Exploration and Validation of Potential Biomarkers and Therapeutic Targets in Ferroptosis of Asthma

References

• Mohan A, Ludwig A, Brehm C, Lugogo NL, Sumino K, Hanania NA. Revisiting mild asthma: current knowledge and future needs. Chest. 2022;161(1):26–39. doi:10.1016/j.chest.2021.09.004
   PubMed Web of Science ®Google Scholar
• Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention, 2022 (GINA, 2022). Available from: https://ginasthma.org/. Accessed February 26, 2023.
   Google Scholar
• Rupani H, Fong WCG, Kyyaly A, Kurukulaaratchy RJ. Recent insights into the management of inflammation in asthma. J Inflamm Res. 2021;14:4371–4397. doi:10.2147/JIR.S295038
   PubMed Web of Science ®Google Scholar
• Dixon SJ, Lemberg KM, Lamprecht MR, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012;149(5):1060–1072. doi:10.1016/j.cell.2012.03.042
   PubMed Web of Science ®Google Scholar
• Angeli JPF, Shah R, Pratt DA, Conrad M. Ferroptosis inhibition: mechanisms and opportunities. Trends Pharmacol Sci. 2017;38(5):489–498. doi:10.1016/j.tips.2017.02.005
   PubMed Web of Science ®Google Scholar
• Li J, Cao F, Yin HL, et al. Ferroptosis: past, present and future. Cell Death Dis. 2020;11(2):88. doi:10.1038/s41419-020-2298-2
   PubMed Web of Science ®Google Scholar
• Brown CW, Amante JJ, Chhoy P, et al. Prominin2 drives ferroptosis resistance by stimulating iron export. Dev Cell. 2019;51(5):575–586.e4. doi:10.1016/j.devcel.2019.10.007
   PubMed Web of Science ®Google Scholar
• Yang WS, Kim KJ, Gaschler MM, Patel M, Shchepinov MS, Stockwell BR. Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis. Proc Natl Acad Sci U S A. 2016;113(34):E4966–E4975. doi:10.1073/pnas.1603244113
   PubMed Web of Science ®Google Scholar
• Dixon SJ, Patel DN, Welsch M, et al. Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis. Elife. 2014;3:e02523. doi:10.7554/eLife.02523
   PubMed Web of Science ®Google Scholar
• Ajoolabady A, Aslkhodapasandhokmabad H, Libby P, et al. Ferritinophagy and ferroptosis in the management of metabolic diseases. Trends Endocrinol Metab. 2021;32(7):444–462. doi:10.1016/j.tem.2021.04.010
   PubMed Web of Science ®Google Scholar
• Fang X, Wang H, Han D, et al. Ferroptosis as a target for protection against cardiomyopathy. Proc Natl Acad Sci U S A. 2019;116(7):2672–2680. doi:10.1073/pnas.1821022116
   PubMed Web of Science ®Google Scholar
• Mahoney-Sanchez L, Bouchaoui H, Boussaad I, et al. Alpha synuclein determines ferroptosis sensitivity in dopaminergic neurons via modulation of ether-phospholipid membrane composition. Cell Rep. 2022;40(8):111231. doi:10.1016/j.celrep.2022.111231
   PubMed Web of Science ®Google Scholar
• Xie J, Zhang T, Li P, Wang D, Liu T, Xu S. Dihydromyricetin attenuates cerebral ischemia reperfusion injury by inhibiting SPHK1/mTOR signaling and targeting ferroptosis. Drug Des Devel Ther. 2022;16:3071–3085. doi:10.2147/DDDT.S378786
   PubMed Web of Science ®Google Scholar
• Walters R, Mousa SA. Modulations of ferroptosis in lung cancer therapy. Expert Opin Ther Targets. 2022;26(2):133–143. doi:10.1080/14728222.2022.2032651
   PubMed Web of Science ®Google Scholar
• Lv X, Dong M, Tang W, et al. Ferroptosis, novel therapeutics in asthma. Biomed Pharmacother. 2022;153:113516. doi:10.1016/j.biopha.2022.113516
   PubMed Web of Science ®Google Scholar
• Yang N, Shang Y. Ferrostatin-1 and 3-methyladenine ameliorate ferroptosis in OVA-induced asthma model and in IL-13-challenged BEAS-2B cells. Oxid Med Cell Longev. 2022;2022:9657933. doi:10.1155/2022/9657933
   PubMed Web of Science ®Google Scholar
• Han F, Li S, Yang Y, Bai Z. Interleukin-6 promotes ferroptosis in bronchial epithelial cells by inducing reactive oxygen species-dependent lipid peroxidation and disrupting iron homeostasis. Bioengineered. 2021;12(1):5279–5288. doi:10.1080/21655979.2021.1964158
   PubMed Web of Science ®Google Scholar
• Tang W, Dong M, Teng F, et al. Environmental allergens house dust mite-induced asthma is associated with ferroptosis in the lungs. Exp Ther Med. 2021;22(6):1483. doi:10.3892/etm.2021.10918
   PubMed Web of Science ®Google Scholar
• Zeng Z, Huang H, Zhang J, et al. HDM induce airway epithelial cell ferroptosis and promote inflammation by activating ferritinophagy in asthma. FASEB J. 2022;36(6):e22359. doi:10.1096/fj.202101977RR
   PubMed Web of Science ®Google Scholar
• Bao C, Liu C, Liu Q, et al. Liproxstatin-1 alleviates LPS/IL-13-induced bronchial epithelial cell injury and neutrophilic asthma in mice by inhibiting ferroptosis. Int Immunopharmacol. 2022;109:108770. doi:10.1016/j.intimp.2022.108770
   PubMed Web of Science ®Google Scholar
• Wang Y, Wan R, Peng W, Zhao X, Bai W, Hu C. Quercetin alleviates ferroptosis accompanied by reducing M1 macrophage polarization during neutrophilic airway inflammation. Eur J Pharmacol. 2023;938:175407. doi:10.1016/j.ejphar.2022.175407
   PubMed Web of Science ®Google Scholar
• Hänzelmann S, Castelo R, Guinney J. GSVA: gene set variation analysis for microarray and RNA-seq data. BMC Bioinform. 2013;14(1):7. doi:10.1186/1471-2105-14-7
   PubMed Web of Science ®Google Scholar
• Newman AM, Liu CL, Green MR, et al. Robust enumeration of cell subsets from tissue expression profiles. Nat Methods. 2015;12(5):453–457. doi:10.1038/nmeth.3337
   PubMed Web of Science ®Google Scholar
• Freshour SL, Kiwala S, Cotto KC, et al. Integration of the drug-gene interaction database (DGIdb 4.0) with open crowdsource efforts. Nucleic Acids Res. 2021;49(D1):D1144–D1151. doi:10.1093/nar/gkaa1084
   PubMed Web of Science ®Google Scholar
• Lin Q, Ni H, Zheng Z, Zhong J, Nie H. Cross-talk of four types of RNA modification writers defines the immune microenvironment in severe asthma. Ann N Y Acad Sci. 2022;1514(1):93–103. doi:10.1111/nyas.14782
   PubMed Web of Science ®Google Scholar
• Min Z, Zeng Y, Zhu T, et al. Lipopolysaccharide-activated bone marrow-derived dendritic cells suppress allergic airway inflammation by ameliorating the immune microenvironment. Front Immunol. 2021;12:595369. doi:10.3389/fimmu.2021.595369
   PubMed Web of Science ®Google Scholar
• Ntontsi P, Photiades A, Zervas E, Xanthou G, Samitas K. Genetics and Epigenetics in Asthma. Int J Mol Sci. 2021;22(5):2412. doi:10.3390/ijms22052412
   PubMed Web of Science ®Google Scholar
• Bønnelykke K, Ober C. Leveraging gene-environment interactions and endotypes for asthma gene discovery. J Allergy Clin Immunol. 2016;137(3):667–679. doi:10.1016/j.jaci.2016.01.006
   PubMed Web of Science ®Google Scholar
• Wen X, Liu HX, Chen LZ, et al. Asthma susceptibility in prenatal nicotine-exposed mice attributed to β-catenin increase during CD4+ T cell development. Ecotoxicol Environ Saf. 2022;238:113572. doi:10.1016/j.ecoenv.2022.113572
   PubMed Web of Science ®Google Scholar
• Nguyen LP, Al-Sawalha NA, Parra S, et al. β2-Adrenoceptor signaling in airway epithelial cells promotes eosinophilic inflammation, mucous metaplasia, and airway contractility. Proc Natl Acad Sci U S A. 2017;114(43):E9163–E9171. doi:10.1073/pnas.1710196114
   PubMed Web of Science ®Google Scholar
• Fayon M, Rebola M, Berger P, et al. Increased secretion of leukemia inhibitory factor by immature airway smooth muscle cells enhances intracellular signaling and airway contractility. Am J Physiol Lung Cell Mol Physiol. 2006;291(2):L244–L251. doi:10.1152/ajplung.00474.2005
   PubMed Web of Science ®Google Scholar
• Friedmann Angeli JP, Schneider M, Proneth B, et al. Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat Cell Biol. 2014;16(12):1180–1191. doi:10.1038/ncb3064
   PubMed Web of Science ®Google Scholar
• Imai H, Hirao F, Sakamoto T, et al. Early embryonic lethality caused by targeted disruption of the mouse PHGPx gene. Biochem Biophys Res Commun. 2003;305(2):278–286. doi:10.1016/s0006-291x(03)00734-4
   PubMed Web of Science ®Google Scholar
• Zhao J, Dar HH, Deng Y, et al. PEBP1 acts as a rheostat between prosurvival autophagy and ferroptotic death in asthmatic epithelial cells. Proc Natl Acad Sci U S A. 2020;117(25):14376–14385. doi:10.1073/pnas.1921618117
   PubMed Web of Science ®Google Scholar
• Michaeloudes C, Abubakar-Waziri H, Lakhdar R, et al. Molecular mechanisms of oxidative stress in asthma. Mol Aspects Med. 2022:85. doi:10.1016/j.mam.2021.101026
   Web of Science ®Google Scholar
• Holgate ST. Innate and adaptive immune responses in asthma. Nat Med. 2012;18(5):673–683. doi:10.1038/nm.2731
   PubMed Web of Science ®Google Scholar
• Xue Q, Yan D, Chen X, et al. Copper-dependent autophagic degradation of GPX4 drives ferroptosis. Autophagy. 2023;19(7):1982–1996. doi:10.1080/15548627.2023.2165323
   PubMed Web of Science ®Google Scholar
• Zou Y, Henry WS, Ricq EL, et al. Plasticity of ether lipids promotes ferroptosis susceptibility and evasion. Nature. 2020;585(7826):603–608. doi:10.1038/s41586-020-2732-8
   PubMed Web of Science ®Google Scholar
• Luoqian J, Yang W, Ding X, et al. Ferroptosis promotes T-cell activation-induced neurodegeneration in multiple sclerosis. Cell Mol Immunol. 2022;19(8):913–924. doi:10.1038/s41423-022-00883-0
   PubMed Web of Science ®Google Scholar
• Xu C, Sun S, Johnson T, et al. The glutathione peroxidase Gpx4 prevents lipid peroxidation and ferroptosis to sustain Treg cell activation and suppression of antitumor immunity. Cell Rep. 2021;35(11):109235. doi:10.1016/j.celrep.2021.109235
   PubMed Web of Science ®Google Scholar
• Wu Y, Chen H, Xuan N, et al. Induction of ferroptosis-like cell death of eosinophils exerts synergistic effects with glucocorticoids in allergic airway inflammation. Thorax. 2020;75(11):918–927. doi:10.1136/thoraxjnl-2020-214764
   PubMed Web of Science ®Google Scholar
• Lin Z, Song J, Gao Y, et al. Hypoxia-induced HIF-1α/lncRNA-PMAN inhibits ferroptosis by promoting the cytoplasmic translocation of ELAVL1 in peritoneal dissemination from gastric cancer. Redox Biol. 2022;52:102312. doi:10.1016/j.redox.2022.102312
   PubMed Web of Science ®Google Scholar
• Techasintana P, Ellis JS, Glascock J, et al. The RNA-binding protein HuR posttranscriptionally regulates IL-2 homeostasis and CD4+ Th2 differentiation. Immunohorizons. 2017;1(6):109–123. doi:10.4049/immunohorizons.1700017
   PubMedGoogle Scholar
• Fattahi F, Ellis JS, Sylvester M, et al. HuR-targeted inhibition impairs Th2 proinflammatory responses in asthmatic CD4+ T cells. J Immunol. 2022;208(1):38–48. doi:10.4049/jimmunol.2100635
   PubMed Web of Science ®Google Scholar
• Rezaee F, Harford TJ, Linfield DT, et al. cAMP-dependent activation of protein kinase A attenuates respiratory syncytial virus-induced human airway epithelial barrier disruption. PLoS One. 2017;12(7):e0181876. doi:10.1371/journal.pone.0181876
   PubMed Web of Science ®Google Scholar
• Koschinski A, Zaccolo M. Activation of PKA in cell requires higher concentration of cAMP than in vitro: implications for compartmentalization of cAMP signalling. Sci Rep. 2017;7(1):14090. doi:10.1038/s41598-017-13021-y
   PubMedGoogle Scholar
• Su H, Xie J, Wen L, et al. LncRNA Gas5 regulates Fn1 deposition via Creb5 in renal fibrosis. Epigenomics. 2021;13(9):699–713. doi:10.2217/epi-2020-0449
   PubMedGoogle Scholar
• L X, Kg N, La S, et al. Single-cell RNA transcriptomic analysis identifies Creb5 and CD11b-DCs as regulator of asthma exacerbations. Mucosal Immunol. 2022;15(6). doi:10.1038/s41385-022-00556-1
   Web of Science ®Google Scholar
• Ercolani L, Ferrari A, De Mei C, Parodi C, Wade M, Grimaldi B. Circadian clock: time for novel anticancer strategies? Pharmacol Res. 2015;100:288–295. doi:10.1016/j.phrs.2015.08.008
   PubMed Web of Science ®Google Scholar
• Powell WT, Rich LM, Vanderwall ER, White MP, Debley JS. Temperature synchronisation of circadian rhythms in primary human airway epithelial cells from children. BMJ Open Respir Res. 2022;9(1):e001319. doi:10.1136/bmjresp-2022-001319
   PubMed Web of Science ®Google Scholar
• Palmieri C, Gillmore R, Menzies-Gow A, et al. Resolution of late-onset asthma following high-dose chemotherapy. Bone Marrow Transplant. 2003;32(8):847–848. doi:10.1038/sj.bmt.1704268
   PubMed Web of Science ®Google Scholar
• Xia T, Ma J, Sun Y, Sun Y. Androgen receptor suppresses inflammatory response of airway epithelial cells in allergic asthma through MAPK1 and MAPK14. Hum Exp Toxicol. 2022;41:9603271221121320. doi:10.1177/09603271221121320
   Web of Science ®Google Scholar
• Ejima A, Abe S, Shimba A, et al. Androgens alleviate allergic airway inflammation by suppressing cytokine production in Th2 cells. J Immunol. 2022;209(6):1083–1094. doi:10.4049/jimmunol.2200294
   PubMed Web of Science ®Google Scholar
• Gandhi VD, Cephus JY, Norlander AE, et al. Androgen receptor signaling promotes Treg suppressive function during allergic airway inflammation. J Clin Invest. 2022;132(4):e153397. doi:10.1172/JCI153397
   PubMed Web of Science ®Google Scholar
• Cerqua I, Terlizzi M, Bilancia R, et al. 5α-dihydrotestosterone abrogates sex bias in asthma like features in the mouse. Pharmacol Res. 2020;158:104905. doi:10.1016/j.phrs.2020.104905
   PubMed Web of Science ®Google Scholar