019;24(Suppl.1):44.
   Google Scholar
• Paterson DH, Warburton DER. Physical activity and functional limitations in older adults: a systematic review related to Canada’s Physical Activity Guidelines. Int J Behav Nutr Phys Act. 2010;7(1):38. doi:10.1186/1479-5868-7-38
   PubMed Web of Science ®Google Scholar
• Walsh LJ, Wong CA, Oborne J, et al. Adverse effects of oral corticosteroids in relation to dose in patients with lung disease. Thorax. 2001;56(4):279–284. doi:10.1136/thorax.56.4.279
   PubMed Web of Science ®Google Scholar
• Vestergaard P, Rejnmark L, Mosekilde L. Fracture risk in patients with chronic lung diseases treated with bronchodilator drugs and inhaled and oral corticosteroids. Chest. 2007;132(5):1599–1607. doi:10.1378/chest.07-1092
   PubMed Web of Science ®Google Scholar
• Ramsahai JM, Wark PA. Appropriate use of oral corticosteroids for severe asthma. Med J Aust. 2018;209(S2):S18–s21. doi:10.5694/mja18.00134
   PubMed Web of Science ®Google Scholar
• McBrien CN, Menzies-Gow A. Time to FOCUS on oral corticosteroid stewardship in asthma management. Respirology. 2019;24(4):304–305. doi:10.1111/resp.13494
   Web of Science ®Google Scholar
• Harb N, Foster JM, Dobler CC. Patient-perceived treatment burden of chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2017;12:1641–1652. doi:10.2147/COPD.S130353
   PubMed Web of Science ®Google Scholar
• Chung KF, Wenzel SE, Brozek JL, et al. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J. 2014;43(2):343–373. doi:10.1183/09031936.00202013
   PubMed Web of Science ®Google Scholar
• Holguin F, Cardet JC, Chung KF, et al. Management of severe asthma: a European Respiratory Society/American Thoracic Society Guideline. Eur Respir J. 2019;1900588.
   Web of Science ®Google Scholar
• Lee J, Tay TR, Radhakrishna N, et al. Nonadherence in the era of severe asthma biologics and thermoplasty. Eur Respir J. 2018;51(4):1701836. doi:10.1183/13993003.01836-2017
   PubMed Web of Science ®Google Scholar
• Tan DJ, Burgess JA, Perret JL, et al. Non-pharmacological management of adult asthma in Australia: cross-sectional analysis of a population-based cohort study. J Asthma. 2020;57(1):105–112. doi:10.1080/02770903.2018.1545030
   PubMed Web of Science ®Google Scholar