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Original Research

Role of Cannabinoid Receptors in Crocin-Induced Hypoalgesia in Neuropathic Pain in Rats

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Pages 97-106 | Published online: 28 Apr 2020

References

  • Deleo JA, Tanga FY, Tawfik VL. Neuroimmune activation and neuroinflammation in chronic pain and opioid tolerance/hyperalgesia. Neuroscientist. 2004;10(1):40–52. doi:10.1177/1073858403259950
  • Vakili A, Shirvanian M, Safakhah H, Rashidy-Pour A. Pentoxifylline decreases allodynia and hyperalgesia in a rat model of neuropathic pain. Daru. 2011;19(4):306–311.
  • Safakhah HA, Bazargani A, Ghanbari A. Effects of forced exercise on neuropathic pain induced by chronic constriction injury of sciatic nerve in male rat. Koomesh. 2016;411–418.
  • Gosselin RD, Suter MR, Ji RR, Decosterd I. Glial cells and chronic pain. Neuroscientist. 2010;16(5):519–531. doi:10.1177/1073858409360822
  • Watkins LR, Maier SF. Glia: a novel drug discovery target for clinical pain. Nat Rev Drug Discov. 2003;2(12):973–985. doi:10.1038/nrd1251
  • Mohamadpour AH, Ayati Z, Parizadeh MR, Rajbai O, Hosseinzadeh H. Safety evaluation of crocin (a constituent of saffron) tablets in healthy volunteers. Iran J Basic Med Sci. 2013;16(1):39.
  • Rios J, Recio M, Giner R, Manez S. An update review of saffron and its active constituents. Phytother Res. 1996;10(3):189–193. doi:10.1002/(SICI)1099-1573(199605)10:3<189::AID-PTR754>3.0.CO;2-C
  • Arefzadeh N, Arshami MH, Mousavi effects of aqueous and alcohol extracts of saffron(Crocus sativus L.) on blood analysis of rats. Paper presented at: therapeutic plants congress; 2012.
  • Abdullaev F, Riveron-Negrete L, Caballero-Ortega H, et al. Use of in vitro assays to assess the potential antigenotoxic and cytotoxic effects of saffron (Crocus sativus L.). Toxicol in Vitro. 2003;17(5–6):731–736. doi:10.1016/S0887-2333(03)00098-5
  • Premkumar K, Abraham SK, Santhiya ST, Gopinath PM, Ramesh A. Inhibition of genotoxicity by saffron (Crocus sativus L.) in mice. Drug Chem Toxicol. 2001;24(4):421–428. doi:10.1081/DCT-100106266
  • Schmidt M, Betti G, Hensel A. Saffron in phytotherapy: pharmacology and clinical uses. Wien Med Wochenschr. 2007;157(13–14):315–319. doi:10.1007/s10354-007-0428-4
  • Kubo I, Kinst-Hori I. Flavonols from saffron flower: tyrosinase inhibitory activity and inhibition mechanism. J Agric Food Chem. 1999;47(10):4121–4125. doi:10.1021/jf990201q
  • Tamaddonfard E, Farshid AA, Eghdami K, Samadi F, Erfanparast A. Comparison of the effects of crocin, safranal and diclofenac on local inflammation and inflammatory pain responses induced by carrageenan in rats. Pharmacol Rep. 2013;65(5):1272–1280. doi:10.1016/S1734-1140(13)71485-3
  • Safakhah HA, Damghanian F, Bandegi AR, Miladi-Gorji H. Effect of crocin on morphine tolerance and serum BDNF levels in a rat model of neuropathic pain. Pharmacol Rep. 2020;72(2):305–313. doi:10.1007/s43440-020-00071-9
  • Bridges D, Ahmad K, Rice AS. The synthetic cannabinoid WIN55, 212‐2 attenuates hyperalgesia and allodynia in a rat model of neuropathic pain. Br J Pharmacol. 2001;133(4):586–594. doi:10.1038/sj.bjp.0704110
  • Safakhah HA, Taghavi T, Rashidy-Pour A, et al. Effects of saffron (Crocus sativus L.) stigma extract and its active constituent crocin on neuropathic pain responses in a rat model of chronic constriction injury. Iran J Pharm Res. 2016;15(1):253.
  • Amin B, Hosseinzadeh H. Evaluation of aqueous and ethanolic extracts of saffron, Crocus sativus L., and its constituents, safranal and crocin in allodynia and hyperalgesia induced by chronic constriction injury model of neuropathic pain in rats. Fitoterapia. 2012;83(5):888–895. doi:10.1016/j.fitote.2012.03.022
  • Karami M, Bathaie SZ, Tiraihi T, Habibi-Rezaei M, Arabkheradmand J, Faghihzadeh S. Crocin improved locomotor function and mechanical behavior in the rat model of contused spinal cord injury through decreasing calcitonin gene related peptide (CGRP). Phytomedicine. 2013;21(1):62–67. doi:10.1016/j.phymed.2013.07.013
  • Mechoulam R, Shabat SB, Hanuš L, et al. Endogenous cannabinoid ligands—chemical and biological studies. J Lipid Mediat Cell Signal. 1996;14(1):45–49. doi:10.1016/0929-7855(96)01507-6
  • Palazzo E, Luongo L, Bellini G, et al. Changes in cannabinoid receptor subtype 1 activity and interaction with metabotropic glutamate subtype 5 receptors in the periaqueductal gray-rostral ventromedial medulla pathway in a rodent neuropathic pain model. CNS Neurol Disord Drug Targets. 2012;11(2):148–161.
  • Toniolo EF, Maique ET, Jr WA F, et al. Hemopressin, an inverse agonist of cannabinoid receptors, inhibits neuropathic pain in rats. Peptides. 2014;56:125–131. doi:10.1016/j.peptides.2014.03.016
  • Svíženská IH, Brázda V, Klusáková I, Dubový P. Bilateral changes of cannabinoid receptor type 2 protein and mRNA in the dorsal root ganglia of a rat neuropathic pain model. J Histochem Cytochem. 2013;61(7):529–547. doi:10.1369/0022155413491269
  • Maccarone R, Rapino C, Zerti D, et al. Modulation of Type-1 and Type-2 cannabinoid receptors by saffron in a rat model of retinal neurodegeneration. PLoS One. 2016;11(11):e0166827. doi:10.1371/journal.pone.0166827
  • Vakili A, Einali MR, Bandegi AR. Protective effect of crocin against cerebral ischemia in a dose-dependent manner in a rat model of ischemic stroke. J Stroke Cerebrovasc Dis. 2014;23(1):106–113. doi:10.1016/j.jstrokecerebrovasdis.2012.10.008
  • Dogrul A, Gul H, Akar A, Yildiz O, Bilgin F, Guzeldemir E. Topical cannabinoid antinociception: synergy with spinal sites. Pain. 2003;105(1–2):11–16. doi:10.1016/S0304-3959(03)00068-X
  • Fernandez-Solari J, Prestifilippo JP, Vissio P, et al. Anandamide injected into the lateral ventricle of the brain inhibits submandibular salivary secretion by attenuating parasympathetic neurotransmission. Braz J Med Biol Res. 2009;42(6):537–544.
  • Deshmukh R, Sharma P. Activation of central cannabinoid CB1 receptors by WIN 55, 212-2 induces hyperphagia and facilitates preferential increase in palatable diet consumption in Wistar rats. Int J Recent Adv Pharm Res. 2012;2:62–69.
  • Goonawardena AV, Plano A, Robinson L, Platt B, Hampson RE, Riedel G. A pilot study into the effects of the CB1 cannabinoid receptor agonist WIN55,212-2 or the Antagonist/Inverse Agonist AM251 on sleep in rats. Sleep Disord. 2011;2011:178469. doi:10.1155/2011/178469
  • Bennett GJ, Xie YK. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain. 1988;33(1):87–107. doi:10.1016/0304-3959(88)90209-6
  • Seyer B, Pham V, Albiston AL, Chai SY. Cannula implantation into the lateral ventricle does not adversely affect recognition or spatial working memory. Neurosci Lett. 2016;628:171–178. doi:10.1016/j.neulet.2016.06.034
  • Paxinos G, Watson CR. The Rat Brain in Stereotaxic Coordinates. 5th ed. Orlando, FL: Academic Press; 2005.
  • Ren K. An improved method for assessing mechanical allodynia in the rat. Physiol Behav. 1999;67(5):711–716. doi:10.1016/S0031-9384(99)00136-5
  • Chaplan SR, Bach F, Pogrel J, Chung J, Yaksh T. Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods. 1994;53(1):55–63. doi:10.1016/0165-0270(94)90144-9
  • Safakhah HA, Tamimi F, Bandegi AR, Ghanbari A. Hypoalgesic effect of Spirulina platensis on the sciatic neuropathic pain induced by chronic constriction injury in male rats. Biomed Res Ther. 2018;5(9):2671–2679. doi:10.15419/bmrat.v5i9.477
  • Noorbala AA, Tahmasebipour N, et al. Effects of saffron (Crocus sativus L.) on mild to moderate depression; A double blinded clinical trial. J Med Plant. 2004;2(10):31–38.
  • Patel S, Sarwat M, Khan TH. Mechanism behind the anti-tumour potential of saffron (Crocus sativus L.): the molecular perspective. Crit Rev Oncol Hematol. 2017;115:27–35. doi:10.1016/j.critrevonc.2017.04.010
  • Bisti S, Maccarone R, Falsini B. Saffron and retina: neuroprotection and pharmacokinetics. Vis Neurosci. 2014;31(4–5):355–361. doi:10.1017/S0952523814000108
  • Tabatabai SM, Dashti S, Doosti F, Hosseinzadeh H. Phytotherapy of opioid dependence and withdrawal syndrome: a review. Phytother Res. 2014;28(6):811–830. doi:10.1002/ptr.5073
  • Hosseinzadeh H, Modaghegh MH, Saffari Z. Crocus sativus L. (Saffron) extract and its active constituents (crocin and safranal) on ischemia-reperfusion in rat skeletal muscle. Evid Based Complement Alternat Med. 2009;6(3):343–350. doi:10.1093/ecam/nem125
  • Ghasemi T, Abnous K, Vahdati F, Mehri S, Razavi BM, Hosseinzadeh H. Antidepressant effect of crocus sativus aqueous extract and its effect on CREB, BDNF, and VGF transcript and protein levels in rat hippocampus. Drug Res. 2015;65(7):337–343. doi:10.1055/s-0034-1371876
  • Mehri S, Abnous K, Mousavi SH, Shariaty VM, Hosseinzadeh H. Neuroprotective effect of crocin on acrylamide-induced cytotoxicity in PC12 cells. Cell Mol Neurobiol. 2012;32(2):227–235. doi:10.1007/s10571-011-9752-8
  • Sani AM, Tajali F, Gazrani S. Role of solvent concentration on qualitative efficacy of saffron(crocus sativus) oral remedy. Natl Congr Ther Plant Nat Prod. 2013;1(1).
  • Costa B, Colleoni M, Conti S, et al. Repeated treatment with the synthetic cannabinoid WIN 55,212-2 reduces both hyperalgesia and production of pronociceptive mediators in a rat model of neuropathic pain. Br J Pharmacol. 2004;141(1):4–8. doi:10.1038/sj.bjp.0705587
  • Dani M, Guindon J, Lambert C, Beaulieu P. The local antinociceptive effects of paracetamol in neuropathic pain are mediated by cannabinoid receptors. Eur J Pharmacol. 2007;573(1–3):214–215. doi:10.1016/j.ejphar.2007.07.012
  • Costa B, Trovato AE, Colleoni M, Giagnoni G, Zarini E, Croci T. Effect of the cannabinoid CB1 receptor antagonist, SR141716, on nociceptive response and nerve demyelination in rodents with chronic constriction injury of the sciatic nerve. Pain. 2005;116(1–2):52–61. doi:10.1016/j.pain.2005.03.043
  • Nam KN, Park YM, Jung HJ, et al. Anti-inflammatory effects of crocin and crocetin in rat brain microglial cells. Eur J Pharmacol. 2010;648(1–3):110–116. doi:10.1016/j.ejphar.2010.09.003
  • Bandegi AR, Rashidy-Pour A, Vafaei AA, Ghadrdoost B. Protective effects of crocus sativus L. extract and crocin against chronic-stress induced oxidative damage of brain, liver and kidneys in rats. Adv Pharm Bull. 2014;4(Suppl 2):493–499. doi:10.5681/apb.2014.073