303
Views
1
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

A Multi-Center Study of the Prevalence and Characteristics of Eosinophilic Phenotype and High IgE Levels Among Chinese Patients with Severe Asthma

ORCID Icon, , ORCID Icon, ORCID Icon, , ORCID Icon, & show all
Pages 173-182 | Received 02 Oct 2022, Accepted 22 Dec 2022, Published online: 25 Jan 2023

References

  • Vos T, Allen C, Arora M, et al.; GBD 2017 Disease Injury Incidence Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the global burden of disease study 2017. Lancet. 2018;392:1789–1858.
  • Chung KF, Wenzel SE, Brozek JL, et al. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J. 2014;43:343–373. doi:10.1183/09031936.00202013
  • Viinanen A, Lassenius MI, Toppila I, et al. The burden of adult asthma in Finland: impact of disease severity and eosinophil count on health care resource utilization. J Asthma. 2020;57:1092–1102. doi:10.1080/02770903.2019.1633664
  • Shantakumar S, Ho YF, Beale J, Gribben B. Characterization and burden of severe eosinophilic asthma in New Zealand: results from the HealthStat Database. Multidiscip Respir Med. 2020;15:662. doi:10.4081/mrm.2020.662
  • Demarche SF, Schleich FN, Paulus VA, Henket MA, Van Hees TJ, Louis RE. Asthma control and sputum eosinophils: a longitudinal study in daily practice. J Allergy Clin Immunol Pract. 2017;5:1335–43 e5. doi:10.1016/j.jaip.2017.01.026
  • Shaw DE, Sousa AR, Fowler SJ, et al.; Group UBS. Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort. Eur Respir J. 2015;46:1308–1321. doi:10.1183/13993003.00779-2015
  • Pavord ID. Eosinophilic phenotypes of airway disease. Ann Am Thorac Soc. 2013;10:S143–9. doi:10.1513/AnnalsATS.201306-168AW
  • Walsh CJ, Zaihra T, Benedetti A, et al. Exacerbation risk in severe asthma is stratified by inflammatory phenotype using longitudinal measures of sputum eosinophils. Clin Exp Allergy. 2016;46:1291–1302. doi:10.1111/cea.12762
  • Heaney LG, Perez de Llano L, Al-Ahmad M, et al. Eosinophilic and noneosinophilic asthma: an expert consensus framework to characterize phenotypes in a global real-life severe asthma cohort. Chest. 2021;160:814–830. doi:10.1016/j.chest.2021.04.013
  • Dean BB, Calimlim BC, Sacco P, Aguilar D, Maykut R, Tinkelman D. Uncontrolled asthma: assessing quality of life and productivity of children and their caregivers using a cross-sectional Internet-based survey. Health Qual Life Outcomes. 2010;8:96. doi:10.1186/1477-7525-8-96
  • Global Initiative for Asthma. Global strategy for asthma management and prevention; 2018. Available from: https://ginasthma.org/wp-content/uploads/2019/01/8-GINA.pdf. Accessed June 29, 2022.
  • Chen S, Golam S, Myers J, Bly C, Smolen H, Xu X. Systematic literature review of the clinical, humanistic, and economic burden associated with asthma uncontrolled by GINA Steps 4 or 5 treatment. Curr Med Res Opin. 2018;34:2075–2088. doi:10.1080/03007995.2018.1505352
  • Brusselle GG, Koppelman GH. Biologic therapies for severe asthma. N Engl J Med. 2022;386:157–171. doi:10.1056/NEJMra2032506
  • Kubo M. Innate and adaptive type 2 immunity in lung allergic inflammation. Immunol Rev. 2017;278:162–172. doi:10.1111/imr.12557
  • McCormick JP, Lee JT. Insights into the Implications of Coexisting Type 2 Inflammatory Diseases. J Inflamm Res. 2021;14:4259–4266. doi:10.2147/JIR.S311640
  • Caminati M, Pham DL, Bagnasco D, Canonica GW. Type 2 immunity in asthma. World Allergy Organ J. 2018;11:13. doi:10.1186/s40413-018-0192-5
  • Chung KF, Dixey P, Abubakar-Waziri H, et al. Characteristics, phenotypes, mechanisms and management of severe asthma. Chin Med J. 2022;135:1141–1155. doi:10.1097/CM9.0000000000001990
  • Pavord ID, Hanania NA, Corren J. Controversies in allergy: choosing a biologic for patients with severe asthma. J Allergy Clin Immunol Pract. 2022;10:410–419. doi:10.1016/j.jaip.2021.12.014
  • Wang G, Wang F, Gibson PG, et al. Severe and uncontrolled asthma in China: a cross-sectional survey from the Australasian Severe Asthma Network. J Thorac Dis. 2017;9:1333–1344. doi:10.21037/jtd.2017.04.74
  • Nagasaki T, Sato K, Kume N, et al. The prevalence and disease burden of severe eosinophilic asthma in Japan. J Asthma. 2019;56:1147–1158. doi:10.1080/02770903.2018.1534967
  • Carr TF, Zeki AA, Kraft M. Eosinophilic and noneosinophilic asthma. Am J Respir Crit Care Med. 2018;197:22–37. doi:10.1164/rccm.201611-2232PP
  • Carosso A, Bugiani M, Migliore E, Anto JM, DeMarco R. Reference values of total serum IgE and their significance in the diagnosis of allergy in young European adults. Int Arch Allergy Immunol. 2007;142:230–238. doi:10.1159/000097025
  • Husereau D, Goodfield J, Leigh R, Borrelli R, Cloutier M, Gendron A. Severe, eosinophilic asthma in primary care in Canada: a longitudinal study of the clinical burden and economic impact based on linked electronic medical record data. Allergy Asthma Clin Immunol. 2018;14:15. doi:10.1186/s13223-018-0241-1
  • Denton E, Price DB, Tran TN, et al. Cluster analysis of inflammatory biomarker expression in the international severe asthma registry. J Allergy Clin Immunol Pract. 2021;9:2680–8 e7. doi:10.1016/j.jaip.2021.02.059
  • Cheng SL, Chiu KC, Ko HK, et al. Comparing patient characteristics, clinical outcomes, and biomarkers of severe asthma patients in Taiwan. Biomedicines. 2021;9:764. doi:10.3390/biomedicines9070764
  • Tran TN, Zeiger RS, Peters SP, et al. Overlap of atopic, eosinophilic, and TH2-high asthma phenotypes in a general population with current asthma. Ann Allergy Asthma Immunol. 2016;116:37–42. doi:10.1016/j.anai.2015.10.027
  • Vignola AM, Chanez P, Chiappara G, et al. Evaluation of apoptosis of eosinophils, macrophages, and T lymphocytes in mucosal biopsy specimens of patients with asthma and chronic bronchitis. J Allergy Clin Immunol. 1999;103:563–573. doi:10.1016/S0091-6749(99)70225-3
  • Poddighe D, Mathias CB, Brambilla I, Marseglia GL, Oettgen HC. Importance of basophils in eosinophilic asthma: the murine counterpart. J Biol Regul Homeost Agents. 2018;32:335–339.
  • Mathias CB, Freyschmidt EJ, Caplan B, et al. IgE influences the number and function of mature mast cells, but not progenitor recruitment in allergic pulmonary inflammation. J Immunol. 2009;182:2416–2424. doi:10.4049/jimmunol.0801569
  • Kraft M, Brusselle G, FitzGerald JM, et al. Patient characteristics, biomarkers and exacerbation risk in severe, uncontrolled asthma. Eur Respir J. 2021;58:2100413. doi:10.1183/13993003.00413-2021
  • Broekema M, Volbeda F, Timens W, et al. Airway eosinophilia in remission and progression of asthma: accumulation with a fast decline of FEV(1). Respir Med. 2010;104:1254–1262. doi:10.1016/j.rmed.2010.03.030
  • Humbles AA, Lloyd CM, McMillan SJ, et al. A critical role for eosinophils in allergic airways remodeling. Science. 2004;305:1776–1779. doi:10.1126/science.1100283
  • Yang YC, Zhang N, Van Crombruggen K, Hu GH, Hong SL, Bachert C. Transforming growth factor-beta1 in inflammatory airway disease: a key for understanding inflammation and remodeling. Allergy. 2012;67:1193–1202. doi:10.1111/j.1398-9995.2012.02880.x
  • Kardas G, Daszynska-Kardas A, Marynowski M, Brzakalska O, Kuna P, Panek M. Role of Platelet-Derived Growth Factor (PDGF) in asthma as an immunoregulatory factor mediating airway remodeling and possible pharmacological target. Front Pharmacol. 2020;11:47. doi:10.3389/fphar.2020.00047
  • Louis R, Lau LC, Bron AO, Roldaan AC, Radermecker M, Djukanovic R. The relationship between airways inflammation and asthma severity. Am J Respir Crit Care Med. 2000;161:9–16. doi:10.1164/ajrccm.161.1.9802048
  • Shaw DE, Berry MA, Hargadon B, et al. Association between neutrophilic airway inflammation and airflow limitation in adults with asthma. Chest. 2007;132:1871–1875. doi:10.1378/chest.07-1047
  • Han YY, Forno E, Celedon JC. Sex steroid hormones and asthma in a nationwide study of U.S. adults. Am J Respir Crit Care Med. 2020;201:158–166. doi:10.1164/rccm.201905-0996OC
  • Senna G, Latorre M, Bugiani M, et al. Sex differences in severe asthma: results from severe asthma network in Italy-SANI. Allergy Asthma Immunol Res. 2021;13:219–228. doi:10.4168/aair.2021.13.2.219
  • Chowdhury NU, Guntur VP, Newcomb DC, Wechsler ME. Sex and gender in asthma. Eur Respir Rev. 2021;30:210067. doi:10.1183/16000617.0067-2021