Evaluation of Antimalarial Activity of Hydromethanolic Crude Extract and Solvent Fractions of the Leaves of Nuxia congesta R. Br. Ex Fresen (Buddlejaceae) in Plasmodium berghei Infected Mice

References

• Iwuafor AA, Egwuatu CC, Nnachi AU, et al. Malaria. parasitemia and the use of insecticide-treated nets (INTs) for malaria control amongst under-5 year old children in Calabar, Nigeria. BMC Infect Dis. 2016;16. doi:10.1186/s12879-016-1459-5
   Web of Science ®Google Scholar
• Che P, Cui L, Kutsch O, Cui L, Li Q. Validating a firefly luciferase-based high-throughput screening assay for antimalarial drug discovery. Assay Drug Dev Technol. 2012;10(1):61–68. doi:10.1089/adt.2011.037822050430
   PubMed Web of Science ®Google Scholar
• Doolan DL. Plasmodium Immunomics. Int J Parasitol. 2011;41(1):3–20. doi:10.1016/j.ijpara.2010.08.00220816843
   PubMed Web of Science ®Google Scholar
• Snow RW, Amratia P, Kabaria CW, Noor AM, Marsh K. The changing limits and incidence of malaria in Africa: 1939–2009. Adv Parasitol. 2012;78:169–262.22520443
   PubMed Web of Science ®Google Scholar
• World Health Organization. World Malaria Report. 2018 Available from: https://apps.who.int›iris›bitstream›handle›9789241565653-eng. Accessed 1020, 2019.
   Google Scholar
• Aregawi M, Lynch M, Bekele W, et al. Time series analysis of trends in malaria cases and deaths at hospitals and the effect of antimalarial interventions, 2001–2011, Ethiopia. PLoS One. 2014;9:11. doi:10.1371/journal.pone.0106359
   Web of Science ®Google Scholar
• Deribew A, Dejene T, Kebede B. Incidence, prevalence and mortality rates of malaria in Ethiopia from 1990 to 2015: analysis of the global burden of diseases 2015. Malar J. 2017;16:271. doi:10.1186/s12936-017-1919-428676108
   PubMed Web of Science ®Google Scholar
• Cui L, Mharakurwa S, Ndiaye D, Rathod PK, Rosenthal PJ. Antimalarial drug resistance: literature review and activities and findings of the ICEMR network. Am J Trop Med Hyg. 2015;93(3):57–68. doi:10.4269/ajtmh.15-0007
   PubMed Web of Science ®Google Scholar
• Murithi CK, Fidahusein DS, Nguta JM, Lukhoba CW. Antimalarial activity and in vivo toxicity of selected medicinal plants naturalised in Kenya. Int Educ Res J. 2014;2:395–406.
   Google Scholar
• Asnake S, Teklehaymanot T, Hymete A, Erko B, Giday M. Survey of medicinal plants used to treat malaria by Sidama People of Boricha District, Sidama Zone, South Region of Ethiopia. Evid Based Complement Alternat Med. 2016;2016:1–9. doi:10.1155/2016/9690164
   Web of Science ®Google Scholar
• Ntie-Kang F, Onguéné PA, Lifongo LL, Ndom JC, Sippl W, Mbaze LM. The potential of anti-malarial compounds derived from African medicinal plants, part ii: a pharmacological evaluation of non-alkaloids and non-terpenoids. Malaria J. 2014;13:81. doi:10.1186/1475-2875-13-81
   Web of Science ®Google Scholar
• Bankole AE, Adekunle AA, Sowemimo AA, Umebese CE, Abiodun O, Gbotosho GO. Phytochemical screening and in vivo antimalarial activity of extracts from three medicinal plants used in malaria treatment in Nigeria. Parasitol Res. 2016;115:299–305. doi:10.1007/s00436-015-4747-x26391173
   PubMed Web of Science ®Google Scholar
• Amelo W, Nagpal P, Makonnen E. Antiplasmodial activity of solvent fractions of methanolic root extract of Dodonaea angustifolia in P. berghei infected mice. BMC Complement Altern Med. 2014;14(1):462. doi:10.1186/1472-6882-14-46225465394
   PubMed Web of Science ®Google Scholar
• Bantie L, Assefa S, Teklehaimanot T, Engidawork E. In vivo antimalarial activity of the crude leaf extract and solvent fractions of Croton macrostachyus Hocsht. (Euphorbiaceae) against P. berghei in Mice. BMC Complement Altern Med. 2014;14:79. doi:10.1186/1472-6882-14-7924580778
   PubMed Web of Science ®Google Scholar
• Girma S, Giday M, Erko B, Mamo H. Effect of Crude Leaf Extract of Osyris quadripartita on P. berghei in Swiss Albino Mice. BMC Complement Altern Med. 2015;15(1):184.26077462
   PubMed Web of Science ®Google Scholar
• Al-Massarani SM, El-Gamal AA, Parvez MK, et al. New cytotoxic seco-type triterpene and labdane-type diterpenes from Nuxia oppositifolia. Molecules. 2017;22(3):389. doi:10.3390/molecules22030389
   Web of Science ®Google Scholar
• Neergheen-Bhujun VS. Underestimating the toxicological challenges associated with the use of herbal medicinal products in developing countries. Biomed Res Int. 2013;2013.
   Web of Science ®Google Scholar
• Oyen LFA, Radlk L Protologue report British association advancem science. 1885: 1081 Available from: www.itto.int/files/itto_project_db_input/2595//E-PD-479-07-R2-M-Timbers-2-5.pdf. Accessed1130, 2019.
   Google Scholar
• Jensen SR, Ravnkilde L, Schripsema J. Unedoside derivatives in nuxia and their biosynthesis. Phytochemistry. 1998;47(6):1007–1011. doi:10.1016/S0031-9422(98)80062-9
   Web of Science ®Google Scholar
• Kipkore W, Wanjohi B, Rono H, Kigen G. A Study of the medicinal plants used by the Marakwet community in Kenya. J Ethnobiol Ethnomed. 2014;10:24. doi:10.1186/1746-4269-10-2424555424
   PubMed Web of Science ®Google Scholar
• Bussmann RW, Swartzinsky P, Worede A, Evangelista P. Plant use in Odo-Bulu and Demaro, Bale region, Ethiopia. J Ethnobiol Ethnomed. 2011;7:28. doi:10.1186/1746-4269-7-2821943288
   PubMed Web of Science ®Google Scholar
• Chekole G, Asfaw Z, Kelbessa E. Ethnobotanical study of medicinal plants in the environs of tara-gedam and amba Remnant forests of Libo Kemkem District, Northwest Ethiopia. J Ethnobiol Ethnomed. 2015;11(1):4.25572933
   PubMed Web of Science ®Google Scholar
• Fenetahun Y, Eshetu G. A review on ethnobotanical studies of medicinal plants use by agro-pastoral communities in, Ethiopia. J Med Plants. 2017;5(1):33–44.
   Google Scholar
• Council NR. Guide for the Care and Use of Laboratory Animals. National Academies Press; 2010.
   Google Scholar
• Tiwari P, Kumar B, Kaur M, Kaur G, Kaur H. Phytochemical screening and extraction: a review. Int Pharm Sci. 2011;1(1):98–106.
   Google Scholar
• Azwanida N. A review on the extraction methods use in medicinal plants, principle, strength and limitation. Med Aromat Plants. 2015;4(196):2167–2412.
   Google Scholar
• Asnake S, Teklehaymanot T, Hymete A, Erko B, Giday M. Evaluation of the antiplasmodial properties of selected plants in Southern Ethiopia. BMC Complement Altern Med. 2015;15(1):448.26698300
   PubMed Web of Science ®Google Scholar
• Cathrine L, KS B. General techniques involved in phytochemical analiysis. Int J Adv Res Chem Sci. 2015;2:4.
   Google Scholar
• Evans WC. Trease and Evans’ Pharmacognosy. Elsevier Health Sciences; 2009.
   Google Scholar
• OECD. Acute Oral Toxicity – Up-And-Down-Procedure (UDP). OECD Guidelines for the Testing of Chemicals. OECD Publishing Paris; 2008:425
   Google Scholar
• Fidock DA, Rosenthal PJ, Croft SL, Brun R, Nwaka S. Antimalarial drug discovery: efficacy models for compound screening. Nat Rev Drug Discov. 2004;3(6):509–520. doi:10.1038/nrd141615173840
   PubMed Web of Science ®Google Scholar
• Tarkang PA, Appiah-Opong R, Ofori MF, Ayong LS, Nyarko AK. Application of multi-target phytotherapeutic concept in malaria drug discovery: a systems biology approach in biomarker identification. Biomark Res. 2016;4(1):25.27999673
   PubMedGoogle Scholar
• Arrey Tarkang P, Okalebo FA, Ayong LS, Agbor GA, Guantai AN. Anti-malarial activity of a polyherbal product (nefang) during early and established plasmodium infection in rodent models. Malaria J. 2014;13(1):456.
   Web of Science ®Google Scholar
• Somsak V, Polwiang N, Chachiyo S. In vivo antimalarial activity of annona muricata leaf extract in mice infected with Plasmodium berghei. J Pathog. 2016;2016.
   Google Scholar
• Beeson JG, Drew DR, Boyle MJ, Feng G, Fowkes FJ, Richards JS. Merozoite surface proteins in red blood cell invasion, immunity and vaccines against malaria. FEMS Microbiol Rev. 2016;40(3):343–372. doi:10.1093/femsre/fuw00126833236
   PubMed Web of Science ®Google Scholar
• Pérez-Moreno G, Cantizani J, Sánchez-Carrasco P, et al. Discovery of new compounds active against Plasmodium falciparum by high throughput screening of microbial natural products. PLoS One. 2016;11(1):e0145812. doi:10.1371/journal.pone.014581226735308
   PubMed Web of Science ®Google Scholar
• Gabryszewski SJ, Dhingra SK, Combrinck JM, et al. Evolution of fitness cost-neutral mutant PfCRT conferring P. falciparum 4-aminoquinoline drug resistance is accompanied by altered parasite metabolism and digestive vacuole physiology. PLoS Pathog. 2016;12(11):e1005976. doi:10.1371/journal.ppat.100597627832198
   PubMed Web of Science ®Google Scholar
• Lima RBS, Rocha e Silva LF, Melo MRS, et al. In vitro and in vivo anti-malarial activity of plants from the Brazilian amazon. Malaria J. 2015;14(1):508.
   Web of Science ®Google Scholar
• Batista R, De Jesus Silva A Jr, De Oliveira AB. Plant-derived antimalarial agents: new leads and efficient phytomedicines. part II. non-alkaloidal natural products. Molecules. 2009;14(8):3037–3072. doi:10.3390/molecules1408303719701144
   PubMed Web of Science ®Google Scholar
• Mambu L, Grellier P, Florent L, et al. Clerodane and labdane diterpenoids from Nuxia sphaerocephala. Phytochemistry. 2006;67(5):444–451. doi:10.1016/j.phytochem.2005.11.02416427101
   PubMed Web of Science ®Google Scholar
• Amoa Onguéné P, Ntie-Kang F, Lifongo LL, Ndom JC, Sippl W, Mbaze LM. The potential of anti-malarial compounds derived from african medicinal plants, part I: a pharmacological evaluation of alkaloids and terpenoids. Malaria J. 2013;12:449. doi:10.1186/1475-2875-12-449
   PubMed Web of Science ®Google Scholar
• Rasoanaivo P, Wright CW, Willcox ML, Gilbert B. Whole plant extracts versus single compounds for the treatment of malaria: synergy and positive interactions. Malaria J. 2011;10(1):54. doi:10.1186/1475-2875-10-S1-S4
   Web of Science ®Google Scholar
• Boaduo NKK. Evaluation of six plant species used traditionally in the treatment and control of diabetes mellitus. University of Pretoria; 2010.
   Google Scholar
• Adugna M, Feyera T, Taddese W and Admasu P. In vivo antimalarial activity of crude extract of aerial part of artemisia abyssinica against plasmodium berghei in Mice. Global J Pharmacol. 2014;8(4):557–565.
   Google Scholar
• Chikezie PC, Ibegbulem CO, Mbagwu FN. Medicinal potentials and toxicity concerns of bioactive principles. Med Aromat Plants. 2015;4(3):1–15.
   Google Scholar
• Roth M, Araya JJ, Timmermann BN, Hagenbuch B. Isolation of modulators of the liver-specific organic anion-transporting polypeptides (OATPs) 1B1 and 1B3 from Rollinia emarginata Schlecht (annonaceae). J Pharmacol Exp Ther. 2011;339(2):624–632. doi:10.1124/jpet.111.18456421846839
   PubMed Web of Science ®Google Scholar
• Jensen SR. Chemistry of buddlejaceae. New World Buddlejaceae Fl Neotrop Monogr. 2000;81:42–61.
   Google Scholar
• Radev R. Pharmacological effects of phenylethanoid glycosides. J Clin Med. 2010;2:20–23.
   Google Scholar
• Wink M. Modes of action of herbal medicines and plant secondary metabolites. Medicines. 2015;2(3):251–286. doi:10.3390/medicines203025128930211
   PubMedGoogle Scholar
• Kefe A, Giday M, Mamo H, Erko B. Antimalarial properties of crude extracts of seeds of Brucea antidysenterica and leaves of Ocimum lamiifolium In: BMC Complementary and Alternative Medicine. 2016:16.
   Google Scholar
• Toma A, Deyno S, Fikru A, Eyado A, Beale A. In vivo antiplasmodial and toxicological effect of ethanol extract of echinops kebericho traditionally used in treatment of malaria in Ethiopia. Malaria. 2015;14(1):196.
   Web of Science ®Google Scholar
• Jonville M, Kodja H, Humeau L, et al. Screening of medicinal plants from reunion island for antimalarial and cytotoxic activity. J Ethnopharmacol. 2008;120(3):382–386. doi:10.1016/j.jep.2008.09.00518848979
   PubMed Web of Science ®Google Scholar
• Jonville M, Kodja H, Strasberg D, et al. Antiplasmodial, anti-inflammatory and cytotoxic activities of various plant extracts from the mascarene archipelago. J Ethnopharmacol. 2011;136(3):525–531. doi:10.1016/j.jep.2010.06.01320600776
   PubMed Web of Science ®Google Scholar
• Alli LA, Adesokan AA, OA S. Antimalarial activity of fractions of aqueous extract of Acacia nilotica root. J Intercult Ethnopharmacol. 2016;5(2):6.
   Google Scholar