Flavonoids as GABA_A receptor ligands: the whole story?

References

• TapasARSakarkarDMKakdeRBFlavonoids as nutraceuticals: a reviewTrop J Pharm Res2008710891099
   Web of Science ®Google Scholar
• BuerCSIminNDjordjevicMAFlavonoids: new roles for old moleculesJ Integr Plant Biol2010529811120074144
   PubMed Web of Science ®Google Scholar
• SpencerJPEBeyond antioxidants: the cellular and molecular interactions of flavonoids and how these underpin their actions on the brainProc Nutr Soc20106924426020158941
   PubMed Web of Science ®Google Scholar
• TaylorLPGrotewoldEFlavonoids as developmental regulatorsCurr Opin Plant Biol2005831732315860429
   PubMed Web of Science ®Google Scholar
• GonzálezRBallesterILópez-PosadasREffects of flavonoids and other polyphenols on inflammationCrit Rev Food Sci Nutr20115133136221432698
   PubMed Web of Science ®Google Scholar
• ShanmugamMKKannaiyanRSethiGTargeting cell signaling and apoptotic pathways by dietary agents: role in the prevention and treatment of cancerNutr Cancer20116316117321294053
   PubMed Web of Science ®Google Scholar
• XiaoZPPengZYPengMJYanWBOuyangYZZhuHLFlavonoids health benefits and their molecular mechanismMini Rev Med Chem20111116917721222576
   PubMed Web of Science ®Google Scholar
• TuñónMJGarcía-MediavillaMVSánchez-CamposSGonzález-GallegoJPotential of flavonoids as anti-inflammatory agents: modulation of pro-inflammatory gene expression and signal transduction pathwaysCurr Drug Metab20091025627119442088
   PubMed Web of Science ®Google Scholar
• WilliamsonGManachCBioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studiesAm J Clin Nutr200581243S255S15640487
   PubMed Web of Science ®Google Scholar
• ManachCWilliamsonGMorandCScalbertARémésyCBioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studiesAm J Clin Nutr200581230S242S15640486
   PubMed Web of Science ®Google Scholar
• SpencerJPEAbd El MohsenMMMinihaneAMMathersJCBiomarkers of the intake of dietary polyphenols: strengths, limitations and application in nutrition researchBr J Nutr200899122217666146
   PubMed Web of Science ®Google Scholar
• SpencerJPEMetabolism of tea flavonoids in the gastrointestinal tractJ Nutr2003133Suppl3255S3261S14519823
   PubMed Web of Science ®Google Scholar
• DayAJCanadaFJDiazJCDietary flavonoid and isoflavone glycosides are hydrolysed by the lactase site of lactase phlorizin hydrolaseFEBS Lett200046816617010692580
   PubMed Web of Science ®Google Scholar
• WalgrenRALinJTKinneRKWalleTCellular uptake of dietary flavonoid quercetin 4′-beta-glucoside by sodium-dependent glucose transporter SGLT1J Pharmacol Exp Ther200029483784310945831
   PubMed Web of Science ®Google Scholar
• WolfframSBlockMAderPQuercetin-3-glucoside is transported by the glucose carrier SGLT1 across the brush border membrane of rat small intestineJ Nutr200213263063511925453
   PubMed Web of Science ®Google Scholar
• NemethKPlumbGWBerrinJGDeglycosylation by small intestinal epithelial cell beta-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humansEur J Nutr200342294212594539
   PubMed Web of Science ®Google Scholar
• Radominska-PandyaALittleJMPandyaJTUDP-glucuronosyltransferases in human intestinal mucosaBiochim Biophys Acta199813941992089795217
   PubMed Web of Science ®Google Scholar
• O’LearyKADayAJNeedsPWMellonFAO’BrienNMWilliamsonGMetabolism of quercetin-7- and quercetin-3-glucuronides by an in vitro hepatic model: the role of human beta-glucuronidase, sulfotransferase, catechol-O-methyltransferase and multi-resistant protein 2 (MRP2) in flavonoid metabolismBiochem Pharmacol20036547949112527341
   PubMed Web of Science ®Google Scholar
• MatsukawaNMatsumotoMHaraHHigh biliary excretion levels of quercetin metabolites after administration of a quercetin glycoside in conscious bile duct cannulated ratsBiosci Biotechnol Biochem2009731863186519661706
   PubMed Web of Science ®Google Scholar
• SchelineRRMetabolism of oxygen heterocyclic compoundsHandbook of Mammalian Metabolism of Plant CompoundsBoca Raton, FLCRC Press Inc1999
   Google Scholar
• UnwinNThe structure of ion channels in membranes of excitable cellsNeuron198936656762484344
   PubMed Web of Science ®Google Scholar
• BarnardEASkolnickPOlsenRWInternational Union of Pharmacology. XV. Subtypes of γ-aminobutyric acid A receptors: Classification on the basis of subunit structure and receptor functionPharmacol Rev1998502913139647870
   PubMed Web of Science ®Google Scholar
• WhitingPMcKernanRMIversenLLAnother mechanism for creating diversity in gamma-aminobutyrate type A receptors: RNA splicing directs expression of two forms of gamma 2 phosphorylation siteProc Natl Acad Sci U S A199087996699701702226
   PubMed Web of Science ®Google Scholar
• McKinleyDDLennonDJCarterDBCloning, sequence analysis and expression of two forms of mRNA coding for the human beta 2 subunit of the GABAA receptorMol Brain Res1995281751797707873
   PubMedGoogle Scholar
• OlsenRWSieghartWInternational Union of Pharmacology. LXX. Subtypes of gamma-aminobutyric acid(A) receptors: Classification on the basis of subunit composition, pharmacology, and function. UpdatePharmacol Rev20086024326018790874
   PubMed Web of Science ®Google Scholar
• BenkeDFakitsasPRoggenmoserCMichelCRudolphUMohlerHAnalysis of the presence and abundance of GABAA receptors containing two different types of alpha subunits in murine brain using point-mutated alpha subunitsJ Biol Chem2004279436544366015304513
   PubMed Web of Science ®Google Scholar
• LuscherBFuchsTKilpatrickCLGABAA receptor trafficking-mediated plasticity of inhibitory synapsesNeuron20117038540921555068
   PubMed Web of Science ®Google Scholar
• KorpiERGründerGLüddensHDrug interactions at GABA(A) receptorsProg Neurobiol20026711315912126658
   PubMed Web of Science ®Google Scholar
• SieghartWStructure and pharmacology of gamma-aminobutyric acid A receptor subtypesPharmacol Rev1995471812347568326
   PubMed Web of Science ®Google Scholar
• IversenLGABA pharmacology – what prospects for the future?Biochem Pharmacol2004681537154015451396
   PubMed Web of Science ®Google Scholar
• SieghartWStructure, pharmacology, and function of GABAA receptor subtypesAdv Pharmacol20065423126317175817
   PubMedGoogle Scholar
• OlsenRWSieghartWGABAA receptors: Subtypes provide diversity of function and pharmacologyNeuropharmacology20095614114818760291
   PubMed Web of Science ®Google Scholar
• RudolphUMohlerHAnalysis of GABAA receptor function and dissection of the pharmacology of benzodiazepines and general anesthetics through mouse geneticsAnnu Rev Pharmacol Toxicol20044447549814744255
   PubMed Web of Science ®Google Scholar
• WhitingPJGABAA-receptors: a viable target for novel anxiolytics?Curr Opin Pharmacol20066242916359919
   PubMed Web of Science ®Google Scholar
• RudolphUCrestaniFBenkeDH. Benzodiazepine actions mediated by specific gammaaminobutyric acid(A) receptor subtypesNature199940179680010548105
   PubMed Web of Science ®Google Scholar
• McKernanRMRosahlTWReynoldsDSSedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtypeNat Neurosci2000358759210816315
   PubMed Web of Science ®Google Scholar
• LowKCrestaniFKeistRMolecular and neuronal substrate for the selective attenuation of anxietyScience200029013113411021797
   PubMed Web of Science ®Google Scholar
• DiasRSheppardWFFradleyRLEvidence for a significant role of alpha3-containing GABAA receptors in mediating the anxiolytic effects of benzodiazepinesJ Neurosci200525106821068816291941
   PubMed Web of Science ®Google Scholar
• CollinsonNKuenziFMJarolimekWEnhanced learning and memory and altered GABAergic synaptic transmission in mice lacking the alpha5 subunit of the GABAA receptorJ Neurosci2002225572558012097508
   PubMed Web of Science ®Google Scholar
• MalherbePDraguhnAMulthaupGBeyreutherKMöhlerHGABAA-receptor expressed from rat brain α- and β-subunit cDNAs displays potentiation by benzodiazepine receptor ligandsMol Brain Res199081992081977069
   PubMedGoogle Scholar
• WaltersRJHadleySHMorrisDWAminJBenzodiazepines act on GABAA receptors via two distinct and separable mechanismsNat Neurosci200031274128111100148
   PubMed Web of Science ®Google Scholar
• LukKCSternLWeigeleMO’BrienRASpirstNIsolation and identification of “diazepam-like” compounds from bovine urineJ Nat Prod1983468528616330305
   PubMed Web of Science ®Google Scholar
• MedinaJHDanelonJLWasowskiCLevi de SteinMPaladiniACProduction of benzodiazepine-like compounds in bovine rumenBiochem Biophys Res Commun1991181104810551764056
   PubMed Web of Science ®Google Scholar
• NielsenMFrokjaerSBraestrupCHigh affinity of naturally-occurring biflavonoid, amentoflavone, to brain benzodiazepine receptors in vitroBiochem Pharmacol198837328532872840912
   PubMed Web of Science ®Google Scholar
• HansenRSPaulsenIDaviesMDeterminants of amentoflavone interaction at the GABA(A) receptorEur J Pharmacol200551919920716129428
   PubMed Web of Science ®Google Scholar
• HanrahanJRChebibMDavucheronNMHallBJJohnstonGARSemisynthetic preparation of amentoflavone: A negative modulator at GABAA receptorsBioorg Med Chem Lett2003132281228412824018
   PubMed Web of Science ®Google Scholar
• ButterweckVNahrstedtAEvansJIn vitro receptor screening of pure constituents of St John’s wort reveals novel interactions with a number of GPCRsPsychopharmacology200216219320212110997
   PubMed Web of Science ®Google Scholar
• MedinaJHPeñaCLevi de SteinMWolfmanCPaladiniACBenzodiazepine-like molecules as well as other ligands for the brain benzodiazepine receptor are relatively common constituents of plantsBiochem Biophys Res Commun19891655475532557016
   PubMed Web of Science ®Google Scholar
• MedinaJHViolaHWolfmanCOverview – flavonoids: a new family of benzodiazepine receptor ligandsNeurochem Res1997224194259130252
   PubMed Web of Science ®Google Scholar
• PaladiniACMarderMViolaHWolfmanCWasowskiCMedinaJHFlavonoids and the central nervous system: from forgotten factors to potent anxiolytic compoundsJ Pharm Pharmacol19995151952610411210
   PubMed Web of Science ®Google Scholar
• MarderMPaladiniACGABA(A)-receptor ligands of flavonoid structureCurr Top Med Chem2002285386712171576
   PubMedGoogle Scholar
• MedinaJHPaladiniACWolfmanCChrysin (5,7 di-OH flavone) a naturally-occurring ligand for benzodiazepine receptors, with anticonvulsant propertiesBiochem Pharmacol199040222722322173925
   PubMed Web of Science ®Google Scholar
• WolfmanCViolaHPaladiniACDajasFMedinaJHPossible anxiolytic effects of chrysin, a central benzodiazepine receptor ligand isolated from Passiflora coeruleaPharmacol Biochem Behav199447147906886
   PubMed Web of Science ®Google Scholar
• ZhaiKHuLChenJFuCYChenQChrysin induces hyperalgesia via the GABAA receptor in micePlanta Med2008741229123418612941
   PubMed Web of Science ®Google Scholar
• ViolaHWasowskiCLevi de SteinMApigenin, a component of Matricaria recutita flowers, is a central benzodiazepine receptors-ligand with anxiolytic effectsPlanta Med1995612132167617761
   PubMed Web of Science ®Google Scholar
• AvalloneRZanoliPPuiaGKleinschnitzMSchreierPBaraldiMPharmacological profile of apigenin, a flavonoid isolated from Matricaria chamomillaBiochem Pharmacol2000591387139410751547
   PubMed Web of Science ®Google Scholar
• ZanoliPAvalloneRBaraldiMBehavioral characterization of the flavonoids apigenin and chrysinFitoterapia200071S117S12310930722
   PubMed Web of Science ®Google Scholar
• DekermendjianKKahnbergPWittMRSternerONielsenMLiljeforsTStructure–activity relationships and molecular modeling analysis of flavonoids binding to the benzodiazepine site of the rat brain GABAA receptor complexJ Med Chem1999424343435010543878
   PubMed Web of Science ®Google Scholar
• GoutmanJDWaxembergMDDonate-OliverFPomataPECalvoDJFlavonoid modulation of ionic currents mediated by GABAA and GABAC receptorsEur J Pharmacol2003461798712586201
   PubMed Web of Science ®Google Scholar
• CampbellELChebibMJohnstonGARThe dietary flavonoids apigenin and (−)-epigallocatechin gallate enhance the positive modulation by diazepam of the activation by GABA of recombinant GABAA receptorsBiochem Pharmacol2004681631163815451406
   PubMed Web of Science ®Google Scholar
• ViolaHWolfmanCLevi de SteinMIsolation of pharmacologically active benzodiazepine receptor ligands from Tília tomentosa (Tiliaceae)J Ethnopharmacol19944447537990504
   PubMed Web of Science ®Google Scholar
• ViolaHMarderMWolfmanCWasowskiCMedinaJHPaladiniACSedative and hypnotic properties of Salvia guaranítica St Hil and of its active principle, cirsiliolPhytomedicine199744550
   Web of Science ®Google Scholar
• MarderMViolaHWasowskiCCirsiliol and caffeic acid ethyl ester isolated from Salvia guaranitica, are competitive ligands for the central benzodiazepine receptorsPhytomedicine19963293123194857
   PubMed Web of Science ®Google Scholar
• VissiennonaCNieberKKelberOButterweckVRoute of administration determines the anxiolytic activity of the flavonols kaempferol, quercetin and myricetin – are they prodrugs?J Nutr Biochem2011811 Epub ahead of print
   Web of Science ®Google Scholar
• GrundmannONakajimaJKamataKSeoSButterweckVKaempferol from the leaves of Apocynum venetum possesses anxiolytic activities in the elevated plus maze test in micePhytomedicine20091629530219303276
   PubMed Web of Science ®Google Scholar
• HuiKMHuenMSWangHYAnxiolytic effect of wogonin, a benzodiazepine receptor ligand isolated from Scutellaria baicalensis GeorgiBiochem Pharmacol2002641415142412392823
   PubMed Web of Science ®Google Scholar
• ParkHGYoonSYChoiJYAnticonvulsant effect of wogonin isolated from Scutellaria baicalensisEur J Pharmacol200757411211917692312
   PubMed Web of Science ®Google Scholar
• HuenMSLeungJWNgW5,7-Dihydroxy-6-methoxyflavone, a benzodiazepine site ligand isolated from Scutellaria baicalensis Georgi, with selective antagonistic propertiesBiochem Pharmacol200366125113212818372
   PubMed Web of Science ®Google Scholar
• ShenXLNielsenMWittMRSternerOBergendorffOKhayyalMInhibition of [methyl-3H]diazepam binding to rat brain membranes in vitro by dinatin and skrofuleinZhongguo Yao Li Xue Bao1994153853887717057
   PubMed Web of Science ®Google Scholar
• KavvadiasDMonscheinVSandPRiedererPSchreierPConstituents of sage (Salvia officinalis) with in vitro affinity to human brain benzodiazepine receptorPlanta Med20036911311712624814
   PubMed Web of Science ®Google Scholar
• KavvadiasDSandPYoudimKAThe flavone hispidulin, a benzodiazepine receptor ligand with positive allosteric properties, traverses the blood-brain barrier and exhibits anticonvulsive effectsBr J Pharmacol200414281182015231642
   PubMed Web of Science ®Google Scholar
• ShenXLWittMRNielsenMSternerOInhibition of [3H] flunitraze-pam binding to rat brain membranes in vitro by puerarin and daidzeinYao Xue Xue Bao19963159628762462
   PubMedGoogle Scholar
• HäberleinHTschierschKPSchäferHLFlavonoids from Leptospermum scoparium with affinity to the benzodiazepine receptor characterized by structure activity relationships and in vivo studies of a plant extractPharmazie1994499129227838881
   PubMed Web of Science ®Google Scholar
• WasowskiCMarderMViolaHMedinaJHPaladiniACIsolation and identification of 6-methylapigenin, a competitive ligand for the brain GABA(A) receptors, from Valeriana wallichiiPlanta Med20026893493612391561
   PubMed Web of Science ®Google Scholar
• MarderMViolaHWasowskiCFernandezSMedinaJHPaladiniAC6-Methylapigenin and hesperidin: new valeriana flavonoids with activity on the CNSPharmacol Biochem Behav20037553754512895671
   PubMed Web of Science ®Google Scholar
• AdachiNTomonagaSTachibanaTDenbowDMFuruseM(−)-Epigallocatechin gallate attenuates acute stress responses through GABAergic system in the brainEur J Pharmacol200653117117516457806
   PubMed Web of Science ®Google Scholar
• VignesMMauriceTLantéFAnxiolytic properties of green tea polyphenol (−)-epigallocatechin gallate (EGCG)Brain Res2006111010211516859659
   PubMed Web of Science ®Google Scholar
• CampbellELChebibMJohnstonGAThe dietary flavonoids apigenin and (−)-epigallocatechin gallate enhance the positive modulation by diazepam of the activation by GABA of recombinant GABA(A) receptorsBiochem Pharmacol2004681631163815451406
   PubMed Web of Science ®Google Scholar
• PaladiniACMarderMViolaHWolfmanCWasowskiCMedinaJHFlavonoids and the central nervous system: from forgotten factors to potent anxiolytic compoundsJ Pharm Pharmacol19995151952610411210
   PubMed Web of Science ®Google Scholar
• MarderMPaladiniACGABA(A)-receptor ligands of flavonoid structureCurr Top Med Chem2002285386712171576
   PubMedGoogle Scholar
• ShenYLindemeyerAKGonzalezCDihydromyricetin as a novel anti-alcohol intoxication medicationJ Neurosci20123239040122219299
   PubMed Web of Science ®Google Scholar
• ColetaMCamposMGCotrimMDLimaTCCunhaAPAssessment of luteolin (3′,4′,5,7-tetrahydroxyflavone) neuropharmacological activityBehav Brain Res2008189758218249450
   PubMed Web of Science ®Google Scholar
• RainesTJonesPMoeNDuncanRMcCallSCeremugaTEInvestigation of the anxiolytic effects of luteolin, a lemon balm flavonoid in the male Sprague-Dawley ratAANA J200977333619263826
   PubMedGoogle Scholar
• WangFXuZRenLTsangSYXueHGABA A receptor subtype selectivity underlying selective anxiolytic effect of baicalinNeuropharmacology2008551231123718723037
   PubMed Web of Science ®Google Scholar
• YoonSYde la PeñaICShinCYConvulsion-related activities of Scutellaria flavones are related to the 5,7-dihydroxyl structuresEur J Pharmacol201165915516021440538
   PubMed Web of Science ®Google Scholar
• de CarvalhoRSDuarteFSde LimaTCInvolvement of GABAergic non-benzodiazepine sites in the anxiolytic-like and sedative effects of the flavonoid baicalein in miceBehav Brain Res2011221758221377498
   PubMed Web of Science ®Google Scholar
• HuenMSHuiKMLeungJWNaturally occurring 2′-hydroxyl-substituted flavonoids as high-affinity benzodiazepine site ligandsBiochem Pharmacol2003662397240714637197
   PubMed Web of Science ®Google Scholar
• ChoSKimSJinZIsoliquiritigenin, a chalcone compound, is a positive allosteric modulator of GABAA receptors and shows hypnotic effectsBiochem Biophys Res Commun201141363764221945440
   PubMed Web of Science ®Google Scholar
• JamalHAnsariWHRizviSJEvaluation of chalcones – a flavonoid subclass, for, their anxiolytic effects in rats using elevated plus maze and open field behaviour testsFundam Clin Pharmacol20082267368119049672
   PubMed Web of Science ®Google Scholar
• SternbachLHThe benzodiazepine storyProg Drug Res19782222926630117
   PubMedGoogle Scholar
• MarderMViolaHWasowskiC6 Bromoflavone, a high affinity ligand for the benzodiazepine receptors is a member of a family of active flavonoidsBiochem Biophys Res Commun19962233843898670291
   PubMed Web of Science ®Google Scholar
• ViolaHMarderMWolfmanCWasowskiCMedinaJHPaladiniAC6-Bromo-3′-nitroflavone, a new high affinity benzodiazepine receptor agonist recognizes two populations of cerebral cortical binding sitesBioorg Med Chem Lett19977373378
   Web of Science ®Google Scholar
• WolfmanCViolaHMarderMPharmacological characterization of 6-bromo-3′-nitroflavone, a synthetic flavonoid with high affinity for the benzodiazepine receptorPharmacol Biochem Behav1998612392469768558
   PubMed Web of Science ®Google Scholar
• ViolaHMarderMNuñezJ6-Methyl-3′-bromoflavone, a high-affinity ligand for the benzodiazepine binding site of the GABAA receptor with some antagonistic propertiesBiochem Biophys Res Commun199926264364610471378
   PubMed Web of Science ®Google Scholar
• ViolaHWolfmanCMarderM6-Chloro-3′-nitroflavone is a potent ligand for the benzodiazepine binding site of the GABA(A) receptor devoid of intrinsic activityPharmacol Biochem Behav20006531332010672984
   PubMed Web of Science ®Google Scholar
• ViolaHMarderMWasowskiCGiorgiOPaladiniACMedinaJH6,3′-Dibromoflavone and 6-nitro-3′-bromoflavone: new additions to the 6,3′-disubstituted flavone family of high-affinity ligands of the brain benzodiazepine binding site with agonistic propertiesBiochem Biophys Res Commun200027369469810873666
   PubMed Web of Science ®Google Scholar
• MarderMViolaHWasowskiC6,3′-Dinitroflavone, a novel high affinity ligand for the benzodiazepine receptor with potent anxiolytic propertiesBioorg Med Chem Lett1995527172720
   Web of Science ®Google Scholar
• WolfmanCViolaHMarderMAnxioselective properties of 6,3′-dinitroflavone, a high-affinity benzodiazepine receptor ligandEur J Pharmacol199631823299007508
   PubMed Web of Science ®Google Scholar
• FurtmuellerRFurtmuellerBRamerstorferJ6,3′-Dinitroflavone is a low efficacy modulator of GABAA receptorsEur J Pharmacol200859114214618639544
   PubMed Web of Science ®Google Scholar
• GriebelGPerraultGTanSSchoemakerHSangerDJPharmacological studies on synthetic flavonoids: comparison with diazepamNeuropharmacology19993896597710428415
   PubMed Web of Science ®Google Scholar
• RenLChanWMWangFEffects of flavone 6-substitutions on GABAA receptors efficacyEur J Pharmacol201167012112921914441
   PubMed Web of Science ®Google Scholar
• RenLWangFXuZChanWMZhaoCXueHGABA(A) receptor subtype selectivity underlying anxiolytic effect of 6-hydroxyflavoneBiochem Pharmacol2010791337134420067772
   PubMed Web of Science ®Google Scholar
• HallBJChebibMHanrahanJRJohnstonGAFlumazenil-independent positive modulation of gamma-aminobutyric acid action by 6-methylflavone at human recombinant alpha1beta2gamma2L and alpha1beta2 GABAA receptorsEur J Pharmacol20044911815102527
   PubMed Web of Science ®Google Scholar
• HallBJChebibMHanrahanJRJohnstonGA6-Methylflavanone, a more efficacious positive allosteric modulator of gamma-aminobutyric acid (GABA) action at human recombinant alpha2beta2gamma2L than at alpha1beta2gamma2L and alpha1beta2 GABA(A) receptors expressed in Xenopus oocytesEur J Pharmacol20055129710415840393
   PubMed Web of Science ®Google Scholar
• KarimNCurmiJGavandeN2′-Methoxy-6-methylflavone: a novel anxiolytic and sedative with subtype selective activating and modulating actions at GABA(A) receptorsBr J Pharmacol2012165488089621797842
   PubMed Web of Science ®Google Scholar
• KarimNGavandeNWellendorphPJohnstonGAHanrahanJRChebibM3-Hydroxy-2′-methoxy-6-methylflavone: a potent anxiolytic with a unique selectivity profile at GABA(A) receptor subtypesBiochem Pharmacol2011821971198321924247
   PubMed Web of Science ®Google Scholar
• FernandezSPMewettKNHanrahanJRChebibMJohnstonGAFlavan-3-ol derivatives are positive modulators of GABA(A) receptors with higher efficacy for the alpha(2) subtype and anxiolytic action in miceNeuropharmacology20085590090718657554
   PubMed Web of Science ®Google Scholar
• MewettKNFernandezSPPasrichaAKSynthesis and biological evaluation of flavan-3-ol derivatives as positive modulators of GABAA receptorsBioorg Med Chem2009177156717319783443
   PubMed Web of Science ®Google Scholar
• FernandezSPKarimNMewettKNChebibMJohnstonGAHanrahanJRFlavan-3-ol esters: new agents for exploring modulatory sites on GABA(A) receptorsBr J Pharmacol201216596597721806603
   PubMed Web of Science ®Google Scholar
• FacklamMSchochPHaefelyWERelationship between benzodiazepine receptor occupancy and potentiation of gamma-aminobutyric acid-stimulated chloride flux in vitro of four ligands of differing intrinsic efficaciesJ Pharmacol Exp Ther1992261110611121318370
   PubMed Web of Science ®Google Scholar
• BraestrupCNielsenMHonoreTJensenLPetersenEBenzodiazepine receptor ligands with positive and negative efficacyNeuropharmacology198322145114576322039
   PubMed Web of Science ®Google Scholar
• AiJDekermendjianKWangXNielsenMWittMR6-Methylflavone, a benzodiazepine receptor ligand with antagonistic properties on rat brain and human recombinant GABAA receptors in vitroDrug Dev Res19974199108
   Web of Science ®Google Scholar
• MarderMZinczukJColomboMISynthesis of halogenated/nitrated flavone derivatives and evaluation of their affinity for the central benzodiazepine receptorBioorg Med Chem Lett1997720032008
   Web of Science ®Google Scholar
• DekermendjianKKahnbergPWittMRSternerONielsenMLiljerforsTStructure-activity relationships and molecular modeling analysis of flavonoids binding to the benzodiazepine site of the rat brain GABA(A) receptor complexJ Med Chem1999424343435010543878
   PubMed Web of Science ®Google Scholar
• MarderMViolaHBacigaluppoJADetection of benzodiazepine receptor ligands in small libraries of flavone derivatives synthesized by solution phase combinatorial chemistryBiochem Biophys Res Commun19982494814859712722
   PubMed Web of Science ®Google Scholar
• MarderMEstiuGBlanchLBMolecular modeling and QSAR analysis of the interaction of flavone derivatives with the benzodiazepine binding site of the GABA(A) receptor complexBioorg Med Chem2001932333511249125
   PubMed Web of Science ®Google Scholar
• WangFXuZYuenCT6,2′-Dihydroxyflavone, a subtype-selective partial inverse agonist of GABAA receptor benzodiazepine siteNeuropharmacology20075357458217681556
   PubMed Web of Science ®Google Scholar
• GavandeNKarimNJohnstonGAHanrahanJRChebibMIdentification of benzopyran-4-one derivatives (isoflavones) as positive modulators of GABA(A) receptorsChem Med Chem201161340134621560249
   PubMed Web of Science ®Google Scholar