Hematological Abnormalities and Associated Factors Among Undernourished Under-Five Children Attending University of Gondar Specialized Referral Hospital, Northwest Ethiopia

References

• Borelli P, Blatt SL, Rogero MM, Fock RA. Haematological alterations in protein malnutrition. Rev Bras Hematol Hemoter. 2004;26(1):49–56. doi:10.1590/S1516-84842004000100010
   Google Scholar
• Blaney S, Menasria L, Main B, et al. Determinants of undernutrition among young children living in Soth Nikum district, Siem Reap, Cambodia. Nutrients. 2019;11(3):685. doi:10.3390/nu11030685
   Web of Science ®Google Scholar
• Santos EW, Oliveira DC, Silva GB, et al. Hematological alterations in protein malnutrition. Nutr Rev. 2017;75(11):909–919. doi:10.1093/nutrit/nux04129025154
   PubMed Web of Science ®Google Scholar
• WHO. UNICEF/WHO/The World Bank group joint child malnutrition estimates: levels and trends in child malnutrition: key findings of the 2020 edition; 2020 Available from: https://apps.who.int/iris/handle/10665/331621. Accessed 127, 2020.
   Google Scholar
• Ethiopia: mini demographic and health survey 2019. Available from: https://dhsprogram.com/pubs/pdf/PR120/PR120.pdf. Accessed 1019, 2019.
   Google Scholar
• WHO, Unicef. WHO Child Growth Standards and the Identification of Severe Acute Malnutrition in Infants and Children: Joint Statement by the World Health Organization and the United Nations Children’s Fund. 2009.
   Google Scholar
• Mary E. Protein energy malnutrition, pathophysiology, clinical consequences and treatment. Nutr Paediatr. 2008;171–184.
   Google Scholar
• McKenna SL, Cotter TG. Functional aspects of apoptosis in hematopoiesis and consequences of failure. Adv Cancer Res. 1997;71(7):121–164.9111865
   PubMed Web of Science ®Google Scholar
• Gohain EK, Pathak K, Choudhury B, Case Control A. Study of hematological changes in children with protein energy malnutrition attending Gauhati medical college and hospital. J Appl Dent. 2016;15(10):25–29.
   Google Scholar
• Borelli P, Barros FEV, Nakajima K, et al. Protein-energy malnutrition halts hemopoietic progenitor cells in the G0/G1 cell cycle stage, thereby altering cell production rates. Braz J Med Biol Res. 2009;42(6):523–530. doi:10.1590/S0100-879X200900060000819448901
   PubMed Web of Science ®Google Scholar
• Oliveira D, Hastreiter AA, Borelli P, Fock RA. The influence of protein malnutrition on the production of GM-CSF and M-CSF by macrophages. Braz J Pharm Sci. 2016;52(3):375–382. doi:10.1590/s1984-82502016000300003
   Web of Science ®Google Scholar
• Fock RA, Blatt SL, Beutler B, et al. Study of lymphocyte subpopulations in bone marrow in a model of protein–energy malnutrition. Nutrition. 2010;26(10):1021–1028. doi:10.1016/j.nut.2009.08.02620036516
   PubMed Web of Science ®Google Scholar
• Borelli P, Blatt S, Pereira J, et al. Reduction of erythroid progenitors in protein–energy malnutrition. Br J Nutr. 2007;97(2):307–314. doi:10.1017/S000711450717273117298699
   PubMed Web of Science ®Google Scholar
• El Nawawy A, Barakat S, El Walily T, Moneim A, Deghady A, Hussein M. Evaluation of erythropoiesis in protein energy malnutrition. East Mediterr Health J. 2002;(8):2–3.
   Google Scholar
• Warrier R, Dole M, Warrier J, Suskind R. The anemia of malnutrition In: Nestle Nutrition Workshop Series (USA). 1990:61–72.
   Google Scholar
• Özkale M, Sipahi T. Hematologic and bone marrow changes in children with protein-energy malnutrition. Pediatr Hematol Oncol J. 2014;31(4):349–358. doi:10.3109/08880018.2013.813098
   Google Scholar
• Tekile AK, Woya AA, Basha GW. Prevalence of malnutrition and associated factors among under-five children in Ethiopia: evidence from the 2016 Ethiopia demographic and health survey. BMC Res Notes. 2019;12(1):391. doi:10.1186/s13104-019-4444-431296269
   PubMed Web of Science ®Google Scholar
• Girum T, Kote M, Tariku B, Bekele H. Survival status and predictors of mortality among severely acute malnourished children< 5 years of age admitted to stabilization centers in gedeo zone: a retrospective cohort study. Ther Clin Risk Manag. 2017;13:101.28176953
   PubMed Web of Science ®Google Scholar
• Jarso H, Workicho A, Alemseged F. Survival status and predictors of mortality in severely malnourished children admitted to Jimma University specialized hospital from 2010 to 2012, Jimma, Ethiopia: a retrospective longitudinal study. BMC Pediatr. 2015;15(1):76. doi:10.1186/s12887-015-0398-426174805
   PubMed Web of Science ®Google Scholar
• Jáuregui-Lobera I. Iron deficiency and cognitive functions. Neuropsych Dis Treat. 2014;10:2087. doi:10.2147/NDT.S72491
   PubMed Web of Science ®Google Scholar
• Yaikhomba T, Poswal L, Goyal S. Assessment of iron, folate and vitamin B12 status in severe acute malnutrition. Indian J Pediatr. 2015;82(6):511–514. doi:10.1007/s12098-014-1600-725338494
   PubMed Web of Science ®Google Scholar
• Arun Kumar Arya PK, Midha T, Singh M, Singh M. Hematological profile of children with severe acute malnutrition: a tertiary care centre experience. Int J Contemp Pediatr. 2017;4(5):1577–1580. doi:10.18203/2349-3291.ijcp20173072
   Google Scholar
• Gibson R. Strategies for preventing micronutrient deficiencies in developing countries. Asia Pac J Clin Nutr. 2004;13.
   Google Scholar
• Stoltzfus RJ, Chway HM, Montresor A, et al. Low dose daily iron supplementation improves iron status and appetite but not anemia, whereas quarterly anthelminthic treatment improves growth, appetite and anemia in Zanzibari preschool children. J Nutr. 2004;134(2):348–356. doi:10.1093/jn/134.2.34814747671
   PubMed Web of Science ®Google Scholar
• Buitrón D, Hurtig A-K, San MS. Nutritional status of Naporuna children under five in the Amazon region of Ecuador. Pan Am j Public Health. 2004;15(3):151–159.
   Web of Science ®Google Scholar
• Espinoza M, Perelli J, Olmos R, Bertin P, Jara V, Ramírez P. Nutritional assessment as predictor of complications after hematopoietic stem cell transplantation. Rev Bras Hematol Hemoter. 2016;38(1):7–14. doi:10.1016/j.bjhh.2015.10.00226969769
   PubMedGoogle Scholar
• Basheir HM, Hamza KM. Hematological parameters of malnourished sudanese children under 5 years–Khartoum state–2011. J Clin Med. 2015;1(4):152–156.
   Google Scholar
• Dwivedi D, Singh V, Singh J, Sharma S. Study of anaemia in children with severe acute malnutrition. J Nepal Paediatr Soc. 2017;37(3):250–253. doi:10.3126/jnps.v37i3.18480
   Google Scholar
• Savino W. The thymus gland is a target in malnutrition. Eur J Clin Nutr. 2002;56(S3):S46. doi:10.1038/sj.ejcn.1601485
   PubMed Web of Science ®Google Scholar
• Saka A, Saka M, Ojuawo A, et al. Haematological profile in children with protein energy malnutrition in North Central Nigeria. Glob J Med Res. 2012;12(4):1–7.
   Google Scholar
• Üner A, Çalişkan Ü, Öner AF, Koç H, Kasap AF. Platelet functions in patients with protein-energy malnutrition. Clin Appl Thromb Hemost. 2001;7(4):286–288. doi:10.1177/10760296010070040611697710
   PubMed Web of Science ®Google Scholar
• Speth C, Löffler J, Krappmann S, Lass-Flörl C, Rambach G. Platelets as immune cells in infectious diseases. Future Microbiol. 2013;8(11):1431–1451. doi:10.2217/fmb.13.10424199802
   PubMed Web of Science ®Google Scholar
• Choudhury J. Thrombocytosis in under-five children with lower respiratory tract infection. Ann Med Health Sci Res. 2017;7(6):47–51.
   Google Scholar
• Gordon DM, Frenning S, Draper HR, Kokeb M. Prevalence and burden of diseases presenting to a general pediatrics ward in Gondar, Ethiopia. J Trop Pediatrics. 2013;59(5):350–357. doi:10.1093/tropej/fmt031
   Web of Science ®Google Scholar
• Wagnew F, Dejenu G, Eshetie S, Alebel A, Worku W, Abajobir AA. Treatment cure rate and its predictors among children with severe acute malnutrition in northwest Ethiopia: a retrospective record review. PLoS One. 2019;14(2):e0211628. doi:10.1371/journal.pone.021162830785917
   PubMed Web of Science ®Google Scholar
• WHO. Haemoglobin Concentrations for the Diagnosis of Anaemia and Assessment of Severity. World Health Organization; 2011.
   Google Scholar
• Janus J, Moerschel SK. Evaluation of anemia in children. Am Fam Physician. 2010;81(12):1462–1471.20540485
   PubMed Web of Science ®Google Scholar
• Geletaw T, Tadesse MZ, Demisse AG. Hematologic abnormalities and associated factors among HIV infected children pre-and post-antiretroviral treatment, North West Ethiopia. J Blood Med. 2017;4(8):99–105. doi:10.2147/JBM.S137067
   Google Scholar
• Wollo E. Risk factors for child under-nutrition with a human rights edge in rural villages of North Wollo, Ethiopia. East Afr Med J. 2005;82:625–630.16619706
   PubMedGoogle Scholar
• Leal LP, Batista Filho M, Lira P, Figueiroa JN, Osório MM. Prevalence of anemia and associated factors in children aged 6–59 months in Pernambuco, Northeastern Brazil. Rev Saude Publica. 2011;45(3):457–466. doi:10.1590/S0034-8910201100030000321552753
   PubMed Web of Science ®Google Scholar
• Badham J, Zimmermann MB, Kraemer K. The Guidebook Nutritional Anemia: Task Force Sight and Life. 2007:228.
   Google Scholar
• Keerthiwansa J, Gajealan S, Sivaraja S, Subashini K. Malnutrition and anaemia among hospitalised children in Vavuniya. Ceylon Med J. 2014;59(4):141–143. doi:10.4038/cmj.v59i4.786925556413
   PubMedGoogle Scholar
• Rahman MS, Mushfiquee M, Masud MS, Howlader T. Association between malnutrition and anemia in under-five children and women of reproductive age: evidence from Bangladesh demographic and health survey 2011. PLoS One. 2019;14(7):e0219170. doi:10.1371/journal.pone.021917031269082
   PubMed Web of Science ®Google Scholar
• Nayana N, Sreenivas N, Jayaram S. Study of anemia among protein energy malnourished children in Mysore. Int J Evid Based Healthc. 2015;2(9):1198–1210. doi:10.18410/jebmh/2015/174
   Google Scholar
• Thakur N, Chandra J, Pemde H, Singh V. Anemia in severe acute malnutrition. Nutrition. 2014;30(4):440–442. doi:10.1016/j.nut.2013.09.01124332525
   PubMed Web of Science ®Google Scholar
• de Fátima Costa Caminha M, da Figueira MAS, Falbo AR, de Araújo de Amorim RC, Gallindo TC, Filho MB. Co-existence of micronutrient deficiencies in hospitalized children with severe malnutrition treated according to the WHO protocol. Trop Doct. 2011;41(4):230–232. doi:10.1258/td.2011.10014021878443
   PubMed Web of Science ®Google Scholar
• Akalu TY, Baraki AG, Wolde HF, et al. Anemia and determinants among severely malnourished children admitted to Amhara regional referral hospitals, Northwest Ethiopia. Open J Nutr Food Sci. 2020;2(1):1007.
   Google Scholar
• Simbauranga RH, Kamugisha E, Hokororo A, Kidenya BR, Makani J. Prevalence and factors associated with severe anaemia amongst under-five children hospitalized at Bugando Medical Centre, Mwanza, Tanzania. BMC Hematol. 2015;15(1):13. doi:10.1186/s12878-015-0033-526464799
   PubMedGoogle Scholar
• Page A-L, de Rekeneire N, Sayadi S, et al. Infections in children admitted with complicated severe acute malnutrition in Niger. PLoS One. 2013;8(7):e68699. doi:10.1371/journal.pone.006869923874731
   PubMed Web of Science ®Google Scholar
• Edozien JC, Khan MR, Waslien CI. Human protein deficiency: results of a Nigerian village study. T. J Nutr. 1976;106(3):312–328. doi:10.1093/jn/106.3.312
   Web of Science ®Google Scholar
• Fondu P, Hariga-Muller C, Mozes N, Neve J, Van Steirteghem A, Mandelbaum I. Protein-energy malnutrition and anemia in Kivu. Am J Clin Nutr. 1978;31(1):46–56. doi:10.1093/ajcn/31.1.46413429
   PubMed Web of Science ®Google Scholar
• Cunha MCR, da Silva Lima F, Vinolo MAR, et al. Protein malnutrition induces bone marrow mesenchymal stem cells commitment to adipogenic differentiation leading to hematopoietic failure. PLoS One. 2013;8(3):e58872. doi:10.1371/journal.pone.005887223516566
   PubMed Web of Science ®Google Scholar
• Onyemaobi G, Onimawo I. Anaemia prevalence among under-five children in Imo State, Nigeria. Aust J Basic Appl Sci. 2011;5(2):122–126.
   Google Scholar
• Goswmai S, Das KK. Socio‐economic and demographic determinants of childhood anemia. J Pediatr. 2015;91(5):471–477. doi:10.1016/j.jped.2014.09.009
   Web of Science ®Google Scholar
• Ray S, Chandra J, Bhattacharjee J, Sharma S, Agarwala A. Determinants of nutritional anaemia in children less than five years age. Int J Contemp Pediatr. 2018;3(2):403–408.
   Google Scholar
• Santos R, Gonzalez ESC, Albuquerque E, et al. Prevalence of anemia in under five-year-old children in a children’s hospital in Recife, Brazil. Rev Bras Hematol Hemoter. 2011;33(2):100–104. doi:10.5581/1516-8484.2011002823284255
   PubMedGoogle Scholar
• Chaparro CM. Setting the stage for child health and development: prevention of iron deficiency in early infancy. J Nutr. 2008;138(12):2529–2533. doi:10.1093/jn/138.12.252919022984
   PubMed Web of Science ®Google Scholar
• Rahman MA, Mannan M, Rahman MH. Influence of infection on iron profile in severely malnourished children. Indian J Pediatr. 2009;76(9):907. doi:10.1007/s12098-009-0098-x19381490
   PubMed Web of Science ®Google Scholar
• Odebunmi J, Adefioye O, Adeyeba O. Hookworm infection among school children in Vom, Plateau State, Nigeria. Am Eurasian J Sci Res. 2007;1:39–42.
   Google Scholar
• Cherayil BJ. The role of iron in the immune response to bacterial infection. Immunol Res. 2011;50(1):1–9. doi:10.1007/s12026-010-8199-121161695
   PubMed Web of Science ®Google Scholar
• Bondi SA, Lieuw K. Excessive cow’s milk consumption and iron deficiency in toddlers: two unusual presentations and review. Infant Child Adolesc Nutr. 2009;1(3):133–139. doi:10.1177/1941406409335481
   Google Scholar
• Sullivan PB. Cows’ milk induced intestinal bleeding in infancy. Arch Dis Child. 1993;68(2):240. doi:10.1136/adc.68.2.2408481050
   PubMed Web of Science ®Google Scholar
• Amsalu S, Tigabu Z. Risk factors for ever acute malnutrition in children under the age of five: a case-control study. Ethiop J Health Dev. 2008;22(1):21–25. doi:10.4314/ejhd.v22i1.10058
   Google Scholar
• Gebreegziabiher G, Etana B, Niggusie D. Determinants of anemia among children aged 6–59 months living in Kilte Awulaelo Woreda, northern Ethiopia. Anemia. 2014;2014:245870. doi:10.1155/2014/24587025302116
   PubMedGoogle Scholar
• Grüber C, Keil T, Kulig M, et al. History of respiratory infections in the first 12 yr among children from a birth cohort. Pediatr Allergy Immunol. 2008;19(6):505–512. doi:10.1111/j.1399-3038.2007.00688.x18167154
   PubMed Web of Science ®Google Scholar