References
- Janus J, Moerschel SK. Evaluation of anemia in children. Am Fam Physician. 2010;81(12):1462–1471.
- Kassebaum NJ, Jasrasaria R, Naghavi M, et al. A systematic analysis of global anemia burden from 1990 to 2010. Blood. 2014;123:615–624.
- Steinbicker AU, Muckenthaler MU. Out of balance–systemic iron homeostasis in iron-related disorders. Nutrients. 2013;5:3034–3061.
- Weiss G, Ganz T, Goodnough LT. Anemia of inflammation. Blood. 2019;133:40–50.
- Nemeth E, Valore EV, Territo M, et al. Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood. 2003;101:2461–2463.
- Theurl I, Mattle V, Seifert M, et al. Dysregulated monocyte iron homeostasis and erythropoietin formation in patients with anemia of chronic disease. Blood. 2006;107:4142–4148.
- Zarychanski R, Houston DS. Anemia of chronic disease: a harmful disorder or an adaptive, beneficial response? CMAJ. 2008;179:333–337.
- Hsu C, McCulloch CE, Curhan GC. Iron status and hemoglobin level in chronic renal insufficiency. J Am Soc Nephrol. 2002;13:2783–2786.
- Weiss G, Schett G. Anaemia in inflammatory rheumatic diseases. Nat Rev Rheumatol. 2013;9:205–215.
- Abdel-Khalek MA, El-Barbary AM, Essa SA, et al. Serum hepcidin: a direct link between anemia of inflammation and coronary artery atherosclerosis in patients with rheumatoid arthritis. J Rheumatol. 2011;38:2153–2159.
- Matsumoto M, Tsujino T, Lee-Kawabata M, et al. Iron regulatory hormone hepcidin decreases in chronic heart failure patients with anemia. Circ J. 2010;74:301–306.
- Begum S, Latunde-Dada G. Anemia of Inflammation with An Emphasis on Chronic Kidney Disease. Nutrients. 2019;11:2424.
- Wawer AA, Jennings A, Fairweather-Tait SJ. Iron status in the elderly: a review of recent evidence. Mech Ageing Dev. 2018;175:55–73.
- Vanasse GJ, Berliner N. Anemia in elderly patients: an emerging problem for the 21st century. Hematology Am Soc Hematol Educ Program. 2010;2010:271–275.
- Ganz T. Anemia of Inflammation. N Engl J Med. 2019;381:1148–1157.
- Polin V, Coriat R, Perkins G, et al. Iron deficiency: from diagnosis to treatment. Dig Liver Dis. 2013;45:803–809.
- Hameed R, Peters RL, Field MJ. e al. Self-reported asthma prevalence and control in a population-based cohort of Australian school students aged 10-14 years. Arch Dis Child. 2019;104:612–613.
- Hill DA, Grundmeier RW, Ram G, et al. The epidemiologic characteristics of healthcare provider-diagnosed eczema, asthma, allergic rhinitis, and food allergy in children: a retrospective cohort study. BMC Pediatr. 2016;16:133.
- Karimkhani C, Dellavalle RP, Coffeng LE, et al. Global skin disease morbidity and mortality: an update from the global burden of disease study 2013. JAMA Dermatol. 2017;153:406–412.
- Scott SP, Chen-Edinboro LP, Caulfield LE, et al. The impact of anemia on child mortality: an updated review. Nutrients. 2014;6:5915–5932.
- Narla S, Silverberg JI. Association between atopic dermatitis and autoimmune disorders in US adults and children: a cross-sectional study. J Am Acad Dermatol. 2019;80:382–389.
- Drury KE, Schaeffer M, Silverberg JI. Association between atopic disease and anemia in US children. JAMA Pediatr. 2016;170:29–34.
- Rhew K, Oh JM. Association between atopic disease and anemia in pediatrics: a cross-sectional study. BMC Pediatr. 2019;19:455.
- Rhew K, Brown JD, Oh JM. Atopic disease and anemia in Korean patients: cross-sectional study with propensity score analysis. Int J Environ Res Public Health. 2020;17:1978.
- Kim L, Kim JA, Kim S. A guide for the utilization of health insurance review and assessment service national patient samples. Epidemiol Health. 2014;36:e2014008.
- Rubin DB. Using propensity scores to help design observational studies: application to the tobacco litigation. Health Serv Outcomes Res Methodol. 2001;2:169–188.
- Dugdale M. Anemia. Obstet Gynecol Clin North Am. 2001;28:363–381.
- Republic of Korea Ministry of Health and Welfare. Medical Service Usage Status Report 2017. Available from: https://www.mohw.go.kr/react/gm/sgm0704vw.jsp?PAR_MENU_ID=13&MENU_ID=13040801&page=1&CONT_SEQ=356233&PAR_CONT_SEQ=355637. (Accessed December 20, 2020.
- Licari A, Castagnoli R, Brambilla I, et al. Asthma endotyping and biomarkers in childhood asthma. Pediatr Allergy Immunol Pulmonol. 2018;31:44–55.
- Gibson PG, Simpson JL, Saltos N. Heterogeneity of airway inflammation in persistent asthma: evidence of neutrophilic inflammation and increased sputum interleukin-8. Chest. 2001;119:1329–1336.
- Raundhal M, Morse C, Khare A, et al. High IFN-γ and low SLPI mark severe asthma in mice and humans. J Clin Invest. 2015;125:3037–3050.
- Caffarelli C, Santamaria F, Cesari S, et al. Progress in pediatrics in 2011. Choices in Endocrinology, Gastroenterology, Hemato-Oncology, Infectious Diseases, Otolaryngology, Pharmacotherapy and Respiratory Tract Illnesses Ital J Pediatr. 2012;38:23.
- Berry MA, Hargadon B, Shelley M, et al. Evidence of a role of tumor necrosis factor alpha in refractory asthma. N Engl J Med. 2006;354:697–708.
- Wenzel SE, Barnes PJ, Bleecker ER, et al. A randomized, double-blind, placebo-controlled study of tumor necrosis factor-alpha blockade in severe persistent asthma. Am J Respir Crit Care Med. 2009;179:549–558.
- Morjaria JB, Chauhan AJ, Babu KS, et al. The role of a soluble TNFalpha receptor fusion protein (etanercept) in corticosteroid refractory asthma: a double blind, randomised, placebo controlled trial. Thorax. 2008;63:584–591.
- Jensen ME, Gibson PG, Collins CE, et al. Diet-induced weight loss in obese children with asthma: a randomized controlled trial. Clin Exp Allergy. 2013;43:775–784.
- Zein JG, Dweik RA, Comhair SA, et al. Asthma is more severe in older adults. PLoS One. 2015;10:e0133490.
- Morceau F, Dicato M, Diederich M. Pro-inflammatory cytokine-mediated anemia: regarding molecular mechanisms of erythropoiesis. Mediators Inflamm. 2009;2009:405016.
- Libregts SF, Gutiérrez L, de Bruin AM, et al. Chronic IFN-γ production in mice induces anemia by reducing erythrocyte life span and inhibiting erythropoiesis through an IRF-1/PU.1 axis. Blood. 2011;118:2578–2588.
- Milner JD, Orekov T, Ward JM, et al. Sustained IL-4 exposure leads to a novel pathway for hemophagocytosis, inflammation, and tissue macrophage accumulation. Blood. 2010;116:2476–2483.
- Nemeth E, Rivera S, Gabayan V, et al. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest. 2004;113:1271–1276.
- Rodriguez R, Jung CL, Gabayan V, et al. Hepcidin induction by pathogens and pathogen-derived molecules is strongly dependent on interleukin-6. Infect Immun. 2014;82:745–752.
- Paul AGA, Muehling LM, Eccles JD, et al. T cells in severe childhood asthma. Clin Exp Allergy. 2019;49:564–581.
- Wisniewski JA, Muehling LM, Eccles JD, et al. TH1 signatures are present in the lower airways of children with severe asthma, regardless of allergic status. J Allergy Clin Immunol. 2018;141:2048–2060.e13.
- Chien JW, Lin CY, Yang KD, et al. Increased IL-17A secreting CD4+ T cells, serum IL-17 levels and exhaled nitric oxide are correlated with childhood asthma severity. Clin Exp Allergy. 2013;43:1018–1026.
- Cai T, Qiu J, Ji Y, et al. IL-17-producing ST2(+) group 2 innate lymphoid cells play a pathogenic role in lung inflammation. J Allergy Clin Immunol. 2019;143:229–244.e9.
- Hutchinson C. A review of iron studies in overweight and obese children and adolescents: a double burden in the young? Eur J Nutr. 2016;55:2179–2197.
- Triche EW, Lundsberg LS, Wickner PG, et al. Association of maternal anemia with increased wheeze and asthma in children. Ann Allergy Asthma Immunol. 2011;106:131–139.e1.
- Sanad M, Osman M, Gharib A. Obesity modulate serum hepcidin and treatment outcome of iron deficiency anemia in children: a case control study. Ital J Pediatr. 2011;37:34.
- Theurl M, Nairz M, Schroll A, et al. Hepcidin as a predictive factor and therapeutic target in erythropoiesis-stimulating agent treatment for anemia of chronic disease in rats. Haematologica. 2014;99:1516–1524.
- Bregman DB, Morris D, Koch TA, et al. Hepcidin levels predict nonresponsiveness to oral iron therapy in patients with iron deficiency anemia. Am J Hematol. 2013;88:97–101.