161
Views
5
CrossRef citations to date
0
Altmetric
Original Research

Increase in FeNO Levels Following IL5/IL5R-Targeting Therapies in Severe Asthma: A Case Series

, , , , &
Pages 691-701 | Published online: 19 May 2022

References

  • FitzGerald JMLC, Lougheed MD, Lougheed MD, et al. Recognition and management of severe asthma, A Canadian Thoracic Society position statement. Can J Respir Crit Care Sleep Med. 2017;1(4):199–221. doi:10.1080/24745332.2017.1395250
  • Shaw DE, Sousa AR, Fowler SJ, et al. Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort. Eur Respir J. 2015;46(5):1308–1321. doi:10.1183/13993003.00779-2015
  • Global initiative for asthma. Difficult-to-treat & Severe asthma in adolescent and adult patients - diagnosis and management. Available from: www.ginasthma.org. Accessed May 5, 2022.
  • Schleich FN, Chevremont A, Paulus V, et al. Importance of concomitant local and systemic eosinophilia in uncontrolled asthma. Eur Respir J. 2014;44(1):97–108. doi:10.1183/09031936.00201813
  • Coverstone AM, Seibold MA, Peters MC. Diagnosis and management of T2-high asthma. J Allergy Clin Immunol Pract. 2020;8(2):442–450. doi:10.1016/j.jaip.2019.11.020
  • Donohue JF, Jain N. Exhaled nitric oxide to predict corticosteroid responsiveness and reduce asthma exacerbation rates. Respir Med. 2013;107(7):943–952. doi:10.1016/j.rmed.2013.02.018
  • Szefler SJ, Wenzel S, Brown R, et al. Asthma outcomes, biomarkers. J Allergy Clin Immunol. 2012;129(3Suppl):S9–23. doi:10.1016/j.jaci.2011.12.979
  • Pavord ID, Korn S, Howarth P, et al. Mepolizumab for severe eosinophilic asthma (DREAM), a multicentre, double-blind, placebo-controlled trial. Lancet. 2012;380(9842):651–659. doi:10.1016/s0140-6736(12)60988-x
  • Castro M, Wenzel SE, Bleecker ER, et al. Benralizumab, an anti-interleukin 5 receptor α monoclonal antibody, versus placebo for uncontrolled eosinophilic asthma, a phase 2b randomised dose-ranging study. Lancet Respir Med. 2014;2(11):879–890. doi:10.1016/s2213-2600(14)70201-2
  • Hsu C, Diaz J. M201 should FENO be used as a biomarker to measure response to benralizumab? Ann Allergy Asthma Immunol. 2019;123(5):S99. doi:10.1016/j.anai.2019.08.188
  • Dweik RA, Boggs PB, Erzurum SC, et al. An official ATS clinical practice guideline, interpretation of exhaled nitric oxide levels (FENO) for clinical applications. Am J Respir Crit Care Med. 2011;184(5):602–615. doi:10.1164/rccm.9120-11ST
  • Jeppegaard M, Veidal S, Sverrild A, Backer V, Porsbjerg C. Validation of ATS clinical practice guideline cut-points for FeNO in asthma. Respir Med. 2018;144:22–29. doi:10.1016/j.rmed.2018.09.014
  • Liu J, Xu R, Zhan C, et al. Clinical utility of ultrahigh fractional exhaled nitric oxide in predicting bronchial hyperresponsiveness in patients with suspected asthma. Postgrad Med J. 2019;95(1128):541–546. doi:10.1136/postgradmedj-2018-136333
  • Guo FH, De Raeve HR, Rice TW, Stuehr DJ, Thunnissen FB, Erzurum SC. Continuous nitric oxide synthesis by inducible nitric oxide synthase in normal human airway epithelium in vivo. Proc Natl Acad Sci U S A. 1995;92(17):7809–7813. doi:10.1073/pnas.92.17.7809
  • Duong-Quy S. Clinical utility of the exhaled Nitric Oxide (NO) measurement with portable devices in the management of allergic airway inflammation and asthma. J Asthma Allergy. 2019;12:331–341. doi:10.2147/jaa.S190489
  • Rabe KF, Nair P, Brusselle G, et al. Efficacy and safety of dupilumab in glucocorticoid-dependent severe asthma. N Engl J Med. 2018;378(26):2475–2485. doi:10.1056/NEJMoa1804093
  • Castro M, Corren J, Pavord ID, et al. Dupilumab efficacy and safety in moderate-to-severe uncontrolled asthma. N Engl J Med. 2018;378(26):2486–2496. doi:10.1056/NEJMoa1804092
  • Wenzel S, Ford L, Pearlman D, et al. Dupilumab in persistent asthma with elevated eosinophil levels. N Engl J Med. 2013;368(26):2455–2466. doi:10.1056/NEJMoa1304048
  • Izumo T, Tone M, Kuse N, et al. Effectiveness and safety of benralizumab for severe asthma in clinical practice (J-BEST), a prospective study. Ann Transl Med. 2020;8(7):438. doi:10.21037/atm.2020.04.01
  • Ramonell RP, Lee FE, Levy JM, Kuruvilla M. Exhaled nitric oxide measurements are not influenced by anti-eosinophil therapy in patients with asthma, A retrospective analysis. Ann Allergy Asthma Immunol. 2021;126(1):102–104. doi:10.1016/j.anai.2020.09.005
  • Crimi C, Campisi R, Nolasco S, et al. Mepolizumab effectiveness in patients with severe eosinophilic asthma and co-presence of bronchiectasis, A real-world retrospective pilot study. Respir Med. 2021;185:106491. doi:10.1016/j.rmed.2021.106491
  • Pelaia C, Crimi C, Benfante A, et al. Therapeutic effects of benralizumab assessed in patients with severe eosinophilic asthma, real-life evaluation correlated with allergic and non-allergic phenotype expression. J Asthma Allergy. 2021;14:163–173. doi:10.2147/jaa.S297273
  • Gratziou C, Lignos M, Dassiou M, Roussos C. Influence of atopy on exhaled nitric oxide in patients with stable asthma and rhinitis. Eur Respir J. 1999;14(4):897–901. doi:10.1034/j.1399-3003.1999.14d28.x
  • Galli J, Montuschi P, Passàli GC, Laruffa M, Parrilla C, Paludetti G. Exhaled nitric oxide measurement in patients affected by nasal polyposis. Otolaryngol Head Neck Surg. 2012;147(2):351–356. doi:10.1177/0194599812442322
  • Watkins DN, Lewis RH, Basclain KA, et al. Expression and localization of the inducible isoform of nitric oxide synthase in nasal polyp epithelium. Clin Exp Allergy. 1998;28(2):211–219. doi:10.1046/j.1365-2222.1998.00215.x
  • Maniscalco M, Calabrese C, D’Amato M, et al. Association between exhaled nitric oxide and nasal polyposis in severe asthma. Respir Med. 2019;152:20–24. doi:10.1016/j.rmed.2019.04.017
  • Clearie KL, McKinlay L, Williamson PA, Lipworth BJ. Fluticasone/Salmeterol combination confers benefits in people with asthma who smoke. Chest. 2012;141(2):330–338. doi:10.1378/chest.11-0392
  • Bleecker ER, FitzGerald JM, Chanez P, et al. Efficacy and safety of benralizumab for patients with severe asthma uncontrolled with high-dosage inhaled corticosteroids and long-acting β(2)-agonists (SIROCCO), a randomised, multicentre, placebo-controlled phase 3 trial. Lancet. 2016;388(10056):2115–2127. doi:10.1016/s0140-6736(16)31324-1
  • FitzGerald JM, Bleecker ER, Nair P, et al. Benralizumab, an anti-interleukin-5 receptor α monoclonal antibody, as add-on treatment for patients with severe, uncontrolled, eosinophilic asthma (CALIMA), a randomised, double-blind, placebo-controlled phase 3 trial. Lancet. 2016;388(10056):2128–2141. doi:10.1016/s0140-6736(16)31322-8
  • Ortega HG, Liu MC, Pavord ID, et al. Mepolizumab treatment in patients with severe eosinophilic asthma. N Engl J Med. 2014;371(13):1198–1207. doi:10.1056/NEJMoa1403290
  • Haldar P, Brightling CE, Hargadon B, et al. Mepolizumab and exacerbations of refractory eosinophilic asthma. N Engl J Med. 2009;360(10):973–984. doi:10.1056/NEJMoa0808991
  • Nair P, Wenzel S, Rabe KF, et al. Oral glucocorticoid-sparing effect of benralizumab in severe asthma. N Engl J Med. 2017;376(25):2448–2458. doi:10.1056/NEJMoa1703501
  • Flood-Page P, Swenson C, Faiferman I, et al. A study to evaluate safety and efficacy of mepolizumab in patients with moderate persistent asthma. Am J Respir Crit Care Med. 2007;176(11):1062–1071. doi:10.1164/rccm.200701-085OC
  • GlaxoSmithKline. PRODUCT MONOGRAPH – NUCALA. Updated Nov 5; 2021. Available from: https://ca.gsk.com/media/6195/nucala-pm-en.pdf. Accessed May 5, 2022.
  • AstraZeneca. Product Monograph – Fasenra. Updated August 20; 2021. Available from: https://www.astrazeneca.ca/content/dam/az-ca/downloads/productinformation/fasenra-product%20monograph-en.pdf. Accessed May 5, 2022.
  • Moran AM, Ramakrishnan S, Borg CA, et al. Blood eosinophil depletion with mepolizumab, benralizumab, and prednisolone in eosinophilic asthma. Am J Respir Crit Care Med. 2020;202(9):1314–1316. doi:10.1164/rccm.202003-0729LE