Implications of Atopic Dermatitis on the Quality of Life of 6–11 Years Old Children and Caregivers (PEDI-BURDEN)

References

• Silverberg JI, Barbarot S, Gadkari A, et al. Atopic dermatitis in the pediatric population. Ann Allergy Asthma Immunol. 2021;126(4):417–428.e2. doi:10.1016/j.anai.2020.12.020
   PubMed Web of Science ®Google Scholar
• Weidinger S, Beck LA, Bieber T, Kabashima K, Irvine AD. Atopic dermatitis. Nat Rev Dis Primers. 2018;4:1. doi:10.1038/s41572-018-0001-z
   PubMed Web of Science ®Google Scholar
• Langan SM, Irvine AD, Weidinger S. Atopic dermatitis. Lancet. 2020;396(10247):345–360. doi:10.1016/S0140-6736(20)31286-1
   PubMed Web of Science ®Google Scholar
• Girolomoni G, de Bruin-Weller M, Aoki V, et al. Nomenclature and clinical phenotypes of atopic dermatitis. Ther Adv Chronic Dis. 2021;12:20406223211002979. doi:10.1177/20406223211002979
   Web of Science ®Google Scholar
• Silverberg JI, Gelfand JM, Margolis DJ, et al. Patient burden and quality of life in atopic dermatitis in US adults. Ann Allergy Asthma Immunol. 2018;121(3):340–347. doi:10.1016/j.anai.2018.07.006
   PubMed Web of Science ®Google Scholar
• Simpson EL, Bieber T, Eckert L, et al. Patient burden of moderate to severe atopic dermatitis (AD): insights from a phase 2b clinical trial of dupilumab in adults. J Am Acad Dermatol. 2016;74(3):491–498. doi:10.1016/j.jaad.2015.10.043
   PubMed Web of Science ®Google Scholar
• Mollanazar NK, Smith PK, Yosipovitch G. Mediators of chronic pruritus in atopic dermatitis: getting the itch out? Clin Rev Allergy Immunol. 2016;51(3):263–292.
   PubMed Web of Science ®Google Scholar
• Bawany F, Northcott CA, Beck LA, Pigeon WR, Disturbances S. Atopic dermatitis: relationships, methods for assessment, and therapies. J Allergy Clin Immunol Pract. 2021;9(4):1488–1500. doi:10.1016/j.jaip.2020.12.007
   PubMed Web of Science ®Google Scholar
• Camfferman D, Kennedy JD, Gold M, Martin AJ, Lushington K. Eczema and sleep and its relationship to daytime functioning in children. Sleep Med Rev. 2010;14(6):359–369. doi:10.1016/j.smrv.2010.01.004
   PubMed Web of Science ®Google Scholar
• Na CH, Chung J, Simpson EL. Quality of life and disease impact of atopic dermatitis and psoriasis on children and their families. Children. 2019;6(12):133. doi:10.3390/children6120133
   PubMedGoogle Scholar
• Slattery MJ, Essex MJ, Paletz EM, et al. Depression, anxiety, and dermatologic quality of life in adolescents with atopic dermatitis. J Allergy Clin Immunol. 2011;128(3):668–671. doi:10.1016/j.jaci.2011.05.003
   PubMed Web of Science ®Google Scholar
• Fishbein AB, Cheng BT, Tilley CC, et al. Sleep disturbance in school-aged children with atopic dermatitis: prevalence and severity in a cross-sectional sample. J Allergy Clin Immunol Pract. 2021;9(8):3120–3129.e3. doi:10.1016/j.jaip.2021.04.064
   PubMed Web of Science ®Google Scholar
• Kelly KA, Balogh EA, Kaplan SG, Feldman SR. Skin disease in children: effects on quality of life, stigmatization, bullying, and suicide risk in pediatric acne, atopic dermatitis, and psoriasis patients. Children. 2021;8(11):1057. doi:10.3390/children8111057
   PubMedGoogle Scholar
• Kern C, Wan J, LeWinn KZ, et al. Association of atopic dermatitis and mental health outcomes across childhood: a longitudinal cohort study. JAMA Dermatol. 2021;157(10):1200–1208. doi:10.1001/jamadermatol.2021.2657
   PubMed Web of Science ®Google Scholar
• Brenninkmeijer EEA, Legierse CM, Sillevis Smitt JH, Last BF, Grootenhuis MA, Bos JD. The course of life of patients with childhood atopic dermatitis. Pediatr Dermatol. 2009;26(1):14–22. doi:10.1111/j.1525-1470.2008.00745.x
   PubMed Web of Science ®Google Scholar
• Magin P. Appearance-related bullying and skin disorders. Clin Dermatol. 2013;31(1):66–71. doi:10.1016/j.clindermatol.2011.11.009
   PubMed Web of Science ®Google Scholar
• Chernyshov PV. Stigmatization and self-perception in children with atopic dermatitis. Clin Cosmet Investig Dermatol. 2016;9:159–166. doi:10.2147/CCID.S91263
   PubMedGoogle Scholar
• Hon KLE, Leung TF, Wong KY, Chow CM, Chuh A, Ng PC. Does age or gender influence quality of life in children with atopic dermatitis? Clin Exp Dermatol. 2008;33(6):705–709. doi:10.1111/j.1365-2230.2008.02853.x
   PubMed Web of Science ®Google Scholar
• Lawson V, Lewis‐Jones MS, Finlay AY, Reid P, Owens RG. The family impact of childhood atopic dermatitis: the dermatitis family impact questionnaire. Br J Dermatol. 1998;138(1):107–113. doi:10.1046/j.1365-2133.1998.02034.x
   PubMed Web of Science ®Google Scholar
• Zuberbier T, Orlow SJ, Paller AS, et al. Patient perspectives on the management of atopic dermatitis. J Allergy Clin Immunol. 2006;118(1):226–232. doi:10.1016/j.jaci.2006.02.031
   PubMed Web of Science ®Google Scholar
• Stingeni L, Belloni Fortina A, Baiardini I, Hansel K, Moretti D, Cipriani F. Atopic dermatitis and patient perspectives: insights of bullying at school and career discrimination at work. J Asthma Allergy. 2021;14:919–928. doi:10.2147/JAA.S317009
   PubMed Web of Science ®Google Scholar
• Balkrishnan R, Housman TS, Grummer S, et al. The family impact of atopic dermatitis in children: the role of the parent caregiver. Pediatr Dermatol. 2003;20(1):5–10. doi:10.1046/j.1525-1470.2003.03002.x
   PubMed Web of Science ®Google Scholar
• Carroll CL, Balkrishnan R, Feldman SR, Fleischer AB Jr, Manuel JC. The burden of atopic dermatitis: impact on the patient, family, and society. Pediatr Dermatol. 2005;22(3):192–199. doi:10.1111/j.1525-1470.2005.22303.x
   PubMed Web of Science ®Google Scholar
• Yang EJ, Beck KM, Sekhon S, Bhutani T, Koo J. The impact of pediatric atopic dermatitis on families: a review. Pediatr Dermatol. 2018;36(1):66–71. doi:10.1111/pde.13727
   PubMed Web of Science ®Google Scholar
• Capozza K, Gadd H, Kelley K, Russell S, Shi V, Schwartz A. Insights from caregivers on the impact of pediatric atopic dermatitis on families: “I’m tired, overwhelmed, and feel like i’m failing as a mother”. Dermatitis. 2020;31(3):223–227. doi:10.1097/DER.0000000000000582
   PubMed Web of Science ®Google Scholar
• Barbarot S, Silverberg JI, Gadkari A. Pediatric population: results from an international cross-sectional study. J Pediatr. 2022;246:220–226.e5. doi:10.1016/j.jpeds.2022.04.027
   PubMed Web of Science ®Google Scholar
• Girolomoni G, Abeni D, Masini C, et al. The epidemiology of atopic dermatitis in Italian schoolchildren. Allergy. 2003;58(5):420–425. doi:10.1034/j.1398-9995.2003.00112.x
   PubMed Web of Science ®Google Scholar
• Ricci G, Bendandi B, Bellini F, Patrizi A, Masi M. Atopic dermatitis: quality of life of young Italian children and their families and correlation with severity score. Pediatr Allergy Immunol. 2007;18(3):245–249. doi:10.1111/j.1399-3038.2006.00502.x
   PubMed Web of Science ®Google Scholar
• Monti F, Agostini F, Gobbi F, Neri E, Schianchi S, Arcangeli F. Quality of life measures in Italian children with atopic dermatitis and their families. Ital J Pediatr. 2011;37(1):59. doi:10.1186/1824-7288-37-59
   PubMedGoogle Scholar
• Lewis-Jones MS, Finlay AY. The Children’s Dermatology Life Quality Index (CDLQI): initial validation and practical use. Br J Dermatol. 1995;132(6):942–949. doi:10.1111/j.1365-2133.1995.tb16953.x
   PubMed Web of Science ®Google Scholar
• Berry JO, Jones WH. The parental stress scale: initial psychometric evidence. J Soc Pers Relat. 1995;12(3):463–472. doi:10.1177/0265407595123009
   Web of Science ®Google Scholar
• Thomas KS, Apfelbacher CA, Chalmers JR, et al. Recommended core outcome instruments for health-related quality of life, long-term control and itch intensity in atopic eczema trials: results of the HOME VII consensus meeting. Br J Dermatol. 2020;185:139–146. doi:10.1111/bjd.19751
   Web of Science ®Google Scholar
• Asher MI, Keil U, Anderson HR, et al. International Study of Asthma and Allergies in Childhood (ISAAC): rationale and methods. Eur Respir J. 1995;8(3):483–491. doi:10.1183/09031936.95.08030483
   PubMed Web of Science ®Google Scholar
• Weidinger S, Simpson EL, Eckert L, et al. 15115 The patient-reported disease burden in pediatric patients with atopic dermatitis: a cross-sectional study in the United States, Canada, Europe, and Japan. J Am Acad Dermatol. 2020;83(6):AB29. doi:10.1016/j.jaad.2020.06.203
   Web of Science ®Google Scholar
• Yaghmaie P, Koudelka CW, Simpson EL. Mental health comorbidity in patients with atopic dermatitis. J Allergy Clin Immunol. 2013;131(2):428–433. doi:10.1016/j.jaci.2012.10.041
   PubMed Web of Science ®Google Scholar
• Strom MA, Fishbein AB, Paller AS, Silverberg JI. Association between atopic dermatitis and attention deficit hyperactivity disorder in U.S. children and adults. Br J Dermatol. 2016;175(5):920–929. doi:10.1111/bjd.14697
   PubMed Web of Science ®Google Scholar
• Ben-Gashir MA, Seed PT, Hay RJ. Quality of life and disease severity are correlated in children with atopic dermatitis. Br J Dermatol. 2004;150(2):284–290. doi:10.1111/j.1365-2133.2004.05776.x
   PubMed Web of Science ®Google Scholar
• Chernyshov PV, Ho RC, Monti F, et al. An international multi-center study on self-assessed and family quality of life in children with atopic dermatitis. Acta Dermatovenerol Croat. 2015;23(4):247–253.
   PubMed Web of Science ®Google Scholar
• Xie Q-W, Chan CL, Chan CH. The wounded self-lonely in a crowd: a qualitative study of the voices of children living with atopic dermatitis in Hong Kong. Health Soc Care Community. 2020;28(3):862–873. doi:10.1111/hsc.12917
   PubMed Web of Science ®Google Scholar
• Silverberg J, Simpson E, Weidinger S, et al. Children With Atopic Dermatitis (AD) have a high burden of atopic comorbidities: results from a large worldwide survey. J Allergy Clin Immunol. 2021;147(2):AB31. doi:10.1016/j.jaci.2020.12.149
   Web of Science ®Google Scholar
• Gilaberte Y, Pérez-Gilaberte JB, Poblador-Plou B, Bliek-Bueno K, Gimeno-Miguel A, Prados-Torres A. Prevalence and comorbidity of atopic dermatitis in children: a large-scale population study based on real-world data. J Clin Med. 2020;9:6. doi:10.3390/jcm9061632
   Web of Science ®Google Scholar
• Ravn NH, Halling A-S, Berkowitz AG, et al. How does parental history of atopic disease predict the risk of atopic dermatitis in a child? A systematic review and meta-analysis. J Allergy Clin Immunol. 2020;145(4):1182–1193. doi:10.1016/j.jaci.2019.12.899
   PubMed Web of Science ®Google Scholar
• Daud LR, Garralda ME, David TJ. Psychosocial adjustment in preschool children with atopic eczema. Arch Dis Child. 1993;69(6):670–676. doi:10.1136/adc.69.6.670
   PubMed Web of Science ®Google Scholar
• El Hachem M, Gesualdo F, Ricci G, et al. Topical corticosteroid phobia in parents of pediatric patients with atopic dermatitis: a multicentre survey. Ital J Pediatr. 2017;43(1):22. doi:10.1186/s13052-017-0330-7
   PubMedGoogle Scholar
• Kojima R, Fujiwara T, Matsuda A, et al. Factors associated with steroid phobia in caregivers of children with atopic dermatitis. Pediatr Dermatol. 2013;30(1):29–35. doi:10.1111/j.1525-1470.2012.01808.x
   PubMed Web of Science ®Google Scholar
• Ezzedine K, Shourick J, Merhand S, Sampogna F, Taieb C. Perceived clinical severity of atopic dermatitis in adolescents: comparison between patients’ and parents’ evaluation. J Am Acad Dermatol. 2021;84(1):164–165. doi:10.1016/j.jaad.2020.04.037
   PubMed Web of Science ®Google Scholar
• Xu X, Olsson M, Bajpai R, et al. Concordance between physician-rated and caregiver-perceived disease severity in children with atopic dermatitis: a cross-sectional study. Acta Derm Venereol. 2020;100(18):adv00308. doi:10.2340/00015555-3540
   PubMedGoogle Scholar
• Lewis-Jones S. Quality of life and childhood atopic dermatitis: the misery of living with childhood eczema. Int J Clin Pract. 2006;60(8):984–992. doi:10.1111/j.1742-1241.2006.01047.x
   PubMed Web of Science ®Google Scholar
• Vivar KL, Kruse L. The impact of pediatric skin disease on self-esteem. Int J Womens Dermatol. 2017;4(1):27–31. doi:10.1016/j.ijwd.2017.11.002
   PubMedGoogle Scholar
• Silverberg JI. Associations between atopic dermatitis and other disorders. F1000Res. 2018;7:303. doi:10.12688/f1000research.12975.1
   PubMedGoogle Scholar
• Capozza K, Funk M, Hering M, et al. Patients’ and caregivers’ experiences with atopic dermatitis-related burden, medical care, and treatments in 8 countries. J Allergy Clin Immunol Pract. 2022;11(1):264–273.
   PubMed Web of Science ®Google Scholar