Heterogeneity in Hematological Parameters of High and Low Altitude Tibetan Populations

References

• Beall CM. Two routes to functional adaptation: Tibetan and Andean high-altitude natives. Proc Natl Acad Sci U S A. 2007;104(Suppl 1):8655–8660. doi:10.1073/pnas.0701985104
   PubMed Web of Science ®Google Scholar
• Luks AM, Swenson ER, Bärtsch P. Acute high-altitude sickness. Eur Respir Rev. 2017;26(143):143. doi:10.1183/16000617.0096-2016
   Web of Science ®Google Scholar
• Aldenderfer MS. Moving up in the World: archaeologists seek to understand how and when people came to occupy the Andean and Tibetan plateaus. Am Sci. 2003;91(6):542–549. doi:10.1511/2003.6.542
   Google Scholar
• Aldenderfer M. Peopling the Tibetan plateau: insights from archaeology. High Alt Med Biol. 2011;12(2):141–147. doi:10.1089/ham.2010.1094
   Web of Science ®Google Scholar
• Simonson TS, Yang Y, Huff CD, et al. Genetic evidence for high-altitude adaptation in Tibet. Science. 2010;329(5987):72–75. doi:10.1126/science.1189406
   PubMed Web of Science ®Google Scholar
• Yang J, Jin ZB, Chen J, et al. Genetic signatures of high-altitude adaptation in Tibetans. Proc Natl Acad Sci U S A. 2017;114(16):4189–4194. doi:10.1073/pnas.1617042114
   Web of Science ®Google Scholar
• Jeong C, Alkorta-Aranburu G, Basnyat B, et al. Admixture facilitates genetic adaptations to high altitude in Tibet. Nat Commun. 2014;5(1):3281. doi:10.1038/ncomms4281
   Web of Science ®Google Scholar
• Huerta-Sánchez E, Jin X, Bianba Z, et al. Altitude adaptation in Tibetans caused by introgression of Denisovan-like DNA. Nature. 2014;512(7513):194–197. doi:10.1038/nature13408
   PubMed Web of Science ®Google Scholar
• Zhuang J, Droma T, Sun S, et al. Hypoxic ventilatory responsiveness in Tibetan compared with Han residents of 3658 m. J Appl Physiol. 1993;74(1):303–311. doi:10.1152/jappl.1993.74.1.303
   PubMed Web of Science ®Google Scholar
• Bigham A, Bauchet M, Pinto D, et al. Identifying signatures of natural selection in Tibetan and Andean populations using dense genome scan data. PLoS Genet. 2010;6(9):e1001116. doi:10.1371/journal.pgen.1001116
   PubMed Web of Science ®Google Scholar
• Droma T, McCullough RG, McCullough RE, et al. Increased vital and total lung capacities in Tibetan compared to Han residents of Lhasa (3658 m). Am J Phys Anthropol. 1991;86(3):341–351. doi:10.1002/ajpa.1330860303
   PubMed Web of Science ®Google Scholar
• Moore LG. Measuring high-altitude adaptation. J Appl Physiol. 2017;123(5):1371–1385. doi:10.1152/japplphysiol.00321.2017
   Web of Science ®Google Scholar
• Brutsaert TD. Population genetic aspects and phenotypic plasticity of ventilatory responses in high altitude natives. Respir Physiol Neurobiol. 2007;158(2–3):151–160. doi:10.1016/j.resp.2007.03.004
   Web of Science ®Google Scholar
• Gassmann M, Muckenthaler MU. Adaptation of iron requirement to hypoxic conditions at high altitude. J Appl Physiol. 2015;119(12):1432–1440. doi:10.1152/japplphysiol.00248.2015
   Web of Science ®Google Scholar
• West JB. Other Recent High-Altitude Studies. In: High Life. New York, NY: Springer; 1998:364–400.
   Google Scholar
• Beall CM, Brittenham GM, Strohl KP, et al. Hemoglobin concentration of high-altitude Tibetans and Bolivian Aymara. Am J Phys Anthropol. 1998;106(3):385–400. doi:10.1002/(SICI)1096-8644(199807)106:3<385::AID-AJPA10>3.0.CO;2-X
   PubMed Web of Science ®Google Scholar
• Garruto RM, Chin CT, Weitz CA, Liu JC, Liu RL, He X. Hematological differences during growth among Tibetans and Han Chinese born and raised at high altitude in Qinghai, China. Am J Phys Anthropol. 2003;122(2):171–183. doi:10.1002/ajpa.10283
   Web of Science ®Google Scholar
• Wu T, Wang X, Wei C, et al. Hemoglobin levels in Qinghai-Tibet: different effects of gender for Tibetans vs. Han. J Appl Physiol. 2005;98(2):598–604. doi:10.1152/japplphysiol.01034.2002
   PubMed Web of Science ®Google Scholar
• Basu M, Malhotra AS, Pal K, et al. Erythropoietin levels in lowlanders and high-altitude natives at 3450 m. Aviat Space Environ Med. 2007;78(10):963–967. doi:10.3357/ASEM.2085.2007
   Google Scholar
• Brothers MD, Wilber RL, Byrnes WC. Physical fitness and hematological changes during acclimatization to moderate altitude: a retrospective study. High Alt Med Biol. 2007;8(3):213–224. doi:10.1089/ham.2007.8308
   Web of Science ®Google Scholar
• Akunov A, Sydykov A, Toktash T, Doolotova A, Sarybaev A. Hemoglobin changes after long-term intermittent work at high altitude. Front Physiol. 2018;9:1552. doi:10.3389/fphys.2018.01552
   Web of Science ®Google Scholar
• Moore LG, Young D, McCullough RE, Droma T, Zamudio S. Tibetan protection from intrauterine growth restriction (IUGR) and reproductive loss at high altitude. Am J Hum Biol. 2001;13(5):635–644. doi:10.1002/ajhb.1102
   Web of Science ®Google Scholar
• Petousi N, Robbins PA. Human adaptation to the hypoxia of high altitude: the Tibetan paradigm from the pregenomic to the postgenomic era. J Appl Physiol. 2014;116(7):875–884. doi:10.1152/japplphysiol.00605.2013
   Web of Science ®Google Scholar
• Gelfi C, De Palma S, Ripamonti M, et al. New aspects of altitude adaptation in Tibetans: a proteomic approach. FASEB J. 2004;18(3):612–614. doi:10.1096/fj.03-1077fje
   PubMed Web of Science ®Google Scholar
• Zubieta-Calleja G. Human Adaptation to High Altitude and to Sea Level: Acid-Base Equilibrium, Ventilation and Circulation in Chronic Hypoxia. 1st ed. Düsseldorf, German: VDM Verlag Dr. Müller; 2010.
   Google Scholar
• Zubieta-Calleja GR, Paulev PE, Zubieta-Calleja L, Zubieta-Castillo G. Altitude adaptation through hematocrit changes. J Physiol Pharmacol. 2007;58 Suppl 5(Suppl Pt 2):811–818.
   Google Scholar
• McKenzie DC, Goodman LS, Nath C, et al. Cardiovascular adaptations in Andean natives after 6 wk of exposure to sea level. J Appl Physiol. 1991;70(6):2650–2655. doi:10.1152/jappl.1991.70.6.2650
   Web of Science ®Google Scholar
• Prakash LTO. Tibetan refugees in India: the case of Bylakuppe in Karnataka. Indian J Soc Dev. 2011;11(2):503–515.
   Google Scholar
• Jian C. The Tibetan Rebellion of 1959 and China’s changing relations with India and the Soviet Union. J Cold War Stud. 2006;8(3):54–101. doi:10.1162/jcws.2006.8.3.54
   Google Scholar
• Petech L. The Kingdom of Ladakh: C. 950-1842 A.D. Rome: Istituto italiano per il Medio ed Estremo Oriente; 1977.
   Google Scholar
• Goldstein MC. Tibet, China, and the United States: Reflections on the Tibet Question. Washington, D.C.: The Atlantic Council of the United States; 1995.
   Google Scholar
• Tamang R, Chaubey G, Nandan A, et al. Reconstructing the demographic history of the Himalayan and adjoining populations. Hum Genet. 2018;137(2):129–139. doi:10.1007/s00439-018-1867-2
   Web of Science ®Google Scholar
• Mondal H, Budh DP. Hematocrit; 2020 July 10. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing. 2020 Jan. Available from: https://www.ncbi.nlm.nih.gov/books/NBK542276/. Accessed March 03, 2021.
   Google Scholar
• van Lerberghe W, Keegels G, Cornelis G, Ancona C, Mangelschots E, van Balen H. Haemoglobin measurement: the reliability of some simple techniques for use in a primary health care setting. Bull World Health Organ. 1983;61(6):957–965.
   Web of Science ®Google Scholar
• Maakaron JE, Taher AT, Conrad ME. Anemia Workup; 2019. Avialable from: https://emedicine.medscape.com/article/198475-workup#c8. Accessed March 03, 2021.
   Google Scholar
• Yanamandra U, Senee H, Yanamadra S, et al. Erythropoietin and ferritin response in native highlanders aged 4–19 years from the Leh-Ladakh region of India. Br J Haematol. 2019;184(2):263–268. doi:10.1111/bjh.15553
   Web of Science ®Google Scholar
• Lee G, Choi S, Kim K, et al. Association of hemoglobin concentration and its change with cardiovascular and all-cause mortality. J Am Heart Assoc. 2018;7(3).
   Web of Science ®Google Scholar
• Smith M, Arthur D, Camitta B, et al. Uniform approach to risk classification and treatment assignment for children with acute lymphoblastic leukemia. J Clin Oncol. 1996;14(1):18–24. doi:10.1200/JCO.1996.14.1.18
   PubMed Web of Science ®Google Scholar
• Horne BD, Anderson JL, John JM, et al. Which white blood cell subtypes predict increased cardiovascular risk? J Am Coll Cardiol. 2005;45(10):1638–1643. doi:10.1016/j.jacc.2005.02.054
   PubMed Web of Science ®Google Scholar
• Ensrud K, Grimm RH Jr The white blood cell count and risk for coronary heart disease. Am Heart J. 1992;124(1):207–213. doi:10.1016/0002-8703(92)90942-O
   PubMed Web of Science ®Google Scholar
• Simonson TS, Wei G, Wagner HE, et al. Low haemoglobin concentration in Tibetan males is associated with greater high-altitude exercise capacity. J Physiol. 2015;593(14):3207–3218. doi:10.1113/JP270518
   Web of Science ®Google Scholar
• Wagner PD, Simonson TS, Wei G, et al. Sea-level haemoglobin concentration is associated with greater exercise capacity in Tibetan males at 4200 m. Exp Physiol. 2015;100(11):1256–1262. doi:10.1113/EP085036
   Web of Science ®Google Scholar
• Beall CM, Goldstein MC. Hemoglobin concentration of pastoral nomads permanently resident at 4850–5450 meters in Tibet. Am J Phys Anthropol. 1987;73(4):433–438. doi:10.1002/ajpa.1330730404
   Web of Science ®Google Scholar
• Petousi N, Croft QP, Cavalleri GL, et al. Tibetans living at sea level have a hyporesponsive hypoxia-inducible factor system and blunted physiological responses to hypoxia. J Appl Physiol. 2014;116(7):893–904. doi:10.1152/japplphysiol.00535.2013
   Web of Science ®Google Scholar
• León-Velarde F, Maggiorini M, Reeves JT, et al. Consensus statement on chronic and subacute high altitude diseases. High Alt Med Biol. 2005;6(2):147–157. doi:10.1089/ham.2005.6.147
   PubMed Web of Science ®Google Scholar
• Sahota IS, Panwar NS. Prevalence of chronic mountain sickness in high altitude districts of Himachal Pradesh. Indian J Occup Environ Med. 2013;17(3):94–100. doi:10.4103/0019-5278.130839
   Google Scholar
• Negi PC, Asotra S, Marwah R, et al. Epidemiological study of chronic mountain sickness in natives of Spiti Valley in the Greater Himalayas. High Alt Med Biol. 2013;14(3):220–229. doi:10.1089/ham.2012.1127
   PubMed Web of Science ®Google Scholar
• Villafuerte FC, Corante N. Chronic mountain sickness: clinical aspects, etiology, management, and treatment. High Alt Med Biol. 2016;17(2):61–69. doi:10.1089/ham.2016.0031
   PubMed Web of Science ®Google Scholar
• Monge C, León-Velarde F, Arregui A. Increasing prevalence of excessive erythrocytosis with age among healthy high-altitude miners. N Engl J Med. 1989;321(18):1271.
   Web of Science ®Google Scholar
• Hancco I, Bailly S, Baillieul S, et al. Excessive erythrocytosis and chronic mountain sickness in dwellers of the highest city in the world. Front Physiol. 2020;11:773. doi:10.3389/fphys.2020.00773
   PubMed Web of Science ®Google Scholar
• Ahmed P, Chaudhry QU, Satti TM, Raza S, Mahmood SK. Erythrocytosis following allogeneic hemopoietic SCT in three cases of aplastic anemia. Bone Marrow Transplant. 2011;46(8):1163–1165. doi:10.1038/bmt.2010.265
   Web of Science ®Google Scholar
• Winslow RM, Chapman KW, Gibson CC, et al. Different hematologic responses to hypoxia in Sherpas and Quechua Indians. J Appl Physiol. 1989;66(4):1561–1569. doi:10.1152/jappl.1989.66.4.1561
   Web of Science ®Google Scholar
• Chen MH, Raffield LM, Mousas A, et al. Trans-ethnic and ancestry-specific blood-cell genetics in 746,667 individuals from 5 global populations. Cell. 2020;182(5):1198–1213.e1114. doi:10.1016/j.cell.2020.06.045
   PubMed Web of Science ®Google Scholar
• Beall CM, Cavalleri GL, Deng L, et al. Natural selection on EPAS1 (HIF2alpha) associated with low hemoglobin concentration in Tibetan highlanders. Proc Natl Acad Sci U S A. 2010;107(25):11459–11464. doi:10.1073/pnas.1002443107
   PubMed Web of Science ®Google Scholar
• Cho JI, Basnyat B, Jeong C, et al. Ethnically Tibetan women in Nepal with low hemoglobin concentration have better reproductive outcomes. Evol Med Public Health. 2017;2017(1):82–96. doi:10.1093/emph/eox008
   Web of Science ®Google Scholar
• West JB. Barcroft’s bold assertion: all dwellers at high altitudes are persons of impaired physical and mental powers. J Physiol. 2016;594(5):1127–1134. doi:10.1113/JP270284
   Web of Science ®Google Scholar
• Mokhtari M, Najafi S. Evaluation of the correlation of automated and manual results of complete blood count in oncologic patients. Comp Clin Path. 2016;25(6):1151–1154. doi:10.1007/s00580-016-2319-9
   Google Scholar
• Ike SO, Nubila T, Ukaejiofo EO, Nubila IN, Shu EN, Ezema I. Comparison of haematological parameters determined by the Sysmex KX - 2IN automated haematology analyzer and the manual counts. BMC Clin Pathol. 2010;10(1):3. doi:10.1186/1472-6890-10-3
   Google Scholar
• Harris N, Jou JM, Devoto G, et al. Performance evaluation of the ADVIA 2120 hematology analyzer: an international multicenter clinical trial. Lab Hematol. 2005;11(1):62–70. doi:10.1532/LH96.04064
   Google Scholar
• ADVIA 2120i Hematology System with Autoslide. Erlangen: Siemens Healthineers; 2021. Available from: https://www.siemens-healthineers.com/en-us/hematology/systems/advia-2120-hematology-system-with-autoslide. Accessed March 03, 2021.
   Google Scholar
• Wu DW, Li YM, Wang F. How Long can we Store Blood Samples: A Systematic Review and Meta-Analysis. EBioMedicine. 2017;24:277–285.
   Web of Science ®Google Scholar