Potential Antiaging Effects of DLBS1649, a Centella asiatica Bioactive Extract

References

• Argyropoulou A, Aligiannis N, Trougakos IP, et al. Natural compounds with anti-ageing activity. Nat Prod Rep. 2013;30:1412–1437. doi:10.1039/c3np70031c
   PubMed Web of Science ®Google Scholar
• Wong KK, Maser RS, Bachoo RM, et al. Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates aging. Nature. 2003;421(6923):643–648. doi:10.1038/nature01385
   PubMed Web of Science ®Google Scholar
• Ideker T, Thorsson V, Ranish JA, et al. Integrated genomic and proteomic analysis of a systematically perturbed metabolic network. Science. 2001;292(5518):929–934. doi:10.1126/science.292.5518.929
   PubMed Web of Science ®Google Scholar
• Sniderman AD, Furberg CD. Age as a modifiable risk factor for cardiovascular disease. Lancet. 2008;371(9623):1547–1549. doi:10.1016/S0140-6736(08)60313-X
   PubMed Web of Science ®Google Scholar
• Shen CY, Jiang JG, Li Yang L, et al. Anti-ageing active ingredients from herbs and nutraceuticals used in traditional Chinese medicine: pharmacological mechanisms and implications for drug discovery. Br J Pharmacol. 2017;174(11):1395–1425. doi:10.1111/bph.13631
   PubMed Web of Science ®Google Scholar
• Muraki K, Nyhan K, Han L. Mechanisms of telomere loss and their consequences for chromosome instability. Front Oncol. 2012;135(2):13.
   Google Scholar
• Finkel T, Serrano M, Blasco MA. The common biology of cancer and ageing. Nature. 2007;448(7155):767–774. doi:10.1038/nature05985
   PubMed Web of Science ®Google Scholar
• Chan S, Blackburn EH. Telomeres and telomerase. Philos Trans R Soc Lond B-Biol Sci. 2004;359(1441):109–121. doi:10.1098/rstb.2003.1370
   PubMed Web of Science ®Google Scholar
• Blackburn EH. Switching and signaling at the telomere. Cell. 2001;106(6):661–673. doi:10.1016/S0092-8674(01)00492-5
   PubMed Web of Science ®Google Scholar
• Oberdoerffer P, Sinclair DA. The role of nuclear architecture in genomic instability and ageing. Nat Rev Mol Cell Biol. 2007;8(9):692–702. doi:10.1038/nrm2238
   PubMed Web of Science ®Google Scholar
• Westphal CH, Dipp MA, Guarente L. A therapeutic role for sirtuins in diseases of aging? Trends Biochem Sci. 2007;32(12):555–560. doi:10.1016/j.tibs.2007.09.008
   PubMed Web of Science ®Google Scholar
• Tjandrawinata RR, Arifin PF, Tandrasasmita OM, Rahmi D, Aripin A. DLBS1425, a Phaleria macrocarpa (Scheff.) Boerl. extract confers anti proliferative and proapoptotic effects via eicosanoid pathway. J Exp Ther Oncol. 2010;8(3):187–201.
   Google Scholar
• Tjandrawinata RR, Nofiarny D, Susanto LW, Hendri P, Clarissa A. Symptomatic treatment of premenstrual syndrome and/or primary dysmenorrhea with DLBS1442, a bioactive extract of Phaleria macrocarpa. Int J Gen Med. 2011;4:465.
   PubMedGoogle Scholar
• Tjandrawinata RR, Suastika K, Nofiarny D. DLBS3233 extract, a novel insulin sensitizer with negligible risk of hypoglycemia: a phase-I study. Int J Diabetes Metab. 2012;21:13–20. doi:10.1159/000497721
   Google Scholar
• Tjandrawinata RR, Nailufar F, Arifin PF. Hydrogen potassium adenosine triphosphatase activity inhibition and downregulation of its expression by bioactive fraction DLBS2411 from Cinnamomum burmannii in gastric parietal cells. Int J Gen Ed. 2013;6:807. doi:10.2147/IJGM.S50134
   Google Scholar
• Karsono AH, Tandrasasmita OM, Tjandrawinata RR. Bioactive fraction from Lagerstroemia speciosa leaves (DLBS3733) reduces fat droplet by inhibiting adipogenesis and lipogenesis. J Exp Pharmacol. 2019;11:39. doi:10.2147/JEP.S181642
   Google Scholar
• Tolkah NM. Genetic variation of Centella asiatica based on randomly amplified polymorphic DNA. Ethnobot J. 1999;22:7–13.
   Google Scholar
• Brinkhaus B, Lindner M, Schuppan D, et al. Chemical, pharmacological, and clinical profile of the East Asian medicinal plant. Centella Asiatica Phytomedicine. 2000;7(5):427–448. doi:10.1016/S0944-7113(00)80065-3
   PubMed Web of Science ®Google Scholar
• James JT, Dubery IA. Pentacyclic triterpenoids from the medicinal herb, Centella asiatica (L.) Urban. Molecules. 2009;14(10):3922–3941. doi:10.3390/molecules14103922
   PubMed Web of Science ®Google Scholar
• Tenni R, Zanaboni G, De Agustini MP, et al. Effect of the triterpenoids fraction of Centella asiatica on macromolecules of the connective matrix in human skin fibroblast cultures. Ital J Biochem. 1988;37(2):69–77.
   Google Scholar
• Bonte F, Dumas M, Chaudagne C, et al. Influence of asiatic acid, madecassic acid and asiaticoside on human collagen I synthesis. Planta Med. 1994;60(2):133–135. doi:10.1055/s-2006-959434
   Web of Science ®Google Scholar
• Maquart FX, Chasting F, Simeon A, et al. Triterpenes from Centella asiatica stimulate extracellular matrix accumulation in rat experimental wounds. Eur J Dermatol. 1999;9(4):289–296.
   PubMed Web of Science ®Google Scholar
• Kim WJ, Kim JD, Veriansyah B, Kim J, Oh SG, Tjandrawinata RR. Extraction of Asiaticoside from Centella asiatica: effects of solvents and extraction methods. Biochemistry. 2004;23:339–344.
   Google Scholar
• Gupta YK, Kumar MHV, Srivastava AK. Effect of Centella asiatica on pentylenetetrazole-induced kindling, cognition, and oxidative stress in rats. Pharmacol Biochem Behav. 2003;74(3):579–585. doi:10.1016/S0091-3057(02)01044-4
   PubMed Web of Science ®Google Scholar
• Rao SB, Chetana M, Uma DP. Centella asiatica treatment during postnatal period enhances learning and memory in mice. Physiol Behav. 2005;86(4):449–457. doi:10.1016/j.physbeh.2005.07.019
   PubMed Web of Science ®Google Scholar
• Chen Y, Han T, Rui Y, et al. Effects of total triterpenes of Centella asiatica on the Depression behavior and concentration of amino acid in forced swimming mice. Zhong Yao Cai. 2003;26(12):870–873.
   Google Scholar
• Fitrawan LO, Ariastuti R, Tjandrawinata RR, Nugroho AE, Pramono S. Antidiabetic effect of combination of fractionated-extracts of Andrographis paniculata and Centella asiatica: in vitro study. Asian Pac J of Trop Biomed. 2018;8(11):527. doi:10.4103/2221-1691.245957
   Web of Science ®Google Scholar
• Parvathi D, Amritha A, Paul SFD. Wonder animal model for genetic studies–Drosophila melanogaster–its life cycle and breeding methods–a review. Sri Ramanchandra J Med. 2009;2:33–38.
   Google Scholar
• Panchal K, Tiwari AK. Drosophila melanogaster “a potential model organism” for identification of pharmacological properties of plants/plant-derived components. Biomed Pharmacother. 2017;89:1331–1345.
   PubMed Web of Science ®Google Scholar
• Jafari M. Drosophila melanogaster as a model system for the evaluation of anti-aging compounds. Fly. 2010;4(3):253–257. doi:10.4161/fly.4.3.11997
   PubMed Web of Science ®Google Scholar
• Walter MF, Biessmann MR, Benitez C, Török T, Mason JM, Biessmann H. Effects of telomere length in Drosophila melanogaster on life span, fecundity, and fertility. Chromosoma. 2007;116(1):41–51. doi:10.1007/s00412-006-0081-5
   PubMed Web of Science ®Google Scholar
• Capkova FR, Biessmann H, Mason JM. Regulation of telomere length in Drosophila. Cytogenet Genome Res. 2008;122(3–4):356–364. doi:10.1159/000167823
   Web of Science ®Google Scholar
• George JA, DeBaryshe PG, Traverse KL, Celniker SE, Pardue ML. Genomic organization of the Drosophila telomere retrotransposable elements. Genome Res. 2006;16(10):1231–1240. doi:10.1101/gr.5348806
   Web of Science ®Google Scholar
• Kim JH, Hwang KH, Park KS, et al. Biological role of anti-aging protein klotho. J Lifestyle Med. 2015;5(1):1–6. doi:10.15280/jlm.2015.5.1.1
   PubMedGoogle Scholar
• Morrison S, McGee SL. 3T3-L1 adipocytes display phenotypic characteristics of multiple adipocyte lineages. Adipocyte. 2015;4(4):295–302. doi:10.1080/21623945.2015.1040612
   PubMed Web of Science ®Google Scholar
• O’Callaghan N, Dhillon V, Thomas P, Fenech M. A quantitative real-time PCR method for absolute telomere length. Biotechniques. 2008;44(6):807–809. doi:10.2144/000112761
   Web of Science ®Google Scholar
• Cawthon RM. Telomere measurement by quantitative PCR. Nucleic Acids Res. 2002;30(10):e47. doi:10.1093/nar/30.10.e47
   PubMed Web of Science ®Google Scholar
• Zou YX, Ruan MH, Luan J. Anti-aging effect of riboflavin via endogenous antioxidant in fruit fly Drosophila melanogaster. J Nutr Health Aging. 2017;21(3):314–319. doi:10.1007/s12603-016-0752-8
   Web of Science ®Google Scholar
• Altman DG. Practical Statistics for Medical Research. Chapman and Hall; 1991.
   Google Scholar
• Uno H, Claggett B, Tian L. Moving beyond the hazard ratio in quantifying the between-group difference in survival analysis. J Clin Oncol. 2014;32(22):2380–2385. doi:10.1200/JCO.2014.55.2208
   PubMed Web of Science ®Google Scholar
• Meeran MFN, Goyal SN, Suchal K, et al. Pharmacological properties, molecular mechanisms, and pharmaceutical development of asiatic acid: a pentacyclic triterpenoid of therapeutic promise. Front Pharmacol. 2018;4(9):892.
   Web of Science ®Google Scholar
• Kamble SM, Patel HM, Goyal SN, et al. In-silico evidence for binding of pentacyclic triterpenoids to Keap1-Nrf2 protein-protein binding site. Comb Chem High Throughput Screen. 2017;20(3):215–234. doi:10.2174/1386207319666161214111822
   Web of Science ®Google Scholar
• Kamble SM, Goyal SN, Patil CR. Multifunctional pentacyclic triterpenoids as adjuvants in cancer chemotherapy: a review. RSC Adv. 2014;4:33370–33382. doi:10.1039/C4RA02784A
   Web of Science ®Google Scholar
• Lokanathan Y, Omar N, Puzi NNA, et al. Recent updates in neuroprotective and neuroregenerative potential of Centella asiatica. Malays J Med Sci. 2016;23(1):4–14.
   PubMedGoogle Scholar
• Soumyanath A, Zhong YP, Gold SA, et al. Centella asiatica accelerates nerve regeneration upon oral administration and contains multiple active fractions increasing neurite elongation in vitro. J Pharm Pharmacol. 2005;57(9):1221–1229. doi:10.1211/jpp.57.9.0018
   PubMed Web of Science ®Google Scholar
• Tiwari S, Singh S, Patwardhan K, et al. Effect of Centella asiatica on mild cognitive impairment (MCI) and other common age-related clinical problems. Dig J Nanomater Biostruct. 2008;3(4):215–220.
   Google Scholar
• Bylka W, Znajdek-wiżeń P, Studzińska-Sroka E, et al. Centella asiatica in cosmetology. Postep Derm Alergol. 2013;1:46–49.
   Google Scholar
• James J, Dubery I. Identification and quantification of triterpenoid Centelloids in Centella asiatica (L.) urban by densitometric TLC. J Planar Chromatogr. 2011;24:82–87. doi:10.1556/JPC.24.2011.1.16
   Web of Science ®Google Scholar
• Guo L, Wei XD, Ou Q, et al. Effect of astragaloside on the expression of telomerase activity and klotho gene in aged HELF cells. Chin J Gerontol. 2010;13:1819–1822.
   Google Scholar
• Salvador L, Singaravelu G, Calvin B, et al. A natural product telomerase activator lengthens telomeres in humans: a randomized, double-blind, and placebo-controlled study. Rejuvenation Res. 2016;19(6):478–484. doi:10.1089/rej.2015.1793
   Web of Science ®Google Scholar
• Guruprasad KP, Dash S, Marigowda B, et al. Influence of Amalaki Rasayana on telomerase activity and telomere length in human blood mononuclear cells. J Ayurveda Integr Med. 2017;8(2):105–112. doi:10.1016/j.jaim.2017.01.007
   Web of Science ®Google Scholar
• Wu KJ, Grandori C, Amacker M, et al. Direct activation of TERT transcription by c-MYC. Nat Genet. 1999;21(2):220–224. doi:10.1038/6010
   PubMed Web of Science ®Google Scholar
• Shay JW. Role of telomeres and telomerase in aging and cancer. Discov. 2016;6(6):584–593.
   PubMed Web of Science ®Google Scholar
• Mazucanti CH, Cabral-Costa JV, Vasconcelos AR, et al. Longevity pathways (mTOR, SIRT, Insulin/IGF-1) as key modulatory targets on aging and neurodegeneration. Curr Top Med Chem. 2015;15(21):2116–2138. doi:10.2174/1568026615666150610125715
   PubMed Web of Science ®Google Scholar
• Oliveira RM, Sarkander J, Kazantsev AG, et al. SIRT2 as a therapeutic target for age-related disorders. Front Pharmacol. 2012;3(82):1–9. doi:10.3389/fphar.2012.00082
   Web of Science ®Google Scholar
• Xu MF, Xiong YY, Liu JK, et al. Asiatic acid, a pentacyclic triterpene in Centella asiatica, attenuates glutamate-induced cognitive deficits in mice and apoptosis in SH-SY5Y cells. Acta Pharmacol Sin. 2012;33(5):578–587. doi:10.1038/aps.2012.3
   Web of Science ®Google Scholar
• Qian Y, Xin Z, Lv Y, et al. Asiatic acid suppresses neuroinflammation in BV2 microglia via modulation of the Sirt1/NF-κB signaling pathway. Food Funct. 2018;9(2):1048–1057. doi:10.1039/C7FO01442B
   Web of Science ®Google Scholar
• Han YY, Shen P, Hao J, et al. Ganoderma lucidum polysaccharides improve renal aging through upregulating SIRT1 expression. Int J Clin Exp Med. 2018;11(7):6816–6823.
   Web of Science ®Google Scholar
• Sung B, Chung JW, Bae HR, et al. Humulus japonicus extract exhibits anti-oxidative and anti-aging effects via modulation of the AMPK-SIRT1 pathway. Exp and Ther Med. 2015;9(5):1819–1826. doi:10.3892/etm.2015.2302
   Web of Science ®Google Scholar
• Kou X, Liu X, Chen X, et al. Ampelopsin attenuates brain aging of D-gal-induced rats through miR-34a-mediated SIRT1/mTOR signal pathway. Oncotarget. 2016;7(46):74484–74495. doi:10.18632/oncotarget.12811
   PubMedGoogle Scholar
• Viswanathan M, Kim SK, Berdichevsky A, et al. A role for SIR-2.1 regulation of ER stress response genes in determining Celegans life span. Dev Cell. 2005;9(5):605–615. doi:10.1016/j.devcel.2005.09.017
   Web of Science ®Google Scholar
• Zhou X, Yang Q, Xie Y, et al. Tetrahydroxystilbene glucoside extends mouse life span via upregulating neural klotho and downregulating neural insulin or insulin-like growth factor 1. Neurobiol Aging. 2015;36(3):1462–1470. doi:10.1016/j.neurobiolaging.2014.11.002
   PubMed Web of Science ®Google Scholar
• Liang Y, Liu C, Lu M, et al. Calorie restriction is the most reasonable anti-ageing intervention: a meta-analysis of survival curves. Sci Rep. 2018;8(1):5779. doi:10.1038/s41598-018-24146-z
   Web of Science ®Google Scholar
• Al-Regaiey KA. The effects of calorie restriction on aging: a brief review. Eur Rev Med Pharmacol Sci. 2016;20(11):2468–2473.
   PubMed Web of Science ®Google Scholar
• López-Lluch G, Navas P. Calorie restriction as an intervention in ageing. J Physiol. 2016;594(8):2043–2060. doi:10.1113/JP270543
   Web of Science ®Google Scholar
• Blagosklonny MV. Koschei the immortal and anti-aging drugs. Cell Death Dis. 2014;5(12):e1552. doi:10.1038/cddis.2014.520
   Web of Science ®Google Scholar
• Chang GR, Chiu YS, Wu YY, et al. Rapamycin protects against high-fat diet-induced obesity in C57BL/6J mice. J Pharmacol Sci. 2009;109(4):496–503. doi:10.1254/jphs.08215FP
   Web of Science ®Google Scholar
• Chang GR, Wu YY, Chiu YS, et al. Long-term administration of rapamycin reduces adiposity but impairs glucose tolerance in high-fat diet-fed KK/HlJ mice. Basic Clin Pharmacol Toxicol. 2009;105(3):188–198. doi:10.1111/j.1742-7843.2009.00427.x
   Web of Science ®Google Scholar
• Komarova EA, Antoch MP, Novototskaya LR, et al. Rapamycin extends lifespan and delays tumorigenesis in heterozygous p53± mice. Aging. 2012;4(10):709–714. doi:10.18632/aging.100498
   PubMedGoogle Scholar
• Miller RA, Harrison DE, Astle CM, et al. Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. J Gerontol a Biol Sci Med Sci. 2011;66(2):191–201. doi:10.1093/gerona/glq178
   PubMed Web of Science ®Google Scholar
• Harrison DE, Strong R, Sharp ZD, et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature. 2009;460(7253):392–395. doi:10.1038/nature08221
   PubMed Web of Science ®Google Scholar
• Miller KN, Burhans MS, Clark JP, et al. Aging and caloric restriction impact adipose tissue, adiponectin, and circulating lipids. Aging Cell. 2017;16(3):497–507. doi:10.1111/acel.12575
   PubMed Web of Science ®Google Scholar
• Kim JY, Kim DH, Choi J, et al. Changes in lipid distribution during aging and its modulation by calorie restriction. Age. 2009;12:127–142. doi:10.1007/s11357-009-9089-0
   Google Scholar
• Xu C, Cai Y, Fan P, et al. Calorie restriction prevents metabolic aging caused by abnormal SIRT1 function in adipose tissue. Diabetes. 2015;64(5):1576–1590. doi:10.2337/db14-1180
   Web of Science ®Google Scholar