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ORIGINAL RESEARCH

Interleukin-4 (C590T) Gene Polymorphism in Association with Asthma Severity

, ORCID Icon &
Pages 1269-1278 | Received 11 Jul 2023, Accepted 10 Nov 2023, Published online: 20 Nov 2023

References

  • Stern J, Pier J, Litonjua AA. Asthma epidemiology and risk factors. Semin Immunopathol. 2020;42(1):5–15. PMID: 32020334. doi:10.1007/s00281-020-00785-1
  • Ahmed H, Turner S. Severe asthma in children-a review of definitions, epidemiology, and treatment options in 2019. Pediatr Pulmonol. 2019;54(6):778–787. PMID: 30884194. doi:10.1002/ppul.24317
  • Devani P, Lo DKH, Gaillard EA. Practical approaches to the diagnosis of asthma in school-age children. Expert Rev Respir Med. 2022;16(9):973–981. PMID: 36125212. doi:10.1080/17476348.2022.2126355
  • Harun NS, Lachapelle P, Douglass J. Thunderstorm-triggered asthma: what we know so far. J Asthma Allergy. 2019;12:101–108. PMID: 31190900; PMCID: PMC6512777. doi:10.2147/JAA.S175155
  • Cecchi L, Vaghi A, Bini F, Martini M, Musarra A, Bilò MB. From triggers to asthma: a narrative review on epithelium dysfunction. Eur Ann Allergy Clin Immunol. 2022;54(6):247–257. PMID: 36214074. doi:10.23822/EurAnnACI.1764-1489.271
  • Mims JW. Asthma: definitions and pathophysiology. Int Forum Allergy Rhinol. 2015;5(1):S2–6. PMID: 26335832. doi:10.1002/alr.21609
  • Zinellu E, Piras B, Ruzittu GGM, Fois SS, Fois AG, Pirina P. Recent advances in inflammation and treatment of small airways in asthma. Int J Mol Sci. 2019;20(11):2617. PMID: 31141956; PMCID: PMC6601314. doi:10.3390/ijms20112617
  • Steinke JW, Borish L. Th2 cytokines and asthma. Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists. Respir Res. 2001;2(2):66–70. PMID: 11686867; PMCID: PMC59570. doi:10.1186/rr40
  • Pawankar R, Okuda M, Yssel H, Okumura K, Ra C. Nasal mast cells in perennial allergic rhinitics exhibit increased expression of the Fc epsilonRI, CD40L, IL-4, and IL-13, and can induce IgE synthesis in B cells. J Clin Invest. 1997;99(7):1492–1499. PMID: 9119992; PMCID: PMC507968. doi:10.1172/JCI119311
  • Dabbagh K, Takeyama K, Lee HM, Ueki IF, Lausier JA, Nadel JA. IL-4 induces mucin gene expression and goblet cell metaplasia in vitro and in vivo. J Immunol. 1999;162(10):6233–6237. PMID: 10229869.
  • Shirakawa I, Deichmann KA, Izuhara I, Mao I, Adra CN, Hopkin JM. Atopy and asthma: genetic variants of IL-4 and IL-13 signalling. Immunol Today. 2000;21(2):60–64. PMID: 10652462. doi:10.1016/s0167-5699(99)01492-9
  • Ayakannu R, Abdullah NA, Radhakrishnan AK, Lechimi Raj V, Liam CK. Relationship between various cytokines implicated in asthma. Hum Immunol. 2019;80(9):755–763. PMID: 31054782. doi:10.1016/j.humimm.2019.04.018
  • Kumar P, Sharma DK, Ashawat MS. Pathophysiology and management of atopic dermatitis: a laconic review. Curr Drug Ther. 2020;15(4):321–336. doi:10.2174/1574885514666190828152316
  • Hook S, Cheng P, Holloway J, et al. Analysis of two IL-4 promoter polymorphisms in a cohort of atopic and asthmatic subjects. Exp Clin Immunogenet. 1999;16(1):33–35. PMID: 10087404. doi:10.1159/000019094
  • Rosenwasser LJ, Borish L. Genetics of atopy and asthma: the rationale behind promoter-based candidate gene studies (IL-4 and IL-10). Am J Respir Crit Care Med. 1997;156(4 Pt 2):S152–5. PMID: 9351597. doi:10.1164/ajrccm.156.4.12tac-14
  • Noguchi E, Shibasaki M, Arinami T, et al. Evidence for linkage between asthma/atopy in childhood and chromosome 5q31-q33 in a Japanese population. Am J Respir Crit Care Med. 1997;156(5):1390–1393. PMID: 9372650. doi:10.1164/ajrccm.156.5.9702084
  • Jin X, Zheng J. IL-4-C-590T locus polymorphism and susceptibility to asthma in children: a meta-analysis. J Pediatr. 2021;97(3):264–272. PMID: 32781035; PMCID: PMC9432276. doi:10.1016/j.jped.2020.05.005
  • Louis R, Satia I, Ojanguren I, et al. European respiratory society guidelines for the diagnosis of asthma in adults. Eur Respir J. 2022;15:2101585. PMID: 35169025. doi:10.1183/13993003.01585-2021
  • Ibrahim MA, Ismail AI, Rani MF. A brief review of severe asthma. J Res Health Sci. 2021;6(2):4–12. doi:10.24191/jchs.v6i2.14942
  • Hijazi Z, Haider MZ. Interleukin-4 gene promoter polymorphism [C590T] and asthma in Kuwaiti Arabs. Int Arch Allergy Immunol. 2000;122(3):190–194. doi:10.1159/000024396
  • Hong EP, Park JW. Sample size and statistical power calculation in genetic association studies. Genomics Inform. 2012;10(2):117–122. PMID: 23105939; PMCID: PMC3480678. doi:10.5808/GI.2012.10.2.117
  • Zhang JH, Zhang M, Wang YN, Zhang XY. Correlation between IL-4 and IL-13 gene polymorphisms and asthma in Uygur children in Xinjiang. Exp Ther Med. 2019;17(2):1374–1382. PMID: 30680016; PMCID: PMC6327510. doi:10.3892/etm.2018.7096
  • Pijnenburg MW, Frey U, De Jongste JC, Saglani S. Childhood asthma: pathogenesis and phenotypes. Eur Respir J. 2022;59(6):2100731. PMID: 34711541. doi:10.1183/13993003.00731-2021
  • Hussein IA, Jaber SH. Genotyping of IL-4 −590 (C>T) Gene in Iraqi Asthma Patients. Dis Markers. 2017;2017:5806236. PMID: 28386156; PMCID: PMC5366214. doi:10.1155/2017/5806236
  • Berenguer AG, Fernandes AT, Oliveira S, et al. Genetic polymorphisms and asthma: findings from a case-control study in the Madeira island population. Biol Res. 2014;47(1):40. PMID: 25299150; PMCID: PMC4167518. doi:10.1186/0717-6287-47-40
  • Smolnikova MV, Smirnova SV, Freidin MB, Tyutina OS. Immunological parameters and gene polymorphisms (C-590T IL4, C-597A IL10) in severe bronchial asthma in children from the Krasnoyarsk region, West Siberia. Int J Circumpolar Health. 2013;72:21159. PMID: 23984295; PMCID: PMC3753143. doi:10.3402/ijch.v72i0.21159
  • Liu T, Yin W, Luo L, Wu Y, Qin S, Qin X. Association between Interleukin-4-590C>T polymorphism and the susceptibility to asthma: a meta-analysis of case-control study. J Healthc Eng. 2022;2022:1712715. PMID: 35392151; PMCID: PMC8983229. doi:10.1155/2022/1712715
  • Morales E, Duffy D. Genetics and gene-environment interactions in childhood and adult onset asthma. Front Pediatr. 2019;7:499. PMID: 31921716; PMCID: PMC6918916. doi:10.3389/fped.2019.00499
  • Tang L, Lin HG, Chen BF. Association of IL-4 promoter polymorphisms with asthma: a meta-analysis. Genet Mol Res. 2014;13(1):1383–1394. PMID: 24634237. doi:10.4238/2014.February.28.11
  • Park SY, Kim JH, Kim HJ, et al. High prevalence of asthma in elderly women: findings from a Korean national health database and adult asthma cohort. Allergy Asthma Immunol Res. 2018;10(4):387–396. PMID: 29949835; PMCID: PMC6021593. doi:10.4168/aair.2018.10.4.387
  • Baptist AP, Hamad A, Patel MR. Special challenges in treatment and self-management of older women with asthma. Ann Allergy Asthma Immunol. 2014;113(2):125–130. PMID: 25065349; PMCID: PMC4153393. doi:10.1016/j.anai.2014.05.013
  • Balzano G, Fuschillo S, De Angelis E, Gaudiosi C, Mancini A, Caputi M. Persistent airway inflammation and high exacerbation rate in asthma that starts at menopause. Monaldi Arch Chest Dis. 2007;67(3):135–141. PMID: 18018752. doi:10.4081/monaldi.2007.484
  • Zemp E, Schikowski T, Dratva J, Schindler C, Probst-Hensch N. Asthma and the menopause: a systematic review and meta-analysis. Maturitas. 2012;73(3):212–217. PMID: 22964072. doi:10.1016/j.maturitas.2012.08.010
  • Laidlaw TM, Mullol J, Woessner KM, Amin N, Mannent LP. Chronic rhinosinusitis with Nasal Polyps and asthma. J Allergy Clin Immunol Pract. 2021;9(3):1133–1141. PMID: 33065369. doi:10.1016/j.jaip.2020.09.063
  • Birs I, Boulay ME, Bertrand M, Côté A, Boulet LP. Heterogeneity of asthma with nasal polyposis phenotypes: a cluster analysis. Clin Exp Allergy. 2023;53(1):52–64. PMID: 36317421. doi:10.1111/cea.14247
  • Akdis CA, Bachert C, Cingi C, et al. Endotypes and phenotypes of chronic rhinosinusitis: a PRACTALL document of the European Academy of allergy and clinical immunology and the American Academy of allergy, asthma & immunology. J Allergy Clin Immunol. 2013;131(6):1479–1490. PMID: 23587334; PMCID: PMC4161279. doi:10.1016/j.jaci.2013.02.036
  • Mohammadi M, Dabiri S, Mollaei HR, et al. C-590T promoter polymorphism of the Interleukin (IL)-4 gene is associated with an increased usceptibility to nasal polyposis. Rep Biochem Mol Biol. 2019;7(2):129–135. PMID: 30805391; PMCID: PMC6374060.
  • Yea SS, Yang YI, Park SK, et al. Interleukin-4 C-590T polymorphism is associated with protection against nasal polyps in a Korean population. Am J Rhinol. 2006;20(5):550–553. PMID: 17063753. doi:10.2500/ajr.2006.20.2936
  • Nikakhlagh S, Ghadiri A, Saki N, Kardoni M, Konari A. Evaluation of C-590T Promoter of IL-4 gene polymorphisms in patients with sinonasal polyposis. Int J Pharm Res Allied Sci. 2016;5(2):39–43.
  • Chen W, Marra CA, Lynd LD, FitzGerald JM, Zafari Z, Sadatsafavi M. The natural history of severe asthma and influences of early risk factors: a population-based cohort study. Thorax. 2016;71(3):267–275. PMID: 26732738. doi:10.1136/thoraxjnl-2015-207530
  • Trivedi M, Denton E. Asthma in children and adults-what are the differences and what can they tell us about asthma? Front Pediatr. 2019;7:256. PMID: 31294006; PMCID: PMC6603154. doi:10.3389/fped.2019.00256
  • Schatz M, Rosenwasser L. The allergic asthma phenotype. J Allergy Clin Immunol Pract. 2014;2(6):645–8; quiz 649. PMID: 25439351. doi:10.1016/j.jaip.2014.09.004
  • Naeem A, Silveyra P. Sex differences in paediatric and adult asthma. Eur Med J. 2019;4(2):27–35. PMID: 31328173; PMCID: PMC6641536. doi:10.33590/emj/10312930
  • Christou EAA, Giardino G, Stefanaki E, Ladomenou F. Asthma: an undermined state of immunodeficiency. Int Rev Immunol. 2019;38(2):70–78. PMID: 30939053. doi:10.1080/08830185.2019.1588267
  • Dharmage SC, Perret JL, Custovic A. Epidemiology of asthma in children and adults. Front Pediatr. 2019;7:246. PMID: 31275909; PMCID: PMC6591438. doi:10.3389/fped.2019.00246
  • Fuchs O, Bahmer T, Rabe KF, von Mutius E. Asthma transition from childhood into adulthood. Lancet Respir Med. 2017;5(3):224–234. PMID: 27666650. doi:10.1016/S2213-2600(16)30187-4