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Journal of Asthma and Allergy Volume 15, 2022 - Issue
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Original Research

Real World Biologic Use and Switch Patterns in Severe Asthma: Data from the International Severe Asthma Registry and the US CHRONICLE Study

Andrew N Menzies-Gow1 UK Severe Asthma Network and National Registry, Royal Brompton & Harefield Hospitals, London, UKView further author information
,
Claire McBrien2 Kingston Hospital, London, UKView further author information
,
Bindhu Unni3 Observational and Pragmatic Research Institute, Singapore, SingaporeView further author information
,
Celeste M Porsbjerg4 Respiratory Research Unit, Bispebjerg University Hospital, Copenhagen, DenmarkView further author information
,
Mona Al-Ahmad5 Al-Rashed Allergy Center, Ministry of Health, Microbiology Department, Faculty of Medicine, Kuwait University, Kuwait, KuwaitORCID Iconhttps://orcid.org/0000-0003-2950-5363View further author information
ORCID Icon,
Christopher S Ambrose6 AstraZeneca, Gaithersburg, MD, USAORCID Iconhttps://orcid.org/0000-0003-4175-7336View further author information
ORCID Icon,
Karin Dahl Assing7 Department of Respiratory Medicine, Aalborg University Hospital, Aalborg, DenmarkView further author information
,
Anna von Bülow4 Respiratory Research Unit, Bispebjerg University Hospital, Copenhagen, DenmarkView further author information
,
John Busby8 UK Severe Asthma Network and National Registry, Queen’s University Belfast, Belfast, Northern IrelandView further author information
,
Borja G Cosio9 Son Espases University Hospital-IdISBa-Ciberes, Mallorca, SpainORCID Iconhttps://orcid.org/0000-0002-6388-8209View further author information
ORCID Icon,
J Mark FitzGerald10 The Centre for Lung Health, Vancouver Coastal Health Research Institute, UBC, Vancouver, CanadaView further author information
,
Esther Garcia Gil11 AstraZeneca, Barcelona, SpainView further author information
,
Susanne Hansen12 Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, DenmarkView further author information
,
Liam G aHeaney8 UK Severe Asthma Network and National Registry, Queen’s University Belfast, Belfast, Northern IrelandView further author information
,
Mark Hew13 Allergy, Asthma & Clinical Immunology Service, Alfred Health, Melbourne, Australia;14 Public Health and Preventive Medicine, Monash University, Melbourne, AustraliaView further author information
,
David J Jackson15 UK Severe Asthma Network andNational Registry, Guy’s and St Thomas’ NHS Trust, London, UK;16 School of Immunology & Microbial Sciences, King’s College London, London, UKView further author information
,
Maria Kallieri17 2nd Respiratory Medicine Department, National and Kapodistrian University of Athens Medical School, Attikon University Hospital, Athens, GreeceView further author information
,
Stelios Loukides17 2nd Respiratory Medicine Department, National and Kapodistrian University of Athens Medical School, Attikon University Hospital, Athens, GreeceORCID Iconhttps://orcid.org/0000-0002-4278-9922View further author information
ORCID Icon,
Njira L Lugogo18 Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI, USAView further author information
,
Andriana I Papaioannou17 2nd Respiratory Medicine Department, National and Kapodistrian University of Athens Medical School, Attikon University Hospital, Athens, GreeceORCID Iconhttps://orcid.org/0000-0001-9708-3241View further author information
ORCID Icon,
Désirée Larenas-Linnemann19 Directora Centro de Excelencia en Asma y Alergia, Hospital Médica Sur, Ciudad de México, MexicoORCID Iconhttps://orcid.org/0000-0002-5713-5331View further author information
ORCID Icon,
Wendy C Moore20 Pulmonary, Critical Care, Allergy, and Immunologic Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USAView further author information
,
Luis A Perez-de-Llano21 Department of Respiratory Medicine, Hospital Universitario Lucus Augusti, Lugo, SpainORCID Iconhttps://orcid.org/0000-0003-2652-6847View further author information
ORCID Icon,
Linda M Rasmussen22 Allergy Clinic, Department of Dermato-Allergology, Gentofte Hospital, Copenhagen, DenmarkView further author information
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Johannes M Schmid23 University Hospital of Aarhus, Aarhus, DenmarkView further author information
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Salman Siddiqui24 University of Leicester, Department of Respiratory Sciences & NIHR Leicester Biomedical Research Centre (Respiratory Theme), Leicester, UKView further author information
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Marianna Alacqua25 AstraZeneca, Cambridge, UKView further author information
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Trung N Tran6 AstraZeneca, Gaithersburg, MD, USAView further author information
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Charlotte Suppli Ulrik26 Department of Respiratory Medicine, Copenhagen University Hospital-Hvidovre, Hvidovre, DenmarkORCID Iconhttps://orcid.org/0000-0001-8689-3695View further author information
ORCID Icon,
John W Upham27 Diamantina Institute & PA-Southside Clinical Unit, The University of Queensland, Brisbane, AustraliaView further author information
,
Eileen Wang28 Division of Allergy & Clinical Immunology, Department of Medicine, National Jewish Health, Denver, CO, USA;29 Division of Allergy & Clinical Immunology, Department of Internal Medicine, University of Colorado School of Medicine, Aurora, CO, USAView further author information
,
Lakmini Bulathsinhala3 Observational and Pragmatic Research Institute, Singapore, Singapore;30 Optimum Patient Care, Cambridge, UKView further author information
,
Victoria A Carter3 Observational and Pragmatic Research Institute, Singapore, Singapore;30 Optimum Patient Care, Cambridge, UKView further author information
,
Isha Chaudhry3 Observational and Pragmatic Research Institute, Singapore, Singapore;30 Optimum Patient Care, Cambridge, UKView further author information
,
Neva Eleangovan3 Observational and Pragmatic Research Institute, Singapore, Singapore;30 Optimum Patient Care, Cambridge, UKView further author information
,
Ruth B Murray3 Observational and Pragmatic Research Institute, Singapore, Singapore;30 Optimum Patient Care, Cambridge, UKView further author information
,
Chris A Price3 Observational and Pragmatic Research Institute, Singapore, Singapore;30 Optimum Patient Care, Cambridge, UKView further author information
&
David B Price3 Observational and Pragmatic Research Institute, Singapore, Singapore;30 Optimum Patient Care, Cambridge, UK;31 Centre of Academic Primary Care, Division of Applied Health Sciences, University of Aberdeen, Aberdeen, UKCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-9728-9992View further author information
ORCID Icon show all
Pages 63-78 | Published online: 13 Jan 2022

References

  • McGregor MC, Krings JG, Nair P, Castro M. Role of biologics in asthma. Am J Respir Crit Care Med. 2019;199:433–445. doi:10.1164/rccm.201810-1944CI
  • Hillas G, Fouka E, Papaioannou AI. Antibodies targeting the interleukin-5 signaling pathway used as add-on therapy for patients with severe eosinophilic asthma: a review of the mechanism of action, efficacy, and safety of the subcutaneously administered agents, mepolizumab and benralizumab. Expert Rev Respir Med. 2020;14(4):353–365. doi:10.1080/17476348.2020.1718495
  • Le Floc’h A, Allinne J, Nagashima K, et al. Dual blockade of IL-4 and IL-13 with dupilumab, an IL-4Rα antibody, is required to broadly inhibit type 2 inflammation. Allergy Eur J Allergy Clin Immunol. 2020;75(5):1188–1204. doi:10.1111/all.14151
  • Ortega HG, Liu MC, Pavord ID, et al. Mepolizumab treatment in patients with severe eosinophilic asthma. N Engl J Med. 2014;371(13):1198–1207. doi:10.1056/NEJMoa1403290
  • Castro M, Zangrilli J, Wechsler ME, et al. Reslizumab for inadequately controlled asthma with elevated blood eosinophil counts: results from two multicentre, parallel, double-blind, randomised, placebo-controlled, Phase 3 trials. Lancet Respir Med. 2015;3(5):355–366. doi:10.1016/S2213-2600(15)00042-9
  • FitzGerald JM, Bleecker ER, Menzies-Gow A, et al. Predictors of enhanced response with benralizumab for patients with severe asthma: pooled analysis of the SIROCCO and CALIMA studies. Lancet Respir Med. 2018;6:51–64. doi:10.1016/S2213-2600(17)30344-2
  • Castro M, Corren J, Pavord ID, et al. Dupilumab efficacy and safety in moderate-to-severe uncontrolled asthma. N Engl J Med. 2018;378(26):2486–2496. doi:10.1056/NEJMoa1804092
  • Ramonell RP, Iftikhar IH. Effect of anti-IL5, anti-IL5R, anti-IL13 therapy on asthma exacerbations: a network meta-analysis. Lung. 2020;198(1):95–103. doi:10.1007/s00408-019-00310-8
  • Menzella F, Ruggiero P, Galeone C, et al. Significant improvement in lung function and asthma control after benralizumab treatment for severe refractory eosinophilic asthma. Pulm Pharmacol Ther. 2020;64:101966. doi:10.1016/j.pupt.2020.101966
  • Volmer T, Effenberger T, Trautner C, Buhl R. Consequences of long-term oral corticosteroid therapy and its side-effects in severe asthma in adults: a focused review of the impact data in the literature. Eur Respir J. 2018;52(4):1800703. doi:10.1183/13993003.00703-2018
  • Wang E, Wechsler ME, Tran TN, et al. Characterization of severe asthma worldwide: data from the international severe asthma registry. Chest. 2020;157(4):790–804. doi:10.1016/j.chest.2019.10.053
  • Canonica GW, Alacqua M, Altraja A, et al. International severe asthma registry: mission Statement. Chest. 2020;157(4):805–814. doi:10.1016/j.chest.2019.10.051
  • Fitzgerald JM, Tran TN, Alacqua M, et al. International severe asthma registry (ISAR): protocol for a global registry. BMC Med Res Methodol. 2020;20. doi:10.1186/s12874-020-01065-0
  • Bulathsinhala L, Eleangovan N, Heaney LG, et al. Development of the International Severe Asthma Registry (ISAR): a modified Delphi study. J Allergy Clin Immunol Pract. 2019;7:578–588.e2. doi:10.1016/j.jaip.2018.08.016
  • Ambrose C, Chipps BE, Moore WC, et al. The CHRONICLE study of US adults with subspecialist-treated severe asthma: objectives, design, and initial results. Pragmatic Obs Res. 2020;11:77–90.
  • Moore WC, Panettieri RA, Trevor J, et al. Biologic and maintenance systemic corticosteroid therapy among US subspecialist-treated patients with severe asthma. Ann Allergy Asthma Immunol. 2020;125(3):294–303.e1. doi:10.1016/j.anai.2020.04.004
  • Global Initiative for Asthma. Global statement for asthma management and prevention 2018. Available from: https://ginasthma.org/wp-content/uploads/2018/04/wms-GINA-2018-report-V1.3-002.pdf. Accessed December 25, 2021.
  • Kuruvilla M, Ariue B, Oppenheimer JJ, Singh U, Bernstein JA. Clinical use of biologics for asthma treatment by allergy specialists: a questionnaire survey. Ann Allergy Asthma Immunol. 2020;125(4):433–439. doi:10.1016/j.anai.2020.06.041
  • Albers FC, Müllerová H, Gunsoy NB, et al. Biologic treatment eligibility for real-world patients with severe asthma: the IDEAL study. J Asthma. 2018;55(2):152–160. doi:10.1080/02770903.2017.1322611
  • Llanos JP, Bell CF, Packnett E, et al. Real-world characteristics and disease burden of patients with asthma prior to treatment initiation with mepolizumab or omalizumab: a retrospective cohort database study. J Asthma Allergy. 2019;12:43–58. doi:10.2147/JAA.S189676
  • Kim J, Naclerio R. Therapeutic potential of dupilumab in the treatment of chronic rhinosinusitis with nasal polyps: evidence to date. Ther Clin Risk Manag. 2020;16:31–37. doi:10.2147/TCRM.S210648
  • Menzies-Gow A, Bafadhel M, Busse WW, et al. An expert consensus framework for asthma remission as a treatment goal. J Allergy Clin Immunol. 2020;145(3):757–765. doi:10.1016/j.jaci.2019.12.006

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