433
Views
23
CrossRef citations to date
0
Altmetric
Review

Diagnosis and management of eosinophilic asthma: a US perspective

&
Pages 53-65 | Published online: 11 Apr 2014

References

  • BatemanEDBousheyHABousquetJGOAL Inverstigators GroupCan guideline-defined asthma control be achieved? The Gaining Optimal Asthma Control studyAm J Respir Crit Care Med2004170883684415256389
  • Centers for Disease Control and PreventionVital signs: asthma prevalence, disease characteristics, and self-management education: United States, 2001–2009MMWR Morb Mortal Wkly Rep2011601754755221544044
  • CisternasMGBlancPDYenIHA comprehensive study of the direct and indirect costs of adult asthmaJ Allergy Clin Immunol20031111212121812789219
  • WenzelSEAsthma: defining of the persistent adult phenotypesLancet200636880481316935691
  • AndersonGPEndotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous diseaseLancet20083721107111918805339
  • LotvallJAkdisCABacharierLBAsthma endotypes: a new approach to classification of disease entities within the asthma syndromeJ Allergy Clin Immunol201112735536021281866
  • SimpsonJLScottRBoyleMJGibsonPGInflammatory subtypes in asthma: assessment and identification using induced sputumRespirology200611546116423202
  • WenzelSESchwartzLBLangmackELEvidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristicsAm J Respir Crit Care Med19991601001100810471631
  • AmelinkMde GrootJCde NijsSBSevere adult-onset asthma: a distinct phenotypeJ Allergy Clin Immunol201313233634123806634
  • HoustonJCDe NavasquezSTrounceJRA clinical and pathological study of fatal cases of status asthmaticusThorax1953820721313102418
  • BousquetJChanezPLacosteJYEosinophilic inflammation in asthmaN Engl J Med1990323103310392215562
  • JatakanonALimSBarnesPJChanges in sputum eosinophils predict loss of asthma controlAm J Respir Crit Care Med2000161647210619799
  • DeykinALazarusSCFahyJVSputum eosinophil counts predict asthma control after discontinuation of inhaled corticosteroidsJ Allergy Clin Immunol200511572072715805990
  • MeijerRJPostmaDSKauffmanHFArendsLRKoeterGHKerstjensHAAccuracy of eosinophils and eosinophil cationic protein to predict steroid improvement in asthmaClin Exp Allergy2002321096110312100060
  • BerryMMorganAShawDEPathological features and inhaled corticosteroid response of eosinophilic and non-eosinophilic asthmaThorax2007621043104917356056
  • HaldarPBrightlingCEHargadonBMepolizumab and exacerbations of refractory eosinophilic asthmaN Engl J Med200936097398419264686
  • NairPPizzichiniMMKjarsgaardMMepolizumab for prednisone-dependent asthma with sputum eosinophiliaN Engl J Med200936098599319264687
  • HamidQTulicMImmunobiology of asthmaAnnu Rev Physiol20097148950719575684
  • BarrettNAAustenKFInnate cells and T helper 2 cell immunity in airway inflammationImmunity20093142543719766085
  • DohertyTBroideDCytokines and growth factors in airway remodeling in asthmaCurr Opin Immunol20071967668017720466
  • GartyBZKosmanEGanorEEmergency room visits of asthmatic children, relation to air pollution, weather, and airborne allergensAnn Allergy Asthma Immunol1998815635709892028
  • D’AmatoGCecchiLLiccardiGThunderstorm-related asthma: not only grass pollen and sporesJ Allergy Clin Immunol200812153753818155276
  • HolgateSTInnate and adaptive immune responses in asthmaNat Med20121867368322561831
  • LeeHCHeadleyMBLooYMThymic stromal lymphopoietin is induced by respiratory syncytial virus-infected airway epithelial cells and promotes a type 2 response to infectionJ Allergy Clin Immunol201213011871196. e522981788
  • ZieglerSFThymic stromal lymphopoietin and allergic diseaseJ Allergy Clin Immunol201213084585222939755
  • BarnesPJThe cytokine network in asthma and chronic obstructive pulmonary diseaseJ Clin Invest20081183546355618982161
  • WardlawAJBrightlingCGreenRWoltmannGPavordIEosinophils in asthma and other allergic diseasesBr Med Bull200056985100311359633
  • CollinsPDMarleauSGriffiths-JohnsonDAJosePJWilliamsTJCooperation between interleukin-5 and the chemokine eotaxin to induce eosinophil accumulation in vivoJ Exp Med1995182116911747561691
  • ZietkowskiZTomasiakMMSkiepkoRBodzenta-LukaszykARANTES in exhaled breath condensate of stable and unstable asthma patientsRespir Med20081021198120218603420
  • BroideDHPaineMMFiresteinGSEosinophils express interleukin 5 and granulocyte macrophage-colony-stimulating factor mRNA at sites of allergic inflammation in asthmaticsJ Clin Invest199290141414241401075
  • BroideDHFiresteinGSEndobronchial allergen challenge in asthma. Demonstration of cellular source of granulocyte macrophage colony-stimulating factor by in situ hybridizationJ Clin Invest199188104810531885766
  • DaviesDLarbiKAllenAVCAM-1 contributes to rapid eosinophil accumulation induced by the chemoattractants PAF and LTB4: evidence for basal expression of functional VCAM-1 in rat skinImmunology19999715015810447726
  • StirlingRGvan RensenELBarnesPJChungKFInterleukin-5 induces CD34(+) eosinophil progenitor mobilization and eosinophil CCR3 expression in asthmaAm J Respir Crit Care Med20011641403140911704586
  • ChoJYMillerMBaekKJInhibition of airway remodeling in IL-5-deficient miceJ Clin Invest200411355156014966564
  • FahyJVEosinophilic and neutrophilic inflammation in asthma: insights from clinical studiesProc Am Thorac Soc2009625625919387026
  • GreenRHBrightlingCEMcKennaSAsthma exacerbations and sputum eosinophil counts: a randomised controlled trialLancet20023601715172112480423
  • WoodruffPGKhashayarRLazarusSCRelationship between airway inflammation, hyperresponsiveness, and obstruction in asthmaJ Allergy Clin Immunol200110875375811692100
  • LouisRLauLCBronAORoldaanACRadermeckerMDjukanovicRThe relationship between airways inflammation and asthma severityAm J Respir Crit Care Med200016191610619791
  • PorsbjergCLundTKPedersenLBackerVInflammatory subtypes in asthma are related to airway hyperresponsiveness to mannitol and exhaled NOJ Asthma20094660661219657904
  • CrimiESpanevelloANeriMIndPWRossiGABrusascoVDissociation between airway inflammation and airway hyperresponsiveness in allergic asthmaAm J Respir Crit Care Med1998157499445270
  • MirandaCBusackerABalzarSTrudeauJWenzelSEDistinguishing severe asthma phenotypes: role of age at onset and eosinophilic inflammationJ Allergy Clin Immunol200411310110814713914
  • ten BrinkeAZwindermanAHSterkPJRabeKFBelEH“Refractory” eosinophilic airway inflammation in severe asthma: effect of parenteral corticosteroidsAm J Respir Crit Care Med200417060160515215154
  • ThomsonNCChaudhuriRWhy is eosinophilic bronchitis not asthma?Am J Respir Crit Care Med20041704515220118
  • BrightlingCEBraddingPSymonFAHolgateSTWardlawAJPavordIDMast-cell infiltration of airway smooth muscle in asthmaN Engl J Med20023461699170512037149
  • KanazawaHNomuraSYoshikawaJRole of microvascular permeability on physiologic differences in asthma and eosinophilic bronchitisAm J Respir Crit Care Med20041691125113015044203
  • FrickWESedgwickJBBusseWWThe appearance of hypodense eosinophils in antigen-dependent late phase asthmaAm Rev Respir Dis1989139140114062729749
  • UlrikCSPeripheral eosinophil counts as a marker of disease activity in intrinsic and extrinsic asthmaClin Exp Allergy1995258208278564720
  • HastieATMooreWCLiHBiomarker surrogates do not accurately predict sputum eosinophil and neutrophil percentages in asthmatic subjectsJ Allergy Clin Immunol2013132728023706399
  • D’SilvaLCookRJAllenCJHargreaveFEParameswaranKChanging pattern of sputum cell counts during successive exacerbations of airway diseaseRespir Med20071012217222017606366
  • GoodJTJrKolakowskiCAGroshongSDMurphyJRMartinRJRefractory asthma: importance of bronchoscopy to identify phenotypes and direct therapyChest201114159960621835905
  • SilkoffPELentAMBusackerAAExhaled nitric oxide identifies the persistent eosinophilic phenotype in severe refractory asthmaJ Allergy Clin Immunol20051161249125516337453
  • MahrTAMalkaJSpahnJDInflammometry in pediatric asthma: a review of fractional exhaled nitric oxide in clinical practiceAllergy Asthma Proc20133421021923462278
  • BarnesPJDweikRAGelbAFExhaled nitric oxide in pulmonary diseases: a comprehensive reviewChest201013868269220822990
  • SmithADCowanJOBrassettKPHerbisonGPTaylorDRUse of exhaled nitric oxide measurements to guide treatment in chronic asthmaN Engl J Med20053522163217315914548
  • TseliouEBessaVHillasGExhaled nitric oxide and exhaled breath condensate pH in severe refractory asthmaChest201013810711320173051
  • BlanchardCMinglerMKMcBrideMPeriostin facilitates eosinophil tissue infiltration in allergic lung and esophageal responsesMucosal Immunol2008128929619079190
  • OuyangGLiuMRuanKSongGMaoYBaoSUpregulated expression of periostin by hypoxia in non-small-cell lung cancer cells promotes cell survival via the Akt/PKB pathwayCancer Lett200928121321919328625
  • JiaGEricksonRWChoyDFPeriostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patientsJ Allergy Clin Immunol2012130647654. e1022857879
  • CorrenJLemanskeRFHananiaNALebrikizumab treatment in adults with asthmaN Engl J Med20113651088109821812663
  • MasuokaMShiraishiHOhtaSPeriostin promotes chronic allergic inflammation in response to Th2 cytokinesJ Clin Invest20121222590260022684102
  • GordonEDSidhuSSWangZEA protective role for periostin and TGF-beta in IgE-mediated allergy and airway hyperresponsivenessClin Exp Allergy20124214415522093101
  • KulkarniNSHollinsFSutcliffeAEosinophil protein in airway macrophages: a novel biomarker of eosinophilic inflammation in patients with asthmaJ Allergy Clin Immunol20101266169. e320639010
  • BarnesPJSevere asthma: advances in current management and future therapyJ Allergy Clin Immunol2012129485922196524
  • IrusenEMatthewsJGTakahashiABarnesPJChungKFAdcockIMp38 Mitogen-activated protein kinase-induced glucocorticoid receptor phosphorylation reduces its activity: role in steroid-insensitive asthmaJ Allergy Clin Immunol200210964965711941315
  • ManeechotesuwanKXinYItoKRegulation of Th2 cytokine genes by p38 MAPK-mediated phosphorylation of GATA-3J Immunol20071782491249817277157
  • CuendaARousseauSp38 MAP-kinases pathway regulation, function and role in human diseasesBiochim Biophys Acta200717731358137517481747
  • BarnesPJAdcockIMGlucocorticoid resistance in inflammatory diseasesLancet20093731905191719482216
  • MizueYGhaniSLengLRole for macrophage migration inhibitory factor in asthmaProc Natl Acad Sci U S A2005102144101441516186482
  • PelaiaGVatrellaAMaselliRThe potential of biologics for the treatment of asthmaNat Rev Drug Discov20121195897223197041
  • SainiSSMacGlashanDWJrSterbinskySADown-regulation of human basophil IgE and FC epsilon RI alpha surface densities and mediator release by anti-IgE-infusions is reversible in vitro and in vivoJ Immunol19991625624563010228046
  • HumbertMBeasleyRAyresJBenefits of omalizumab as add-on therapy in patients with severe persistent asthma who are inadequately controlled despite best available therapy (GINA 2002 step 4 treatment): INNOVATEAllergy20056030931615679715
  • AyresJGHigginsBChilversERAyreGBloggMFoxHEfficacy and tolerability of anti-immunoglobulin E therapy with omalizumab in patients with poorly controlled (moderate-to-severe) allergic asthmaAllergy20045970170815180756
  • VignolaAMHumbertMBousquetJEfficacy and tolerability of anti-immunoglobulin E therapy with omalizumab in patients with concomitant allergic asthma and persistent allergic rhinitis: SOLARAllergy20045970971715180757
  • BusseWCorrenJLanierBQOmalizumab, anti-IgE recombinant humanized monoclonal antibody, for the treatment of severe allergic asthmaJ Allergy Clin Immunol200110818419011496232
  • SolerMMatzJTownleyRThe anti-IgE antibody omalizumab reduces exacerbations and steroid requirement in allergic asthmaticsEur Respir J20011825426111529281
  • LanierBQCorrenJLumryWLiuJFowler-TaylorAGuptaNOmalizumab is effective in the long-term control of severe allergic asthmaAnn Allergy Asthma Immunol20039115415912952109
  • HolgateSTChuchalinAGHebertJEfficacy and safety of a recombinant anti-immunoglobulin E antibody (omalizumab) in severe allergic asthmaClin Exp Allergy20043463263815080818
  • BousquetJRabeKHumbertMPredicting and evaluating response to omalizumab in patients with severe allergic asthmaRespir Med20071011483149217339107
  • NogaOHanfGBrachmannIEffect of omalizumab treatment on peripheral eosinophil and T-lymphocyte function in patients with allergic asthmaJ Allergy Clin Immunol20061171493149916751018
  • DjukanovicRWilsonSJKraftMEffects of treatment with anti-immunoglobulin E antibody omalizumab on airway inflammation in allergic asthmaAm J Respir Crit Care Med200417058359315172898
  • NogaOHanfGKunkelGImmunological and clinical changes in allergic asthmatics following treatment with omalizumabInt Arch Allergy Immunol2003131465212759489
  • MilgromHFickRBJrSuJQTreatment of allergic asthma with monoclonal anti-IgE antibody. rhuMAb-E25 Study GroupN Engl J Med19993411966197310607813
  • HolgateSCasaleTWenzelSBousquetJDenizYReisnerCThe anti-inflammatory effects of omalizumab confirm the central role of IgE in allergic inflammationJ Allergy Clin Immunol200511545946515753888
  • ChandHSSchuylerMJosteNAnti-IgE therapy results in decreased myeloid dendritic cells in asthmatic airwaysJ Allergy Clin Immunol201012511571158. e520304471
  • KayaHGumusSUcarEOmalizumab as a steroid-sparing agent in chronic eosinophilic pneumoniaChest201214251351622871762
  • HamidQAzzawiMYingSExpression of mRNA for interleukin-5 in mucosal bronchial biopsies from asthmaJ Clin Invest199187154115462022726
  • HumbertMCorriganCJKimmittPTillSJKayABDurhamSRRelationship between IL-4 and IL-5 mRNA expression and disease severity in atopic asthmaAm J Respir Crit Care Med19971567047089309982
  • GarlisiCGKungTTWangPEffects of chronic anti-interleukin-5 monoclonal antibody treatment in a murine model of pulmonary inflammationAm J Respir Cell Mol Biol1999202482559922215
  • GnanakumaranGBabuKSTechnology evaluation: mepolizumab, GlaxoSmithKlineCurr Opin Mol Ther2003532132512870444
  • Menzies-GowAFlood-PagePSehmiRAnti-IL-5 (mepolizumab) therapy induces bone marrow eosinophil maturational arrest and decreases eosinophil progenitors in the bronchial mucosa of atopic asthmaticsJ Allergy Clin Immunol200311171471912704348
  • KipsJCO’ConnorBJLangleySJEffect of SCH55700, a humanized anti-human interleukin-5 antibody, in severe persistent asthma: a pilot studyAm J Respir Crit Care Med20031671655165912649124
  • LeckieMJten BrinkeAKhanJEffects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic responseLancet20003562144214811191542
  • Flood-PagePSwensonCFaifermanIA study to evaluate safety and efficacy of mepolizumab in patients with moderate persistent asthmaAm J Respir Crit Care Med20071761062107117872493
  • CastroMMathurSHargreaveFReslizumab for poorly controlled, eosinophilic asthma: a randomized, placebo-controlled studyAm J Respir Crit Care Med20111841125113221852542
  • BusseWWKatialRGossageDSafety profile, pharmacokinetics, and biologic activity of MEDI-563, an anti-IL-5 receptor alpha antibody, in a phase I study of subjects with mild asthmaJ Allergy Clin Immunol201012512371244. e220513521
  • LavioletteMGossageDLGauvreauGEffects of benralizumab on airway eosinophils in asthmatic patients with sputum eosinophiliaJ Allergy Clin Immunol201313210861096. e523866823
  • IngramJLKraftMIL-13 in asthma and allergic disease: asthma phenotypes and targeted therapiesJ Allergy Clin Immunol201213082984222951057
  • HartTKBlackburnMNBrigham-BurkeMPreclinical efficacy and safety of pascolizumab (SB 240683): a humanized anti-interleukin-4 antibody with therapeutic potential in asthmaClin Exp Immunol20021309310012296858
  • HendersonWRJrChiEYMaliszewskiCRSoluble IL-4 receptor inhibits airway inflammation following allergen challenge in a mouse model of asthmaJ Immunol20001641086109510623860
  • BorishLCNelsonHSCorrenJEfficacy of soluble IL-4 receptor for the treatment of adults with asthmaJ Allergy Clin Immunol200110796397011398072
  • WenzelSWilbrahamDFullerRGetzEBLongphreMEffect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studiesLancet20073701422143117950857
  • WenzelSFordLPearlmanDDupilumab in persistent asthma with elevated eosinophil levelsN Engl J Med20133682455246623688323
  • PopeSMBrandtEBMishraAIL-13 induces eosinophil recruitment into the lung by an IL-5- and eotaxin-dependent mechanismJ Allergy Clin Immunol200110859460111590387
  • SpahnJDSzeflerSJSursWDohertyDENimmagaddaSRLeungDYA novel action of IL-13: induction of diminished monocyte glucocorticoid receptor-binding affinityJ Immunol1996157265426598805670
  • YangGVolkAPetleyTAnti-IL-13 monoclonal antibody inhibits airway hyperresponsiveness, inflammation and airway remodelingCytokine20042822423215566951
  • BreeASchlermanFJWadanoliMIL-13 blockade reduces lung inflammation after Ascaris suum challenge in cynomolgus monkeysJ Allergy Clin Immunol20071191251125717379289
  • GauvreauGMBouletLPCockcroftDWEffects of interleukin-13 blockade on allergen-induced airway responses in mild atopic asthmaAm J Respir Crit Care Med20111831007101421057005
  • PiperEBrightlingCNivenRA phase II placebo-controlled study of tralokinumab in moderate-to-severe asthmaEur Respir J20134133033822743678
  • TamachiTMaezawaYIkedaKIL-25 enhances allergic airway inflammation by amplifying a TH2 cell-dependent pathway in miceJ Allergy Clin Immunol200611860661416950278
  • FujitaJKawaguchiMKokubuFInterleukin-33 induces interleukin-17F in bronchial epithelial cellsAllergy20126774475022540331
  • ShiLLeuSWXuFLocal blockade of TSLP receptor alleviated allergic disease by regulating airway dendritic cellsClin Immunol200812920221018757241
  • AmgenDouble-blind, Multiple Dose Study in Subjects With Mild Atopic Asthma Available from: http://clinicaltrials.gov/show/NCT01405963. NLM identifier: NCT01405963Accessed February 3, 2014
  • GauvreauGMBouletLPCockcroftDWAntisense therapy against CCR3 and the common beta chain attenuates allergen-induced eosinophilic responsesAm J Respir Crit Care Med200817795295818244953
  • KrinnerEMRaumTPetschSA human monoclonal IgG1 potently neutralizing the pro-inflammatory cytokine GM-CSFMol Immunol20074491692516697465
  • KiwamotoTKawasakiNPaulsonJCBochnerBSSiglec-8 as a drugable target to treat eosinophil and mast cell-associated conditionsPharmacol Ther201213532733622749793
  • WenzelSEBarnesPJBleeckerERA randomized, double-blind, placebo-controlled study of tumor necrosis factor-alpha blockade in severe persistent asthmaAm J Respir Crit Care Med200917954955819136369
  • HolgateSTNoonanMChanezPEfficacy and safety of etanercept in moderate-to-severe asthma: a randomised, controlled trialEur Respir J2011371352135921109557
  • CastroMMusaniAIMayseMLShargillNSBronchial thermoplasty: a novel technique in the treatment of severe asthmaTher Adv Respir Dis2010410111620435668
  • CastroMRubinASLavioletteMEffectiveness and safety of bronchial thermoplasty in the treatment of severe asthma: a multicenter, randomized, double-blind, sham-controlled clinical trialAm J Respir Crit Care Med201218111612419815809
  • ThomsonNCRubinASNivenRMLong-term (5 year) safety of bronchial thermoplasty: Asthma Intervention Research (AIR) trialBMC Pulm Med201111821314924