572
Views
5
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

Pomegranate Seeds and Peel Ethanolic Extracts Anticancer Potentials and Related Genetic, Histological, Immunohistochemical, Apoptotic and Oxidative Stress Profiles: In vitro Study

ORCID Icon, , , ORCID Icon, , ORCID Icon, , , ORCID Icon, , , & ORCID Icon show all
Pages 191-205 | Received 10 Jan 2023, Accepted 01 Apr 2023, Published online: 15 Apr 2023

References

  • Pogribny IP, Rusyn I. Environmental toxicants, epigenetics, and cancer. Adv Exp Med Biol. 2013;754:215–232.
  • Oh ES, Petronis A. Origins of human disease: the chrono-epigenetic perspective. Nat Rev Genet. 2021;22(8):533–546. doi:10.1038/s41576-021-00348-6
  • Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin. 2015;65:87–108. doi:10.3322/caac.21262
  • Khan N, Afaq F, Mukhtar H. Lifestyle as risk factor for cancer: evidence from human studies. Cancer Lett. 2010;293:133–143. doi:10.1016/j.canlet.2009.12.013
  • Siegel RL, Miller KD, Jemal A. Cancer statistics, 2016. CA Cancer J Clin. 2016;66:7–30. doi:10.3322/caac.21332
  • DiMarco-Crook C, Xiao H. Diet-based strategies for cancer chemoprevention: the role of combination regimens using dietary bioactive components. Annu Rev Food Sci Technol. 2015;6:505–526. doi:10.1146/annurev-food-081114-110833
  • Key TJ, Schatzkin A, Willett WC, Allen NE, Spencer EA, Travis RC. Diet, nutrition and the prevention of cancer. Public Health Nutr. 2004;7:187–200. doi:10.1079/PHN2003588
  • Barnard RJ. Prevention of cancer through lifestyle changes. Evid Based Complement Altern Med. 2004;1:233–239. doi:10.1093/ecam/neh036
  • Newman DJ, Cragg GM. Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007;70:461–477. doi:10.1021/np068054v
  • Boeing H, Bechthold A, Bub A, et al. Critical review: vegetables and fruit in the prevention of chronic diseases. Eur J Nutr. 2012;51:637–663. doi:10.1007/s00394-012-0380-y
  • Sauvaget C, Nagano J, Hayashi M, Spencer E, Shimizu Y, Allen N. Vegetables and fruit intake and cancer mortality in the Hiroshima/Nagasaki Life Span Study. Br J Cancer. 2003;88:689–694. doi:10.1038/sj.bjc.6600775
  • Gundgaard J, Nielsen JN, Olsen J, Sørensen J. Increased intake of fruit and vegetables: estimation of impact in terms of life expectancy and healthcare costs. Public Health Nutr. 2003;6:25–30. doi:10.1079/PHN2002355
  • Huang WY, Cai YZ, Zhang Y. Natural phenolic compounds from medicinal herbs and dietary plants: potential use for cancer prevention. Nutr Cancer. 2010;62:1–20. doi:10.1080/01635580903191585
  • Khan N, Afaq F, Mukhtar H. Cancer chemoprevention through dietary antioxidants: progress and promise. Antioxid Redox Signal. 2008;10:475–510. doi:10.1089/ars.2007.1740
  • Anand P, Kunnumakkara AB, Sundaram C, et al. Cancer is a preventable disease that requires major lifestyle changes. Pharm Res. 2008;25:2097–2116. doi:10.1007/s11095-008-9661-9
  • Maphetu N, Unuofin JO, Masuku NP, Olisah C, Lebelo SL. Medicinal uses, pharmacological activities, phytochemistry, and the molecular mechanisms of Punica granatum L. (pomegranate) plant extracts: a review. Biomed Pharmacother. 2022;1(153):113256. doi:10.1016/j.biopha.2022.113256
  • Viuda-Martos M, Fernández-López J, Pérez-álvarez JA. Pomegranate and its many functional components as related to human health: a review. Compr Rev Food Sci Food Saf. 2010;9:635–654. doi:10.1111/j.1541-4337.2010.00131.x
  • Aviram M, Kaplan M, Rosenblat M, Fuhrman B. Dietary antioxidants and paraoxonases against LDL oxidation and atherosclerosis development. Handb Exp Pharmacol. 2005;170:263–300.
  • Debib A, Menadi S, Sahnouni„ F, Boukhatem MN, Ouahchia C, Kaced A. Bacterial inhibitory effect of Algerian pomegranate (Punica Granatum L.) extracts (Peel, Juice, And Seed) against multidrug resistant bacteria. J Microbiol Biotechnol Food Sci. 2022;11(4):e4622. doi:10.55251/jmbfs.4622
  • Lim HK, Asharani PV, Hande MP, et al. Cytotoxicity and genotoxicity of silver nanoparticles in human cells. ACS Nano. 2009;3(2):279–290. Pubmed: 19236062. doi:10.1021/nn800596w
  • Alshehri MA, Wierzbicki PM, Hassan F, et al. Mohamed. In vitro evaluation of electroporated gold nanoparticles and extremely-low frequency electromagnetic field anticancer activity against Hep-2 laryngeal cancer cells. Folia Histochem Cytobiol. 2019;57(4):159–167. doi:10.5603/FHC.a2019.0018
  • Burnette WN. ”Western blotting”: electrophoretic transfer of proteins from sodium dodecyl sulfate--polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A. Anal Biochem. 1981;112:195–203. doi:10.1016/0003-2697(81)90281-5
  • Sambrook J, Fritsch EF, Maniatis T. Molecular cloning: a laboratory manual. In: Cold Spring Harbor Laboratory. New York: Cold Spring Harbor; 1989.
  • Longtin R. The pomegranate: nature’s power fruit? JNCI J Natl Cancer Inst. 2003;95:346–348. doi:10.1093/jnci/95.5.346
  • Howell AB, D’Souza DH. The pomegranate: effects on bacteria and viruses that influence human health. Evid Based Complement Alternat Med. 2013;2013:606212. doi:10.1155/2013/606212
  • Lansky EP, Newman RA. Punica granatum (pomegranate) and its potential for prevention and treatment of inflammation and cancer. J Ethnopharmacol. 2007;19(109):177–206. doi:10.1016/j.jep.2006.09.006
  • Ismail T, Sestili P, Akhtar S. Pomegranate peel and fruit extracts: a review of potential anti-inflammatory and antiinfective effects. J Ethnopharmacol. 2012;143:397–405. doi:10.1016/j.jep.2012.07.004
  • Tehran: Soroush publications 1362. Avicenna (Abue-Alisina). Cannon of Medicine (Qanon) II; 2021:306–307.
  • Lloyd JU. Punica granatum. Chicago, IL: The Western Druggist; 1897. Available from: http://www.swsbm.com/.ManualsOther/Punicagranatum-Lloyd. Accessed April 5, 2023.
  • Sharma P, McClees SF, Afaq F. Pomegranate for prevention and treatment of cancer: an update. Molecules. 2017;22:E177. doi:10.3390/molecules22010177
  • Adhami VM, Khan N, Mukhtar H. Cancer chemoprevention by pomegranate: laboratory and clinical evidence. Nutr Cancer. 2009;61:811–815. doi:10.1080/01635580903285064
  • Menezes SM, Cordeiro LN, Viana GS. Punica granatum (pomegranate) extract is active against dental plaque. J Herb Pharmacother. 2006;6:79–92. doi:10.1080/J157v06n02_07
  • Malik A, Mukhtar H. Prostate cancer prevention through pomegranate fruit. Cell Cycle. 2006;5:371–373.
  • Malik A, Afaq F, Sarfaraz S, et al. Pomegranate fruit juice for chemoprevention and chemotherapy of prostate cancer. Proc Natl Acad Sci U S A. 2005;102:14813–14818. doi:10.1073/pnas.0505870102
  • Amakura Y, Okada M, Tsuji S, Tonogai Y. High-performance liquid chromatographic determination with photodiode array detection of ellagic acid in fresh and processed fruits. J Chromatogr A. 2000;896:87–93. doi:10.1016/S0021-9673(00)00414-3
  • West T, Atzeva M, Holtzman DM. Pomegranate polyphenols and resveratrol protect the neonatal brain against hypoxic ischemic injury. Dev Neurosci. 2007;29:363–372. doi:10.1159/000105477
  • Quirynen M, Teughels W, Haake SK, Newman MG. Microbiology of periodontal diseases. In: Giannobile WV, editor. Carranza’s Clinical Periodontology. 10th ed. Missouri: WB Saunders Company; 2006:134–169.
  • Mehta VV, Rajesh G, Rao A, et al. Antimicrobial efficacy of Punica granatum mesocarp, Nelumbo nucifera Leaf, Psidium guajava Leaf and Coffea Canephora extract on common oral pathogens: an in vitro study. J Clin Diagn Res. 2014;8:ZC65–ZC68. doi:10.1152/ajplegacy.1975.229.3.570
  • Dahlawi H, Jordan-Mahy N, Clench M, et al. Polyphenols are responsible for the proapoptotic properties of pomegranate juice on leukemia cell lines. Food Sci Nutr. 2013;1:196–208. doi:10.1002/fsn3.26
  • Kim ND, Mehta R, Yu W, et al. Chemopreventive and adjuvant therapeutic potential of pomegranate (Punica granatum) for human breast cancer. Breast Cancer Res Treat. 2002;71:203–217. doi:10.1023/A:1014405730585
  • Adhami VM, Malik A, Zaman N, et al. Combined inhibitory effects of green tea polyphenols and selective cyclooxygenase-2 inhibitors on the growth of human prostate cancer cells both in vitro and in vivo. Clin Cancer Res. 2007;13:1611–1619.
  • Kawaii S, Lansky EP. Differentiation-promoting activity of pomegranate (Punica granatum) fruit extracts in HL-60 human promyelocytic leukemia cells. J Med Food. 2004;7:13–18. doi:10.1089/109662004322984644
  • Mehta R, Lansky EP. Breast cancer chemopreventive properties of pomegranate (Punica granatum) fruit extracts in a mouse mammary organ culture. Eur J Cancer Prev. 2004;13:345–348. doi:10.1097/01.cej.0000136571.70998.5a
  • Cortez-Trejo MC, Olivas-Aguirre FJ, Dufoo-Hurtado E, et al. Potential anticancer activity of pomegranate (Punica granatum L) fruits of different color: in vitro and in silico evidence. Biomolecules. 2022;12:1649. doi:10.3390/biom12111649
  • Mavlyanov SM, Islambekov SY, Karimdzhanov AK, Ismailov AI. Polyphenols of pomegranate peels show marked anti-tumor and anti-viral action. Chem Nat Compounds. 1997;33:98–99. doi:10.1007/BF02273936
  • Adams LS, Seeram NP, Aggarwal BB, et al. Pomegranate juice, total pomegranate ellagitannins, and punicalagin suppress inflammatory cell signaling in colon cancer cells. J Agric Food Chem. 2006;54:980–985. doi:10.1021/jf052005r
  • Tang Y, Zhao DY, Elliott S, et al. Epigallocatechin-3 gallate induces growth inhibition and apoptosis in human breast cancer cells through survivin suppression. Int J Oncol. 2007;31:705–711.
  • Jia L, Wang G, Hou C, Jianke L, Luo Y, Baicun L. Punicalagin and ellagic acid from pomegranate peel induce apoptosis and inhibits proliferation in human HepG2 hepatoma cells through targeting mitochondria. Food Agric Immunol. 2019;30(1):897–912. doi:10.1080/09540105.2019.1642857
  • Diplock AT, Charleux JL, Crozier-Willi G, et al. Functional food science and defence against reactive oxygen species. Br J Nutr. 1998;80(Suppl 1):S77–S112. doi:10.1079/BJN19980106
  • Tang Q, Huang G. Improving method, properties and application of charide as emulsifier. Food Chem. 2022;15(376):131937. doi:10.1016/j.foodchem.2021.131937
  • Bouayed J, Bohn T. Exogenous antioxidants—double-edged swords in cellular redoc state: health beneficial effects at physiologic doses versus deleterious effects at high doses. Oxid Med Cell Longev. 2010;3(4):228–237. doi:10.4161/oxim.3.4.12858
  • Song B, Jianke L, Jianke L. Pomegranate peel extract polyphenols induced apoptosis in human hepatoma cells by mitochondrial pathway. Food Chem Toxicol. 2016;93:158–166. doi:10.1016/j.fct.2016.04.0
  • He XY, Li MY, Zhao W, Liu L, Kong XH, Li JK. Chemical fingerprint and quantitative analysis for quality control of polyphenols extracted from pomegranate peel by HPLC. Food Chem. 2015;176:7–11. doi:10.1016/j.foodchem.2014.12.040
  • Larrosa M, Tomas-Barberan FA, Espin JC. The dietary hydrolysable tannin punicalagin releases ellagic acid that induces apoptosis in human colon adenocarcinoma Caco-2 cells by using the mitochondrial pathway. J Nutr Biochem. 2006;17:611–625. doi:10.1016/j.jnutbio.2005.09.004
  • Adamu BA, Emiru YK, Sintayehu B, Araya EM, Periasamy G, Hiben MG. In vivo hepatoprotective and in vitro radical scavenging activities of extracts of Rumex abyssinicus jacq Rhizome. J Exp Pharmacol. 2020;12:221. doi:10.2147/JEP.S258566
  • Alberts B, Bray D, Hopkin K, et al. Essential Cell Biology. 4th ed. NY: Garland Science, Taylor & Francis Group; 2013:605–607.