Catha edulis Forsk and Ascorbic Acid Effects on Hematological Indices in Rat

References

• Tesfaye G, Derese A, Hambsa MT. Substance use and associated factors among university students in Ethiopia: a cross-sectional study. J Addict. 2014;2014:1–8. doi:10.1155/2014/969837
   Google Scholar
• Al-Habori M. The potential adverse effects of habitual use of Catha edulis (khat). Expert Opin Drug Saf. 2005;4(6):1145–1154. doi:10.1517/14740338.4.6.1145
   PubMedGoogle Scholar
• Sunbul EA, Sunbul M, Yanartas O, et al. Increased neutrophil/lymphocyte ratio in patients with depression is correlated with the severity of depression and cardiovascular risk factors. Psychiatry Investig. 2016;13(1):121–126. doi:10.4306/pi.2016.13.1.121
   PubMed Web of Science ®Google Scholar
• Odenwald M, Neuner F, Schauer M, et al. Catha edulis forskuse as risk factor for psychotic disorders: a cross-sectional and case-control study in Somalia. BMC Med. 2005;3(5):1–10. doi:10.1186/1741-7015-3-5.2
   Google Scholar
• Issa FH, Al-Habori M, Chance ML. Effect of Catha edulis forsk (Catha edulis) use on the bioavailability, plasma levels and antimalarial activity of chloroquine. Med J. 2016;16(2):182–188.
   Google Scholar
• El-Sayed MK, Amin HK. Effect of Catha edulis on insulin, resistin and cortisol levels in type-2 diabetics and nondiabetics. Am J Biochem Biotech. 2012;8(3):157–163. doi:10.3844/ajbbsp.2012.157.163
   Google Scholar
• El-Sayed MK, Amin HK. Catha edulis chewing effects on the treatment of paranoid schizophrenic patients. Neuropsychiatr Dis Treat. 2015;11:1067–1076. doi:10.2147/NDT.S81011
   Web of Science ®Google Scholar
• Algabr M, Dunia AM, Aissaoui H, et al. Flavonoids glycosides from leaves of Catha edulis (Celastraceae). Der Pharma Chem. 2015;7(11):193–196.
   Google Scholar
• Al-Alimi KR, Razak A, Saub R, Alabsi AM. Tannins acid, ascorbic acid and fluoride from Catha edulis forskChewing plant. Int J Dent Oral Health. 2017;3(4):1–4. doi:10.16966/2378-7090.240
   Google Scholar
• Bin-Jaliah I, Dallak MA, Al-Hashem FH, et al. Derangement of hemopoiesis and hematological indices in Catha edulis forsk(Catha edulis) - treated rats. Afr J Biotech. 2014;13(2):349–355. doi:10.5897/AJB2013.13373
   Google Scholar
• Oliveira CP, Kassab P, Lopasso FP, et al. Protective effect of ascorbic acid in experimental gastric cancer: reduction of oxidative stress. World J Gastroenterol. 2003;9(3):446–448. doi:10.3748/wjg.v9.i3.446
   Web of Science ®Google Scholar
• Padayatty SJ, Riordan HD, Hewitt SM, Arie Katz L, Hoffer J, Mark L. Intravenously administered vitamin C as cancer therapy: three cases. CMA. 2006;174(7):937–942. doi:10.1503/cmaj.050346
   Web of Science ®Google Scholar
• Klimant E, Wright H, Rubin D, Seely D, Markman M. Intravenous vitamin C in the supportive care of cancer patients: a review and rational approach. Curr Oncol. 2018;25(2):139–148. doi:10.3747/co.25.3790
   Web of Science ®Google Scholar
• Aburawi SM, Fathia A, Ghambirlou F, Attumi AA, Altubuly RA, Kara AA. Effect of ascorbic acid on mental depression drug therapy: clinical study. Clin Study J. 2014;4(1):1–8. doi:10.4172/2161-0487.1000131
   Google Scholar
• Moretti M, Budni J, Santos D, et al. Protective effects of ascorbic acid on behavior and oxidative status of restraint-stressed mice. J Mol Neurosci. 2013;49(1):68–79. doi:10.1007/s12031-012-9892-4
   Web of Science ®Google Scholar
• Alfaifi H, Abdelwahab SI, Mohan S, et al. Catha edulis forsk (Khat): evaluation of its antidepressant-like activity. Pharmacogn Mag. 2017;13(50):354–358. doi:10.4103/pm.pm_442_16
   Web of Science ®Google Scholar
• National Institution of Health. Guide for the Care and Use of Laboratory Animals. 8th ed. National Academic Press (US); 2011.
   Google Scholar
• Mohammed F, Engidawork E, Nedi T. The effect of acute and subchronic administration of Crude Catha edulis forskExtract (Catha Edulis F.) on weight in mice. ASRJETS. 2015;14(1):132–141.
   Google Scholar
• Foster MN, Carr AC, Alina Antony A, Selene PS, Fitzpatric MG. Intravenous vitamin C administration improved blood cell counts and health-related quality of life of patient with history of relapsed acute myeloid leukaemia. Antioxidants. 2018;7(7):92. doi:10.3390/antiox7070092
   Web of Science ®Google Scholar
• Ketema T, Yohannes M, Alemayehu E, Ambelu A. Effect of chronic Catha edulis forsk(Catha edulis, Forsk) use on outcome of Plasmodium berghei ANKA infection in Swiss albino mice. BMC Infect Dis. 2015;15(1):170. doi:10.1186/s12879-015-0911-2
   Web of Science ®Google Scholar
• Alele PE, Abayomi M, Ajayi AM, Imaniramp L. Chronic Catha edulis forsk(Catha edulis) and alcohol marginally alter complete blood counts, clinical chemistry, and testosterone in male rats. J Exp Pharmacol. 2013;5:33–44. doi:10.2147/JEP.S46635
   Google Scholar
• Sharaf A, Farrag AR, Fahmy H. Protective effects of vitamin C on hematological and biochemical parameters of intoxicated male albino rats with lead and cadmium. MEJAST. 2017;7(1):57–67.
   Google Scholar
• Nencini P, Ahmed AM, Amiconi G, Elmi AS. Tolerance develops to sympathetic effects of Catha edulis forskin humans. Pharmacology. 1984;28(3):150–154. doi:10.1159/000137956
   PubMed Web of Science ®Google Scholar
• Alsalahi A, Abdulla MA, Al-Mamary M, et al. Toxicological features of Catha edulis (Khat) on livers and kidneys of male and female Sprague-Dawley rats: a subchronic study. Evid Based Complement Alternat Med. 2012;2012:1–11. doi:10.1155/2012/829401
   Web of Science ®Google Scholar
• Al-Mamary H, El-Shaibany A, Al-Habori M, Al-Meeri A, Al-Zubairi AS, Al-Mamary M. Effect of Catha edulis on the activities of enzyme markers of carcinogenicity in chemically-induced hepatocellular carcinoma in rabbits. Int J Cancer Res. 2014;10(1):1–13. doi:10.3923/ijcr.2014.1.13
   Google Scholar
• Safhi MM, Alam MF, Hussain S, et al. Cathinone, an active principle of Catha edulis, accelerates oxidative stress in the limbic area of Swiss albino mice. J Ethnopharmacol. 2014;156:102–106. doi:10.1016/j.jep.2014.08.004
   Web of Science ®Google Scholar
• Abdelwahab SI, Alsanosy R, Taha E, Syam MS. Catha edulis forskInduced toxicity: role on its modulating effects on inflammation and oxidative stability. Biomed Res Int. 2018;2018:1–8. doi:10.1155/2018/5896041
   Web of Science ®Google Scholar
• Manzar MD, Salahuddin M, Sony P, et al. Sleep disturbances and memory impairment among pregnant women consuming khat: an under-recognized problem. Ann Thorac Med. 2018;12:247–251.
   Web of Science ®Google Scholar
• Ahmed MB, El-Qirbi AB. Biochemical effects of Catha edulis, cathine and cathinone on adrenocortical functions. J Ethnopharmacol. 1993;39(30):213–216. doi:10.1016/0378-8741(93)90039-8
   Web of Science ®Google Scholar
• Deutsch V, Lerner-Geva L, Reches A, Boyko V, Limor R, Grisaru D. Sustained leukocyte count during rising cortisol level. Acta Haematol. 2007;118(2):73–76. doi:10.1159/000103216
   Web of Science ®Google Scholar
• Nishitani N, Hisataka Sakakibara H. Association of psychological stress response of fatigue with white blood cell count in male daytime workers. Ind Health. 2014;52(6):531–534. doi:10.2486/indhealth.2013-0045
   Web of Science ®Google Scholar
• Al-Zubairi A, Al-Habori M, Al-Geiry A. Effect of Catha edulis (khat) chewing on plasma lipid peroxidation. J Ethnopharmacol. 2003;87(1):3–9. doi:10.1016/S0378-8741(03)00101-6
   Web of Science ®Google Scholar
• Boudjeltia KZ, Faraut B, Stenuit P, et al. Sleep restriction increases white blood cells, mainly neutrophil count, in young healthy men: a pilot study. Vasc Health Risk Manag. 2008;4(6):1467–1470. doi:10.2147/VHRM.S3934
   PubMedGoogle Scholar
• Rosales C. Neutrophil: a cell with many roles in inflammation or several cell types. Front Physiol. 2018;9(113):1–17. doi:10.3389/fphys.2018.00113
   Web of Science ®Google Scholar
• Boneberg EM, Seydlitz EV, Propster K, Watzl H, Rock-stroh B, Illges H. D3 dopamine receptor mRNA is elevated in T cells of schizophrenic patients whereas D4 dopamine receptor mRNA is reduced in CD4+ -T cells. J Neuroimmunol. 2006;173(2):180–187. doi:10.1016/j.jneuroim.2005.11.018
   Web of Science ®Google Scholar
• Bogale T, Engidawork E, Yisma E. Subchronic oral administration of crude Catha edulis forskextract (Catha edulis forsk) induces schizophernic-like symptoms in mice. BMC Complement Altern Med. 2016;16(153):1–12. doi:10.1186/s12906-016-1145-6
   Web of Science ®Google Scholar
• Hritcu L. Hematological disorders in 6-hydroxydopamine induced rat model of Parkinson’s disease. Turk J Hematol. 2008;25:140–144.
   Google Scholar
• Cosentino M, Marino F, Maestroni GJ. Sympathoadrenergic modulation of hematopoiesis: a review of available evidence and of therapeutic perspectives. Front Cell Neurosci. 2015;9(302):1–12. doi:10.3389/fncel.2015.00302
   Google Scholar
• Owu DU, Nwokocha CR, Ikpi DE, Ogar EI. Effect of vitamin C supplementation on platelet aggregation and serum electrolytes levels in streptozotocin-induced diabetes mellitus in rats. Niger J Physiol Sci. 2016;31(1):55–61. Available from: www.njps.com.ng.
   PubMedGoogle Scholar
• Cengiz M, Candır BA, Yılmaz G, Akyol G, Ozenirler S. Is increased red cell distribution width an indicating marker of nonalcoholic steatohepatitis and fibrotic stage? World J Gastroenterol. 2013;19(42):7412–7418. doi:10.3748/wjg.v19.i42.7412
   Web of Science ®Google Scholar
• Xu WS, Qiu XM, Ou QS, et al. Red blood cell distribution width levels correlate with liver fibrosis and inflammation A noninvasive serum marker panel to predict the severity of fibrosis and inflammation in patients with hepatitis B. Medicine. 2015;94(10):1–7.
   Web of Science ®Google Scholar
• Alhaddad OM, Elsabaawy MM, Waked IA. Catha edulis forskIntertwined liver damage. J Infect Dis Ther. 2017;5(5):1–3. doi:10.4172/2332-0877.1000337
   Google Scholar
• Carrera G, Mitjavila S, Derache R. Effect of tannic acid on vitamin B 12 absorption in rats. Sci Hebd Seances. 1973;276(2):239–242.
   Google Scholar
• Afsana K, Shiga K, Ishizuka S, Hara H. Reducing effects of ingesting tannic acid on the absorption of iron but not zinc, copper and magnesium by rats. Biosci Biotec Biochem. 2004;68(3):584–592. doi:10.1271/bbb.68.584
   PubMed Web of Science ®Google Scholar
• Al-Dubai W, Al-Ghazaly J, Al-Habori M, Saif-Ali R, Mohammed A. Catha Edulis (Khat) chewing decreases serum levels of iron, ferritin and vitamin B12 and increases folic acid. Int J Vit Nutr Res. 2014;84(5–6):223–228. doi:10.1024/0300-9831/a000208
   Web of Science ®Google Scholar
• Gkamprela E, Deutsch M, Pectasides D. Iron deficiency anemia in chronic liver disease: etiopathogenesis, diagnosis and treatment. Ann Gastroenterol. 2017;30(4):405–413.
   PubMed Web of Science ®Google Scholar
• Swaminathan A, Amitkumar K, Ganapathy S, Ayyavoo S. Evaluation of the impact of cigarette smoking on platelet parameters. Natl J Physiol Pharm Pharmacol. 2015;5(5):426–430. doi:10.5455/njppp.2015.5.1009201570
   Google Scholar
• Budak YU, Polat M, Huysal K. The use of platelet indices, plateletcrit, average size of platelets and Platelet size variability in emergency non-traumatic abdominal surgery: a systematic review. Biochem Med. 2016;26(2):178–193. doi:10.11613/BM.2016.020
   Web of Science ®Google Scholar
• Almis BH, Aksoy I. Average size of platelets level in patients with generalized anxiety disorder. Psychiatry Clin Psychol. 2018;28(1):43–47. doi:10.1080/24750573.2017.1385210
   Web of Science ®Google Scholar
• Zhang X, Cui -M-M, Fu S, et al. Platelet size variability correlates with the prognosis of gastric cancer. Oncotarget. 2017;8(12):2013–20219.
   Google Scholar
• Gawlita M, Wasilewski J, Osadnik T, Reguła R, Bujak K, Gonera M. Average size of platelets and platelet-large cell ratio as prognostic factors for coronary artery disease and myocardial infarction. Folia Cardiol. 2016;10(6):418–422. doi:10.5603/FC.2015.0079
   Google Scholar
• Nigussie T, Gobena T, Mossie A. Association between Catha edulis forskchewing and gastrointestinal disorders: a cross-sectional study. Ethiop J Health Sci. 2013;23(2):123–130.
   PubMedGoogle Scholar
• Sadighara P, Salar-Amoli J. High concentrations of vitamin C induce oxidative stress in blood. Biharean Biol. 2009;3(1):33–35.
   Google Scholar
• Mohammed BM, Sanford KW, Fisher BJ, et al. Impact of high dose vitamin C on platelet function. World J Crit Care Med. 2017;6(1):37–47. doi:10.5492/wjccm.v6.i1.37
   PubMedGoogle Scholar
• Ehrlich D, Humpe C, Platelets in psychiatric disorders. World J Psychiatr. 2012;2(6):91–94. doi:10.5498/wjp.v2.i6.91
   PubMedGoogle Scholar