Prevalence, Clinical Manifestations, Treatment, and Clinical Course of Chronic Urticaria in Elderly: A Systematic Review

References

• Wamble DE, Ciarametaro M, Dubois R. The effect of medical technology innovations on patient outcomes, 1990-2015: results of a physician survey. J Manag Care Spec Pharm. 2019;25(1):66–71. doi:10.18553/jmcp.2018.18083
   PubMed Web of Science ®Google Scholar
• Buxbaum JD, Chernew ME, Fendrick AM, Cutler DM. Contributions of public health, pharmaceuticals, and other medical care To US life expectancy changes, 1990-2015. Health Aff. 2020;39(9):1546–1556.
   PubMed Web of Science ®Google Scholar
• United Nations Department of Economic and Social Affairs Population Division. World Population Ageing 2020 Highlights: living arrangements of older persons. New York: United Nations Publication; 2020:1. Available from: https://www.un.org/development/desa/pd/sites/www.un.org.development.desa.pd/files/undesa_pd-2020_world_population_ageing_highlights.pdf. Accessed Oct 12, 2021.
   Google Scholar
• World Health Organization (WHO). Decade of healthy ageing: baseline report: summary. Geneva: World Health Organization; 2021:20. Available from: https://www.who.int/publications/i/item/9789240023307. Accessed Oct 12, 2021.
   Google Scholar
• Ward JR, Bernhard JD. Willan’s itch and other causes of pruritus in the elderly. Int J Dermatol. 2005;44(4):267–273.
   PubMed Web of Science ®Google Scholar
• Thaipisuttikul Y. Pruritic skin diseases in the elderly. J Dermatol. 1998;25(3):153–157.
   PubMedGoogle Scholar
• Zuberbier T, Abdul latiff AH, Abuzakouk M, et al. The International EAACI/GA2LEN/EuroGuiDerm/APAAACI Guideline for the Definition, Classification, Diagnosis and Management of Urticaria. Allergy. 2022;77(3):734–766.
   PubMed Web of Science ®Google Scholar
• Maurer M, Eyerich K, Eyerich S, et al. Urticaria: collegium Internationale Allergologicum (CIA) Update 2020. Int Arch Allergy Immunol. 2020;181(5):321–333.
   PubMed Web of Science ®Google Scholar
• Saini S, Shams M, Bernstein JA, Maurer M. Urticaria and Angioedema Across the Ages. J Allergy Clin Immunol Pract. 2020;8(6):1866–1874.
   PubMed Web of Science ®Google Scholar
• Chuamanochan M, Kulthanan K, Tuchinda P, Chularojanamontri L, Nuchkull P. Clinical features of chronic urticaria in aging population. Asian Pac J Allergy Immunol. 2016;34(3):201–205. doi:10.12932/AP0708
   PubMed Web of Science ®Google Scholar
• Ban G-Y, Kim M-Y, Yoo H-S, et al. Clinical features of elderly chronic urticaria. Korean J Intern Med. 2014;29(6):800–806. doi:10.3904/kjim.2014.29.6.800
   PubMed Web of Science ®Google Scholar
• Juhlin L. Recurrent urticaria: clinical investigation of 330 patients. Br J Dermatol. 1981;104(4):369–381. doi:10.1111/j.1365-2133.1981.tb15306.x
   PubMed Web of Science ®Google Scholar
• Al-Thani MH, Al-Thani AAM, Cheema S, et al. Prevalence and determinants of metabolic syndrome in Qatar: results from a National Health Survey. BMJ Open. 2016;6(9):e009514.
   PubMed Web of Science ®Google Scholar
• Bonomini F, Rodella LF, Rezzani R. Metabolic syndrome, aging and involvement of oxidative stress. Aging Dis. 2015;6(2):109–120.
   PubMed Web of Science ®Google Scholar
• Syed MA, Alnuaimi AS, Zainel AJ, Qotba HA. Prevalence of non-communicable diseases by age, gender and nationality in publicly funded primary care settings in Qatar. BMJ Nutr Prev Health. 2019;2(1):20–29.
   PubMedGoogle Scholar
• Gunalan P, Indradevi R, Oudeacoumar P, et al. Pattern of skin diseases in geriatric patients attending tertiary care centre. J Evol Med Dent Sci. 2017;6:1566–1570.
   Web of Science ®Google Scholar
• Kolkhir P, Metz M, Altrichter S, Maurer M. Comorbidity of chronic spontaneous urticaria and autoimmune thyroid diseases: a systematic review. Allergy. 2017;72(10):1440–1460.
   PubMed Web of Science ®Google Scholar
• Kim BR, Yang S, Choi JW, Choi CW, Youn SW. Epidemiology and comorbidities of patients with chronic urticaria in Korea: a nationwide population-based study. J Dermatol. 2018;45(1):10–16.
   PubMed Web of Science ®Google Scholar
• Chen YJ, Wu CY, Shen JL, Chen TT, Chang YT. Cancer risk in patients with chronic urticaria: a population-based cohort study. Arch Dermatol. 2012;148(1):103–108.
   PubMedGoogle Scholar
• Magen E, Mishal J, Schlesinger M. Clinical and laboratory features of chronic idiopathic urticaria in the elderly. Int J Dermatol. 2013;52(11):1387–1391.
   PubMed Web of Science ®Google Scholar
• Flohr C, Hay R. Putting the burden of skin diseases on the global map. Br J Dermatol. 2021;184(2):189–190.
   PubMed Web of Science ®Google Scholar
• Maurer M, Ortonne J-P, Zuberbier T. Chronic urticaria: an internet survey of health behaviours, symptom patterns and treatment needs in European adult patients. Br J Dermatol. 2009;160(3):633–641.
   PubMed Web of Science ®Google Scholar
• Gonçalo M, Gimenéz-Arnau A, Al-Ahmad M, et al. The global burden of chronic urticaria for the patient and society. Br J Dermatol. 2021;184(2):226–236.
   PubMed Web of Science ®Google Scholar
• Moher D, Shamseer L, Clarke M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev. 2015;4(1):548.
   Google Scholar
• Mekkes JR, van der Schaar, WW, Bos JD. Anamnese en diagnostiek van chronische urticaria. Ned Tijdschr Geneeskd. 1986;130:1801–1805.
   PubMedGoogle Scholar
• Barlow RJ, Warburton F, Watson K, Black AK, Greaves MW. Diagnosis and incidence of delayed pressure urticaria in patients with chronic urticaria. J Am Acad Dermatol. 1993;29(6):954–958.
   PubMed Web of Science ®Google Scholar
• Hashiro M, Okumura M. Anxiety, depression, psychosomatic symptoms and autonomic nervous function in patients with chronic urticaria. J Dermatol Sci. 1994;8(2):129–135.
   PubMedGoogle Scholar
• Krupashankar DS, Shashikala K, Madala R. Clinical and investigative assessment of patients with positive versus negative autologous serum skin test: a study of 80 South Indian patients. Indian J Dermatol. 2012;57(6):434–438.
   PubMedGoogle Scholar
• Gaig P, Olona M, Muñoz Lejarazu D, et al. Epidemiology of urticaria in Spain. J Investig Allergol Clin Immunol. 2004;14(3):214–220.
   PubMed Web of Science ®Google Scholar
• Chu CY, Cho YT, Jiang JH, Lin EI, Tang CH. Epidemiology and comorbidities of patients with chronic urticaria in Taiwan: a nationwide population-based study. J Dermatol Sci. 2017;88(2):192–198.
   PubMed Web of Science ®Google Scholar
• Eun SJ, Lee JY, Kim DY, Yoon HS. Natural course of new-onset urticaria: results of a 10-year follow-up, nationwide, population-based study. Allergol Int. 2019;68(1):52–58.
   PubMed Web of Science ®Google Scholar
• Seo JH, Kwon JW. Epidemiology of urticaria including physical urticaria and angioedema in Korea. Korean J Intern Med. 2019;34(2):418–425.
   PubMed Web of Science ®Google Scholar
• Wertenteil S, Strunk A, Garg A. Prevalence estimates for chronic urticaria in the United States: a sex- and age-adjusted population analysis. J Am Acad Dermatol. 2019;81(1):152–156.
   PubMed Web of Science ®Google Scholar
• Jankowska-Konsur A, Reich A, Szepietowski J. Polish Chronic Urticaria Working G. Clinical characteristics and epidemiology of chronic urticaria: a nationwide, multicentre study on 1091 patients. Postepy Dermatol Alergol. 2019;36(2):184–191.
   PubMed Web of Science ®Google Scholar
• Lapi F, Cassano N, Pegoraro V, et al. Epidemiology of chronic spontaneous urticaria: results from a nationwide, population-based study in Italy. Br J Dermatol. 2016;174(5):996–1004.
   PubMed Web of Science ®Google Scholar
• Curto-Barredo L, Archilla LR, Vives GR, Pujol RM, Giménez-Arnau AM. Clinical features of chronic spontaneous urticaria that predict disease prognosis and refractoriness to standard treatment. Acta Derm Venereol. 2018;98(7):641–647.
   PubMed Web of Science ®Google Scholar
• Curto-Barredo L, Pujol RM, Roura-Vives G, Gimenez-Arnau AM. Chronic urticaria phenotypes: clinical differences regarding triggers, activity, prognosis and therapeutic response. Eur J Dermatol. 2019;29(6):627–635.
   PubMed Web of Science ®Google Scholar
• Hiragun M, Hiragun T, Mihara S, Akita T, Tanaka J, Hide M. Prognosis of chronic spontaneous urticaria in 117 patients not controlled by a standard dose of antihistamine. Allergy. 2013;68(2):229–235.
   PubMed Web of Science ®Google Scholar
• Jo YH, Yoo HW, Kim SH, Kim YM, Kim HY. Clinical characteristics and treatment response of chronic spontaneous urticaria according to age: a single-center Korean study. Asian Pac J Allergy Immunol. 2019. doi:10.12932/AP-050719-0594
   PubMedGoogle Scholar
• Nettis E, Cegolon L, Di Leo E, Canonica WG, Detoraki A. Omalizumab in elderly patients with chronic spontaneous urticaria: an Italian real-life experience. Ann Allergy Asthma Immunol. 2018;120(3):318–323.
   PubMed Web of Science ®Google Scholar
• Yang HY, Sun CC, Wu YC, Wang JD. Stress, insomnia, and chronic idiopathic urticaria–a case-control study. J Formos Med Assoc. 2005;104(4):254–263.
   PubMed Web of Science ®Google Scholar
• Vikramkumar AG, Kuruvila S, Ganguly S. Autologous serum skin test as an indicator of chronic autoimmune urticaria in a tertiary care hospital in South India. Indian Dermatol Online J. 2014;5(Suppl 2):S87–S91.
   PubMedGoogle Scholar
• Dover JS, Black AK, Ward AM, Greaves MW. Delayed pressure urticaria. Clinical features, laboratory investigations, and response to therapy of 44 patients. J Am Acad Dermatol. 1988;18(6):1289–1298.
   PubMed Web of Science ®Google Scholar
• Katsarou-Katsari A, Makris M, Lagogianni E, Gregoriou S, Theoharides T, Kalogeromitros D. Clinical features and natural history of acquired cold urticaria in a tertiary referral hospital: a 10-year prospective study. J Eur Acad Dermatol Venereol. 2008;22(12):1405–1411.
   PubMed Web of Science ®Google Scholar
• Napolitano M, Fabbrocini G, Stingeni L, Patruno C. Prevalence of Chronic Inducible Urticaria in Elderly Patients. J Clin Med. 2021;10(2):247.
   PubMed Web of Science ®Google Scholar
• Gaber M, Hasanin AZ. Skin diseases in elderly. Menoufia Medl J. 2020;33(1):272–276.
   Google Scholar
• Dávila I, Del Cuvillo A, Mullol J, et al. Use of second generation H1 antihistamines in special situations. J Investig Allergol Clin Immunol. 2013;23(Suppl 1):S1–S16.
   PubMedGoogle Scholar
• Godse KV. Omalizumab in treatment-resistant chronic spontaneous urticaria. Indian J Dermatol. 2011;56(4):444.
   PubMedGoogle Scholar
• Groffik A, Mitzel-Kaoukhov H, Magerl M, Maurer M, Staubach P. Omalizumab–an effective and safe treatment of therapy-resistant chronic spontaneous urticaria. Allergy. 2011;66(2):303–305.
   PubMed Web of Science ®Google Scholar
• Kaplan AP, Joseph K, Maykut RJ, Geba GP, Zeldin RK. Treatment of chronic autoimmune urticaria with omalizumab. J Allergy Clin Immunol. 2008;122(3):569–573.
   PubMed Web of Science ®Google Scholar
• Kirkpatrick CH. A mechanism for urticaria/angioedema in patients with thyroid disease. J Allergy Clin Immunol. 2012;130(4):988–990.
   PubMed Web of Science ®Google Scholar
• Metz M, Altrichter S, Ardelean E, et al. Anti-immunoglobulin E treatment of patients with recalcitrant physical urticaria. Int Arch Allergy Immunol. 2011;154(2):177–180.
   PubMed Web of Science ®Google Scholar
• Mitzel-Kaoukhov H, Staubach P, Müller-Brenne T. Effect of high-dose intravenous immunoglobulin treatment in therapy-resistant chronic spontaneous urticaria. Ann Allergy Asthma Immunol. 2010;104(3):253–258.
   PubMed Web of Science ®Google Scholar
• O’Donnell BF, Barr RM, Black AK, et al. Intravenous immunoglobulin in autoimmune chronic urticaria. Br J Dermatol. 1998;138(1):101–106.
   PubMed Web of Science ®Google Scholar
• Song CH, Stern S, Giruparajah M, Berlin N, Sussman GL. Long-term efficacy of fixed-dose omalizumab for patients with severe chronic spontaneous urticaria. Ann Allergy Asthma Immunol. 2013;110(2):113–117.
   PubMed Web of Science ®Google Scholar
• Wong CG, Borici-Mazi R. Delayed-onset cold anaphylaxis after hymenoptera sting. Ann Allergy Asthma Immunol. 2012;109(1):77–78.
   PubMed Web of Science ®Google Scholar
• Kulthanan K, Tuchinda P, Chularojanamontri L, Likitwattananurak C, Ungaksornpairote C. Omalizumab therapy for treatment of recalcitrant chronic spontaneous urticaria in an Asian population. J Dermatolog Treat. 2017;28(2):160–165.
   PubMed Web of Science ®Google Scholar
• Pannofino A. Recurrent oedema of the uvula in a patient with chronic spontaneous urticaria successfully treated with omalizumab. J Dermatolog Treat. 2018;29(Suppl 4):S8–S9.
   PubMed Web of Science ®Google Scholar
• Staubach P, Metz M, Chapman-Rothe N, et al. Omalizumab rapidly improves angioedema-related quality of life in adult patients with chronic spontaneous urticaria: x-ACT study data. Allergy. 2018;73(3):576–584.
   PubMed Web of Science ®Google Scholar
• Sussman GL, Hebert J, Simons FER. A 63-year-old man with chronic spontaneous urticaria. Cmaj. 2016;188(4):279–283.
   PubMed Web of Science ®Google Scholar
• Uysal P, Eller E, Mortz CG, Bindslev-Jensen C. An algorithm for treating chronic urticaria with omalizumab: dose interval should be individualized. J Allergy Clin Immunol. 2014;133(3):914–915.
   PubMed Web of Science ®Google Scholar
• Romano C, Sellitto A, De Fanis U, et al. Omalizumab for difficult-to-treat dermatological conditions: clinical and Immunological features from a retrospective real-life experience. Clin Drug Investig. 2015;35(3):159–168.
   PubMed Web of Science ®Google Scholar
• Magen E, Schlesinger M, Hadari I. Chronic urticaria can be triggered by eradication of Helicobacter pylori. Helicobacter. 2013;18(1):83–87.
   PubMed Web of Science ®Google Scholar
• Lee N, Lee JD, Lee HY, Kang DR, Ye YM. Epidemiology of Chronic Urticaria in Korea Using the Korean Health Insurance Database, 2010-2014. Allergy Asthma Immunol Res. 2017;9(5):438–445.
   PubMed Web of Science ®Google Scholar
• Lanigan SW, Adams SJ, Gilkes JJ, Robinson TW. Association between urticaria and hypothyroidism. Lancet. 1984;1(8392):1476.
   PubMed Web of Science ®Google Scholar
• Lanigan SW, Short P, Moult P. The association of chronic urticaria and thyroid autoimmunity. Clin Exp Dermatol. 1987;12(5):335–338.
   PubMed Web of Science ®Google Scholar
• Leznoff A, Josse RG, Denburg J, Dolovich J. Association of chronic urticaria and angioedema with thyroid autoimmunity. Arch Dermatol. 1983;119(8):636–640.
   PubMedGoogle Scholar
• Goldsobel AB, Rohr AS, Siegel SC, et al. Efficacy of doxepin in the treatment of chronic idiopathic urticaria. J Allergy Clin Immunol. 1986;78(5 Pt 1):867–873.
   PubMed Web of Science ®Google Scholar
• Amoroso A, Garzia P, Pasquarelli C, Sportelli G, Afeltra A. Hashimoto’s thyroiditis associated with urticaria and angio-oedema: disappearance of cutaneous and mucosal manifestations after thyroidectomy. J Clin Pathol. 1997;50(3):254–256.
   PubMed Web of Science ®Google Scholar
• Cebeci F, Tanrikut A, Topcu E, Onsun N, Kurtulmus N, Uras AR. Association between chronic urticaria and thyroid autoimmunity. Eur J Dermatol. 2006;16(4):402–405.
   PubMed Web of Science ®Google Scholar
• Feibelmann TC, Gonçalves FT, Daud MS, Jorge Ade S, Mantese SA, Jorge PT. Avaliação da associação entre doença auto-imune de tireóide e urticária crônica idiopática [Assessment of association between autoimmune thyroid disease and chronic urticaria]. Arq Bras Endocrinol Metabol. 2007;51(7):1077–1083.
   PubMedGoogle Scholar
• Mozena JD, Tiñana A, Negri J, Steinke JW, Borish L. Lack of a role for cross-reacting anti-thyroid antibodies in chronic idiopathic urticaria. J Invest Dermatol. 2010;130(7):1860–1865.
   PubMed Web of Science ®Google Scholar
• Sugiyama A, Nishie H, Takeuchi S, Yoshinari M, Furue M. Hashimoto’s disease is a frequent comorbidity and an exacerbating factor of chronic spontaneous urticaria. Allergol Immunopathol. 2015;43(3):249–253.
   PubMed Web of Science ®Google Scholar
• Chung BY, Um JY, Kang SY, Kim HO, Park CW. Natural History of Chronic Urticaria in Korea. Ann Dermatol. 2020;32(1):38–46.
   PubMed Web of Science ®Google Scholar
• Lefévre AC, Deleuran M, Vestergaard C. A long term case series study of the effect of omalizumab on chronic spontaneous urticaria. Ann Dermatol. 2013;25(2):242–245.
   PubMed Web of Science ®Google Scholar
• Ivyanskiy I, Sand C, Thomsen SF. Omalizumab for chronic urticaria: a case series and overview of the literature. Case Rep Dermatol. 2012;4(1):19–26.
   PubMedGoogle Scholar
• O’Donnell BF, Francis DM, Swana GT, Seed PT, Kobza black A, Greaves MW. Thyroid autoimmunity in chronic urticaria. Br J Dermatol. 2005;153(2):331–335.
   PubMed Web of Science ®Google Scholar
• Asero R, Lorini M, Tedeschi A. Association of chronic urticaria with thyroid autoimmunity and Raynaud phenomenon with anticentromere antibodies. J Allergy Clin Immunol. 2003;111(5):1129–1130.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Morita E, Matsuo H, Ueda D, Dekio S. Urticarial erythema associated with IgA myeloma. J Dermatol. 2004;31(8):661–665.
   PubMed Web of Science ®Google Scholar
• Staubach P, Vonend A, Burow G, Metz M, Magerl M, Maurer M. Patients with chronic urticaria exhibit increased rates of sensitisation to Candida albicans, but not to common moulds. Mycoses. 2009;52(4):334–338.
   PubMed Web of Science ®Google Scholar
• Armengot-Carbo M, Velasco-Pastor M, Rodrigo-Nicolas B, Pont-Sanjuan V, Quecedo-Estebanez E, Gimeno-Carpio E. Omalizumab in chronic urticaria: a retrospective series of 15 cases. Dermatol Ther. 2013;26(3):257–259.
   PubMed Web of Science ®Google Scholar
• Zimmer S, Peveling-Oberhag A, Weber A, Gilfert T, Rady-Pizarro U, Staubach P. Unique coexistence of cold and solar urticaria and its efficient treatment. Br J Dermatol. 2016;174(5):1150–1152.
   PubMed Web of Science ®Google Scholar
• Sagi L, Solomon M, Baum S, Lyakhovitsky A, Trau H, Barzilai A. Evidence for methotrexate as a useful treatment for steroid-dependent chronic urticaria. Acta Derm Venereol. 2011;91(3):303–306.
   PubMed Web of Science ®Google Scholar
• Hu HH, Ying KJ, Wu XH, Chai Y. Urticaria as the initial presentation of early stage bronchioloalveolar carcinoma: a case report. Chin Med J. 2012;125(11):2065–2066.
   PubMed Web of Science ®Google Scholar
• Baroni A, Faccenda F, Russo T, Piccolo V. Figurate paraneoplastic urticaria and prostate cancer. Ann Dermatol. 2012;24(3):366–367.
   PubMed Web of Science ®Google Scholar
• Asero R, Cugno M, Tedeschi A. Activation of blood coagulation in plasma from chronic urticaria patients with negative autologous plasma skin test. J Eur Acad Dermatol Venereol. 2011;25(2):201–205.
   PubMed Web of Science ®Google Scholar
• Vaida GA, Goldman MA, Bloch KJ. Testing for hepatitis B virus in patients with chronic urticaria and angioedema. J Allergy Clin Immunol. 1983;72(2):193–198.
   PubMed Web of Science ®Google Scholar
• Rumbyrt JS, Katz JL, Schocket AL. Resolution of chronic urticaria in patients with thyroid autoimmunity. J Allergy Clin Immunol. 1995;96(6 Pt 1):901–905.
   PubMed Web of Science ®Google Scholar
• Manganoni AM, Tucci G, Venturini M, Farisoglio C, Baronchelli C, Calzavara Pinton PG. Chronic urticaria associated with thyroid carcinoma: report of 4 cases. J Investig Allergol Clin Immunol. 2007;17(3):192–195.
   PubMed Web of Science ®Google Scholar
• Martina E, Damiani G, Grieco T, Foti C, Pigatto PDM, Offidani A. It is never too late to treat chronic spontaneous urticaria with omalizumab: real-life data from a multicenter observational study focusing on elderly patients. Dermatol Ther. 2021;34(2):e14841.
   PubMed Web of Science ®Google Scholar
• Kasperska-Zajac A, Jarząb J, Żerdzińska A, Bąk K, Grzanka A. Effective treatment of different phenotypes of chronic urticaria with omalizumab: case reports and review of literature. Int J Immunopathol Pharmacol. 2016;29(2):320–328.
   PubMed Web of Science ®Google Scholar
• Zubrinich CM, Puy RM, O’Hehir RE, Hew M. Strongyloides infection as a reversible cause of chronic urticaria. J Asthma Allergy. 2019;12:67–69.
   PubMed Web of Science ®Google Scholar
• Napolitano M, Patruno C. Chronic urticaria can be caused by cancer and resolves with its cure. Allergy. 2018;73(8):1750–1751.
   PubMed Web of Science ®Google Scholar
• McGirt LY, Vasagar K, Gober LM, Saini SS, Beck LA. Successful treatment of recalcitrant chronic idiopathic urticaria with sulfasalazine. Arch Dermatol. 2006;142(10):1337–1342.
   PubMedGoogle Scholar
• Anderson MH, Wray BB, Hooks VH 3rd. Urticaria in a 68-year-old man. Ann Allergy. 1991;66(3):207–211.
   PubMedGoogle Scholar
• Aldasouqi S, Satoh P, Cardona Z, Alrasheed T, McLeod M, Mohan M. Chronic Autoimmune Urticaria and Cognitive Impairment as Unusual Presenting Symptoms of Primary Hyperparathyroidism. Endocr Pract. 2018;24(Suppl 1):S134.
   Google Scholar
• Urbach E. Endogenous Allergy. Arch Dermatol Syphilol. 1942;45(4):697–722.
   Google Scholar
• Fricke J, Ávila G, Keller T, et al. Prevalence of chronic urticaria in children and adults across the globe: systematic review with meta-analysis. Allergy. 2020;75(2):423–432.
   PubMed Web of Science ®Google Scholar
• Cassano N, Colombo D, Bellia G, Zagni E, Vena GA. Gender-related differences in chronic urticaria. G Ital Dermatol Venereol. 2016;151(5):544–552.
   PubMed Web of Science ®Google Scholar
• Ghazanfar MN, Kibsgaard L, Thomsen SF, Vestergaard C. Risk of comorbidities in patients diagnosed with chronic urticaria: a nationwide registry-study. World Allergy Organ J. 2020;13(1):100097. doi:10.1016/j.waojou.2019.100097
   PubMed Web of Science ®Google Scholar
• Deza G, Brasileiro A, Bertolín-Colilla M, Curto-Barredo L, Pujol RM, Giménez-Arnau AM. Acquired cold urticaria: clinical features, particular phenotypes, and disease course in a tertiary care center cohort. J Am Acad Dermatol. 2016;75(5):918–924. doi:10.1016/j.jaad.2016.06.017
   PubMed Web of Science ®Google Scholar
• Horton BT. Hypersensitiveness to cold: with local and systemic manifestations of a histamine-like character: its amenability to treatment. J Am Med Assoc. 1936;107(16):1263–1269. doi:10.1001/jama.1936.02770420001001
   Google Scholar
• Jain SV, Mullins RJ. Cold urticaria: a 20-year follow-up study. J Eur Acad Dermatol Venereol. 2016;30(12):2066–2071. doi:10.1111/jdv.13841
   PubMed Web of Science ®Google Scholar
• Kulthanan K, Tuchinda P, Chularojanamontri L, Kiratiwongwan R. Cold Urticaria: clinical Features and Natural Course in a Tropical Country. Allergy Asthma Immunol Res. 2019;11(4):538–547. doi:10.4168/aair.2019.11.4.538
   PubMed Web of Science ®Google Scholar
• Mathelier-Fusade P. Clinical predictive factors of severity in cold urticaria. Arch Dermatol. 1998;134(1):106–107. doi:10.1001/archderm.134.1.106
   PubMedGoogle Scholar
• Neittaanmäki H. Cold urticaria. Clinical findings in 220 patients. J Am Acad Dermatol. 1985;13(4):636–644. doi:10.1016/S0190-9622(85)70208-3
   PubMed Web of Science ®Google Scholar
• Sánchez-Borges M, Ansotegui IJ, Baiardini I, et al. The challenges of chronic urticaria part 1: epidemiology, immunopathogenesis, comorbidities, quality of life, and management. World Allergy Organ J. 2021;14(6):100533. doi:10.1016/j.waojou.2021.100533
   PubMed Web of Science ®Google Scholar
• Ferrer M. Epidemiology, healthcare, resources, use and clinical features of different types of urticaria. Alergológica 2005. J Investig Allergol Clin Immunol. 2009;19(Suppl 2):S21–S26.
   PubMed Web of Science ®Google Scholar
• Kulthanan K, Jiamton S, Thumpimukvatana N, Pinkaew S. Chronic idiopathic urticaria: prevalence and clinical course. J Dermatol. 2007;34(5):294–301. doi:10.1111/j.1346-8138.2007.00276.x
   PubMed Web of Science ®Google Scholar
• Small P, Barrett D, Biskin N, Champlin E. Chronic urticaria and angioedema. Clin Allergy. 1982;12(2):131–136. doi:10.1111/j.1365-2222.1982.tb01631.x
   PubMedGoogle Scholar
• Zhong H, Song Z, Chen W, et al. Chronic urticaria in Chinese population: a hospital-based multicenter epidemiological study. Allergy. 2014;69(3):359–364. doi:10.1111/all.12338
   PubMed Web of Science ®Google Scholar
• Dressler C, Werner RN, Eisert L, Zuberbier T, Nast A, Maurer M. Chronic inducible urticaria: a systematic review of treatment options. J Allergy Clin Immunol. 2018;141(5):1726–1734. doi:10.1016/j.jaci.2018.01.031
   PubMed Web of Science ®Google Scholar
• Chang H-W, Cheng H-M, Yen H-R, et al. Association between chronic idiopathic urticaria and hypertension: a population-based retrospective cohort study. Ann Allergy Asthma Immunol. 2016;116(6):554–558. doi:10.1016/j.anai.2016.04.001
   PubMed Web of Science ®Google Scholar
• Shalom G, Magen E, Babaev M, et al. Chronic urticaria and the metabolic syndrome: a cross-sectional community-based study of 11 261 patients. J Eur Acad Dermatol Venereol. 2018;32(2):276–281. doi:10.1111/jdv.14548
   PubMed Web of Science ®Google Scholar
• Chung S-D, Wang K-H, Tsai M-C, Lin H-C, Chen C-H, Taniyama Y. Hyperlipidemia is associated with chronic urticaria: a population-based study. PLoS One. 2016;11(3):e0150304. doi:10.1371/journal.pone.0150304
   PubMed Web of Science ®Google Scholar
• Ye YM, Jin HJ, Hwang EK, et al. Co-existence of chronic urticaria and metabolic syndrome: clinical implications. Acta Derm Venereol. 2013;93(2):156–160. doi:10.2340/00015555-1443
   PubMed Web of Science ®Google Scholar
• Suastika K, Dwipayana P, Ratna Saraswati IM, et al. Relationship between age and metabolic disorders in the population of Bali. Journal of Clinical Gerontology and Geriatrics. 2011;2(2):47–52. doi:10.1016/j.jcgg.2011.03.001
   Google Scholar
• Zbiciak-Nylec M, Wcisło-Dziadecka D, Kasprzyk M, et al. Overweight and obesity may play a role in the pathogenesis of chronic spontaneous urticaria. Clin Exp Dermatol. 2018;43(5):525–528. doi:10.1111/ced.13368
   PubMed Web of Science ®Google Scholar
• Kolkhir P, Pogorelov D, Olisova O, Maurer M. Comorbidity and pathogenic links of chronic spontaneous urticaria and systemic lupus erythematosus - A systematic review. Clin Exp Allergy. 2016;46(2):275–287. doi:10.1111/cea.12673
   PubMed Web of Science ®Google Scholar
• Verneuil L, Leconte C, Ballet JJ, et al. Association between chronic urticaria and thyroid autoimmunity: a prospective study involving 99 patients. Dermatology. 2004;208(2):98–103. doi:10.1159/000076480
   PubMed Web of Science ®Google Scholar
• Pan X-F, Gu J-Q, Shan Z-Y. The prevalence of thyroid autoimmunity in patients with urticaria: a systematic review and meta-analysis. Endocrine. 2015;48(3):804–810. doi:10.1007/s12020-014-0367-y
   PubMed Web of Science ®Google Scholar
• Kasumagic-Halilovic E, Beslic N, Ovcina-Kurtovic N. Thyroid Autoimmunity in Patients with Chronic Urticaria. Med Arch. 2017;71(1):29–31. doi:10.5455/medarh.2017.71.29-31
   PubMedGoogle Scholar
• Kolkhir P, Borzova E, Grattan C, Asero R, Pogorelov D, Maurer M. Autoimmune comorbidity in chronic spontaneous urticaria: a systematic review. Autoimmun Rev. 2017;16(12):1196–1208. doi:10.1016/j.autrev.2017.10.003
   PubMed Web of Science ®Google Scholar
• Ramos-Casals M, García-Carrasco M, Brito MP, López-Soto A, Font J. Autoimmunity and geriatrics: clinical significance of autoimmune manifestations in the elderly. Lupus. 2003;12(5):341–355. doi:10.1191/0961203303lu383ed
   PubMed Web of Science ®Google Scholar
• White MC, Holman DM, Goodman RA, Richardson LC. Cancer risk among older adults: time for cancer prevention to go silver. Gerontologist. 2019;59(Suppl 1):S1–S6.
   PubMed Web of Science ®Google Scholar
• Larenas-Linnemann D, Saini SS, Azamar-Jácome AA, Jensen-Jarolim E, Maurer M. Very rarely chronic urticaria can be caused by cancer and if so, resolves with its cure. Allergy. 2018;73(9):1925–1926.
   PubMed Web of Science ®Google Scholar
• Staubach P, Onnen K, Vonend A, et al. Autologous whole blood injections to patients with chronic urticaria and a positive autologous serum skin test: a placebo-controlled trial. Dermatology. 2006;212(2):150–159.
   PubMed Web of Science ®Google Scholar
• Yeh JW, Yang HS, Yang CC. Dermatological diseases associated with Hepatitis B virus infection. Dermatol Sin. 2020;38(3):142–150.
   Web of Science ®Google Scholar
• Kolkhir P, Pereverzina N, Olisova O, Maurer M. Comorbidity of viral hepatitis and chronic spontaneous urticaria: a systematic review. Allergy. 2018;73(10):1946–1953.
   PubMed Web of Science ®Google Scholar
• Caproni M, Volpi W, Giomi B, et al. Chronic idiopathic and chronic autoimmune urticaria: clinical and immunopathological features of 68 subjects. Acta Derm Venereol. 2004;84(4):288–290.
   PubMed Web of Science ®Google Scholar
• Sabroe RA, Seed PT, Francis DM, Barr RM, Black AK, Greaves MW. Chronic idiopathic urticaria: comparison of the clinical features of patients with and without anti-FcepsilonRI or anti-IgE autoantibodies. J Am Acad Dermatol. 1999;40(3):443–450.
   PubMed Web of Science ®Google Scholar
• Metz M, Giménez-Arnau A, Borzova E, Grattan CE, Magerl M, Maurer M. Frequency and clinical implications of skin autoreactivity to serum versus plasma in patients with chronic urticaria. J Allergy Clin Immunol. 2009;123(3):705–706.
   PubMed Web of Science ®Google Scholar
• Kolkhir P, Balakirski G, Merk HF, Olisova O, Maurer M. Chronic spontaneous urticaria and internal parasites–a systematic review. Allergy. 2016;71(3):308–322.
   PubMed Web of Science ®Google Scholar
• Vázquez-Nava F, Martinez-Burnes J. Prevalence and factors associates to chronic urticaria. Analysis of the allergic rhinitis and symptoms related to asthma as a factors associated to chronic urticaria in a urban area of northeastern of Mexico. Alergologia e inmunologia clinica. 2004;19:16–24.
   Google Scholar
• Zazzali JL, Broder MS, Chang E, Chiu MW, Hogan DJ. Cost, utilization, and patterns of medication use associated with chronic idiopathic urticaria. Ann Allergy Asthma Immunol. 2012;108(2):98–102.
   PubMed Web of Science ®Google Scholar
• Zuberbier T, Balke M, Worm M, Edenharter G, Maurer M. Epidemiology of urticaria: a representative cross-sectional population survey. Clin Exp Dermatol. 2010;35(8):869–873.
   PubMed Web of Science ®Google Scholar
• Broder MS, Raimundo K, Antonova E, Chang E. Resource use and costs in an insured population of patients with chronic idiopathic/spontaneous urticaria. Am J Clin Dermatol. 2015;16(4):313–321.
   PubMed Web of Science ®Google Scholar
• Balp MM. The Burden of Chronic Urticaria from Brazilian Patients’ Perspective. Dermatol Ther. 2017;7(4):535–545.
   Web of Science ®Google Scholar
• Balp MM, Vietri J, Tian H, Isherwood G. The Impact of Chronic Urticaria from the Patient’s Perspective: a Survey in Five European Countries. Patient. 2015;8(6):551–558.
   PubMedGoogle Scholar
• Vietri J, Turner SJ, Tian H, Isherwood G, Balp MM, Gabriel S. Effect of chronic urticaria on US patients: analysis of the National Health and Wellness Survey. Ann Allergy Asthma Immunol. 2015;115(4):306–311.
   PubMed Web of Science ®Google Scholar
• Sibbald RG, Cheema AS, Lozinski A, Tarlo S. Chronic urticaria. Evaluation of the role of physical, immunologic, and other contributory factors. Int J Dermatol. 1991;30(6):381–386.
   PubMed Web of Science ®Google Scholar
• Giménez-Arnau AM, Ferrer M, Peter H-J, Maurer M, Pujol RM. Urticaria crónica: estudio etiológico prospectivo e importancia del síndrome autoinmune. Actas Dermo-Sifiliográficas. 2004;95(9):560–566.
   Google Scholar
• Kozel MM, Mekkes JR, Bossuyt PM, Bos JD. Natural course of physical and chronic urticaria and angioedema in 220 patients. J Am Acad Dermatol. 2001;45(3):387–391.
   PubMed Web of Science ®Google Scholar
• van der Valk PG, Moret G, Kiemeney LA. The natural history of chronic urticaria and angioedema in patients visiting a tertiary referral centre. Br J Dermatol. 2002;146(1):110–113.
   PubMed Web of Science ®Google Scholar
• Humphreys F, Hunter JA. The characteristics of urticaria in 390 patients. Br J Dermatol. 1998;138(4):635–638.
   PubMed Web of Science ®Google Scholar
• Schnyder B, Helbling A, Pichler WJ. Chronic idiopathic urticaria: natural course and association with Helicobacter pylori infection. Int Arch Allergy Immunol. 1999;119(1):60–63.
   PubMed Web of Science ®Google Scholar
• Vázquez Nava F, Almeida Arvizu VM, Sánchez Nuncio HR, Villanueva Carreto Mde L, Guidos Fogelbach GA. Prevalence and potential triggering factors of chronic urticaria and angioedema in an urban area of northeastern Mexico. Rev Alerg Mex. 2004;51(5):181–188.
   PubMedGoogle Scholar
• Lindelöf B, Sigurgeirsson B, Wahlgren CF, Eklund G. Chronic urticaria and cancer: an epidemiological study of 1155 patients. Br J Dermatol. 1990;123(4):453–456.
   PubMed Web of Science ®Google Scholar
• Quaranta JH, Rohr AS, Rachelefsky GS, et al. The natural history and response to therapy of chronic urticaria and angioedema. Ann Allergy. 1989;62(5):421–424.
   PubMedGoogle Scholar
• Nettis E, Dambra P, D’Oronzio L, et al. Reactivity to autologous serum skin test and clinical features in chronic idiopathic urticaria. Clin Exp Dermatol. 2002;27(1):29–31.
   PubMed Web of Science ®Google Scholar
• Asero R. Sex differences in the pathogenesis of chronic urticaria. J Allergy Clin Immunol. 2003;111(2):425–426.
   PubMed Web of Science ®Google Scholar
• Kim A. Association of chronic urticaria with Helicobacter Pylori infection in Erbil: a case-control study. Zanco J Med Sci. 2016;20:1376–1384.
   Google Scholar
• Confino-Cohen R, Chodick G, Shalev V, Leshno M, Kimhi O, Goldberg A. Chronic urticaria and autoimmunity: associations found in a large population study. J Allergy Clin Immunol. 2012;129(5):1307–1313.
   PubMed Web of Science ®Google Scholar
• Ozkan M, Oflaz SB, Kocaman N, et al. Psychiatric morbidity and quality of life in patients with chronic idiopathic urticaria. Ann Allergy Asthma Immunol. 2007;99(1):29–33.
   PubMed Web of Science ®Google Scholar
• Campos V, Yassumoto L, Filho O, Antunes R, Calamita Z. Chronic spontaneous urticaria: cutaneous reaction and laboratory aspects. Jornal Brasileiro de Patologia e Medicina Laboratorial. 2016;52:84–90.
   Google Scholar
• Guttman-Yassky E, Bergman R, Maor C, Mamorsky M, Pollack S, Shahar E. The autologous serum skin test in a cohort of chronic idiopathic urticaria patients compared to respiratory allergy patients and healthy individuals. J Eur Acad Dermatol Venereol. 2007;21(1):35–39.
   PubMed Web of Science ®Google Scholar
• Najib U, Bajwa ZH, Ostro MG, Sheikh J. A retrospective review of clinical presentation, thyroid autoimmunity, laboratory characteristics, and therapies used in patients with chronic idiopathic urticaria. Ann Allergy Asthma Immunol. 2009;103(6):496–501.
   PubMed Web of Science ®Google Scholar
• Viswanathan RK, Biagtan MJ, Mathur SK. The role of autoimmune testing in chronic idiopathic urticaria. Ann Allergy Asthma Immunol. 2012;108(5):337–341.
   PubMed Web of Science ®Google Scholar
• Ertaş R, Hawro T, Altrichter S, et al. Antinuclear antibodies are common and linked to poor response to omalizumab treatment in patients with CSU. Allergy. 2020;75(2):468–470.
   PubMed Web of Science ®Google Scholar
• Chanprapaph K, Iamsumang W, Wattanakrai P, Vachiramon V. Thyroid Autoimmunity and Autoimmunity in Chronic Spontaneous Urticaria Linked to Disease Severity, Therapeutic Response, and Time to Remission in Patients with Chronic Spontaneous Urticaria. Biomed Res Int. 2018;2018:9856843.
   PubMed Web of Science ®Google Scholar
• Kim JH, Oh TS, Lee SG, Kim IH. Prognostic significance of thyroid autoantibodies in urticaria. Korean J Dermatol. 2011;49(10):872–876.
   Google Scholar
• Lee KR, Lee EG, Lee HJ, Yoon MS. Assessment of treatment efficacy and sebosuppressive effect of fractional radiofrequency microneedle on acne vulgaris. Lasers Surg Med. 2013;45(10):639–647.
   PubMed Web of Science ®Google Scholar
• Kayastha AK. Chronic Idiopathic Urticaria and its association with antithyroglobulin antibody. Postgrad Med J NAMS. 2011;11(2):24–27.
   Google Scholar
• Sánchez-Borges M, Asero R, Ansotegui IJ, et al. Diagnosis and treatment of urticaria and angioedema: a worldwide perspective. World Allergy Organ J. 2012;5(11):125–147.
   PubMedGoogle Scholar
• Tarbox JA, Gutta RC, Radojicic C, Lang DM. Utility of routine laboratory testing in management of chronic urticaria/angioedema. Ann Allergy Asthma Immunol. 2011;107(3):239–243.
   PubMed Web of Science ®Google Scholar
• Jiamton S, Swad-Ampiraks P, Kulthanan K, Suthipinittharm P. Urticaria and angioedema in Siriraj medical students. J Med Assoc Thai. 2003;86(1):74–81.
   PubMedGoogle Scholar
• Champion RH, Roberts SO, Carpenter RG, Roger JH. Urticaria and angio-oedema. A review of 554 patients. Br J Dermatol. 1969;81(8):588–597.
   PubMed Web of Science ®Google Scholar
• Toubi E, Kessel A, Avshovich N, et al. Clinical and laboratory parameters in predicting chronic urticaria duration: a prospective study of 139 patients. Allergy. 2004;59(8):869–873.
   PubMed Web of Science ®Google Scholar
• Prosty C, Gabrielli S, Le M, et al. Prevalence, Management, and Anaphylaxis Risk of Cold Urticaria: a Systematic Review and Meta-Analysis. J Allergy Clin Immunol Pract. 2022;10(2):586–596.e584.
   PubMed Web of Science ®Google Scholar
• Magen E, Waitman DA, Dickstein Y, Davidovich V, Kahan NR. Clinical-laboratory characteristics of ANA-positive chronic idiopathic urticaria. Allergy Asthma Proc. 2015;36(2):138–144.
   PubMed Web of Science ®Google Scholar
• Zauli D, Deleonardi G, Foderaro S, et al. Thyroid autoimmunity in chronic urticaria. Allergy Asthma Proc. 2001;22(2):93–95.
   PubMed Web of Science ®Google Scholar
• Amin P, Levin L, Holmes SJ, Picard J, Bernstein JA. Investigation of patient-specific characteristics associated with treatment outcomes for chronic urticaria. J Allergy Clin Immunol Pract. 2015;3(3):400–407.
   PubMed Web of Science ®Google Scholar
• Missaka RF, Penatti HC, Silvares MR, Nogueira CR, Mazeto GM. Autoimmune thyroid disease as a risk factor for angioedema in patients with chronic idiopathic urticaria: a case-control study. Sao Paulo Med J. 2012;130(5):294–298.
   PubMed Web of Science ®Google Scholar
• Rujitharanawong C, Tuchinda P, Chularojanamontri L, Chanchaemsri N, Kulthanan K. Cholinergic Urticaria: clinical Presentation and Natural History in a Tropical Country. Biomed Res Int. 2020;2020:7301652.
   PubMed Web of Science ®Google Scholar
• Vollono L, Piccolo A, Lanna C, et al. Omalizumab for chronic spontaneous urticaria in “complex” patients: data from real-life clinical practice. Drug Des Devel Ther. 2019;13:3181–3186.
   PubMed Web of Science ®Google Scholar
• Chiu HY, Muo CH, Sung FC. Associations of chronic urticaria with atopic and autoimmune comorbidities: a nationwide population-based study. Int J Dermatol. 2018;57(7):822–829.
   PubMed Web of Science ®Google Scholar
• Cascone N, Nee TL, Boeckman JE, Petrov AA, Fajt ML. The Impact of Allergic Disease in Adults with Chronic Idiopathic Urticaria. J Allergy Clin Immunol. 2019;143(2 suppl):AB75.
   Web of Science ®Google Scholar
• Miller DA, Freeman GL, Akers WA. Chronic urticaria: a clinical study of fifty patients. Am J Med. 1968;44(1):68–86.
   PubMed Web of Science ®Google Scholar
• Lee HC, Hong JB, Chu CY. Chronic idiopathic urticaria in Taiwan: a clinical study of demographics, aggravating factors, laboratory findings, serum autoreactivity and treatment response. J Formos Med Assoc. 2011;110(3):175–182.
   PubMed Web of Science ®Google Scholar
• Gallo C, Vighi G, Schroeder J, et al. Chronic urticaria atopic dermatitis and celiac disease. Am J Gastroenterol. 1992;87(11):1684.
   PubMed Web of Science ®Google Scholar
• Aitella E, De Bartolomeis F, Savoia A, Fabiani M, Romano M, Astarita C. The overlap syndrome of urticaria and gastroesophageal reflux disease. PLoS One. 2018;13(11):e0207602.
   PubMed Web of Science ®Google Scholar
• Doong JC, Chichester K, Oliver ET, Schwartz LB, Saini SS. Chronic Idiopathic Urticaria: systemic Complaints and Their Relationship with Disease and Immune Measures. J Allergy Clin Immunol Pract. 2017;5(5):1314–1318.
   PubMed Web of Science ®Google Scholar
• Fernandez Romero DS, Malbran A. Chronic urticaria with alterations of the thyroid function and thyroid peroxidase antibodies. Medicina. 2005;65(3):231–234.
   PubMed Web of Science ®Google Scholar
• Aamir IS, Tauheed S, Majid F, Atif A. Frequency of autoimmune thyroid disease in chronic urticaria. J Coll Physicians Surg Pak. 2010;20(3):158–161.
   PubMed Web of Science ®Google Scholar
• Staubach P, Dechene M, Metz M, et al. High prevalence of mental disorders and emotional distress in patients with chronic spontaneous urticaria. Acta Derm Venereol. 2011;91(5):557–561.
   PubMed Web of Science ®Google Scholar
• Uguz F, Engin B, Yilmaz E. Axis I and Axis II diagnoses in patients with chronic idiopathic urticaria. J Psychosom Res. 2008;64(2):225–229.
   PubMed Web of Science ®Google Scholar
• Staubach P, Eckhardt-Henn A, Dechene M, et al. Quality of life in patients with chronic urticaria is differentially impaired and determined by psychiatric comorbidity. Br J Dermatol. 2006;154(2):294–298.
   PubMed Web of Science ®Google Scholar
• Barbosa F, Freitas J, Barbosa A. Chronic idiopathic urticaria and anxiety symptoms. J Health Psychol. 2011;16(7):1038–1047.
   PubMed Web of Science ®Google Scholar
• Najmosadat A, Mahbooobeh R, Shadi P, Shadi G. Psychological status in patients with chronic urticaria. Med J Islam Repub Iran. 2011;25(4):200–204.
   Google Scholar
• Pulimood S, Rajagopalan B, Rajagopalan M, Jacob M, John JK. Psychiatric morbidity among dermatology inpatients. Natl Med J India. 1996;9(5):208–210.
   PubMed Web of Science ®Google Scholar
• Calikuşu C, Yücel B, Polat A, Baykal C. The relation of psychogenic excoriation with psychiatric disorders: a comparative study. Compr Psychiatry. 2003;44(3):256–261.
   PubMed Web of Science ®Google Scholar
• Lindelöf B, Wahlgren CF. Chronic urticaria associated with internal malignancy. Int J Dermatol. 1990;29(5):384.
   PubMed Web of Science ®Google Scholar
• Breathnach SM, Allen R, Ward AM, Greaves MW. Symptomatic dermographism: natural history, clinical features laboratory investigations and response to therapy. Clin Exp Dermatol. 1983;8(5):463–476.
   PubMed Web of Science ®Google Scholar
• Magerl M, Altrichter S, Borzova E, et al. The definition, diagnostic testing, and management of chronic inducible urticarias - The EAACI/GA(2) LEN/EDF/UNEV consensus recommendations 2016 update and revision. Allergy. 2016;71(6):780–802.
   PubMed Web of Science ®Google Scholar
• Kontou-Fili K, Borici-Mazi R, Kapp A, Matjevic LJ, Mitchel FB. Physical urticaria: classification and diagnostic guidelines. An EAACI position paper. Allergy. 1997;52(5):504–513.
   PubMed Web of Science ®Google Scholar
• Calamita Z, Pelá calamita AB. Chronic spontaneous urticaria: epidemiological characteristics focusing on the histocompatibility profile and presence of antibodies. Inflamm Allergy Drug Targets. 2013;12(1):8–11.
   PubMedGoogle Scholar
• Viswanathan RK, Biagtan MJ, Mathur SK. Autoimmune profiling in chronic idiopathic urticaria – is there utility or futility? J Allergy Clin Immunol. 2012;129(2suppl):AB224.
   Google Scholar
• Kim DH, Sung NH, Lee AY. Effect of Levothyroxine Treatment on Clinical Symptoms in Hypothyroid Patients with Chronic Urticaria and Thyroid Autoimmunity. Ann Dermatol. 2016;28(2):199–204.
   PubMed Web of Science ®Google Scholar
• Kessel A, Helou W, Bamberger E, et al. Elevated serum total IgE–a potential marker for severe chronic urticaria. Int Arch Allergy Immunol. 2010;153(3):288–293.
   PubMed Web of Science ®Google Scholar
• Stutes SA, Cho CB, Altrich M, Ardoin SP, Ogbogu PU. Auto-antibodies in Chronic Idiopathic Urticaria (CIU) and Non-urticarial Systemic Autoimmune Disorders. J Allergy Clin Immunol. 2012;129(2 suppl):AB224.
   Web of Science ®Google Scholar
• Krupa Shankar DS, Ramnane M, Rajouria EA. Etiological approach to chronic urticaria. Indian J Dermatol. 2010;55(1):33–38.
   PubMedGoogle Scholar
• Abd El-Azim M, Abd El-Azim S. Chronic autoimmune urticaria: frequency and association with immunological markers. J Investig Allergol Clin Immunol. 2011;21(7):546–550.
   PubMed Web of Science ®Google Scholar
• Sajedi V, Movahedi M, Aghamohammadi A, et al. Comparison between sensitivity of autologous skin serum test and autologous plasma skin test in patients with Chronic Idiopathic Urticaria for detection of antibody against IgE or IgE receptor (FcεRIα). Iran J Allergy Asthma Immunol. 2011;10(2):111–117.
   PubMed Web of Science ®Google Scholar
• George M, Balachandran C, Prabhu S. Chronic idiopathic urticaria: comparison of clinical features with positive autologous serum skin test. Indian J Dermatol Venereol Leprol. 2008;74(2):105–108.
   PubMed Web of Science ®Google Scholar
• Godse KV. Autologous serum skin test in chronic idiopathic urticaria. Indian J Dermatol Venereol Leprol. 2004;70(5):283–284.
   PubMedGoogle Scholar
• Kulthanan K, Jiamton S, Gorvanich T, Pinkaew S. Autologous serum skin test in chronic idiopathic urticaria: prevalence, correlation and clinical implications. Asian Pac J Allergy Immunol. 2006;24(4):201–206.
   PubMed Web of Science ®Google Scholar
• Lunge SB, Borkar M, Pande S. Correlation of serum antithyroid microsomal antibody and autologous serum skin test in patients with chronic idiopathic urticaria. Indian Dermatol Online J. 2015;6(4):248–252.
   PubMedGoogle Scholar
• Marasoğlu Çelen O, Kutlubay Z, Aydemir EH. Usefulness of the autologous serum test for the diagnosis of chronic idiopathic urticaria. Ann Dermatol. 2014;26(5):592–597.
   PubMed Web of Science ®Google Scholar
• Curto-Barredo L, Yelamos J, Gimeno R, Mojal S, Pujol RM, Giménez-Arnau A. Basophil Activation Test identifies the patients with Chronic Spontaneous Urticaria suffering the most active disease. Immun Inflamm Dis. 2016;4(4):441–445.
   PubMedGoogle Scholar
• Magen E, Zueva E, Mishal J, Schlesinger M. The clinical and laboratory characteristics of acute spontaneous urticaria and its progression to chronic spontaneous urticaria. Allergy Asthma Proc. 2016;37(5):394–399.
   PubMed Web of Science ®Google Scholar
• Rojo-Gutiérrez MI, Flores-Ruvalcaba CN, Mellado-ábrego J, Castillo-Narváez G, Ramírez-Rojo DP. Usefulness of studies looking for autoimmunity in patients with spontaneous chronic urticaria. Rev Alerg Mex. 2015;62(3):175–181.
   PubMedGoogle Scholar
• Turktas I, Gokcora N, Demirsoy S, Cakir N, Onal E. The association of chronic urticaria and angioedema with autoimmune thyroiditis. Int J Dermatol. 1997;36(3):187–190.
   PubMed Web of Science ®Google Scholar
• Díaz-Angulo S, López-Hoyos M, Muñoz cacho P, et al. Prevalence of thyroid autoimmunity in Spanish patients with chronic idiopathic urticaria: a case-control study involving 343 subjects. J Eur Acad Dermatol Venereol. 2016;30(4):692–693.
   PubMed Web of Science ®Google Scholar
• Palma-Carlos AG, Palma-Carlos ML. Chronic urticaria and thyroid auto-immunity. Eur Ann Allergy Clin Immunol. 2005;37(4):143–146.
   PubMedGoogle Scholar
• Chomiciene A, Jurgauskiene L, Blaziene A. Chronic urticaria and thyroid autoimmunity markers. Cent Eur J Med. 2012;7(6):736–741.
   Google Scholar
• Alcaraz Calderón L, Escárcega Barbosa D, Castrejón Vázquez MI, et al. Presence of anti-Helicobacter pylori, antithyroid, and high-affinity IgE receptor antibodies in patients with chronic urticaria. Rev Alerg Mex. 2003;50(3):96–102.
   PubMedGoogle Scholar
• Czarnecka-Operacz M, Sadowska-Przytocka A, Jenerowicz D, Szeliga A, Adamski Z, Łącka K. Thyroid function and thyroid autoantibodies in patients with chronic spontaneous urticaria. Postepy Dermatol Alergol. 2017;34(6):566–572.
   PubMed Web of Science ®Google Scholar
• Leznoff A, Sussman GL. Syndrome of idiopathic chronic urticaria and angioedema with thyroid autoimmunity: a study of 90 patients. J Allergy Clin Immunol. 1989;84(1):66–71.
   PubMed Web of Science ®Google Scholar
• Collet E, Petit JM, Lacroix M, Bensa AF, Morvan C, Lambert D. Chronic urticaria and autoimmune thyroid diseases. Ann Dermatol Venereol. 1995;122(6–7):413–416.
   PubMedGoogle Scholar
• Ryhal B, DeMera RS, Shoenfeld Y, Peter JB, Gershwin ME. Are autoantibodies present in patients with subacute and chronic urticaria? J Investig Allergol Clin Immunol. 2001;11(1):16–20.
   PubMed Web of Science ®Google Scholar
• Kikuchi Y, Fann T, Kaplan AP. Antithyroid antibodies in chronic urticaria and angioedema. J Allergy Clin Immunol. 2003;112(1):218.
   PubMed Web of Science ®Google Scholar
• Atta AM, Rodrigues MZ, Sousa CP, Medeiros Júnior M, Sousa-Atta ML. Autoantibody production in chronic idiopathic urticaria is not associated with Helicobacter pylori infection. Braz J Med Biol Res. 2004;37(1):13–17.
   PubMed Web of Science ®Google Scholar
• Caproni M, Giomi B, Volpi W, et al. Chronic idiopathic urticaria: infiltrating cells and related cytokines in autologous serum-induced wheals. Clin Immunol. 2005;114(3):284–292.
   PubMed Web of Science ®Google Scholar
• Fusari A, Colangelo C, Bonifazi F, Antonicelli L. The autologous serum skin test in the follow-up of patients with chronic urticaria. Allergy. 2005;60(2):256–258.
   PubMed Web of Science ®Google Scholar
• Gangemi S, Saitta S, Lombardo G, Patafi M, Benvenga S. Serum thyroid autoantibodies in patients with idiopathic either acute or chronic urticaria. J Endocrinol Invest. 2009;32(2):107–110.
   PubMed Web of Science ®Google Scholar
• Ye YM, Park JW, Kim SH, et al. Prognostic Factors for Chronic Spontaneous Urticaria: a 6-Month Prospective Observational Study. Allergy Asthma Immunol Res. 2016;8(2):115–123.
   PubMed Web of Science ®Google Scholar
• Lee SY, Song WJ, Jung JW, et al. Thyroid autoantibodies and the prognosis of chronic idiopathic urticaria. Allergy Asthma Respir Dis. 2013;1(2):151–156.
   Google Scholar
• Dionigi PC, Menezes MC, Forte WC. A prospective ten-year follow-up of patients with chronic urticaria. Allergol Immunopathol. 2016;44(4):286–291.
   PubMed Web of Science ®Google Scholar
• Oguz Topal I, Kocaturk E, Gungor S, Durmuscan M, Sucu V, Yıldırmak S. Does replacement of vitamin D reduce the symptom scores and improve quality of life in patients with chronic urticaria? J Dermatolog Treat. 2016;27(2):163–166.
   PubMed Web of Science ®Google Scholar
• Okba AM, Sheha DS, Moustafa AS, El-Sherbeny AA, Mohamed NA, Aglan MF. Association between thyroid autoimmunity and chronic urticaria in patients versus healthy controls. Egypt J Obes Diabetes Endocrinol. 2015;1(2):84.
   Google Scholar
• Chaykivska Z, Antoszczyk G, Czarnobilska E. The elevated level of anti-thyroid antibodies aTPO in chronic spontaneous urticaria. Przegl Lek. 2015;72(12):736–738.
   PubMedGoogle Scholar
• Shin YS, Suh DH, Yang EM, Ye YM, Park HS. Serum Specific IgE to Thyroid Peroxidase Activates Basophils in Aspirin Intolerant Urticaria. J Korean Med Sci. 2015;30(6):705–709.
   PubMed Web of Science ®Google Scholar
• Arshi S, Babaie D, Nabavi M, et al. Circulating level of CD4+ CD25+ FOXP3+ T cells in patients with chronic urticaria. Int J Dermatol. 2014;53(12):e561–566.
   PubMed Web of Science ®Google Scholar
• Boonpiyathad T, Pradubpongsa P, Sangasapaviriya A. Vitamin d supplements improve urticaria symptoms and quality of life in chronic spontaneous urticaria patients: a prospective case-control study. Dermatoendocrinol. 2014;6:125. doi:10.4161/derm.29727
   Google Scholar
• Irani C, Jammal M, Asmar G, Hajj H, Halaby G. Chronic urticaria and autoimmune thyroiditis. J Med Liban. 2012;60(2):88–90.
   PubMedGoogle Scholar
• Concha LB, Chang CC, Szema AM, Dattwyler RJ, Carlson HE. IgE antithyroid antibodies in patients with Hashimoto’s disease and chronic urticaria. Allergy Asthma Proc. 2004;25(5):293–296.
   PubMed Web of Science ®Google Scholar
• Al-Balbeesi AO. Significance of antithyroid antibodies and other auto-antibodies in Saudi patients with chronic urticaria. Possible parameters in predicting chronic over three years disease. J Dermatol Dermatol Surg. 2011;15(2):47–51.
   Google Scholar
• Buss YA, Garrelfs UC, Sticherling M. Chronic urticaria–which clinical parameters are pathogenetically relevant? A retrospective investigation of 339 patients. J Dtsch Dermatol Ges. 2007;5(1):22–29.
   PubMedGoogle Scholar
• Staubach P, Metz M, Chapman-Rothe N, et al. Effect of omalizumab on angioedema in H1 -antihistamine-resistant chronic spontaneous urticaria patients: results from X-ACT, a randomized controlled trial. Allergy. 2016;71(8):1135–1144.
   PubMed Web of Science ®Google Scholar
• Kaplan AP, Spector SL, Meeves S, Liao Y, Varghese ST, Georges G. Once-daily fexofenadine treatment for chronic idiopathic urticaria: a multicenter, randomized, double-blind, placebo-controlled study. Ann Allergy Asthma Immunol. 2005;94(6):662–669.
   PubMed Web of Science ®Google Scholar
• Perez A, Woods A, Grattan CE. Methotrexate: a useful steroid-sparing agent in recalcitrant chronic urticaria. Br J Dermatol. 2010;162(1):191–194.
   PubMed Web of Science ®Google Scholar
• Sanada S, Tanaka T, Kameyoshi Y, Hide M. The effectiveness of montelukast for the treatment of anti-histamine-resistant chronic urticaria. Arch Dermatol Res. 2005;297(3):134–138.
   PubMed Web of Science ®Google Scholar
• Reisman RE, Livingston A. Late-onset allergic reactions, including serum sickness, after insect stings. J Allergy Clin Immunol. 1989;84(3):331–337.
   PubMed Web of Science ®Google Scholar
• Greene SL, Reed CE, Schroeter AL. Double-blind crossover study comparing doxepin with diphenhydramine for the treatment of chronic urticaria. J Am Acad Dermatol. 1985;12(4):669–675.
   PubMed Web of Science ®Google Scholar