The Effect of Sertraline on Hemodynamic Parameters and Nitric Oxide Production in Isolated Rat Hearts Subjected to Ischemia and Reperfusion

References

• Paraskevaidis I, Parissis JT, Fountoulaki K, Filippatos G, Kremastinos D. Selective serotonin re-uptake inhibitors for the treatment of depression in coronary artery disease and chronic heart failure: evidence for pleiotropic effects. Cardiovasc Hematol Agents Med Chem. 2006;4:361–367. doi:10.2174/18715250678411145417073612
   PubMedGoogle Scholar
• Roose SP. Treatment of depression in patients with heart disease. Biol Psychiatry. 2003;54:262–268. doi:10.1016/S0006-3223(03)00320-212893102
   PubMed Web of Science ®Google Scholar
• Schlienger RG, Fischer LM, Jick H, Meier CR. Current use of selective serotonin reuptake inhibitors and risk of acute myocardial infarction. Drug Saf Int J Med Toxicol Drug Exp. 2004;27:1157–1165. doi:10.2165/00002018-200427140-00006
   PubMed Web of Science ®Google Scholar
• Serebruany VL, Glassman AH, Malinin AI, et al. Selective serotonin reuptake inhibitors yield additional antiplatelet protection in patients with congestive heart failure treated with antecedent aspirin. Eur J Heart Fail J Work Group Heart Fail Eur Soc Cardiol. 2003;5:517–521.
   Web of Science ®Google Scholar
• Isbister GK, Bowe SJ, Dawson A, Whyte IM. Relative toxicity of selective serotonin reuptake inhibitors (SSRIs) in overdose. J Toxicol Clin Toxicol. 2004;42:277–285. doi:10.1081/CLT-12003742815362595
   PubMed Web of Science ®Google Scholar
• Pacher P, Kecskemeti V. Cardiovascular side effects of new antidepressants and antipsychotics: new drugs, old concerns? Curr Pharm Des. 2004;10:2463–2475. doi:10.2174/138161204338387215320756
   PubMed Web of Science ®Google Scholar
• Pacher P, Ungvari Z. Selective serotonin-reuptake inhibitor antidepressants increase the risk of falls and hip fractures in elderly people by inhibiting cardiovascular ion channels. Med Hypotheses. 2001;57:469–471. doi:10.1054/mehy.2001.136611601871
   PubMed Web of Science ®Google Scholar
• Serebruany VL, Gurbel PA, O’Connor CM. Platelet inhibition by sertraline and N-desmethylsertraline: a possible missing link between depression, coronary events, and mortality benefits of selective serotonin reuptake inhibitors. Pharmacol Res off J Ital Pharmacol Soc. 2001;43:453–462.
   Web of Science ®Google Scholar
• Musselman DL, Lawson DH, Gumnick JF, et al. Paroxetine for the prevention of depression induced by high-dose interferon alfa. N Engl J Med. 2001;344:961–966. doi:10.1056/NEJM20010329344130311274622
   PubMed Web of Science ®Google Scholar
• Cohen H, Kotler M, Matar M, Kaplan Z. Normalization of heart rate variability in post-traumatic stress disorder patients following fluoxetine treatment: preliminary results. Isr Med Assoc J IMAJ. 2000;2:296–301.10804906
   PubMed Web of Science ®Google Scholar
• Shores MM, Pascualy M, Lewis NL, Flatness D, Veith RC. Short-term sertraline treatment suppresses sympathetic nervous system activity in healthy human subjects. Psychoneuroendocrinology. 2001;26:433–439. doi:10.1016/S0306-4530(01)00002-611259862
   PubMed Web of Science ®Google Scholar
• van Melle JP, de Jonge P, van den Berg MP, Pot HJ, van Veldhuisen DJ. Treatment of depression in acute coronary syndromes with selective serotonin reuptake inhibitors. Drugs. 2006;66:2095–2107. doi:10.2165/00003495-200666160-0000517112303
   PubMed Web of Science ®Google Scholar
• Ferdinandy P, Schulz R. Nitric oxide, superoxide, and peroxynitrite in myocardial ischaemia-reperfusion injury and preconditioning. Br J Pharmacol. 2003;138:532–543. doi:10.1038/sj.bjp.070508012598407
   PubMed Web of Science ®Google Scholar
• Bolli R, Jeroudi MS, Patel MS. et al. Direct evidence that oxygen-derived free radicals contribute to postischemic myocardial dysfunction in the intact dog. Proc Natl Acad Sci U S A. 1989;86:4695–4699. doi:10.1073/pnas.86.12.46952543984
   PubMed Web of Science ®Google Scholar
• Schulz R, Kelm M, Heusch G. Nitric oxide in myocardial ischemia/reperfusion injury. Cardiovasc Res. 2004;61:402–413. doi:10.1016/j.cardiores.2003.09.01914962472
   PubMed Web of Science ®Google Scholar
• Finkel MS, Laghrissi-Thode F, Pollock BG, Rong J. Paroxetine is a novel nitric oxide synthase inhibitor. Psychopharmacol Bull. 1996;32:653–658.8993087
   PubMed Web of Science ®Google Scholar
• Lara N, Archer SL, Baker GB, Le Mellédo J-M. Paroxetine-induced increase in metabolic end products of nitric oxide. J Clin Psychopharmacol. 2003;23:408–412. doi:10.1097/01.jcp.0000085416.08426.1d12920419
   PubMed Web of Science ®Google Scholar
• Chrapko W, Jurasz P, Radomski MW, et al. Alteration of decreased plasma NO metabolites and platelet NO synthase activity by paroxetine in depressed patients. Neuropsychopharmacol off Publ Am Coll Neuropsychopharmacol. 2006;31:1286–1293. doi:10.1038/sj.npp.1300961
   Web of Science ®Google Scholar
• Ikenouchi-Sugita A, Yoshimura R, Hori H, et al. Effects of antidepressants on plasma metabolites of nitric oxide in major depressive disorder: comparison between milnacipran and paroxetine. Prog Neuropsychopharmacol Biol Psychiatry. 2009;33:1451–1453.19664676
   PubMed Web of Science ®Google Scholar
• Skrzypiec-Spring M, Grotthus B, Szelag A, Schulz R. Isolated heart perfusion according to Langendorff - still viable in the new millennium. J Pharmacol Toxicol Methods. 2007;55:113–126. doi:10.1016/j.vascn.2006.05.00616844390
   PubMedGoogle Scholar
• Andreadou I, IIiodromitis EK, Rassaf T, et al. The role of gasotransmitters NO, H2S and CO in myocardial ischaemia/reperfusion injury and cardioprotection by preconditioning, postconditioning and remote conditioning. Br J Pharmacol. 2015;172:1587–1606. doi:10.1111/bph.1281124923364
   PubMed Web of Science ®Google Scholar
• Gaur V, Kumar A. Behavioral, biochemical and cellular correlates in the protective effect of sertraline against transient global ischemia induced behavioral despair: possible involvement of nitric oxide-cyclic guanosine monophosphate study pathway. Brain Res Bull. 2010;82:57–64. doi:10.1016/j.brainresbull.2010.01.01020123004
   PubMed Web of Science ®Google Scholar
• Pacher P, Ungvari Z, Kecskemeti V, Koller A. Serotonin reuptake inhibitor, fluoxetine, dilates isolated skeletal muscle arterioles. Possible role of altered Ca2+ sensitivity. Br J Pharmacol. 1999;127:740–746. doi:10.1038/sj.bjp.070257110401565
   PubMed Web of Science ®Google Scholar
• Ungvari Z, Pacher P, Kecskeméti V, Koller A. Fluoxetine dilates isolated small cerebral arteries of rats and attenuates constrictions to serotonin, norepinephrine, and a voltage-dependent Ca(2+) channel opener. Stroke J Cereb Circ. 1999;30:1949–1954. doi:10.1161/01.STR.30.9.1949
   Web of Science ®Google Scholar
• Ungvari Z, Pacher P, Koller A. Serotonin reuptake inhibitor fluoxetine decreases arteriolar myogenic tone by reducing smooth muscle [Ca2+]i. J Cardiovasc Pharmacol. 2000;35:849–854. doi:10.1097/00005344-200006000-0000410836717
   PubMed Web of Science ®Google Scholar
• Deák F, Lasztóczi B, Pacher P, et al. Inhibition of voltage-gated calcium channels by fluoxetine in rat hippocampal pyramidal cells. Neuropharmacology. 2000;39:1029–1036. doi:10.1016/S0028-3908(99)00206-310727713
   PubMed Web of Science ®Google Scholar
• Pacher P, Ungvari Z, Kecskeméti V, Friedmann T, Furst S. Serotonin reuptake inhibitors fluoxetine and citalopram relax intestinal smooth muscle. Can J Physiol Pharmacol. 2001;79:580–584. doi:10.1139/y01-03011478591
   PubMed Web of Science ®Google Scholar
• Velasco A, Alamo C, Hervás J, Carvajal A. Effects of fluoxetine hydrochloride and fluvoxamine maleate on different preparations of isolated guinea pig and rat organ tissues. Gen Pharmacol. 1997;28:509–512. doi:10.1016/S0306-3623(96)00274-19147017
   PubMedGoogle Scholar
• Boulton DW, Balch AH, Royzman K, et al. The pharmacokinetics of standard antidepressants with aripiprazole as adjunctive therapy: studies in healthy subjects and in patients with major depressive disorder. J Psychopharmacol. 2010;24:537–546. doi:10.1177/026988110809652218832427
   PubMed Web of Science ®Google Scholar
• Pacher P, Magyar J, Szigligeti P, et al. Electrophysiological effects of fluoxetine in mammalian cardiac tissues. Naunyn Schmiedebergs Arch Pharmacol. 2000;361:67–73. doi:10.1007/s00210990015410651149
   PubMed Web of Science ®Google Scholar
• Pousti A, Malihi G, Naghibi B. Effect of citalopram on ouabain-induced arrhythmia in isolated guinea-pig atria. Hum Psychopharmacol. 2003;18:121–124. doi:10.1002/hup.44612590405
   PubMed Web of Science ®Google Scholar
• Pousti A, Deemyad T, Brumand K, Bakhtiarian A. The effect of fluvoxamine on ouabain-induced arrhythmia in isolated guinea-pig atria. Pharmacol Res. 2005;52:151–153. doi:10.1016/j.phrs.2005.01.00215967380
   PubMed Web of Science ®Google Scholar
• Pousti A, Bakhtiarian A, Najafi R, et al. Effect of sertraline on ouabain-induced arrhythmia in isolated guinea-pig atria. Depress Anxiety. 2009;26:E106–E110. doi:10.1002/da.2040719242981
   PubMedGoogle Scholar
• Gregg DE. Effect of coronary perfusion pressure or coronary flow on oxygen usage of the myocardium. Circ Res. 1963;1:497–500. doi:10.1161/01.RES.13.6.497
   Web of Science ®Google Scholar
• Opie LH. Coronary flow rate and perfusion pressure as determinants of mechanical function and oxidative metabolism of isolated perfused rat heart. J Physiol. 1965;180:529–541. doi:10.1113/jphysiol.1965.sp0077155846791
   PubMed Web of Science ®Google Scholar
• Lamberts RR, Van Rijen MHP, Sipkema P, et al. Increased coronary perfusion augments cardiac contractility in the rat through stretch-activated ion channels. Am J Physiol Heart Circ Physiol. 2002;282:H1334–H1340. doi:10.1152/ajpheart.00327.200111893569
   PubMed Web of Science ®Google Scholar
• Dijkman MA, Heslinga JW, Sipkema P, Westerhof N. Perfusion-induced changes in cardiac O2 consumption and contractility are based on different mechanisms. Am J Physiol. 1996;271:H984–989. doi:10.1152/ajpheart.1996.271.3.H9848853332
   PubMed Web of Science ®Google Scholar
• Dijkman MA, Heslinga JW, Sipkema P, Westerhof N. Perfusion-induced changes in cardiac contractility and oxygen consumption are not endothelium-dependent. Cardiovasc Res. 1997;33:593–600. doi:10.1016/S0008-6363(96)00260-X9093529
   PubMed Web of Science ®Google Scholar
• Muto T, Usuda H, Yamamura A, et al. Protective effects of fluvoxamine against ischemia/reperfusion injury in isolated, perfused guinea-pig hearts. Biol Pharm Bull. 2014;37:731–739. doi:10.1248/bpb.b13-0055224789996
   PubMed Web of Science ®Google Scholar
• McDermott JS, Salmen HJ, Cox BF, Gintant GA. Importance of species selection in arrythmogenic models of Q-T interval prolongation. Antimicrob Agents Chemother. 2002;46:938–939. doi:10.1128/AAC.46.3.938-939.200211850295
   PubMed Web of Science ®Google Scholar
• Suzuki J, Tsubone H, Sugano S. Studies on the positive T wave on ECG in the rat - based on the analysis for direct cardiac electrograms in the ventricle. Adv Anim Cardiol. 1993;26:24–32.
   Google Scholar
• Thomas D, Gut B, Wendt-Nordahl G, Kiehn J. The antidepressant drug fluoxetine is an inhibitor of human ether-a-go-go-related gene (HERG) potassium channels. J Pharmacol Exp Ther. 2002;300:543–548. doi:10.1124/jpet.300.2.54311805215
   PubMed Web of Science ®Google Scholar
• Witchel HJ, Pabbathi VK, Hofmann G, Paul AA, Hancox JC. Inhibitory actions of the selective serotonin re-uptake inhibitor citalopram on HERG and ventricular L-type calcium currents. FEBS Lett. 2002;512:59–66. doi:10.1016/S0014-5793(01)03320-811852052
   PubMed Web of Science ®Google Scholar
• Park KS, Kong ID, Park KC, Lee JW. Fluoxetine inhibits L-type Ca2+ and transient outward K+ currents in rat ventricular myocytes. Yonsei Med J. 1999;40:144–151. doi:10.3349/ymj.1999.40.2.14410333718
   PubMed Web of Science ®Google Scholar
• Hahn SJ, Choi JS, Rhie DJ, et al. Inhibition by fluoxetine of voltage-activated ion channels in rat PC12 cells. Eur J Pharmacol. 1999;367:113–118. doi:10.1016/S0014-2999(98)00955-810082273
   PubMed Web of Science ®Google Scholar