Deep Venous Thrombosis in a Patient with a Moderate Pretest Probability and a Negative D-Dimer Test: A Review of the Diagnostic Algorithms

References

• Huisman M, Klok F. Current challenges in diagnostic imaging of venous thromboembolism. Blood. 2015;126(21):2376–2382. doi:10.1182/blood-2015-05-64097926585807
   PubMed Web of Science ®Google Scholar
• Cushman M, Creager M. Improving awareness and outcomes related to venous thromboembolism. JAMA. 2015;314(18):1913. doi:10.1001/jama.2015.1510726547458
   PubMed Web of Science ®Google Scholar
• Grosse S, Nelson R, Nyarko K, Richardson L, Raskob G. The economic burden of incident venous thromboembolism in the United States: a review of estimated attributable healthcare costs. Thromb Res. 2016;137:3–10. doi:10.1016/j.thromres.2015.11.03326654719
   PubMed Web of Science ®Google Scholar
• Riley R, Gilbert A, Dalton J, Pai S, McPherson R. Widely used types and clinical applications of d-dimer assay. Lab Med. 2016;47(2):90–102. doi:10.1093/labmed/lmw00127016528
   PubMed Web of Science ®Google Scholar
• American Society of Hematology. ASH releases new clinical practice guidelines for venous thromboembolism: evidence-based guidelines to drive improved care for patients with blood clots. hematology.org. Available from: https://www.hematology.org/newsroom/press-releases/2018/ash-releases-new-clinical-practice-guidelines-venous-thromboembolism. Accessed 720, 2019.
   Google Scholar
• Heit JA. Epidemiology of venous thromboembolism. Nat Rev Cardiol. 2015;12(8):464–474. doi:10.1038/nrcardio.2015.8326076949
   PubMed Web of Science ®Google Scholar
• Fernandez MM, Hogue S, Preblick R, Kwong WJ. Review of the cost of venous thromboembolism. Clinicoecon Outcomes Res. 2015;7:451–462. doi:10.2147/ceor.s8563526355805
   PubMed Web of Science ®Google Scholar
• Chappell F, Andras A, Welch K, et al. D-Dimer tests for the diagnosis of deep venous thrombosis in symptomatic hospital outpatients with a clinical prediction rule. Cochrane Database Syst Rev. 2016;9. doi:10.1002/14651858.cd012356
   Google Scholar
• Prochaska J, Frank B, Nagler M, et al. Age-related diagnostic value of D-dimer testing and the role of inflammation in patients with suspected deep vein thrombosis. Sci Rep. 2017;7(1):4591. doi:10.1038/s41598-017-04843-x28676651
   PubMed Web of Science ®Google Scholar
• Patel K Deep venous thrombosis (DVT): practice essentials, background, anatomy. emedicine.medscape.com. Available from: https://emedicine.medscape.com/article/1911303-overview. Accessed 727, 2019.
   Google Scholar
• Le Gal G, Righini M. Controversies in the diagnosis of venous thromboembolism. J Thromb Haemost. 2015;13(Suppl 1):S259–S265. doi:10.1111/jth.1293726149033
   PubMed Web of Science ®Google Scholar
• Lo B, Brenner B deep venous thrombosis risk stratification: risk stratification. emedicine.medscape.com. Available from: https://emedicine.medscape.com/article/1918446-overview. Accessed 727, 2019.
   Google Scholar
• Lim W, Le Gal G, Bates S, et al. American society of hematology 2018 guidelines for management of venous thromboembolism: diagnosis of venous thromboembolism. Blood Adv. 2018;2(22):3226–3256. doi:10.1182/bloodadvances.201802482830482764
   PubMed Web of Science ®Google Scholar
• Ekelund S Why D-dimer tests cannot be used to exclude venous thromboembolism in patients with high pretest probability. Acutecaretesting.org. Available from: https://acutecaretesting.org/en/articles/why-ddimer-tests-cannot-be-used-to-exclude-venous-thromboembolism-in-patients. Accessed 728, 2019.
   Google Scholar
• Lægehåndbogen. Dyb vene trombose, DVT - Klinisk scoringssystem (Wells score). Sundhed.dk. Available from: https://www.sundhed.dk/sundhedsfaglig/laegehaandbogen/hjerte-kar/tilstande-og-sygdomme/tromboembolisk-sygdom/dyb-venetrombose-dvt/. Accessed 85, 2019.
   Google Scholar
• Wells P Wells’ criteria for DVT - MDCalc. mdcalc.com. Available from: https://www.mdcalc.com/wells-criteria-dvt. Accessed 85, 2019.
   Google Scholar
• Gurram M, Pulivarthi S. Effectiveness of D-dimer as a screening test for venous thromboembolism: an update. N Am J Med Sci. 2014;6(10):491–499. doi:10.4103/1947-2714.14327825489560
   PubMedGoogle Scholar
• Bounds E, Kok S, Dimer D. In: statPearls [internet]. Treasure island (FL): statPearls. Available from: Ncbi.nlm.nih.gov.https://www.ncbi.nlm.nih.gov/books/NBK431064/. Accessed 730, 2019.
   Google Scholar
• Oxford University Hospitals, NHS Foundation Trust. Oxford haemophilia and thrombosis center out-patient DVT service protocol. oxford: oxford university hospitals; 2019. version 9.6 [updated by curry N]. Available from: https://www.ouh.nhs.uk/services/referrals/specialist-medicine/documents/dvt-protocols.pdf. Accessed 430, 2020.
   Google Scholar
• Roy P, Meyer G, Vielle B, et al. Appropriateness of diagnostic management and outcomes of suspected pulmonary embolism. Ann Intern Med. 2006;144(3):157–164. doi:10.7326/0003-4819-144-3-200602070-0000316461959
   PubMed Web of Science ®Google Scholar
• Giannitsis E, Mair J, Christersson C, et al. How to use D-dimer in acute cardiovascular care. Eur Heart J. 2016;6(1):69–80. doi:10.1177/2048872615610870
   Web of Science ®Google Scholar
• Sevestre M, Quashié C, Genty C, Rolland C, Quéré I, Bosson J. Clinical presentation and mortality in pulmonary embolism: the Optimev study. J Mal Vasc. 2010;35(4):242–249. doi:10.1016/j.jmv.2010.05.00420598461
   PubMedGoogle Scholar
• Gordon N, Schreiber M. Pulmonary emboli and deep vein thromboses: are they always part of the same disease spectrum? Mil Med. 2016;181(5S):104–110. doi:10.7205/milmed-d-15-00156
   Web of Science ®Google Scholar
• Palareti G, Antonucci E, Dentali F, et al. Patients with isolated pulmonary embolism in comparison to those with deep venous thrombosis. Differences in characteristics and clinical evolution. Eur J Intern Med. 2019;69:64–70. doi:10.1016/j.ejim.2019.08.02331500936
   PubMed Web of Science ®Google Scholar
• Sartori M, Cosmi B, Legnani C, et al. The Wells rule and D-dimer for the diagnosis of isolated distal deep vein thrombosis. J Thromb Haemost. 2012;10(11):2264–2269. doi:10.1111/j.1538-7836.2012.04895.x22906051
   PubMed Web of Science ®Google Scholar
• Kraaijpoel N, Carrier M, Le Gal G, et al. Diagnostic accuracy of three ultrasonography strategies for deep vein thrombosis of the lower extremity: a systematic review and meta-analysis. PLoS One. 2020;15(2):e0228788. doi:10.1371/journal.pone.022878832045437
   PubMed Web of Science ®Google Scholar
• Palareti G. How I treat isolated distal deep vein thrombosis (IDDVT). Blood. 2014;123(12):1802–1809. doi:10.1182/blood-2013-10-51261624472834
   PubMed Web of Science ®Google Scholar
• Robert-Ebadi H, Righini M. Should we diagnose and treat distal deep vein thrombosis? Hematology. 2017;2017(1):231–236. doi:10.1182/asheducation-2017.1.23129222260
   PubMed Web of Science ®Google Scholar
• Horner D, Hogg K, Body R. Should we be looking for and treating isolated calf vein thrombosis? Emergency Med J. 2015;33(6):431–437. doi:10.1136/emermed-2014-204230
   Web of Science ®Google Scholar
• Palareti G, Agnelli G, Imberti D, et al. A commentary: to screen for calf DVT or not to screen? The highly variable practice among Italian centers highlights this important and still unresolved clinical option. results from the Italian MASTER registry. Thromb Haemost. 2008;99(01):241–244. doi:10.1160/th07-06-039318217164
   PubMed Web of Science ®Google Scholar
• Asbeutah A, Riha A, Cameron J, McGrath B. Five-year outcome study of deep vein thrombosis in the lower limbs. J Vasc Surg. 2004;40(6):1184–1189. doi:10.1016/j.jvs.2004.10.02515622373
   PubMed Web of Science ®Google Scholar
• Needleman L, Cronan J, Lilly M, et al. Ultrasound for lower extremity deep venous thrombosis. Multidisciplinary recommendations from the society of radiologists in ultrasound consensus conference. Circulation. 2018;137(14):1505–1515. doi:10.1161/circulationaha.117.03068729610129
   PubMed Web of Science ®Google Scholar
• Der Sahakian G, Claessens Y, Allo J, Kansao J, Kierzek G, Pourriat J. Accuracy of D-dimers to rule out venous thromboembolism events across age categories. Emerg Med Int. 2010;2010:1–4. doi:10.1155/2010/185453
   Google Scholar
• Wells P, Anderson D, Rodger M, et al. Evaluation of D-dimer in the diagnosis of suspected deep-vein thrombosis. New Engl J Med. 2003;349(13):1227–1235. doi:10.1056/nejmoa02315314507948
   PubMed Web of Science ®Google Scholar
• Dagkiran H, Atas R, Tomic I, et al. Severe pulmonary embolism with negative D-DIMER-TESTING. J Cardiol Therapy. 2015;2(1): Available from http://www.ghrnet.org/index.php/jct/article/view/1033/1164. Accessed: August 5, 2019.
   Google Scholar
• Singer A, Zheng H, Francis S, et al. D-dimer levels in VTE patients with distal and proximal clots. Am J Emerg Med. 2019;37(1):33–37. doi:10.1016/j.ajem.2018.04.04029703562
   PubMed Web of Science ®Google Scholar
• Baglin T, Keeling D, Kitchen S. Effects on routine coagulation screens and assessment of anticoagulant intensity in patients taking oral dabigatran or rivaroxaban: guidance from the British committee for standards in haematology. Br J Haematol. 2012;159(4):427–429. doi:10.1111/bjh.1205222970737
   PubMed Web of Science ®Google Scholar
• Couturaud F, Kearon C, Bates S, Ginsberg J. Decrease in sensitivity of D-dimer for acute venous thromboembolism after starting anticoagulant therapy. Blood Coagulation Fibrinolysis. 2002;13(3):241–246. doi:10.1097/00001721-200204000-0001011943938
   PubMed Web of Science ®Google Scholar
• Niimi R, Hasegawa M, Shi D, Sudo A. The influence of fondaparinux on the diagnosis of postoperative deep vein thrombosis by soluble fibrin and D-dimer. Thromb Res. 2012;130(5):759–764. doi:10.1016/j.thromres.2011.11.04622192153
   PubMed Web of Science ®Google Scholar
• Legnani C, Martinelli I, Palareti G, et al. D-dimer levels during and after anticoagulation withdrawal in patients with venous thromboembolism treated with non-vitamin K anticoagulants. PLoS One. 2019;14(7):e0219751. doi:10.1371/journal.pone.021975131310608
   PubMed Web of Science ®Google Scholar
• Kawai T, Kuroda Y, Goto K, Matsuda S. Does prophylactic administration of edoxaban increase d-dimer levels after total hip arthroplasty? J Clin Med. 2019;8(5):678. doi:10.3390/jcm8050678
   Web of Science ®Google Scholar
• Wu C, Chen B, Wang J, Yen S, Huang C. Plasma D-dimer is not useful in the prediction of deep vein thrombosis after total knee arthroplasty in patients using rivaroxaban for thromboprophylaxis. J Orthop Surg Res. 2018;13(1). doi:10.1186/s13018-018-0883-1
   Web of Science ®Google Scholar
• Allaham H, Mansour A, Abdullah O, Danila C. D-dimer sensitivity in fully anticoagulated patients with moderate pretest probability for pulmonary thromboembolism. J Am Coll Cardiol. 2019;73(9):2168. doi:10.1016/s0735-1097(19)32774-3
   Web of Science ®Google Scholar
• Qdaisat A, Soud R, Wu C, et al. Poor performance of D-dimer in excluding venous thromboembolism among patients with lymphoma and leukemia. Haematologica. 2019;104(6):e265–e268. doi:10.3324/haematol.2018.21146630630988
   PubMed Web of Science ®Google Scholar
• Pabinger I, van Es N, Heinze G, et al. A clinical prediction model for cancer-associated venous thromboembolism: a development and validation study in two independent prospective cohorts. Lancet Haematol. 2018;5(7):e289–e298. doi:10.1016/s2352-3026(18)30063-229885940
   PubMed Web of Science ®Google Scholar
• Riondino S, Ferroni P, Zanzotto F, Roselli M, Guadagni F. Predicting VTE in cancer patients: candidate biomarkers and risk assessment models. Cancers. 2019;11(1):95. doi:10.3390/cancers11010095
   PubMed Web of Science ®Google Scholar
• Ali S, Dilday E, Tagawa S, et al. D-dimer levels among cancer patients with unsuspected pulmonary embolism: clinical correlates and relevance. Blood. 2012;120(21):1154. doi:10.1182/blood.v120.21.1154.115422879626
   PubMed Web of Science ®Google Scholar
• Zayyan M, Katung G, Abdul-Aziz H, Igashi J D-dimer levels as marker of deep vein thrombosis in patients with cervical cancer: a study of a northern Nigerian patient population. Smjonline.org. Available from: http://www.smjonline.org/text.asp?2019/22/2/86/260840. Accessed 31, 2020.
   Google Scholar
• Yu J, Li D, Lei D, et al. Tumor-specific D-dimer concentration ranges and influencing factors: a cross-sectional study. PLoS One. 2016;11(11):e0165390. doi:10.1371/journal.pone.016539027835633
   PubMed Web of Science ®Google Scholar
• Chen C, Li G, Liu Y, Gu Y. A new D-dimer cutoff value to improve the exclusion of deep vein thrombosis in. Cancer Patients. 2020. doi:10.7314/APJCP.2014.15.4.1655
   Google Scholar
• Ay C, Dunkler D, Pirker R, et al. High D-dimer levels are associated with poor prognosis in cancer patients. Haematologica. 2012;97(8):1158–1164. doi:10.3324/haematol.2011.05471822371182
   PubMed Web of Science ®Google Scholar
• Dai H, Zhou H, Sun Y, et al. D-dimer as a potential clinical marker for predicting metastasis and progression in cancer. Biomed Rep. 2018;9(5):453–457. doi:10.3892/br.2018.115130402229
   PubMed Web of Science ®Google Scholar
• Han D, Hartaigh B, Lee J, et al. Impact of D-dimer for prediction of incident occult cancer in patients with unprovoked venous thromboembolism. PLoS One. 2016;11(4):e0153514. doi:10.1371/journal.pone.015351427073982
   PubMed Web of Science ®Google Scholar
• Gran O, Braekkan S, Paulsen B, Skille H, Hansen J. D-dimer measured at first venous thromboembolism is associated with future risk of cancer. Haematologica. 2016;101(12):e473–e475. doi:10.3324/haematol.2016.15171227612986
   PubMed Web of Science ®Google Scholar
• Awad I. Value of D ultrasound in diagnosis of clinically suspected deep vein thrombosis. IOSR J Dent Med Sci. 2018.
   Google Scholar
• Mohammed S, AL-Najjar S. Role of color flow ultrasound in detection of deep venous thrombosis. J Educ Pract. 2016;27(4):2222.
   Google Scholar
• Michiels J, Moosdorff W, Lao M, et al. Diagnosis and treatment of DVT and prevention of DVT recurrence and the PTS: bridging the gap between DVT and PTS in the primary care setting or outpatient ward. J Vasc Diagn Interv. 2017;5:21–34. doi:10.2147/jvd.s62734
   Google Scholar
• Malato A, Saccullo G, Iorio A, Ageno W, Siragusa S. Residual vein thrombosis and d-dimer for optimizing duration of anticoagulation in idiopathic deep vein thrombosis. Curr Pharm Des. 2010;16(31):3483–3486. doi:10.2174/13816121079356342820858182
   PubMed Web of Science ®Google Scholar
• Napolitano M, Saccullo G, Malato A, et al. Optimal duration of low molecular weight heparin for the treatment of cancer-related deep vein thrombosis: the cancer-DACUS study. J Clin Oncol. 2014;32(32):3607–3612. doi:10.1200/JCO.2013.51.743325267738
   PubMed Web of Science ®Google Scholar
• Siragusa S, Malato A, Bellisi M, et al. Absence of residual vein thrombosis after an episode of idiopathic deep vein thrombosis: short-term anticoagulation is safe. the “extended dacus study”. Blood. 2007;110(11):301. doi:10.1182/blood.v110.11.301.301
   Web of Science ®Google Scholar
• Mitsunaga M, Kogachi S, Yoon H. Risk of venous thromboembolism after a single normal proximal lower extremity venous ultrasound. Perm J. 2017;21:16–140. doi:10.7812/tpp/16-140
   Google Scholar