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Research Letter

Improvement in Lung Function with Dupilumab Does Not Predict Its Effects on Reducing Asthma Exacerbation

, , ORCID Icon, , ORCID Icon, , , , , , , , & show all
Pages 851-854 | Published online: 28 Jun 2022

References

  • Tepper RS, Wise RS, Covar R, et al. Asthma outcomes: pulmonary physiology. J Allergy Clin Immunol. 2012;129(3 Suppl):S65–S87. doi:10.1016/j.jaci.2011.12.986
  • Global Initiative for Asthma (GINA). Global strategy for asthma management and prevention. 2021. Available from: https://ginasthma.org/wp-content/uploads/2021/05/GINA-Main-Report-2021-V2-WMS.pdf. Accessed December 10, 2021.
  • Santanello NC, Zhang J, Seidenberg B, Reiss TF, Barber BL. What are minimal important changes for asthma measures in a clinical trial? Eur Respir J. 1999;14(1):23–27. doi:10.1034/j.1399-3003.1999.14a06.x
  • Castro M, Corren J, Pavord ID, et al. Dupilumab efficacy and safety in moderate-to-severe uncontrolled asthma. N Engl J Med. 2018;378(26):2486–2496. doi:10.1056/NEJMoa1804092
  • Castro M, Rabe KF, Corren J, et al. Dupilumab improves lung function in patients with uncontrolled, moderate-to-severe asthma. ERJ Open Res. 2020;6(1):00204–2019. doi:10.1183/23120541.00204-2019
  • Papi A, Castro M, Corren J, et al. Long-term effect of dupilumab on lung function in patients with type 2 asthma: LIBERTY ASTHMA TRAVERSE study. Presented at the 2021 CHEST Annual Meeting; October 17-20; 2021; Orlando, FL, USA.