Disease Control, Not Severity, Drives Job Absenteeism in Young Adults with Asthma – A Nationwide Cohort Study

References

• Bousquet J, Bousquet PJ, Godard P, Daures J-P. The public health implications of asthma. Bull World Health Organ. 2005;83(7):548–554.
   PubMed Web of Science ®Google Scholar
• Bateman ED, Hurd SS, Barnes PJ, et al. Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J. 2008;31(1):143–178. doi:10.1039/c2jm32759g
   PubMed Web of Science ®Google Scholar
• Porsbjerg C, Ulrik C, Skjold T, et al. Nordic consensus statement on the systematic assessment and management of possible severe asthma in adults. Eur Clin Respir J. 2018;5(1):1440868. doi:10.1080/20018525.2018.1440868
   PubMed Web of Science ®Google Scholar
• von Bülow A, Kriegbaum M, Backer V, Porsbjerg C. The prevalence of severe asthma and low asthma control among Danish adults. J Allergy Clin Immunol Pract. 2014;2(6):759–767. doi:10.1016/j.jaip.2014.05.005
   PubMed Web of Science ®Google Scholar
• Håkansson KEJ, Backer V, Suppli Ulrik C. Socioeconomic biases in asthma control and specialist referral of possible severe asthma. Eur Respir J. 2021;58(6):2100741. doi:10.1183/13993003.00741-2021
   PubMed Web of Science ®Google Scholar
• Busse WW, Kraft M. Current unmet needs and potential solutions to uncontrolled asthma. Eur Respir Rev. 2022;31:163. doi:10.1183/16000617.0176-2021
   Web of Science ®Google Scholar
• Most JF, Ambrose CS, Chung Y, et al. Real-world assessment of asthma specialist visits among US patients with severe asthma. J Allergy Clin Immunol Pract. 2021;9(10):3662–3671.e1. doi:10.1016/j.jaip.2021.05.003
   PubMed Web of Science ®Google Scholar
• Inselman JW, Jeffery MM, Maddux JT, Shah ND, Rank MA. Trends and disparities in asthma biologic use in the United States. J Allergy Clin Immunol Pract. 2020;8(2):549–554.e1. doi:10.1016/j.jaip.2019.08.024
   PubMed Web of Science ®Google Scholar
• Casas-Maldonado F, Álvarez-Gutiérrez FJ, Blanco-Aparicio M, et al. Monoclonal antibody treatment for severe uncontrolled asthma in Spain: analytical map. J Asthma. 2021:1–11. doi:10.1080/02770903.2021.1978483
   PubMed Web of Science ®Google Scholar
• Schatz M, Zeiger RS, Mosen D, et al. Improved asthma outcomes from allergy specialist care: a population-based cross-sectional analysis. J Allergy Clin Immunol. 2005;116(6):1307–1313. doi:10.1016/j.jaci.2005.09.027
   PubMed Web of Science ®Google Scholar
• Erickson S, Tolstykh I, Selby JV, Mendoza G, Iribarren C, Eisner MD. The impact of allergy and pulmonary specialist care on emergency asthma utilization in a large managed care organization. Health Serv Res. 2005;40(5 Pt 1):1443–1465. doi:10.1111/j.1475-6773.2005.00410.x
   PubMed Web of Science ®Google Scholar
• Barcala FJG, La Fuente-Cid RD, Alvarez-Gil R, Tafalla M, Nuevo J, Caamaño-Isorna F. Factors associated with a higher prevalence of work disability among asthmatic patients. J Asthma. 2011;48(2):194–199. doi:10.3109/02770903.2010.539294
   PubMed Web of Science ®Google Scholar
• Hiles SA, Harvey ES, McDonald VM, et al. Working while unwell: workplace impairment in people with severe asthma. Clin Exp Allergy. 2018;48(6):650–662. doi:10.1111/cea.13153
   PubMed Web of Science ®Google Scholar
• Pavord ID, Mathieson N, Scowcroft A, Pedersini R, Isherwood G, Price D. The impact of poor asthma control among asthma patients treated with inhaled corticosteroids plus long-acting β2-agonists in the United Kingdom: a cross-sectional analysis. NPJ Prim care Respir Med. 2017;27(1):17. doi:10.1038/s41533-017-0014-1
   PubMed Web of Science ®Google Scholar
• Guilbert TW, Garris C, Jhingran P, et al. Asthma that is not well-controlled is associated with increased healthcare utilization and decreased quality of life. J Asthma. 2011;48(2):126–132. doi:10.3109/02770903.2010.535879
   PubMed Web of Science ®Google Scholar
• Levy ML, Andrews R, Buckingham R, et al. Why asthma still kills: the National Review of Asthma Deaths (NRAD); 2014. Available from: https://www.rcplondon.ac.uk/projects/outputs/why-asthma-still-kills. Accessed June 14, 2022.
   Google Scholar
• Hansen CL, Baelum J, Skadhauge L, et al. Consequences of asthma on job absenteeism and job retention. Scand J Public Health. 2012;40(4):377–384. doi:10.1177/1403494812449079
   PubMed Web of Science ®Google Scholar
• Danish clinical quality program - Asthma (DrAsthma); 2020. Available from: https://www.rkkp.dk/in-english/. Accessed June 14, 2022.
   Google Scholar
• Amin S, Soliman M, McIvor A, Cave A, Cabrera C. Usage patterns of short-acting β2-agonists and inhaled corticosteroids in asthma: a targeted literature review. J Allergy Clin Immunol Pract. 2020;8(8):2556–2564.e8. doi:10.1016/j.jaip.2020.03.013
   PubMed Web of Science ®Google Scholar
• Canonica GW, Alacqua M, Altraja A, et al. International severe asthma registry: mission statement. Chest. 2020;157(4):805–814. doi:10.1016/j.chest.2019.10.051
   PubMed Web of Science ®Google Scholar
• Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40(5):373–383. doi:10.1016/0021-9681(87)90171-8
   PubMedGoogle Scholar
• Quan H, Li B, Couris CM, et al. Updating and validating the Charlson comorbidity index and score for risk adjustment in hospital discharge abstracts using data from 6 countries. Am J Epidemiol. 2011;173(6):676–682. doi:10.1093/aje/kwq433
   PubMed Web of Science ®Google Scholar
• Chen H, Blanc PD, Hayden ML, et al. Assessing productivity loss and activity impairment in severe or difficult-to-treat asthma. Value Health. 2008;11(2):231–239. doi:10.1111/j.1524-4733.2007.00229.x
   PubMed Web of Science ®Google Scholar
• Sadatsafavi M, Rousseau R, Chen W, Zhang W, Lynd L, FitzGerald JM. The preventable burden of productivity loss due to suboptimal asthma control: a population-based study. Chest. 2014;145(4):787–793. doi:10.1378/chest.13-1619
   PubMed Web of Science ®Google Scholar
• Taponen S, Uitti J, Karvala K, Luukkonen R, Lehtimäki L. Asthma diagnosed in late adulthood is linked to work disability and poor employment status. Respir Med. 2019;147:76–78. doi:10.1016/j.rmed.2019.01.004
   PubMed Web of Science ®Google Scholar
• Ilmarinen P, Tuomisto LE, Kankaanranta H. Phenotypes, risk factors, and mechanisms of adult-onset asthma. Mediators Inflamm. 2015;2015:514868. doi:10.1155/2015/514868
   PubMed Web of Science ®Google Scholar
• Kinman G. Sickness presenteeism at work: prevalence, costs and management. Br Med Bull. 2019;129(1):107–116. doi:10.1093/bmb/ldy043
   PubMed Web of Science ®Google Scholar
• Wong A, Tavakoli H, Sadatsafavi M, Carlsten C, FitzGerald JM. Asthma control and productivity loss in those with work-related asthma: a population-based study. J Asthma. 2017;54(5):537–542. doi:10.1080/02770903.2016.1220011
   PubMed Web of Science ®Google Scholar
• OECD. OECD better life index: Denmark; 2021. Available from: https://www.oecdbetterlifeindex.org/countries/denmark/. Accessed September 27, 2021.
   Google Scholar
• Gruffydd-Jones K, Thomas M, Roman-Rodríguez M, et al. Asthma impacts on workplace productivity in employed patients who are symptomatic despite background therapy: a multinational survey. J Asthma Allergy. 2019;12:183–194. doi:10.2147/JAA.S204278
   PubMed Web of Science ®Google Scholar
• Joshi AV, Madhavan SS, Ambegaonkar A, Smith M, Scott VG, Dedhia H. Association of medication adherence with workplace productivity and health-related quality of life in patients with asthma. J Asthma. 2006;43(7):521–526. doi:10.1080/02770900600857010
   PubMed Web of Science ®Google Scholar
• Janson C, Menzies-Gow A, Nan C, et al. SABINA: an overview of short-acting β2-agonist use in asthma in European Countries. Adv Ther. 2020;37(3):1124–1135. doi:10.1007/s12325-020-01233-0
   PubMed Web of Science ®Google Scholar
• Muñoz X, Romero-Mesones C, Cruz MJ. β2-agonists in asthma: the strange case of Dr Jekyll and Mr Hyde. Arch Bronconeumol. 2020;56(4):204–205. doi:10.1016/j.arbr.2019.07.010
   PubMed Web of Science ®Google Scholar
• Nwaru BI, Ekström M, Hasvold P, Wiklund F, Telg G, Janson C. Overuse of short-acting β 2 -agonists in asthma is associated with increased risk of exacerbation and mortality: a nationwide cohort study of the global SABINA programme. Eur Respir J. 2020;55(4):1901872. doi:10.1183/13993003.01872-2019
   PubMed Web of Science ®Google Scholar
• Carls GS, Roebuck MC, Brennan TA, Slezak JA, Matlin OS, Gibson TB. Impact of medication adherence on absenteeism and short-term disability for five chronic diseases. J Occup Environ Med. 2012;54(7):792–805. doi:10.1097/JOM.0b013e31825463e9
   PubMed Web of Science ®Google Scholar
• Yaghoubi M, Adibi A, Safari A, FitzGerald JM, Sadatsafavi M. The projected economic and health burden of uncontrolled asthma in the United States. Am J Respir Crit Care Med. 2019;200(9):1102–1112. doi:10.1164/rccm.201901-0016OC
   PubMed Web of Science ®Google Scholar
• Zafari Z, Lynd LD, FitzGerald JM, Sadatsafavi M. Economic and health effect of full adherence to controller therapy in adults with uncontrolled asthma: a simulation study. J Allergy Clin Immunol. 2014;134(4):908–915.e3. doi:10.1016/j.jaci.2014.04.009
   PubMed Web of Science ®Google Scholar
• Eisner MD, Yelin EH, Katz PP, Lactao G, Iribarren C, Blanc PD. Risk factors for work disability in severe adult asthma. Am J Med. 2006;119(10):884–891. doi:10.1016/j.amjmed.2006.01.016
   PubMed Web of Science ®Google Scholar
• Hakola R, Kauppi P, Leino T, et al. Persistent asthma, comorbid conditions and the risk of work disability: a prospective cohort study. Allergy. 2011;66(12):1598–1603. doi:10.1111/j.1398-9995.2011.02729.x
   PubMed Web of Science ®Google Scholar
• Ding B, Small M. Disease burden of mild asthma: findings from a cross-sectional real-world survey. Adv Ther. 2017;34(5):1109–1127. doi:10.1007/s12325-017-0520-0
   PubMed Web of Science ®Google Scholar
• Price D, Fletcher M, van der Molen T. Asthma control and management in 8000 European patients: the REcognise Asthma and LInk to Symptoms and Experience (REALISE) survey. NPJ Prim care Respir Med. 2014;24:14009. doi:10.1038/npjpcrm.2014.9
   PubMed Web of Science ®Google Scholar
• Hjollund NH, Larsen FB, Andersen JH. Register-based follow-up of social benefits and other transfer payments: accuracy and degree of completeness in a Danish interdepartmental administrative database compared with a population-based survey. Scand J Public Health. 2007;35(5):497–502. doi:10.1080/14034940701271882
   PubMed Web of Science ®Google Scholar
• Helby J, Nordestgaard BG, Benfield T, Bojesen SE. Asthma, other atopic conditions and risk of infections in 105 519 general population never and ever smokers. J Intern Med. 2017;282(3):254–267. doi:10.1111/joim.12635
   PubMed Web of Science ®Google Scholar
• Håkansson KEJ, Renzi-Lomholt M, Backer V, Ulrik CS. High use of antidepressant medication in both mild-to-moderate and possible severe asthma – a nationwide cohort study. J Asthma Allergy. 2022;15:13–23. doi:10.2147/JAA.S340522
   PubMed Web of Science ®Google Scholar