Chemo Suppressive and Curative Potential of Hypoestes forskalei Against Plasmodium berghei: Evidence for in vivo Antimalarial Activity

References

• Baird JK. Evidence and implications of mortality associated with acute Plasmodium vivax malaria. Clin Microbiol Rev. 2013;26(1):36–57. doi:10.1128/CMR.00074-12
   PubMed Web of Science ®Google Scholar
• WHO. World Malaria Report. Geneva: World Health Organization; 2019.
   Google Scholar
• Guyatt HL, Snow RW. The epidemiology and burden of Plasmodium falciparum-related anemia among pregnant women in sub-Saharan Africa. Am J Trop Med Hyg. 2001;64(1_suppl):36–44. doi:10.4269/ajtmh.2001.64.36
   PubMed Web of Science ®Google Scholar
• Menard D, Dondorp A. Antimalarial drug resistance: a threat to malaria elimination. Cold Spring Harb Perspect Med. 2017;7:7. doi:10.1101/cshperspect.a025619
   Web of Science ®Google Scholar
• Lu F, Culleton R, Zhang M, et al. Emergence of indigenous artemisinin-resistant Plasmodium falciparum in Africa. N Engl J Med. 2017;376(10):991–993. doi:10.1056/NEJMc1612765
   PubMed Web of Science ®Google Scholar
• Russo G, L’Episcopia M, Menegon M, et al. Dihydroartemisinin–piperaquine treatment failure in uncomplicated Plasmodium falciparum malaria case imported from Ethiopia. Infection. 2018;46(6):867–870. doi:10.1007/s15010-018-1174-9
   Web of Science ®Google Scholar
• Misganaw D, Engidawork E, Nedi T. Evaluation of the anti-malarial activity of crude extract and solvent fractions of the leaves of Olea europaea (Oleaceae) in mice. BMC Complement Altern Med. 2019;19(1):171. doi:10.1186/s12906-019-2567-8
   PubMed Web of Science ®Google Scholar
• Almehdar H, Abdallah HM, Osman A-M-M, Abdel-Sattar EA. In vitro cytotoxic screening of selected Saudi medicinal plants. J Nat Med. 2012;66(2):406–412. doi:10.1007/s11418-011-0589-8
   PubMed Web of Science ®Google Scholar
• Ramzi A, Ulrike L, Renate G, Bednarski J. Studies of the in vitro anticancer, antimicrobial and antioxidant potentials of selected Yemeni medicinal plants from the island Soqotra. BMC Compl Alt Med. 2009;9:7. doi:10.1186/1472-6882-9-7
   Web of Science ®Google Scholar
• Bitew H, Gebregergs H, Tuem KB, Yeshak MY. Ethiopian medicinal plants traditionally used for wound treatment: a systematic review. Ethiop J Health Develop. 2019;33:2.
   Web of Science ®Google Scholar
• Fongod A, Modjenpa N, Veranso M. Ethnobotany of Acanthaceae in the Mount Cameroon region. J Med Plants Res. 2013;7:2707–2713.
   Google Scholar
• Sillo AJ, Makirita WE, Swai H, Chacha M. Larvicidal activity of Hypoestes forskaolii (Vahl) R. Br root extracts against Anopheles gambiae Giless. s, Aedes aegypti L, and Culex quinquefasciatus say. J Exp Pharmacol. 2019;11:23.
   Google Scholar
• Abdallah HM, Abdel-Naim AB, Ashour OM, Shehata IA, Abdel-Sattar EA. Anti-inflammatory activity of selected plants from Saudi Arabia. Zeitschrift für Naturforschung C. 2014;69(1–2):1–9. doi:10.5560/ZNC.2012-0168
   PubMed Web of Science ®Google Scholar
• Mothana RA, Al-Musayeib NM, Al-Ajmi MF, Cos P, Maes L. Evaluation of the in vitro antiplasmodial, antileishmanial, and antitrypanosomal activity of medicinal plants used in Saudi and Yemeni traditional medicine. Evid Based Complement Alter Med. 2014;2014.
   Web of Science ®Google Scholar
• Al Haidari RA. A review of traditional uses, phytochemicals and bioactivities of the Genus hypoestes. Afr J Trad Complement Alter Med. 2018;15(3):1–17.
   Google Scholar
• Mothana RA, Al-Musayeib NM, Matheeussen A, Cos P, Maes L. Assessment of the in vitro antiprotozoal and cytotoxic potential of 20 selected medicinal plants from the island of Soqotra. Molecules. 2012;17(12):14349–14360. doi:10.3390/molecules171214349
   Web of Science ®Google Scholar
• B. P. Ethnopharmacological survey of medicinal plants among the Hamer ethnic group, Hamer Woreda, south Omo zone, SNNPR, Ethiopia and evaluation of a selected plant for its antimalarial activity. Doctoral dissertation. Addis Ababa University. 2012.
   Google Scholar
• Muthaura C, Keriko J, Mutai C, et al. Antiplasmodial potential of traditional phytotherapy of some remedies used in treatment of malaria in Meru–Tharaka Nithi County of Kenya. J Ethnopharmacol. 2015;175:315–323. doi:10.1016/j.jep.2015.09.017
   PubMed Web of Science ®Google Scholar
• Al Musayeib NM, Mothana RA, Mohamed GA, Ibrahim SR, Maes L. Hypoestenonols A and B, new fusicoccane diterpenes from Hypoestes forskalei. Phytochem Lett. 2014;10:23–27. doi:10.1016/j.phytol.2014.06.020
   Web of Science ®Google Scholar
• Omole RA, Moshi MJ, Heydenreich M, et al. Two lignans derivatives and two fusicoccane diterpenoids from the whole plant of Hypoestes verticillaris (LF) Sol. Ex roem. & schult. Phytochem Lett. 2019;30:194–200. doi:10.1016/j.phytol.2019.02.019
   Web of Science ®Google Scholar
• Chege PN. The Organisation of Economic Cooperation and Development (OECD) Transfer Pricing Guidelines: An Evaluation of Their Effectiveness in the Kenya’s Tax Regime. University of Nairobi; 2013.
   Google Scholar
• National Research Council. Guide for the Care and Use of Laboratory Animals. National Academies Press; 2010.
   Google Scholar
• Guideline OO. 425: acute oral toxicity—up-and-down procedure. OECD Guidelines Testing Chem. 2001;2:12–16.
   Google Scholar
• Desta B. Ethiopian traditional herbal drugs. Part II: antimicrobial activity of 63 medicinal plants. J Ethnopharmacol. 1993;39(2):129–139.
   Web of Science ®Google Scholar
• Peters W. The four-day suppressive in vivo antimalarial test. Ann Trop Med Parasitol. 1975;69:155–171. doi:10.1080/00034983.1975.11686997
   PubMed Web of Science ®Google Scholar
• Ryley J, Peters W. The antimalarial activity of some quinolone esters. Ann Trop Med Parasitol. 1970;64(2):209–222. doi:10.1080/00034983.1970.11686683
   PubMed Web of Science ®Google Scholar
• Peters W, Robinson B. The chemotherapy of rodent malaria. XLVII. Studies on pyronaridine and other Mannich base antimalarials. Ann Trop Med Parasitol. 1992;86(5):455–465. doi:10.1080/00034983.1992.11812694
   PubMed Web of Science ®Google Scholar
• Mekonnen LB. In vivo antimalarial activity of the crude root and fruit extracts of Croton macrostachyus (Euphorbiaceae) against Plasmodium berghei in mice. J Trad Complement Med. 2015;5(3):168–173. doi:10.1016/j.jtcme.2014.07.002
   Google Scholar
• Amelo W, Nagpal P, Makonnen E. Antiplasmodial activity of solvent fractions of methanolic root extract of Dodonaea angustifolia in Plasmodium berghei infected mice. BMC Complement Altern Med. 2014;14(1):462. doi:10.1186/1472-6882-14-462
   Web of Science ®Google Scholar
• Kalita S, Kumar G, Karthik L, Rao KVB. Phytochemical composition and in vitro hemolytic activity of Lantana camara L. (Verbenaceae) leaves. Pharmacologyonline. 2011;1:59–67.
   Google Scholar
• Sasidharan S, Chen Y, Saravanan D, Sundram K, Latha LY. Extraction, isolation and characterization of bioactive compounds from plants’ extracts. Afr J Trad Complement Alter Med. 2011;8:1.
   PubMed Web of Science ®Google Scholar
• Waako P, Gumede B, Smith P, Folb P. The in vitro and in vivo antimalarial activity of Cardiospermum halicacabum L. and Momordica foetida Schumch. Et Thonn. J Ethnopharmacol. 2005;99(1):137–143. doi:10.1016/j.jep.2005.02.017
   PubMed Web of Science ®Google Scholar
• Peter I, Anatoli V. The Current Global Malaria Situation. Malaria Parasite Biology, Pathogenesis, and Protection. Vol. 1. ASM Press, WDC; 1998:1–22.
   Google Scholar
• Kokwaro G, Mwai L, Nzila A. Artemether/lumefantrine in the treatment of uncomplicated falciparum malaria. Expert Opin Pharmacother. 2007;8(1):75–94. doi:10.1517/14656566.8.1.75
   PubMed Web of Science ®Google Scholar
• Kwaghe A, Ambali A. Preliminary phytochemical screening of fresh and dried Moringa oleifera leaves and that of chloroform, ethylacetate and n-butanol fractions. Sahel J Vet Sci. 2009;8:2.
   Google Scholar
• Bantie L, Assefa S, Teklehaimanot T, Engidawork E. In vivo antimalarial activity of the crude leaf extract and solvent fractions of Croton macrostachyus Hocsht. (Euphorbiaceae) against Plasmodium berghei in mice. BMC Complement Altern Med. 2014;14(1):79. doi:10.1186/1472-6882-14-79
   PubMed Web of Science ®Google Scholar
• Traore M. Investigation of antiplasmodial compounds from two plants, Cochlospermum tinctorium a. rich and Gardenia sokotensis hutch. Afr J Trad Complement Alter Med. 2006;3(4):34–41.
   Google Scholar
• Fidock DA, Rosenthal PJ, Croft SL, Brun R, Nwaka S. Antimalarial drug discovery: efficacy models for compound screening. Nat Rev Drug Discov. 2004;3(6):509. doi:10.1038/nrd1416
   PubMed Web of Science ®Google Scholar
• Olorunniyi O. In vivo antimalarial activity of crude aqueous bark extract of Trichilia monadelpha against plasmodium berghei berghei (NK65) in mice. Int J Pharm Med Bio Sci. 2013;2(4):2278–5221.
   Google Scholar
• Taherkhani M, Rustaiyan A, Nahrevanian H, Naeimi S, Taherkhani T. Comparison of antimalarial activity of Artemisia turanica extract with current drugs in vivo. J Vector Borne Dis. 2013;50(1):51.
   Web of Science ®Google Scholar
• Christian AG, Idris-Usman M, Osunkwo UA. Invivo antimalarial activity of ethanolic leaf extract of Verbena hastate against Plasmodium berghei in mice. J Herbal Med Toxicol. 2010;4(2):17–23.
   Google Scholar
• Krettli AU, Adebayo JO, Krettli LG. Testing of natural products and synthetic molecules aiming at new antimalarials. Curr Drug Targets. 2009;10(3):261–270. doi:10.2174/138945009787581203
   PubMed Web of Science ®Google Scholar
• Abdelsattar E, Abdallah HM, El-Mekkawy S, Ichino C, Kiyohara H, Yamada H. Antimalarial alkaloid from Hypoestes forskaolii. Exp Parasitol. 2020;211:107851. doi:10.1016/j.exppara.2020.107851
   Web of Science ®Google Scholar
• Batista R, De Jesus Silva Júnior A, De Oliveira AB. Plant-derived antimalarial agents: new leads and efficient phytomedicines. Part II. Non-alkaloidal natural products. Molecules. 2009;14(8):3037–3072.
   PubMed Web of Science ®Google Scholar
• Mazid M, Khan T, Mohammad F. Role of secondary metabolites in defense mechanisms of plants. Biol Med. 2011;3(2):232–249.
   Google Scholar
• Soares JBC, Menezes D, Vannier-Santos MA, et al. Interference with hemozoin formation represents an important mechanism of schistosomicidal action of antimalarial quinoline methanols. PLoS Negl Trop Dis. 2009;3(7):477. doi:10.1371/journal.pntd.0000477
   Web of Science ®Google Scholar
• Eastman RT, Fidock DA. Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria. Nat Rev Microbiol. 2009;7(12):864–874. doi:10.1038/nrmicro2239
   PubMed Web of Science ®Google Scholar
• Golenser J, Waknine JH, Krugliak M, Hunt NH, Grau GE. Current perspectives on the mechanism of action of artemisinins. Int J Parasitol. 2006;36(14):1427–1441. doi:10.1016/j.ijpara.2006.07.011
   PubMed Web of Science ®Google Scholar
• Saxena M, Saxena J, Nema R, Singh D, Gupta A. Phytochemistry of medicinal plants. J Pharmacognosy Phytochem. 2013;1:6.
   Google Scholar
• Taramelli D, Monti D, Basilico N, Parapini S, Omodeo-Sale F, Olliaro P. A fine balance between oxidised and reduced haem controls the survival of intraerythrocytic plasmodia. Parassitologia. 1999;41(1–3):205.
   PubMedGoogle Scholar
• Hansen DS. Inflammatory responses associated with the induction of cerebral malaria: lessons from experimental murine models. PLoS Pathog. 2012;8:12. doi:10.1371/journal.ppat.1003045
   Web of Science ®Google Scholar
• Aherne S, Daly T, O’Connor T, O’Brien N. Immunomodulatory effects of β-sitosterol on human Jurkat T cells. Planta Med. 2007;73(09):11. doi:10.1055/s-2007-986793
   Google Scholar
• Pieroni A, Heimler D, Pieters L, Van Poel B, Vlietinck A. In vitro anti-complementary activity of flavonoids from oliva (Olea europaea L.) leaves. Pharmazie. 1996;51(10):765–767.
   PubMed Web of Science ®Google Scholar
• Langhorne J, Quin SJ, Sanni LA. Mouse models of blood-stage malaria infections: immune responses and cytokines involved in protection and pathology. Chem Immunol. 2002;80(80):204–228.
   PubMedGoogle Scholar
• Böttger S, Melzig MF. The influence of saponins on cell membrane cholesterol. Bioorg Med Chem. 2013;21(22):7118–7124. doi:10.1016/j.bmc.2013.09.008
   Web of Science ®Google Scholar
• Dascombe M, Sidara J. The Absence of Fever in Rat Malaria is Associated with Increased Turnover of 5-Hydroxytryptamine in the Brain. Temperature Regulation. Springer; 1994:47–52.
   Google Scholar
• Basir R, Rahiman SF, Hasballah K, et al. Plasmodium berghei ANKA infection in ICR mice as a model of cerebral malaria. Iran J Parasitol. 2012;7(4):62.
   PubMed Web of Science ®Google Scholar
• Abdela J, Engidawork E, Shibeshi W. In vivo antimalarial activity of solvent fractions of the leaves of justicia schimperiana hochst. Ex Nees against Plasmodium berghei in Mice. Ethiop Pharm J. 2014;30(2):95–108.
   Google Scholar
• Ubaha GA, Idowu BA, Omoniyi IT. Effects of Hypoestes forskalei Schult Roem leaf extract on the behavior of Clarias gariepinus. Nat Sci. 2012;10:158–162.
   Google Scholar