139
Views
4
CrossRef citations to date
0
Altmetric
Original Research

Small-Airway Dysfunction is Involved in the Pathogenesis of Asthma: Evidence from Two Mouse Models

, , , , , , , , & show all
Pages 883-896 | Published online: 12 Jul 2021

References

  • Carr TF, Altisheh R, Zitt M. Small airways disease and severe asthma. World Allergy Organ J. 2017;10(1):20. doi:10.1186/s40413-017-0153-4
  • Kuyper LM, Pare PD, Hogg JC, et al. Characterization of airway plugging in fatal asthma. Am J Med. 2003;115(1):6–11. doi:10.1016/S0002-9343(03)00241-9
  • Hamid Q, Song Y, Kotsimbos TC, et al. Inflammation of small airways in asthma. J Allergy Clin Immunol. 1997;100(1):44–51. doi:10.1016/S0091-6749(97)70193-3
  • Postma DS, Brightling C, Baldi S, et al. Exploring the relevance and extent of small airways dysfunction in asthma (ATLANTIS): baseline data from a prospective cohort study [published correction appears in Lancet Respir Med. 2019 Sep;7(9):e28]. Lancet Respir Med. 2019;7(5):402–416. doi:10.1016/S2213-2600(19)30049-9
  • Usmani OS, Singh D, Spinola M, Bizzi A, Barnes PJ. The prevalence of small airways disease in adult asthma: a systematic literature review. Respir Med. 2016;116:19–27. doi:10.1016/j.rmed.2016.05.006
  • Chen X, Wang K, Jiang M, et al. Leukotriene receptor antagonists for small-airway abnormalities in asthmatics: a systematic review and meta-analysis. J Asthma. 2013;50(7):695–704. doi:10.3109/02770903.2013.806543
  • Pellegrino R, Viegi G, Brusasco V, et al. Interpretative strategies for lung function tests. Eur Respir J. 2005;26(5):948–968. doi:10.1183/09031936.05.00035205
  • Devos FC, Maaske A, Robichaud A, et al. Forced expiration measurements in mouse models of obstructive and restrictive lung diseases. Respir Res. 2017;18(1):123. doi:10.1186/s12931-017-0610-1
  • Fei X, Bao W, Zhang P, et al. Inhalation of progesterone inhibits chronic airway inflammation of mice exposed to ozone. Mol Immunol. 2017;85:174–184. doi:10.1016/j.molimm.2017.02.006
  • Heckman EJ, O’Connor GT. Pulmonary function tests for diagnosing lung disease. JAMA. 2015;313(22):2278–2279. doi:10.1001/jama.2015.4466
  • Last JA, Ward R, Temple L, et al. Ovalbumin-induced airway inflammation and fibrosis in mice also exposed to ozone. Inhal Toxicol. 2004;16(1):33–43. doi:10.1080/08958370490258237
  • Zhang JH, Yang X, Chen YP, et al. Nrf2 activator RTA-408 protects against ozone-induced acute asthma exacerbation by suppressing ROS and γδT17 Cells. Inflammation. 2019;42(5):1843–1856. doi:10.1007/s10753-019-01046-6
  • Bao W, Zhang Y, Zhang M, et al. Effects of ozone repeated short exposures on the airway/lung inflammation, airway hyperresponsiveness and mucus production in a mouse model of ovalbumin-induced asthma. Biomed Pharmacother. 2018;101:293–303.14. doi:10.1016/j.biopha.2018.02.079
  • Li F, Zhang P, Zhang M, et al. Hydrogen sulfide prevents and partially reverses ozone-induced features of lung inflammation and emphysema in mice. Am J Respir Cell Mol Biol. 2016;55(1):72–81. doi:10.1165/rcmb.2015-0014OC
  • Pinart M, Hussain F, Shirali S, et al. Role of mitogen-activated protein kinase phosphatase-1 in corticosteroid insensitivity of chronic oxidant lung injury. Eur J Pharmacol. 2014;744:108–114. doi:10.1016/j.ejphar.2014.10.003
  • Zhang X, Bao W, Fei X, et al. Progesterone attenuates airway remodeling and glucocorticoid resistance in a murine model of exposing to ozone. Mol Immunol. 2018;96:69–77. doi:10.1016/j.molimm.2018.02.009
  • Zhang L, Chi X, Luo W, et al. Lung myofibroblast transition and fibrosis is regulated by circ0044226. Int J Biochem Cell Biol. 2020;118:105660. doi:10.1016/j.biocel.2019.105660
  • Royce SG, Miao YR, Lee M, et al. Relaxin reverses airway remodeling and airway dysfunction in allergic airways disease. Endocrinology. 2009;150(6):2692–2699. doi:10.1210/en.2008-1457
  • Li F, Wiegman C, Seiffert JM, et al. Effects of N-acetylcysteine in ozone-induced chronic obstructive pulmonary disease model. PLoS One. 2013;8(11):e80782. doi:10.1371/journal.pone.0080782
  • Sun Z, Li F, Zhou X, Wang W. Generation of a chronic obstructive pulmonary disease model in mice by repeated ozone exposure. J Vis Exp. 2017;126:56095.
  • Liu JQ, Yang D, Folz RJ. A novel bronchial ring bioassay for the evaluation of small airway smooth muscle function in mice. Am J Physiol Lung Cell Mol Physiol. 2006;291(2):L281–L288. doi:10.1152/ajplung.00320.2005
  • Sera T, Uesugi K, Himeno R, Yagi N. Small airway changes in healthy and ovalbumin-treated mice during quasi-static lung inflation. Respir Physiol Neurobiol. 2007;156(3):304–311. doi:10.1016/j.resp.2006.11.006
  • Uemasu K, Tanabe N, Tanimura K, et al. Serine protease imbalance in the small airways and development of centrilobular emphysema in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol. 2020;63(1):67–78. doi:10.1165/rcmb.2019-0377OC
  • Donovan C, Royce SG, Esposito J, et al. Differential effects of allergen challenge on large and small airway reactivity in mice. PLoS One. 2013;8(9):e74101. doi:10.1371/journal.pone.0074101
  • van den Berge M, Ten Hacken NHT, Cohen J, et al. Small airway disease in asthma and COPD: clinical implications [published correction appears in Chest. 2011 Apr;139(4):972]. Chest. 2011;139(2):412–423. doi:10.1378/chest.10-1210
  • Carroll N, Cooke C, James A. The distribution of eosinophils and lymphocytes in the large and small airways of asthmatics. Eur Respir J. 1997;10(2):292–300. doi:10.1183/09031936.97.10020292
  • Taha RA, Minshall EM, Miotto D, et al. Eotaxin and monocyte chemotactic protein-4 mRNA expression in small airways of asthmatic and nonasthmatic individuals. J Allergy Clin Immunol. 1999;103(3 Pt 1):476–483. doi:10.1016/S0091-6749(99)70474-4
  • Cooper PR, Poll CT, Barnes PJ, Sturton RG. Involvement of IL-13 in tobacco smoke-induced changes in the structure and function of rat intrapulmonary airways. Am J Respir Cell Mol Biol. 2010;43(2):220–226. doi:10.1165/rcmb.2009-0117OC
  • Manson ML, Säfholm J, James A, et al. IL-13 and IL-4, but not IL-5 nor IL-17A, induce hyperresponsiveness in isolated human small airways. J Allergy Clin Immunol. 2020;145(3):808–817.e2. doi:10.1016/j.jaci.2019.10.037
  • Zhang Y, Li X, He M, et al. The effects of neutralizing anti-murine interleukin-17A monoclonal antibody on ozone-induced inflammation and glucocorticoids insensitivity in a murine model of asthma. Biomed Pharmacother. 2019;114:108786. doi:10.1016/j.biopha.2019.108786
  • Bao W, Zhang X, Lv C, et al. The value of fractional exhaled nitric oxide and forced mid-expiratory flow as predictive markers of bronchial hyperresponsiveness in adults with chronic cough. J Allergy Clin Immunol Pract. 2018;6(4):1313–1320. doi:10.1016/j.jaip.2017.09.026
  • van der Wiel E, Postma DS, van der Molen T, et al. Effects of small airway dysfunction on the clinical expression of asthma: a focus on asthma symptoms and bronchial hyper-responsiveness. Allergy. 2014;69(12):1681–1688. doi:10.1111/all.12510
  • Kang SH, Kim HY, Seo JH, et al. Bronchial hyperresponsiveness to methacholine and AMP in children with atopic asthma. Allergy Asthma Immunol Res. 2012;4(6):341–345. doi:10.4168/aair.2012.4.6.341
  • Cohen J, Douma WR, Ten Hacken NH, et al. Ciclesonide improves measures of small airway involvement in asthma. Eur Respir J. 2008;31(6):1213–1220. doi:10.1183/09031936.00082407
  • Bonser LR, Erle DJ. Airway mucus and asthma: the role of MUC5AC and MUC5B. J Clin Med. 2017;6(12):112. doi:10.3390/jcm6120112
  • Lipworth B, Manoharan A, Anderson W. Unlocking the quiet zone: the small airway asthma phenotype. Lancet Respir Med. 2014;2(6):497–506. doi:10.1016/S2213-2600(14)70103-1
  • Tagaya E, Tamaoki J. Mechanisms of airway remodeling in asthma. Allergol Int. 2007;56(4):331–340. doi:10.2332/allergolint.R-07-152
  • Halayko AJ, Salari H, Ma X, Stephens NL. Markers of airway smooth muscle cell phenotype. Am J Physiol. 1996;270(6 Pt 1):L1040–51. doi:10.1152/ajplung.1996.270.6.L1040
  • Ramos-Barbón D, Fraga-Iriso R, Brienza NS, et al. T Cells localize with proliferating smooth muscle alpha-actin+ cell compartments in asthma. Am J Respir Crit Care Med. 2010;182(3):317–324. doi:10.1164/rccm.200905-0745OC
  • Maarsingh H, Bidan CM, Brook BS, et al. Small airway hyperresponsiveness in COPD: relationship between structure and function in lung slices. Am J Physiol Lung Cell Mol Physiol. 2019;316(3):L537–L546. doi:10.1152/ajplung.00325.2018
  • Panettieri RA. The Role of Neutrophils in Asthma. Immunol Allergy Clin North Am. 2018;38(4):629–638. doi:10.1016/j.iac.2018.06.005