Efficacy and Safety of Ferric Carboxymaltose in the Management of Iron Deficiency Anemia: A Multi-Center Real-World Study from India

References

• Gardner W, Kassebaum N. Global, regional, and national prevalence of anemia and its causes in 204 countries and territories, 1990–2019. Curr Dev Nutr. 2020;4(Supplement_2):830. doi:10.1093/cdn/nzaa053_035
   Google Scholar
• Shukla A. NFHS 2019–21: anemia rising across all age-groups, fertility rate falls below replacement rate for first time. cnbctv18.com; 2021. Available from: https://www.cnbctv18.com/healthcare/national-family-health-survey-points-to-rising-anemia-lower-fertility-rate-11586522.htm. Accessed December 21, 2021.
   Google Scholar
• Ministry of Health and Family Welfare. Government of India. Anemia Mukt Bharat: Intensified National Iron Plus Initiative (I-NIPI): operational guidelines for programme managers; 2018. Available from: https://www.fitterfly.com/site/pdf/anemia-mukt-bharat.pdf. Accessed January 12, 2022.
   Google Scholar
• Bora K. Temporal trends and differential patterns in the prevalence of severe anaemia in India: observations from country-wide haemoglobin determinations 2008–2018. Trop Med Int Health. 2019;24(7):829–838. doi:10.1111/tmi.13240
   PubMed Web of Science ®Google Scholar
• Rognoni C, Venturini S, Meregaglia M, Marmifero M, Tarricone R. Efficacy and safety of ferric carboxymaltose and other formulations in iron-deficient patients: a systematic review and network meta-analysis of randomised controlled trials. Clin Drug Investig. 2016;36:177–194. doi:10.1007/s40261-015-0361-z
   PubMed Web of Science ®Google Scholar
• Girelli D, Ugolini S, Busti F, Marchi G, Castagna A. Modern iron replacement therapy: clinical and pathophysiological insights. Int J Hematol. 2018;107(1):16–30. doi:10.1007/s12185-017-2373-3
   PubMed Web of Science ®Google Scholar
• Auerbach M, Macdougall I. The available intravenous iron formulations: history, efficacy, and toxicology. Hemodial Int. 2017;21 Suppl 1:S83–S92. doi:10.1111/hdi.12560
   PubMed Web of Science ®Google Scholar
• Muñoz M, Martín-Montañez E. Ferric carboxymaltose for the treatment of iron-deficiency anemia. Expert Opin Pharmacother. 2012;13(6):907–921. doi:10.1517/14656566.2012.669373.
   PubMed Web of Science ®Google Scholar
• Lyseng-Williamson KA, Keating GM. Ferric carboxymaltose: a review of its use in iron-deficiency anaemia. Drugs. 2009;69(6):739–756. doi:10.2165/00003495-200969060-00007
   PubMed Web of Science ®Google Scholar
• Scott LJ. Ferric carboxymaltose: a review in iron deficiency. Drugs. 2018;78(4):479–493. doi:10.1007/s40265-018-0885-7
   PubMed Web of Science ®Google Scholar
• Gupte SA, Venkataraman G, Shah AS, Mudholkar AS, Jangam SM. Clinical effects and safety of ferric carboxymaltose in pregnancy: an Indian real-life experience. J Obstetr Gynaecol Res. 2021;47(10):3464–3470. doi:10.1111/jog.14956
   PubMed Web of Science ®Google Scholar
• Kaur R, Kant S, Haldar P, et al. Single dose of intravenous ferric carboxymaltose prevents anemia for 6 months among moderately or severely anemic postpartum women: a case study from India. Curr Dev Nutr. 2021;5(7):nzab078. doi:10.1093/cdn/nzab078
   PubMed Web of Science ®Google Scholar
• Mishra V, Verneker R, Gandhi K, Choudhary S, Lamba S. Iron Deficiency Anemia with Menorrhagia: ferric Carboxymaltose a Safer Alternative to Blood Transfusion. J Midlife Health. 2018;9(2):92–96. doi:10.4103/jmh.JMH_121_17
   PubMedGoogle Scholar
• Wani S, Noushad M, Ashiq S. REGAIN STUDY: retrospective study to assess the effectiveness, tolerability, and safety of ferric carboxymaltose in the management of iron deficiency anemia in pregnant women. Anemia. 2019;2019:4640635. doi:10.1155/2019/4640635
   PubMed Web of Science ®Google Scholar
• Jones JJ, Mundy LM, Blackman N, Shwarz M. Ferric carboxymaltose for anemic perioperative populations: a systematic literature review of randomized controlled trials. JBM. 2021;12:337–359. doi:10.2147/JBM.S295041
   Web of Science ®Google Scholar
• Qian C, Kwong WJ. Real world outcomes of ferric carboxymaltose and ferumoxytol iron replacement therapy: a retrospective analysis of electronic health records. Blood. 2017;130:2087. doi:10.1182/blood.V130.Suppl_1.2087.2087
   Web of Science ®Google Scholar
• Suvarna VR. Real world evidence (RWE) - Are we (RWE) ready? Perspect Clin Res. 2018;9(2):61–63. doi:10.4103/picr.PICR_36_18
   PubMedGoogle Scholar
• Matt V, Matthew H. The retrospective chart review: important methodological considerations. J Educ Eval Health Prof. 2013;10:12. doi:10.3352/jeehp.2013.10.12
   PubMedGoogle Scholar
• World Health Organization. WHO: haemoglobin concentrations for the diagnosis of anaemia and assessment of severity. Vitamin and Mineral Nutrition Information System. Geneva: World Health Organization. WHO/NMH/NHD/MNM/11.1; 2011. Available from: https://apps.who.int/iris/bitstream/handle/10665/85839/WHO_NMH_NHD_MNM_11.1_eng.pdf. Accessed January 21, 2022.
   Google Scholar
• Naqash A, Ara R, Bader GN. Effectiveness and safety of ferric carboxymaltose compared to iron sucrose in women with iron deficiency anemia: phase IV clinical trials. BMC Women's Health. 2018;18(1):6. doi:10.1186/s12905-017-0506-8
   PubMed Web of Science ®Google Scholar
• Eser A, Kyio NH. Efficacy and safety of intravenous ferric carboxymaltose in iron deficiency anemia; real-life data from Turkey, a single center experience. Med Sci. 2021;10(2):422–426. doi:10.5455/medscience.2021.02.039
   Google Scholar
• Robalo Nunes A, Palricas Costa A, Rocha SL, Garcia de Oliveira A. Efficacy and tolerability of intravenous ferric carboxymaltose in patients with iron deficiency at a hospital outpatient clinic: a retrospective cohort study of real-world clinical practice. Anemia. 2017;2017:3106890. doi:10.1155/2017/3106890
   PubMed Web of Science ®Google Scholar
• Wachsmuth NB, Aigner T, Völzke C, Zapf J, Schmidt WF. Monitoring recovery from iron deficiency using total hemoglobin mass. Med Sci Sports Exerc. 2015;47(2):419–427. doi:10.1249/mss.0000000000000420
   PubMed Web of Science ®Google Scholar
• Jose A, Mahey R, Sharma JB, et al. Comparison of ferric Carboxymaltose and iron sucrose complex for treatment of iron deficiency anemia in pregnancy- randomised controlled trial. BMC Pregnancy Childbirth. 2019;19(1):54. doi:10.1186/s12884-019-2200-3
   PubMed Web of Science ®Google Scholar
• Breymann C, Milman N, Mezzacasa A, Bernard R, Dudenhausen J. FER-ASAP investigators. Ferric carboxymaltose vs. oral iron in the treatment of pregnant women with iron deficiency anemia: an international, open-label, randomized controlled trial (FER-ASAP). J Perinat Med. 2017;45(4):443–453. doi:10.1515/jpm-2016-0050
   PubMed Web of Science ®Google Scholar
• Sharma N, Thiek JL, Natung T, Ahanthem SS. Comparative study of efficacy and safety of ferric carboxymaltose versus iron sucrose in post-partum anaemia. J Obstet Gynaecol India. 2017;67(4):253–257. doi:10.1007/s13224-017-0971-x
   PubMed Web of Science ®Google Scholar
• Krishna K, Krishna A, Teja GD. Role of ferric carboxymaltose in the treatment of postpartum anemia in a tertiary care hospital in Andhra Pradesh. Int J Reprod Contracept Obstetr Gynecol. 2021;10(10):3889–3894. doi:10.18203/2320-1770.ijrcog20213857
   Google Scholar
• Kumari S, Singh S. Iron sucrose or ferric carboxy maltose: comparative study for treatment of post-partum iron deficiency anemia. J Med Res Prof. 2019;5(1):157–162.
   Google Scholar
• LaVallee C, Cronin P, Bansal I, Kwong WJ, Boccia RV. Effectiveness of parenteral iron therapy in the real-world setting: a retrospective analysis. J Clin Haematol. 2020;1(1):103–106. doi:10.33696/haematology.1.004
   PubMedGoogle Scholar
• Garbowski MW, Bansal S, Porter JB, Mori C, Burckhardt S, Hider RC. Intravenous iron preparations transiently generate non-transferrin-bound iron from two proposed pathways. Haematologica. 2020;106(11):2885–2896. doi:10.3324/haematol.2020.250803
   Web of Science ®Google Scholar
• Thomas DW, Hinchliffe RF, Briggs C, et al. Guideline for the laboratory diagnosis of functional iron deficiency. Br J Haematol. 2013;161(5):639–648. doi:10.1111/bjh.12311
   PubMed Web of Science ®Google Scholar
• Callen JL, Westbrook JI, Georgiou A, Li J. Failure to follow-up test results for ambulatory patients: a systematic review. J Gen Intern Med. 2012;27(10):1334–1348. doi:10.1007/s11606-011-1949-5
   PubMed Web of Science ®Google Scholar
• Kanuri G, Chichula D, Sawhney R, et al. Optimizing diagnostic biomarkers of iron deficiency anemia in community-dwelling Indian women and preschool children. Haematologica. 2018;103(12):1991–1996. doi:10.3324/haematol.2018.193243
   PubMed Web of Science ®Google Scholar
• Didzun O, Neve JWD, Awasthi A, et al. Anaemia among men in India: a nationally representative cross-sectional study. Lancet Glob Health. 2019;7(12):e1685–e1694. doi:10.1016/S2214-109X(19)30440-1
   PubMed Web of Science ®Google Scholar
• Mohapatra D, Bhatia V, Parida SP. Diagnostic dilemma in catching anaemia early. Indian J Commun Fam Med. 2018;4(1):69. doi:10.4103/2395-2113.251354
   Google Scholar
• Guyatt GH, Oxman AD, Ali M, Willan A, McIlroy W, Patterson C. Laboratory diagnosis of iron-deficiency anemia. J Gen Intern Med. 1992;7(2):145–153. doi:10.1007/BF02598003
   PubMed Web of Science ®Google Scholar
• Ratre BK, Patel NP, Patel U, Jain R, Sharma VK. Clinical and epidemiological profile of anemia in central India. Int J Med Res Rev. 2014;2(1):45–52. doi:10.17511/ijmrr.2014.i01.09
   Google Scholar
• DeMaeyer EM, Dallman P, Gurney JM, et al. Preventing and controlling iron deficiency anaemia through primary health care: a guide for health administrators and programme managers. World Health Organization; 1989. Available from: https://apps.who.int/iris/handle/10665/39849. Accessed February 24, 2022.
   Google Scholar
• Alleyne M, Horne MK, Miller JL. Individualized treatment for iron deficiency anemia in adults. Am J Med. 2008;121(11):943–948. doi:10.1016/j.amjmed.2008.07.012
   PubMed Web of Science ®Google Scholar
• Pfeiffer CM, Looker AC. Laboratory methodologies for indicators of iron status: strengths, limitations, and analytical challenges. Am J Clin Nutr. 2017;106(suppl_6):1606S–1614S. doi:10.3945/ajcn.117.155887
   PubMed Web of Science ®Google Scholar
• Motta I, Mantovan G, Consonni D, et al. Treatment with ferric carboxymaltose in stable patients with severe iron deficiency anemia in the emergency department. Intern Emerg Med. 2020;15(4):629–634. doi:10.1007/s11739-019-02223-z
   PubMed Web of Science ®Google Scholar