Acute Malaria in Malawian Children and Adults is Characterized by Thrombocytopenia That Normalizes in Convalescence

References

• Murray CJ, Ortblad KF, Guinovart C, et al. Global, regional, and national incidence and mortality for HIV, tuberculosis, and malaria during 1990–2013: a systematic analysis for the global burden of disease study 2013. Lancet. 2014;384(9947):1005–1070. doi:10.1016/S0140-6736(14)60844-8
   PubMed Web of Science ®Google Scholar
• Gething PW, Battle KE, Bhatt S, et al. Declining malaria in Africa: improving the measurement of progress. Malar J. 2014;13:39. doi:10.1186/1475-2875-13-39
   PubMed Web of Science ®Google Scholar
• World Malaria Report 2020. 20 years of global progress and challenges; 2020. Available from: http://www.who.int/malaria/publications/world-malaria-report-2020/report/en/. Accessed August 25, 2022.
   Google Scholar
• Marsh K, Forster D, Waruiru C, et al. Indicators of life-threatening malaria in African children. N Engl J Med. 1995;332:1399–1404. doi:10.1056/NEJM199505253322102
   PubMed Web of Science ®Google Scholar
• Langhorne J, Ndungu FM, Sponaas AM, Marsh K. Immunity to malaria: more questions than answers. Nat Immunol. 2008;9:725–732. doi:10.1038/ni.f.205
   PubMed Web of Science ®Google Scholar
• Newton CR, Peshu N, Kendall B, et al. Brain swelling and ischaemia in Kenyans with cerebral malaria. Arch Dis Child. 1994;70(4):281–287. doi:10.1136/adc.70.4.281
   PubMed Web of Science ®Google Scholar
• Mandala WL, Msefula CL, Gondwe EN, et al. Lymphocyte perturbations in malawian children with severe and uncomplicated malaria. Clin Vaccine Immunol. 2016;23:95–103. doi:10.1128/CVI.00564-15
   Google Scholar
• Pradhan V, Ghosh K. Immunological disturbances associated with malarial infection. J Parasit Dis. 2013;37(1):11–15. doi:10.1007/s12639-012-0174-4
   PubMedGoogle Scholar
• Hviid L, Kurtzhals JA, Goka BQ, Oliver-Commey JO, Nkrumah FK, Theander TG. Rapid reemergence of T cells into peripheral circulation following treatment of severe and uncomplicated Plasmodium falciparum malaria. Infect Immun. 1997;65:4090–4093. doi:10.1128/iai.65.10.4090-4093.1997
   PubMed Web of Science ®Google Scholar
• Gupta NK, Bansal SB, Jain UC, Sahare K. Study of thrombocytopenia in patients of malaria. Tropical Parasitol. 2013;3(1):58–61. doi:10.4103/2229-5070.113914
   PubMedGoogle Scholar
• Lacerda MVG, Mourão MPG, Coelho HCC, Santos JB. Thrombocytopenia in malaria: who cares? Mem Inst Oswaldo Cruz. 2011;106(Suppl 1):52–63. doi:10.1590/S0074-02762011000900007
   PubMed Web of Science ®Google Scholar
• Patel U, Gandhi G, Friedman S, Niranjan S. Thrombocytopenia in malaria. J Natl Med Assoc. 2004;96(9):1212–1214.
   PubMed Web of Science ®Google Scholar
• De Mast Q, De Groot PG, Van Heerde WL, et al. Thrombocytopenia in early malaria is associated with GP1b shedding in absence of systemic platelet activation and consumptive coagulopathy. Brit J Haematol. 2010;151(5):495–503. doi:10.1111/j.1365-2141.2010.08399.x
   PubMed Web of Science ®Google Scholar
• Grau GE, Mackenzie CD, Carr RA, et al. Platelet accumulation in brain microvessels in fatal pediatric cerebral malaria. J Infect Dis. 2003;187:461–466. doi:10.1086/367960
   PubMed Web of Science ®Google Scholar
• Khan SJ, Abbass Y, Marwat MA. Thrombocytopenia as an indicator of malaria in adult population. Malar Res Treat. 2012;2012:405981. doi:10.1155/2012/405981
   PubMedGoogle Scholar
• Gebreweld A, Erkihun Y, Feleke DG, Hailu G, Fiseha T. Thrombocytopenia as a diagnostic marker for malaria in patients with acute febrile illness. J Trop Med. 2021;2021:5585272. doi:10.1155/2021/5585272
   PubMedGoogle Scholar
• Lampah DA, Yeo TW, Malloy M, et al. Severe malarial thrombocytopenia: a risk factor for mortality in Papua, Indonesia. J Infect Dis. 2011;211(4):623–634. doi:10.1093/infdis/jiu487
   Web of Science ®Google Scholar
• Hanson J, Phu NH, Hasan MU, et al. The clinical implications of thrombocytopenia in adults with severe falciparum malaria: a retrospective analysis. BMC Med. 2015;13:97. doi:10.1186/s12916-015-0324-5
   PubMed Web of Science ®Google Scholar
• Munyenyembe AU, Gausi K, Nyirenda TS, Hiestand J, Mallewa J, Mandala WL. HIV infection has a profound effect on hematological factors but not on electrolyte profile of Malawian adults presenting with uncomplicated malaria and severe malaria. J Blood Med. 2018;9:153–162. doi:10.2147/JBM.S172869
   PubMed Web of Science ®Google Scholar
• Marsh K, English M, Crawley J, Peshu N. The pathogenesis of severe malaria in African children. Ann Trop Med Parasitol. 1996;90(4):395–402. doi:10.1080/00034983.1996.11813068
   PubMed Web of Science ®Google Scholar
• Mandala WL, Gondwe EN, MacLennan JM, Molyneux ME, MacLennan CA. Age- and sex-related changes in hematological parameters in healthy Malawians. J Blood Med. 2017;8:123–130. doi:10.2147/JBM.S142189
   PubMed Web of Science ®Google Scholar
• Wilson JJ, Neame PB, Kelton JG. Infection-induced thrombocytopenia. Semin Thromb Hemost. 1982;8(3):217–233. doi:10.1055/s-2007-1005053
   PubMed Web of Science ®Google Scholar
• Ladhani S, Lowe B, Cole AO, Kowuondo K, Newton CR. Changes in white blood cells and platelets in children with falciparum malaria: relationship to disease outcome. Br J Haematol. 2002;119(3):839–847. doi:10.1046/j.1365-2141.2002.03904.x
   PubMed Web of Science ®Google Scholar
• Gérardin P, Rogier C, Ka AS, Jouvencel P, Diatta B, Imbert P. Outcome of life-threatening malaria in African children requiring endotracheal intubation. Malar J. 2007;6:51. doi:10.1186/1475-2875-6-51
   PubMed Web of Science ®Google Scholar
• Pain A, Ferguson DJ, Kai O, et al. Platelet-mediated clumping of Plasmodium falciparum-infected erythrocytes is a common adhesive phenotype and is associated with severe malaria. Proc Natl Acad Sci USA. 2001;98(4):1805–1810. doi:10.1073/pnas.98.4.1805
   PubMed Web of Science ®Google Scholar
• Kim JS, Oh JS, Chang EA, et al. Alteration of platelet counts and lipid profiles after treatment of acute. Plasmodium Vivax Acta Trop. 2008;106(1):39–43. doi:10.1016/j.actatropica.2008.01.002
   PubMed Web of Science ®Google Scholar
• Leowattana W, Tangpukdee N, Thar SK, et al. Changes in platelet count in uncomplicated and severe falciparum malaria. Southeast Asian J Trop Med Public Health. 2010;41(5):1035–1041.
   PubMed Web of Science ®Google Scholar
• Kho S, Barber BE, Johar E, et al. Platelets kill circulating parasites of all major Plasmodium species in human malaria. Blood. 2018;132(12):1332–1344. doi:10.1182/blood-2018-05-849307
   PubMed Web of Science ®Google Scholar
• Gumbo A, Topazian HM, Mwanza A, et al. Occurrence and distribution of non-falciparum malaria parasite species among adolescents and adults in Malawi. J Infect Dis. 2022;225(2):257–268. doi:10.1093/infdis/jiab353
   PubMed Web of Science ®Google Scholar
• Lardinois B, Favresse J, Chatelain B, Lippi G, Mullier F. Pseudothrombocytopenia-A review on causes, occurrence and clinical implications. J Clin Med. 2021;10(4):594. doi:10.3390/jcm10040594
   PubMed Web of Science ®Google Scholar
• Horstmann RD, Dietrich M, Bienzle U, Rasche H. Malaria-induced thrombocytopenia. Blut. 1981;42(3):157–164. doi:10.1007/BF01026385
   PubMedGoogle Scholar
• Naing C, Whittaker MA. Severe thrombocytopaenia in patients with vivax malaria compared to falciparum malaria: a systematic review and meta-analysis. Infect Dis Poverty. 2018;7(1):10. doi:10.1186/s40249-018-0392-9
   PubMed Web of Science ®Google Scholar
• Ansari S, Khoharo HK, Abro A, Akhund IA, Qureshi F. Thrombocytopenia in Plasmodium falciparum malaria. J Ayub Med Coll Abbottabad. 2009;21(2):145–147.
   PubMedGoogle Scholar