110
Views
0
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

Characteristics of Oral Corticosteroid Users Among Persons with Asthma on GINA Step 3 Therapy and Above: A Cross-Sectional Study in Portuguese Community Pharmacies

ORCID Icon, , , , , , ORCID Icon, ORCID Icon, & ORCID Icon show all
Pages 1579-1592 | Received 09 Jun 2022, Accepted 28 Oct 2022, Published online: 09 Nov 2022

References

  • Global Asthma Network. The global asthma report 2018. Auckland, New Zealand; 2018. Available from: http://globalasthmareport.org/resources/Global_Asthma_Report_2018.pdf. Accessed November 8, 2022.
  • Institute for Health Metrics and Evaluation (IHME). GBD 2019 Cause and Risk Summary: [Asthma]. Seattle, USA: IHME; 2020.
  • Sa-Sousa A, Morais-Almeida M, Azevedo LF, et al. Prevalence of asthma in Portugal - The Portuguese National Asthma Survey. Clin Transl Allergy. 2012;2(1):1–12. doi:10.1186/2045-7022-2-15
  • De Sousa JC, Santo ME, Colaço T, Almada-Lobo F, Yaphe J. Asthma in an urban population in Portugal: a prevalence study. BMC Public Health. 2011;11. doi:10.1186/1471-2458-11-347
  • Eurostat - Statistics explained. Respiratory diseases statistics - self-reporting of respiratory diseases (figure 1 - asthma); 2021. Available from: https://ec.europa.eu/eurostat/statistics-explained/index.php?title=Respiratory_diseases_statistics&stable=0&redirect=no. Accessed October 31, 2022.
  • Global Initiative for Asthma (GINA). Pocket guide for asthma management and prevention (2021 update); 2021. Available from: https://ginasthma.org/wp-content/uploads/2021/05/GINA-Pocket-Guide-2021-V2-WMS.pdf. Accessed October 31, 2022.
  • Cunha ÂGJ, Mendes AZ, Carvalho FDW, Paula MAR, Brasil TG. The impact of asthma on quality of life and anxiety: a pilot study. J Asthma. 2018;56:680–685.
  • Suissa S, Ernst P, Benayoun S, Baltzan M, Cai B. Low-dose inhaled corticosteroids and the prevention of death from asthma. N Engl J Med. 2000;343:332–336. doi:10.1056/NEJM200008033430504
  • Adams NP, Bestall JC, Malouf R, Lasserson TJ, Jones P. Beclomethasone versus placebo for chronic asthma (review). Cochrane Database Syst Rev. 2008;(1). doi:10.1002/14651858.CD003135.pub4
  • Juniper EF, Kline PA, Vanzieleghem MA, Ramsdale EH, Byrne PMO, Hargreave FE. Effect of long-term treatment with an inhaled corticosteroid (budesonide) on airway hyperresponsiveness and clinical asthma in nonsteroid-dependent asthmatics. Am Rev Respir Dis. 1990;142(4):832–836. doi:10.1164/ajrccm/142.4.832
  • Ekström M, Nwaru BI, Hasvold P, Wiklund F, Telg G, Janson C. Oral corticosteroid use, morbidity and mortality in asthma: a nationwide prospective cohort study in Sweden. Allergy. 2019;68:1–10. doi:10.15036/arerugi.68.1
  • Tran TN, King E, Sarkar R, et al. Oral corticosteroid prescription patterns for asthma in France, Germany, Italy and the UK. Eur Respir J. 2020;55(6):1902363. doi:10.1183/13993003.02363-2019
  • Bleecker ER, Menzies-Gow AN, Price DB, et al. Systematic literature review of systemic corticosteroid use for asthma management; 2020. Available from: www.atsjournals.org. Accessed October 31, 2022.
  • Ramsahai JM, Wark PA. Appropriate use of oral corticosteroids for severe asthma. Med J Aust. 2018;209(S2):S18–21. doi:10.5694/mja18.00134
  • Sweeney J, Patterson CC, Menzies-Gow A, et al. Comorbidity in severe asthma requiring systemic corticosteroid therapy: cross-sectional data from the optimum patient care research database and the British thoracic difficult asthma registry. Thorax. 2016;71(4):339–346. doi:10.1136/thoraxjnl-2015-207630
  • Volmer T, Effenberger T, Trautner C, Buhl R. Consequences of long-term oral corticosteroid therapy and its side-effects in severe asthma in adults: a focused review of the impact data in the literature. Eur Respir J. 2018;52(4):1800703. doi:10.1183/13993003.00703-2018
  • Janson C, Lisspers K, Ställberg B, et al. Health care resource utilization and cost for asthma patients regularly treated with oral corticosteroids - A Swedish observational cohort study (PACEHR). Respir Res. 2018;19(1). doi:10.1186/s12931-018-0855-3
  • von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement guidelines for reporting observational studies. Ann Intern Med. 2007;18(6):800–804.
  • Fonseca JA, Azevedo L, Morais-Almeida M. Validation of a questionnaire (CARAT10) to assess rhinitis and asthma in patients with asthma. Allergy. 2010;65:1042–1048. doi:10.1111/j.1398-9995.2009.02310.x
  • Sousa AS, Almeida R, Vicente R, et al. High oral corticosteroid exposure and overuse of short-acting beta-2-agonists were associated with insufficient prescribing of controller medication: a nationwide electronic prescribing and dispensing database analysis. Clin Transl Allergy. 2019;9:1–10. doi:10.1186/s13601-019-0243-1
  • Zeiger RS, Schatz M, Li Q, Chen W, Khatry DB, Tran TN. Burden of chronic oral corticosteroid use by adults with persistent asthma. J Allergy Clin Immunol. 2017;5(4):1050–1060.e9. doi:10.1016/j.jaip.2016.12.023
  • Sadatsafavi M, Khakban A, Tavakoli H, Ehteshami-Afshar S, Lynd LD, FitzGerald JM. Trends in oral corticosteroids use in severe asthma: a 14-year population-based study. Respir Res. 2021;22(1). doi:10.1186/s12931-021-01696-x
  • Bugalho de Almeida A, Todo-bom A, Fonseca JA, et al. INASma - Sumário do Inquérito Nacional de Controlo da Asma. DGS; 2010.
  • Tanosaki T, Kabata H, Matsusaka M, et al. Clinical characteristics of patients with not well-controlled severe asthma in Japan: analysis of the Keio Severe Asthma Research Program in Japanese population (KEIO-SARP) registry. Allergol Int. 2021;70(1):61–67. doi:10.1016/j.alit.2020.06.002
  • Wang E, Wechsler ME, Tran TN, Heaney LG, Jones RC. Characterization of severe asthma worldwide data from the international severe asthma registry. Chest. 2020;157:790–804. doi:10.1016/j.chest.2019.10.053
  • Kritikos V, Price D, Papi A, et al. The burden of self-reported rhinitis and associated risk for exacerbations with moderate-severe asthma in primary care patients. J Asthma Allergy. 2020;13:415–428. doi:10.2147/JAA.S266204
  • Global Initiative for Asthma. Global strategy for asthma management and prevention, 2021; 2021.
  • Trevor J, Lugogo N, Carr W, et al. Severe asthma exacerbations in the United States: incidence, characteristics, predictors, and effects of biologic treatments. Ann Allergy Asthma Immunol. 2021;127:579–587.e1. doi:10.1016/j.anai.2021.07.010
  • Baptist AP, Hao W, Song PX, Carpenter L, Steinberg J, Cardozo LJ. A behavioral intervention can decrease asthma exacerbations in older adults. Ann Allergy Asthma Immunol. 2020;124:1.
  • Czira A, Turner M, Martin A, et al. A systematic literature review of burden of illness in adults with uncontrolled moderate/severe asthma. Respir Med. 2022;191:106670. doi:10.1016/j.rmed.2021.106670
  • Ren Tay T, Siang Wong H, Ihsan R, et al. Comparison of the proportion and healthcare utilisation of adult patients with uncontrolled severe asthma versus non-severe asthma seen in a southeast asian hospital-based respiratory specialist clinic. Ann Acad Med Singapore. 2017;46(6):1.
  • Chiner E, Hernández C, Blanco-Aparicio M, Funenga-Fitas E, Jiménez-Ruiz C. Patient perspectives of the influence of severe and non-severe asthma on their quality of life: a national survey of asthma patients in Spain. Clin Respir J. 2021;16:130–141.
  • Romão M, Godinho AR, Teixeira PM, et al. Characteristics of reliever inhaler users and asthma control: a cross-sectional multicenter study in Portuguese community pharmacies. J Asthma Allergy. 2021;2021:14–943. doi:10.2147/JAA.S315678
  • de Boer G, Braunstahl GJ, Hendriks R, Tramper-Stranders G. Asthma exacerbation prevalence during the COVID-19 lockdown in a moderate-severe asthma cohort. BMJ Open Respir Res. 2021;8(1):e000758. doi:10.1136/bmjresp-2020-000758
  • Wee LE, Conceicao EP, Tan JY, Ying Sim JX, Venkatachalam I. Reduction in asthma admissions during the COVID-19 pandemic: consequence of public health measures in Singapore. Eur Respir J. 2021;57(4):2004493. doi:10.1183/13993003.04493-2020
  • Kyriakopoulos C, Gogali A, Exarchos K, et al. Reduction in hospitalizations for respiratory diseases during the first COVID-19 wave in Greece. Respiration. 2021;100(7):588–593. doi:10.1159/000515323
  • Dezman ZDW, Stryckman B, Zachrison KS, et al. Masking for COVID-19 is associated with decreased emergency department utilization for non-COVID viral illnesses and respiratory conditions in Maryland. Am J Med. 2021;134(10):1247–1251. doi:10.1016/j.amjmed.2021.06.008
  • Chan KPF, Kwok WC, Ma TF, et al. Territory-wide study on hospital admissions for asthma exacerbations in the COVID-19 pandemic. Ann Am Thorac Soc. 2021;18(10):1624–1633. doi:10.1513/AnnalsATS.202010-1247OC
  • Sigala Ι, Giannakas T, Giannakoulis VG, et al. Effect of COVID-19-related lockdown on hospital admissions for asthma and COPD exacerbations: associations with air pollution and patient characteristics. J Pers Med. 2021;11(9):867. doi:10.3390/jpm11090867
  • Salciccioli JD, She L, Tulchinsky A, Rockhold F, Carlos Cardet J, Israel E. Effect of COVID-19 on asthma exacerbation. J Allergy Clin Immunol Pract. 2021;9(7):2896–2899.e1. doi:10.1016/j.jaip.2021.04.038
  • Shah SA, Quint JK, Nwaru BI, Sheikh A Impact of COVID-19 national lockdown on asthma exacerbations: interrupted time-series analysis of English primary care data. Available from: http://thorax.bmj.com/. Accessed October 31, 2022.
  • Davies GA, Alsallakh MA, Sivakumaran S, et al. Impact of COVID-19 lockdown on emergency asthma admissions and deaths: national interrupted time series analyses for Scotland and Wales. Thorax. 2021;76(9):867–873. doi:10.1136/thoraxjnl-2020-216380
  • MOAI Consulting. Impacto da pandemia COVID- 19 na prestação de cuidados de saúde em Portugal [Impact of the COVID-19 pandemic in healthcare delivery in Portugal - In Portuguese Language]. Available from: https://www.saudeemdia.pt/dl/202007_ApresentacaoSaudeemDia_v2.pdf. Accessed October 31, 2022.
  • GFK Metris. Estudo à População: acesso a cuidados de saúde em tempos de pandemia [Population survey: access to healthcare during the COVID-19 pandemic - In Portuguese Language]; 2020. Available from: https://www.saudeemdia.pt/dl/estudo_a_populacao.pdf. Accessed October 31, 2022.
  • Mantica G, Riccardi N, Terrone C, Gratarola A. Non-COVID-19 visits to emergency departments during the pandemic: the impact of fear. Public Health. 2020;183:40. doi:10.1016/j.puhe.2020.04.046
  • Voorham J, Xu X, Price DB, et al. Healthcare resource utilization and costs associated with incremental systemic corticosteroid exposure in asthma. Allergy. 2019;74(2):273–283. doi:10.1111/all.13556
  • Gao Dong Y, Ding M, Dong X, et al. Risk factors for severe and critically ill COVID-19 patients: a review. Allergy. 2021;76(2):428–455. doi:10.1111/all.14657
  • Cochrane MG, Bala MV, Downs KE, Mauskopf J, Ben-Joseph RH. Inhaled corticosteroids for asthma therapy: patient compliance, devices, and inhalation technique. Chest. 2000;117(2):542–550. doi:10.1378/chest.117.2.542
  • Bårnes CB, Suppli C, Dmsc U. Asthma and Adherence to Inhaled Corticosteroids: current Status and Future Perspectives. Respir Care. 2015;60:455–468. doi:10.4187/respcare.03200
  • Wu AC, Butler MG, Li L, et al. Primary adherence to controller medications for asthma is poor. Ann Am Thorac Soc. 2011;2011(7):161–166.
  • Jácome C, Pereira AM, Almeida R, et al. Patient-physician discordance in assessment of adherence to inhaled controller medication: a cross-sectional analysis of two cohorts. BMJ Open. 2019;9(11):e031732. doi:10.1136/bmjopen-2019-031732
  • Sá-Sousa A, Almeida R, Vicente R, et al. High oral corticosteroid exposure and overuse of short-acting beta-2-agonists were associated with insufficient prescribing of controller medication: a nationwide electronic prescribing and dispensing database analysis. Clin Transl Allergy. 2019;9(1). doi:10.1186/s13601-019-0286-3
  • Taube C, Bramlage P, Hofer A, Anderson D. Prevalence of oral corticosteroid use in the German severe asthma population. ERJ Open Research. 2019;5(4):00092–2019. doi:10.1183/23120541.00092-2019
  • Price D, Castro M, Bourdin A, Fucile S, Altman P. Short-course systemic corticosteroids in asthma: striking the balance between efficacy and safety. Eur Respir Rev. 2020;29:190151. doi:10.1183/16000617.0151-2019
  • Hua C, Buttgereit F, Combe B. Glucocorticoids in rheumatoid arthritis: current status and future studies. RMD Open. 2020;6(1):e000536. doi:10.1136/rmdopen-2017-000536
  • Sullivan PW, Ghushchyan VH, Globe G, Schatz M. Oral corticosteroid exposure and adverse effects in asthmatic patients. J Allergy Clin Immunol. 2018;141(1):110–116.e7. doi:10.1016/j.jaci.2017.04.009
  • Graff S, Vanwynsberghe S, Brusselle G, et al. Chronic oral corticosteroids use and persistent eosinophilia in severe asthmatics from the Belgian severe asthma registry. Respir Res. 2020;21(1):1–11. doi:10.1186/s12931-020-01460-7
  • Chung LP, Upham JW, Bardin PG, Hew M. Rational oral corticosteroid use in adult severe asthma: a narrative review. Respirology. 2020;25(2):161–172. doi:10.1111/resp.13730
  • Menzies-Gow A, Gurnell M, Heaney LG, et al. Oral corticosteroid elimination via a personalised reduction algorithm in adults with severe, eosinophilic asthma treated with benralizumab (PONENTE): a multicentre, open-label, single-arm study. Lancet Respir Med. 2022;10(1):47–58. doi:10.1016/S2213-2600(21)00352-0