Efficacy of ipamorelin, a ghrelin mimetic, on gastric dysmotility in a rodent model of postoperative ileus

References

• SenagoreAJPathogenesis and clinical and economic consequences of postoperative ileusAm J Health Syst Pharm20076420 Suppl 13S3S717909274
   PubMed Web of Science ®Google Scholar
• de JongeWJvan den WijngaardRMPostoperative ileus is maintained by intestinal immune infiltrates that activate inhibitory neural pathways in miceGastroenterology200312541137114714517797
   PubMed Web of Science ®Google Scholar
• BauerAJBoeckxstaensGEMechanisms of postoperative ileusNeurogastroenterol Motil200416Suppl 2546015357852
   PubMed Web of Science ®Google Scholar
• Greenwood-Van MeerveldBEmerging drugs for postoperative ileusExpert Opin Emerg Drugs200712461962617979603
   PubMed Web of Science ®Google Scholar
• CharoenthongtrakulSGiulianaDLongoKAEnhanced gastrointestinal motility with orally active ghrelin receptor agonistsJ Pharmacol Exp Ther200932931178118619252061
   PubMed Web of Science ®Google Scholar
• De SmetBMitselosADepoortereIMotilin and ghrelin as prokinetic drug targetsPharm Ther20091232207233
   Web of Science ®Google Scholar
• Greenwood-Van MeerveldBKriegsmanMNelsonRGhrelin as a target for gastrointestinal motility disordersPeptides201132112352235621453735
   PubMed Web of Science ®Google Scholar
• LasseterKCShaughnessyLCummingsDGhrelin agonist (TZP-101): safety, pharmacokinetics and pharmacodynamic evaluation in healthy volunteers: a phase I, first-in-human studyJ Clin Pharmacol200848219320218199894
   PubMed Web of Science ®Google Scholar
• EjskjaerNDimcevskiGWoJSafety and efficacy of ghrelin agonist TZP-101 in relieving symptoms in patients with diabetic gastroparesis: a randomized, placebo-controlled studyNeurogastroenterol Motil201022101069e28120524987
   PubMed Web of Science ®Google Scholar
• WoJMEjskjaerNHellstromPMRandomised clinical trial: ghrelin agonist TZP-101 relieves gastroparesis associated with severe nausea and vomiting – randomized clinical study subset dataAliment Pharmacol Ther201133667968821214610
   PubMed Web of Science ®Google Scholar
• DavenportAPBonnerTIFoordSMInternational Union of Pharmacology. LVI. Ghrelin receptor nomenclature, distribution, and functionPharmacol Rev200557454154616382107
   PubMed Web of Science ®Google Scholar
• ArigaHTsukamotoKChenCMantyhCPappasTNTakahashiTEndogenous acyl ghrelin is involved in mediating spontaneous phase III-like contractions of the rat stomachNeurogastroenterol Motil200719867568017640183
   PubMed Web of Science ®Google Scholar
• TackJDepoortereIBisschopsRInfluence of ghrelin on interdigestive gastrointestinal motility in humansGut200655332733316216827
   PubMed Web of Science ®Google Scholar
• DepoortereIDe WinterBThijsTDe ManJPelckmansPPeetersTComparison of the gastroprokinetic effects of ghrelin, GHRP-6 and motilin in rats in vivo and in vitroEur J Pharmacol20055151–316016815890336
   PubMed Web of Science ®Google Scholar
• KitazawaTDe SmetBVerbekeKDepoortereIPeetersTLGastric motor effects of peptide and non-peptide ghrelin agonists in mice in vivo and in vitroGut20055481078108415843418
   PubMed Web of Science ®Google Scholar
• XuLDepoortereITomasettoCEvidence for the presence of motilin, ghrelin, and the motilin and ghrelin receptor in neurons of the myenteric plexusRegul Pept20051241–311912515544849
   PubMedGoogle Scholar
• RaunKHansenBSJohansenNLIpamorelin, the first selective growth hormone secretagogueEur J Endocrinol199813955525619849822
   PubMed Web of Science ®Google Scholar
• VenkovaKMannWNelsonRGreenwood-Van MeerveldBEfficacy of ipamorelin, a novel ghrelin mimetic, in a rodent model of postoperative ileusJ Pharmacol Exp Ther200932931110111619289567
   PubMed Web of Science ®Google Scholar
• MasudaYTanakaTInomataNGhrelin stimulates gastric acid secretion and motility in ratsBiochem Biophys Res Commun2000276390590811027567
   PubMed Web of Science ®Google Scholar
• FujinoKInuiAAsakawaAKiharaNFujimuraMFujimiyaMGhrelin induces fasted motor activity of the gastrointestinal tract in conscious fed ratsJ Physiol2003550Pt 122724012837928
   PubMed Web of Science ®Google Scholar
• SakataIYamazakiMInoueKHayashiYKangawaKSakaiTGrowth hormone secretagogue receptor expression in the cells of the stomach-projected afferent nerve in the rat nodose ganglionNeurosci Lett2003342318318612757895
   PubMed Web of Science ®Google Scholar
• NakamuraTOnageTKitizawaTGhrelin stimulates gastric motility of the guinea pig through activation of capsaicin-sensitive neural pathway: in vivo and in vitro functional studiesNeurogastroenterol Motil200922444645219840269
   PubMed Web of Science ®Google Scholar
• YangCGQiuWCWangZGYuSYanJZhengODown regulation of ghrelin receptors in the small intestine delay small intestinal transit in vagotomized ratsMol Med Report20114610611065
   Web of Science ®Google Scholar
• DassNBMunonyaraMBassilAKGrowth hormone secretagogue receptors in rat and human gastrointestinal tract and the effects of ghrelinNeuroscience2003120244345312890514
   PubMed Web of Science ®Google Scholar
• KalffJCSchrautWHSimmonsRLBauerAJSurgical manipulation of the gut elicits an intestinal muscularis inflammatory response resulting in postsurgical ileusAnn Surg199822856526639833803
   PubMed Web of Science ®Google Scholar
• VenkovaKFraserGHoveydaHRGreenwood-Van MeerveldBProkinetic effects of a new ghrelin receptor agonist TZP-101 in a rat model of postoperative ileusDig Dis Sci20075292241224817436082
   PubMed Web of Science ®Google Scholar
• PeetersTLPotential of ghrelin as a therapeutic approach for gastrointestinal motility disordersCurr Opin Pharmacol20066655355817011824
   PubMed Web of Science ®Google Scholar
• Jiménez-ReinaLCañeteRde la TorreMJBernalGInfluence of chronic treatment with the growth hormone secretagogue Ipamorelin, in young female rats: somatotroph response in vitroHistol Histopathol200217370771412168778
   PubMed Web of Science ®Google Scholar
• TrudelLTomasettoCRioMCGhrelin/motilin-related peptide is a potent prokinetic to reverse gastric postoperative ileus in ratAm J Physiol Gastrointest Liver Physiol20022826G948G95212016119
   PubMed Web of Science ®Google Scholar
• PoitrasPPolvinoWJRocheleauBGastrokinetic effect of ghrelin analog RC-1139 in the rat. Effect on post-operative and on morphine induced ileusPeptides20052691598160116112398
   PubMed Web of Science ®Google Scholar
• ChenYTTsaiSHSheuSYTsaiLHGhrelin improves LPS-induced gastrointestinal motility disturbances: role of NO and prostaglandin E2Shock201033220521219503023
   PubMed Web of Science ®Google Scholar