Asthma Prevalence and Phenotyping in the General Population: The LEAD (Lung, hEart, sociAl, boDy) Study

References

• Dharmage SC, Perret JL, Custovic A. Epidemiology of Asthma in Children and Adults. Front Pediatr. 2019;7:246.
   PubMed Web of Science ®Google Scholar
• Disease GBD, Injury I, Prevalence C. Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet. 2017;390:1211–1259.
   PubMed Web of Science ®Google Scholar
• To T, Stanojevic S, Moores G, et al. Global asthma prevalence in adults: findings from the cross-sectional world health survey. BMC Public Health. 2012;12:204.
   PubMed Web of Science ®Google Scholar
• Asher I, Pearce N. Global burden of asthma among children. Int J Tuberc Lung Dis. 2014;18:1269–1278.
   PubMed Web of Science ®Google Scholar
• Battaglia S, Benfante A, Spatafora M, Scichilone N. Asthma in the elderly: a different disease? Breathe. 2016;12:18–28.
   Google Scholar
• Plaza V, Serra-Batlles J, Ferrer M, Morejon E. Quality of life and economic features in elderly asthmatics. Respiration. 2000;67:65–70.
   PubMed Web of Science ®Google Scholar
• Bellia V, Pedone C, Catalano F, et al. Asthma in the elderly: mortality rate and associated risk factors for mortality. Chest. 2007;132:1175–1182.
   PubMed Web of Science ®Google Scholar
• Chen M, Shepard K, Yang M, et al. Overlap of allergic, eosinophilic and type 2 inflammatory subtypes in moderate-to-severe asthma. Clin Exp Allergy. 2021;51:546–555.
   PubMed Web of Science ®Google Scholar
• Wenzel SE. Severe Adult Asthmas: integrating Clinical Features, Biology, and Therapeutics to Improve Outcomes. Am J Respir Crit Care Med. 2021;203:809–821.
   PubMed Web of Science ®Google Scholar
• Moore WC, Meyers DA, Wenzel SE, et al. Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program. Am J Respir Crit Care Med. 2010;181:315–323.
   PubMed Web of Science ®Google Scholar
• Shaw DE, Sousa AR, Fowler SJ, et al. Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort. Eur Respir J. 2015;46:1308–1321.
   PubMed Web of Science ®Google Scholar
• Loza MJ, Djukanovic R, Chung KF, et al. Validated and longitudinally stable asthma phenotypes based on cluster analysis of the ADEPT study. Respir Res. 2016;17:165.
   PubMed Web of Science ®Google Scholar
• Haldar P, Pavord ID, Shaw DE, et al. Cluster analysis and clinical asthma phenotypes. Am J Respir Crit Care Med. 2008;178:218–224.
   PubMed Web of Science ®Google Scholar
• Reddel HK, Bacharier LB, Bateman ED, et al. Global Initiative for Asthma Strategy 2021: executive Summary and Rationale for Key Changes. Am J Respir Crit Care Med. 2022;205:17–35.
   PubMed Web of Science ®Google Scholar
• Breyer-Kohansal R, Hartl S, Burghuber OC, et al. The LEAD (Lung, Heart, Social, Body) Study: objectives, Methodology, and External Validity of the Population-Based Cohort Study. J Epidemiol. 2019;29:315–324.
   PubMed Web of Science ®Google Scholar
• He X, Cheng G, He L, et al. Adults with current asthma but not former asthma have higher all-cause and cardiovascular mortality: a population-based prospective cohort study. Sci Rep. 2021;11:1329.
   PubMed Web of Science ®Google Scholar
• Eisner MD. Environmental tobacco smoke exposure and pulmonary function among adults in NHANES III: impact on the general population and adults with current asthma. Environ Health Perspect. 2002;110:765–770.
   PubMed Web of Science ®Google Scholar
• Nathan RA, Sorkness CA, Kosinski M, et al. Development of the asthma control test: a survey for assessing asthma control. J Allergy Clin Immunol. 2004;113:59–65.
   PubMed Web of Science ®Google Scholar
• Pellegrino R, Viegi G, Brusasco V, et al. Interpretative strategies for lung function tests. Eur Respir J. 2005;26:948–968.
   PubMed Web of Science ®Google Scholar
• Miller MR, Hankinson J, Brusasco V, et al. Standardisation of spirometry. Eur Respir J. 2005;26:319–338.
   PubMed Web of Science ®Google Scholar
• Hall GL, Filipow N, Ruppel G, et al. Official ERS Technical Standard: Global Lung Function Initiative Reference Values for Static Lung Volumes in Individuals of European Ancestry. Eur Respir J. 2021;57.
   Web of Science ®Google Scholar
• Quanjer PH, Stanojevic S, Cole TJ, et al. Initiative ERSGLF. Multi-ethnic reference values for spirometry for the 3-95-yr age range: the global lung function 2012 equations. Eur Respir J. 2012;40:1324–1343.
   PubMed Web of Science ®Google Scholar
• Crapo RO. Standardization of Spirometry, 1994 Update American Thoracic Society. Am J Respir Crit Care Med. 1994;1995(152):1107–1136.
   Google Scholar
• Kolli F, Breyer MK, Hartl S, et al. Aero-Allergen Sensitization in the General Population: longitudinal Analyses of the LEAD (Lung Heart Social Body) Study. J Asthma Allergy. 2022;15:461–473.
   PubMed Web of Science ®Google Scholar
• de Onis M, Onyango AW, Borghi E, Siyam A, Nishida C, Siekmann J. Development of a WHO growth reference for school-aged children and adolescents. Bull World Health Organ. 2007;85:660–667.
   PubMed Web of Science ®Google Scholar
• Ofenheimer A, Breyer-Kohansal R, Hartl S, et al. Reference values of body composition parameters and visceral adipose tissue (VAT) by DXA in adults aged 18-81 years-results from the LEAD cohort. Eur J Clin Nutr. 2020;74:1181–1191.
   PubMed Web of Science ®Google Scholar
• Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention; 2022. Available from: www.ginasthma.org. Accessed April 3, 2023.
   Google Scholar
• Brusselle GG, Koppelman GH. Biologic Therapies for Severe Asthma. N Engl J Med. 2022;386:157–171.
   PubMed Web of Science ®Google Scholar
• IBM. SPSS Statistics for Windows. Version 27.0 Ed. IBM Corp; 2020.
   Google Scholar
• Sears MR. Trends in the prevalence of asthma. Chest. 2014;145:219–225.
   PubMed Web of Science ®Google Scholar
• Bloom CI, Saglani S, Feary J, Jarvis D, Quint JK. Changing prevalence of current asthma and inhaled corticosteroid treatment in the UK: population-based cohort 2006-2016. Eur Respir J. 2019;53.
   Google Scholar
• Oraka E, Kim HJ, King ME, Callahan DB. Asthma prevalence among US elderly by age groups: age still matters. J Asthma. 2012;49:593–599.
   PubMed Web of Science ®Google Scholar
• Burr ML, Charles TJ, Roy K, Seaton A. Asthma in the elderly: an epidemiological survey. Br Med J. 1979;1:1041–1044.
   PubMed Web of Science ®Google Scholar
• Baptist AP, Busse PJ. Asthma Over the Age of 65: all’s Well That Ends Well. J Allergy Clin Immunol Pract. 2018;6:764–773.
   PubMed Web of Science ®Google Scholar
• Burrows B, Barbee RA, Cline MG, Knudson RJ, Lebowitz MD. Characteristics of asthma among elderly adults in a sample of the general population. Chest. 1991;100:935–942.
   PubMed Web of Science ®Google Scholar
• Gillman A, Douglass JA. Asthma in the elderly. Asia Pac Allergy. 2012;2:101–108.
   PubMedGoogle Scholar
• Bauer BA, Reed CE, Yunginger JW, Wollan PC, Silverstein MD. Incidence and outcomes of asthma in the elderly. A population-based study in Rochester, Minnesota. Chest. 1997;111:303–310.
   PubMed Web of Science ®Google Scholar
• Pakkasela J, Ilmarinen P, Honkamaki J, et al. Age-specific incidence of allergic and non-allergic asthma. BMC Pulm Med. 2020;20:9.
   PubMed Web of Science ®Google Scholar
• Douwes J, Gibson P, Pekkanen J, Pearce N. Non-eosinophilic asthma: importance and possible mechanisms. Thorax. 2002;57:643–648.
   PubMed Web of Science ®Google Scholar
• Esteban-Gorgojo I, Antolin-Amerigo D, Dominguez-Ortega J, Quirce S. Non-eosinophilic asthma: current perspectives. J Asthma Allergy. 2018;11:267–281.
   PubMed Web of Science ®Google Scholar
• Woodruff PG, Modrek B, Choy DF, et al. T-helper type 2-driven inflammation defines major subphenotypes of asthma. Am J Respir Crit Care Med. 2009;180:388–395.
   PubMed Web of Science ®Google Scholar
• Tzortzaki EG, Proklou A, Siafakas NM. Asthma in the Elderly: can We Distinguish It from COPD? J Allergy (Cairo). 2011;2011:843543.
   PubMedGoogle Scholar
• Chen Y, Dales R, Jiang Y. The association between obesity and asthma is stronger in nonallergic than allergic adults. Chest. 2006;130:890–895.
   PubMed Web of Science ®Google Scholar
• Chen Y, Rennie D, Cormier Y, Dosman J. Atopy, obesity, and asthma in adults: the Humboldt study. J Agromedicine. 2009;14:222–227.
   PubMed Web of Science ®Google Scholar
• Benson VS, Hartl S, Barnes N, Galwey N, Van Dyke MK, Kwon N. Blood eosinophil counts in the general population and airways disease: a comprehensive review and meta-analysis. Eur Respir J. 2022;1:59.
   Google Scholar
• Beuther DA, Sutherland ER. Overweight, obesity, and incident asthma: a meta-analysis of prospective epidemiologic studies. Am J Respir Crit Care Med. 2007;175:661–666.
   PubMed Web of Science ®Google Scholar
• Khalid F, Holguin F. A review of obesity and asthma across the life span. J Asthma. 2018;55:1286–1300.
   PubMed Web of Science ®Google Scholar
• Sideleva O, Black K, Dixon AE. Effects of obesity and weight loss on airway physiology and inflammation in asthma. Pulm Pharmacol Ther. 2013;26:455–458.
   PubMed Web of Science ®Google Scholar
• Moitra S, Carsin AE, Abramson MJ, et al. Long-term effect of asthma on the development of obesity among adults: an international cohort study, ECRHS. Thorax. 2022;1:54.
   Google Scholar
• Lang JE, Hossain J, Dixon AE, et al. American Lung Association-Asthma Clinical Research C. Does age impact the obese asthma phenotype? Longitudinal asthma control, airway function, and airflow perception among mild persistent asthmatics. Chest. 2011;140:1524–1533.
   PubMed Web of Science ®Google Scholar
• Yang MS, Choi S, Choi Y, Jin KN. Association Between Airway Parameters and Abdominal Fat Measured via Computed Tomography in Asthmatic Patients. Allergy Asthma Immunol Res. 2018;10:503–515.
   PubMed Web of Science ®Google Scholar
• Shuster A, Patlas M, Pinthus JH, Mourtzakis M. The clinical importance of visceral adiposity: a critical review of methods for visceral adipose tissue analysis. Br J Radiol. 2012;85:1–10.
   PubMed Web of Science ®Google Scholar
• Peters U, Dixon AE, Forno E. Obesity and asthma. J Allergy Clin Immunol. 2018;141:1169–1179.
   PubMed Web of Science ®Google Scholar
• Lenoir M, Williamson A, Stanford RH, Stempel DA. Assessment of asthma control in a general population of asthmatics. Curr Med Res Opin. 2006;22:17–22.
   PubMed Web of Science ®Google Scholar
• von Bulow A, Kriegbaum M, Backer V, Porsbjerg C. The prevalence of severe asthma and low asthma control among Danish adults. J Allergy Clin Immunol Pract. 2014;2:759–767.
   PubMed Web of Science ®Google Scholar
• Backman H, Jansson SA, Stridsman C, et al. Severe asthma-A population study perspective. Clin Exp Allergy. 2019;49:819–828.
   PubMed Web of Science ®Google Scholar
• Schleich F, Brusselle G, Louis R, et al. Heterogeneity of phenotypes in severe asthmatics. The Belgian Severe Asthma Registry (BSAR). Respir Med. 2014;108:1723–1732.
   PubMed Web of Science ®Google Scholar
• Mullerova H, Cockle SM, Gunsoy NB, Nelsen LM, Albers FC. Clinical characteristics and burden of illness among adolescent and adult patients with severe asthma by asthma control: the IDEAL study. J Asthma. 2021;58:459–470.
   PubMed Web of Science ®Google Scholar
• Reddel HK, Bateman ED, Becker A, et al. A summary of the new GINA strategy: a roadmap to asthma control. Eur Respir J. 2015;46:622–639.
   PubMed Web of Science ®Google Scholar
• Aaron SD, Vandemheen KL, Boulet LP, et al. Canadian Respiratory Clinical Research C. Overdiagnosis of asthma in obese and nonobese adults. CMAJ. 2008;179:1121–1131.
   PubMed Web of Science ®Google Scholar
• Janson C, Malinovschi A, Amaral AFS, et al. Bronchodilator reversibility in asthma and COPD: findings from three large population studies. Eur Respir J. 2019;4:54.
   Google Scholar
• Arbes SJ. Do all asthmatics with atopy have atopic asthma? J Allergy Clin Immunol. 2012;130:1202–1204.
   PubMed Web of Science ®Google Scholar