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Original Research

In vitro Antioxidant and in vivo Hepatoprotective Activities of Root Bark Extract and Solvent Fractions of Croton macrostachyus Hochst. Ex Del. (Euphorbiaceae) on Paracetamol-Induced Liver Damage in Mice

ORCID Icon, ORCID Icon, &
Pages 301-311 | Published online: 26 Aug 2020

References

  • Park TY, Hong M, Sung H, Kim S, Suk KT. Effect of korean Red ginseng in chronic liver disease. J Ginseng Res. 2017;41(4):450–455. doi:10.1016/j.jgr.2016.11.004
  • Alqasoumi SI, Abdel-Kader MS. Screening of Some Traditionally Used Plants for Their Hepatoprotective Effect, Phytochemicals as Nutraceuticals - Global Approaches to Their Role in Nutrition and Health. InTech; 2012:256–278.
  • Kumar A. A review on hepatoprotective herbal drugs. Int J Res Pharm Chem. 2012;2(1):96–102.
  • Yin L, Wei L, Fu R, et al. Antioxidant and hepatoprotective activity of Veronica ciliata fisch. extracts against carbon tetrachloride-induced liver injury in mice. Molecules. 2014;19(6):7223–7236. doi:10.3390/molecules19067223
  • Jaeschke H. Acetaminophen: dose-dependent drug hepatotoxicity and acute liver failure in patients. Dig Dis. 2015;33(4):464–471. doi:10.1159/000374090
  • Hussain L, Ikram J, Rehman K, Tariq M, Ibrahim M, Akash MSH. Hepatoprotective effects of Malva sylvestris l. against paracetamol-induced hepatotoxicity. Turk J Biol. 2014;38(3):396–402. doi:10.3906/biy-1312-32
  • Jannu V, Baddam PG, Boorgula AK, Jambula SR. A review on hepatoprotective plants. Int J Drug Dev Res. 2012;4(3):1–8.
  • Sabiba E, Rasool M, Vedi M, et al. Hepatoprotective and antioxidant potential of Withania somnifera against paracetamol-induced liver damage in rats. Int J Pharm Pharm Sci. 2013;5(2):648–651.
  • Jain SK, Rajvaidy S, Desai P, Singh G, Nagori B. Herbal extract as hepatoprotective-a review. J Pharmacogn Phytochem. 2013;2(3):170–175.
  • Manjunath C, Balasubramannian T, Gnanasekaran D, Ashok Kumar U, Brahmaiah Y. Evaluation of hepatoprotective activity of Haldinia cordifolia against paracetamol induced liver damage in rats. Der Pharm Lett. 2012;4(3):768–774.
  • Sobeh M, Mahmoud MF, Hasan RA, Cheng H, El-Shazly AM, Wink M. Senna singueana: antioxidant, hepatoprotective, anti-apoptotic properties and phytochemical profiling of a methanol bark extract. Molecules. 2017;22(9):1502. doi:10.3390/molecules22091502
  • Sobeh M, Mahmoud MF, Hasan RA, et al. Tannin-rich extracts from lannea stuhlmannii and lannea humilis (anacardiaceae) exhibit hepatoprotective activities in vivo via enhancement of the anti-apoptotic protein Bcl-2. Sci Rep. 2018;8(1):1–6. doi:10.1038/s41598-018-27452-8
  • Bantie L, Assefa S, Teklehaimanot T, Engidawork E. In vivo antimalarial activity of the crude leaf extract and solvent fractions of Croton macrostachyus Hocsht. (Euphorbiaceae) against plasmodium berghei in mice. BMC Complement Altern Med. 2014;14(1):1–10. doi:10.1186/1472-6882-14-79
  • Araya S, Abera B, Giday M. Study of plants traditionally used in public and animal health management in Seharti Samre district, Southern Tigray, Ethiopia. J Ethnobiol Ethnomed. 2015;11(1):1–25. doi:10.1186/s13002-015-0015-5
  • Bekele G, Reddy PR. Ethnobotanical study of medicinal plants used to treat human ailments by Guji Oromo Tribes in Abaya district, Borana, Oromia, Ethiopia. J Plant Sci. 2015;3(1):1–8.
  • Lulekal E, Kelbessa E, Bekele T, Yineger H. An ethnobotanical study of medicinal plants in Mana Angetu District, Southeastern Ethiopia. J Ethnobiol Ethnomed. 2008;4(1):1–10. doi:10.1186/1746-4269-4-10
  • Maroyi A. Ethnopharmacological uses, phytochemistry, and pharmacological properties of Croton macrostachyus Hochst. Ex Delile: a comprehensive review. Evid Based Complement Alternat Med. 2017;2017:1–17.
  • Mekuanent T, Zebene A, Solomon Z. Ethnobotanical study of medicinal plants in Chilga District, Northwestern Ethiopia. J Nat Med. 2015;15(2):88–112.
  • Teklay A, Abera B, Giday M. An ethnobotanical study of medicinal plants used in Kilte Awulaelo District, Tigray Region of Ethiopia. J Ethnobiol Ethnomed. 2013;9(1):1–23. doi:10.1186/1746-4269-9-65
  • Wubetu M, Abula T, Dejenu G. Ethnopharmacologic survey of medicinal plants used to treat human diseases by traditional medical practitioners in Dega Damot District, Amhara, Northwestern Ethiopia. BMC Res Notes. 2017;10(1):1–13. doi:10.1186/s13104-017-2482-3
  • Yemane B, Berhane Y, Reddy KS. Ethnobotanical study of medicinal plants in Sub Region Logo Anseba, Region Gash Barka, Eritrea. J Pharm Biol Sci. 2016;11(4):63–73.
  • Aylate A, Agize M, Ekero D, Kiros A, Ayledo G, Gendiche K. In-vitro and in-vivo antibacterial activities of Croton macrostachyus methanol extract against E. Coli and S. Aureus. Adv Anim Vet Sci. 2017;5(3):107–114.
  • Degu A, Engidawork E, Shibeshi W. Evaluation of the anti-diarrheal activity of the leaf extract of Croton macrostachyus Hocsht. Ex Del. (Euphorbiaceae) in mice model. BMC Complement Altern Med. 2016;16(1):1–11. doi:10.1186/s12906-016-1357-9
  • Teugwa M, Sonfack D, Fokom R, Penlap B, Amvam Z. Antifungal and antioxidant activity of crude extracts of three medicinal plants from cameroon pharmacopeia. J Med Plant Res. 2013;7(21):1537–1542.
  • Yassab M, Nedi T, Solomon D, Shibeshi W. Hepatoprotective effect of Croton macrostachyus Hochst. Ex Del leaves against CCl4-induced liver damage. Pharm J. 2016;32(1):23–36. doi:10.4314/epj.v32i1.3
  • Hossain MA, Al-Hdhrami SS, Weli AM, Al-Riyami Q, Al-Sabahi JN. Isolation, fractionation and identification of chemical constituents from the leaves crude extracts of Mentha piperita L grown in Sultanate of Oman. Asian Pac J Trop Biomed. 2014;4(1):368–372. doi:10.12980/APJTB.4.2014C1051
  • Harborne. Phytochemical Methods: A Guide to Modern Techniques of Plant Analysis. United States of America: Chapman and Hall; 1973:1–276.
  • Teshome T, Sintayehu B, Yohannes H, et al. Radical scavenging activity and preliminary phytochemical screening on aerial part extracts of Cineraria abyssinica Sch. Bip. J Pharmacogn Phytochem. 2015;3(6):239–243.
  • OECD. Acute Oral Toxicity: Up and Down Procedure. France: Dixon and Mood; 2008:1–27.
  • Braca A, De Tommasi N, Di Bari L, Pizza C, Politi M, Morelli I. Antioxidant principles from Bauhinia tarapotensis. J Nat Prod. 2001;64(7):892–895. doi:10.1021/np0100845
  • Qadir MI, Ali M, Saleem M, Hanif M. Hepatoprotective activity of aqueous methanolic extract of Viola odorata against paracetamol-induced liver injury in mice. Bangladesh J Pharmacol. 2014;9(2):198–202.
  • Saleem M, Ahmed B, Karim M, et al. Hepatoprotective effect of aqueous methanolic extract of Rumex dentatus in paracetamol-induced hepatotoxicity in mice. Bangladesh J Pharmacol. 2014;9(3):284–289. doi:10.3329/bjp.v9i3.18874
  • Hanafy AA, Badr HM, Ibrahim JM, Amany K, El-Sayed S. Evaluation of hepatoprotective activity of Adansonia digitata extract on acetaminophen-induced hepatotoxicity in rats. Evid Based Complement Alternat Med. 2016;2016:1–7. doi:10.1155/2016/4579149
  • Bernard T Guidelines on the care and use of animals for scientific purposes. National advisory committee for laboratory animal research (NACLAR). Available from: www3. ntu. edu. sg/Research2/ … /NACLAR-guide% Z0Lines.pdf. 2004.
  • Uchida NS, Silva-Filho SE, Cardia GFE, et al. Hepatoprotective effect of Citral on acetaminophen-induced liver toxicity in mice. Evid Based Complement Alternat Med. 2017;2017:1–9. doi:10.1155/2017/1796209
  • Fontana RJ. Acute liver failure including acetaminophen overdose. Med Clin North Am. 2008;92(4):761–794. doi:10.1016/j.mcna.2008.03.005
  • Tittarelli R, Pellegrini M, Scarpellini M, et al. Hepatotoxicity of paracetamol and related fatalities. Eur Rev Med Pharmacol Sci. 2017;21(1):95–101.
  • Alghazeer R, Elgahmasi S, Elnfati AH, et al. Antioxidant activity and hepatoprotective potential of flavonoids from Arbutus pavarii against CCl4 induced hepatic damage. Biotechnol J Int. 2017;21(1):1–12. doi:10.9734/BJI/2018/39528
  • Sharma S, Rana S, Patial V, Gupta M, Bhushan S, Padwad Y. Antioxidant and hepatoprotective effect of polyphenols from Apple pomace extract via apoptosis inhibition and Nrf2 activation in mice. Hum Exp Toxicol. 2016;35(12):1264–1275. doi:10.1177/0960327115627689
  • Torres R, Faini F, Modak B, Urbina F, Labbé C, Guerrero J. Antioxidant activity of coumarins and flavonols from the resinous exudate of. Phytochem. 2006;67(10):984–987. doi:10.1016/j.phytochem.2006.03.016
  • Sintayehu B, Asres K, Raghavendra Y. Radical scavenging activities of the leaf extracts and a flavonoid glycoside isolated from Cineraria abyssinica Sch. Bip. Exa. rich. J Appl Pharm Sci. 2012;2(4):44–49. doi:10.7324/JAPS.2012.2407
  • Mahmood N, Mamat S, Kamisan F, et al. Amelioration of paracetamol-induced hepatotoxicity in rat by the administration of methanol extract of Muntingia Calabura L. leaves. Biomed Res Int. 2014;2014:1–10.
  • Mulla WA, Salunkhe VR, Bhise SB. Hepatoprotective activity of hydroalcoholic extract of leaves of Alocasia indica (Linn.). Indian J Exp Biol. 2009;47(10):816–821.
  • Gutiérrez RM, Solís RV. Hepatoprotective and inhibition of oxidative stress in liver of Prostechea michuacana. Rec Nat Prod. 2009;3(1):46.
  • Okokon JE, Simeon JO, Umoh EE. Hepatoprotective activity of the extract of Homalium letestui stem against paracetamol-induced liver injury. Avicenna J Phytomed. 2017;7(1):27–36.
  • Shrivastava P. Hepatoprotective activity of Bridelia retusa leaves against paracetamol-induced liver damage in swiss albino mice. Drug Invent Today. 2017;9(1).
  • Trifunschi SI, Munteanu MFF, Ardelean DG, Orodan M, Osser GM, Gligor RI. Flavonoids and polyphenols content and antioxidant activity of Ficus carica L. extracts from romania. Matica Srpska J Nat Sci Novi Sad. 2015;128(128):57–65. doi:10.2298/ZMSPN1528057T
  • Yoshioka H, Usuda H, Fujii H, Nonogaki T. Sasa veitchii extracts suppress acetaminophen-induced hepatotoxicity in mice. Environ Health Prev Med. 2017;22(1):1–10. doi:10.1186/s12199-017-0662-3
  • Sharma M, Sharma G, Vishal V, Ranjan B. Hepatotoxicity: a major complication with critical treatment. MOJ Toxicol. 2015;1(3):1–7.
  • Rao C, Singh A, Kumar G, Gupta S, Singh S, Rawat A. Hepatoprotective potential of Ziziphus oenoplia (l.) mill roots against paracetamol-induced hepatotoxicity in rats. Adv J Phytomed Clin Ther. 2015;3(1):064–078.
  • Abdel-Latif MS, K M E. Hepatoprotective effect of coumarin and chlorophyll against aflatoxicosis in rat. J Anim Poult Prod. 2016;7(12):483–490. doi:10.21608/jappmu.2016.48813
  • Huang W, Wang Y, Jiang X, Sun Y, Zhao Z, Li S. Protective effect of flavonoids from Ziziphus jujuba cv. jinsixiaozao against acetaminophen-induced liver injury by inhibiting oxidative stress and inflammation in mice. Molecules. 2017;22(10):1–18. doi:10.3390/molecules22101781
  • Shanmugam B, Shanmugam KR, Doraswamy G, et al. Hepatoprotective effect of Phyllanthus niruri alkaloid fraction in D–galactosamine induced hepatitis in rats. Intl J Pharm Pharm Sci. 2016;8(5):158–161.
  • Tarahovsky YS, Kim YA, Yagolnik EA, Muzafarov EN. Flavonoid–membrane interactions: involvement of flavonoid–metal complexes in raft signaling. Biochim Biophys Acta. 2014;1838(5):1235–1246. doi:10.1016/j.bbamem.2014.01.021
  • Mohammed MS, Osman WJ, Garelnabi EA, et al. Secondary metabolites as anti-inflammatory agents. J Phytopharmacol. 2014;3(4):275–285.
  • Maroyi A. Ethnopharmacological uses, phytochemistry, and pharmacological properties of Croton macrostachyus Hochst. Ex Delile: a comprehensive review. Evid Based Complement Alternat Med. 2017;1:2017.