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REVIEW

Current Opinions on the Relationship Between CMTM Family and Hepatocellular Carcinoma

ORCID Icon, &
Pages 1411-1422 | Received 16 Apr 2023, Accepted 12 Aug 2023, Published online: 25 Aug 2023

References

  • Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 Countries. CA Cancer J Clin. 2021;71(3):209–249. doi:10.3322/caac.21660
  • Lin H, van den Esschert J, Liu C, van Gulik TM. Systematic review of hepatocellular adenoma in China and other regions: hepatocellular adenoma review. J Gastroenterol Hepatol. 2011;26(1):28–35. doi:10.1111/j.1440-1746.2010.06502.x
  • Reig M, Forner A, Rimola J, et al. BCLC strategy for prognosis prediction and treatment recommendation: the 2022 update. J Hepatol. 2022;76(3):681–693. doi:10.1016/j.jhep.2021.11.018
  • Tsilimigras DI, Bagante F, Sahara K, et al. Prognosis after resection of Barcelona Clinic Liver Cancer (BCLC) Stage 0, A, and B Hepatocellular Carcinoma: a comprehensive assessment of the current BCLC classification. Ann Surg Oncol. 2019;26(11):3693–3700. doi:10.1245/s10434-019-07580-9
  • Ligat G, Schuster C, Baumert TF. Hepatitis B virus core variants, liver fibrosis, and Hepatocellular Carcinoma. Hepatology. 2019;69(1):5–8. doi:10.1002/hep.30231
  • McGlynn KA, Petrick JL, El-Serag HB. Epidemiology of Hepatocellular Carcinoma. Hepatology. 2021;73(Suppl 1):4–13. doi:10.1002/hep.31288
  • Han W, Ding P, Xu M, et al. Identification of eight genes encoding chemokine-like factor superfamily members 1–8 (CKLFSF1–8) by in silico cloning and experimental validation. Genomics. 2003;81(6):609–617. doi:10.1016/S0888-7543(03)00095-8
  • Burr ML, Sparbier CE, Chan YC, et al. CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity. Nature. 2017;549(7670):101–105. doi:10.1038/nature23643
  • Guan X, Zhang C, Zhao J, Sun G, Song Q, Jia W. CMTM6 overexpression is associated with molecular and clinical characteristics of malignancy and predicts poor prognosis in gliomas. EBioMedicine. 2018;35:233–243. doi:10.1016/j.ebiom.2018.08.012
  • Cancer research advance in CKLF-like MARVEL transmembrane domain containing member family (review). Available from: https://pubmed.ncbi.nlm.nih.gov/27356683/. Accessed April 4, 2023.
  • Mezzadra R, Sun C, Jae LT, et al. Identification of CMTM6 and CMTM4 as PD-L1 protein regulators. Nature. 2017;549(7670):106–110. doi:10.1038/nature23669
  • Li J, Wang X, Wang X, et al. CMTM family and gastrointestinal tract cancers: a comprehensive review. Cancer Manag Res. 2022;14:1551–1563. doi:10.2147/CMAR.S358963
  • W HAN, Y LOU, Tang J, et al. Molecular cloning and characterization of chemokine-like factor 1 (CKLF1), a novel human cytokine with unique structure and potential chemotactic activity. Biochem J. 2001;357(1):127–135. doi:10.1042/bj3570127
  • Shi S, Rui M, Han W, et al. CKLFSF2 is highly expressed in testis and can be secreted into the seminiferous tubules. Int J Biochem Cell Biol. 2005;37(8):1633–1640. doi:10.1016/j.biocel.2004.04.028
  • Liu B, Li H, Fu W, et al. CMTM3 presents a secreted form released via exosomes. ABBS. 2016;48(6):584–586. doi:10.1093/abbs/gmw029
  • Li H, Guo X, Shao L, et al. CMTM5-v1, a four-transmembrane protein, presents a secreted form released via a vesicle-mediated secretory pathway. BMB Rep. 2010;43(3):182–187. doi:10.5483/BMBRep.2010.43.3.182
  • Barbieri I, Tzelepis K, Pandolfini L, et al. Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control. Nature. 2017;552(7683):126–131. doi:10.1038/nature24678
  • Delic S, Thuy A, Schulze M, et al. Systematic investigation of CMTM family genes suggests relevance to glioblastoma pathogenesis and CMTM1 and CMTM3 as priority targets. Genes Chromosomes Cancer. 2015;54(7):433–443. doi:10.1002/gcc.22255
  • Sánchez-Pulido L, Martín-Belmonte F, Valencia A, Alonso MA. MARVEL: a conserved domain involved in membrane apposition events. Trends Biochem Sci. 2002;27(12):599–601. doi:10.1016/s0968-0004(02)02229-6
  • Cai X, Deng J, Ming Q, Cai H, Chen Z. Chemokine-like factor 1: a promising therapeutic target in human diseases. Exp Biol Med. 2020;245(16):1518–1528. doi:10.1177/1535370220945225
  • Liu DD, Song XY, Yang PF, et al. Progress in pharmacological research of chemokine like factor 1 (CKLF1). Cytokine. 2018;102:41–50. doi:10.1016/j.cyto.2017.12.002
  • Liu Y, Liu L, Zhou Y, et al. CKLF1 enhances inflammation-mediated carcinogenesis and prevents doxorubicin-induced apoptosis via IL6/STAT3 signaling in HCC. Clin Cancer Res. 2019;25(13):4141–4154. doi:10.1158/1078-0432.CCR-18-3510
  • Chen C, Ai Q-D, Wei Y-H, et al. Kanglaite enhances the efficacy of cisplatin in suppression of hepatocellular carcinoma via inhibiting CKLF1 mediated NF-κB pathway and regulating transporter mediated drug efflux. J Ethnopharmacol. 2021;264:113388. doi:10.1016/j.jep.2020.113388
  • Wu K, Li X, Gu H, Yang Q, Liu Y, Wang L. Research advances in CKLF-like MARVEL transmembrane domain-containing family in non-small cell lung cancer. Int J Biol Sci. 2019;15(12):2576–2583. doi:10.7150/ijbs.33733
  • Song X, Zhang S, Tian R, et al. Expression and clinical significance of CMTM1 in hepatocellular carcinoma. Open Med. 2021;16(1):217–223. doi:10.1515/med-2021-0221
  • Si J, Zhang P, Tian D, et al. CMTM1_v17 is associated with chemotherapy resistance and poor prognosis in non-small cell lung cancer. World J Surg Oncol. 2017;15(1):34. doi:10.1186/s12957-016-1094-z
  • Cao L, Yang C, Zhu B, et al. A novel protein CMTM1-v5 specifically induced human lymphoma cells apoptosis in vitro and in vivo. Exp Cell Res. 2019;385(1):111623. doi:10.1016/j.yexcr.2019.111623
  • Wang J, Zhang G, Zhang Y, et al. CMTM1_v17 is a novel potential therapeutic target in breast cancer. Oncol Rep. 2014;32(5):1829–1836. doi:10.3892/or.2014.3429
  • Liang Z, Xie J, Huang L, et al. Comprehensive analysis of the prognostic value of the chemokine-like factor-like MARVEL transmembrane domain-containing family in gastric cancer. J Gastrointest Oncol. 2021;12(2):388–406. doi:10.21037/jgo-21-78
  • Chen S, Hu Q, Chen H, et al. Identification of serum CMTM2 as a potential biomarker for HBV-related disorders. Dis Markers. 2020;2020:2032056. doi:10.1155/2020/2032056
  • Choi JH, Kim YB, Ahn JM, et al. Identification of genomic aberrations associated with lymph node metastasis in diffuse-type gastric cancer. Exp Mol Med. 2018;50(4):1–11. doi:10.1038/s12276-017-0009-6
  • van Doorn R, Slieker RC, Boonk SE, et al. Epigenomic analysis of sézary syndrome defines patterns of aberrant DNA methylation and identifies diagnostic markers. J Invest Dermatol. 2016;136(9):1876–1884. doi:10.1016/j.jid.2016.03.042
  • Guo X, Zhang S, Tan S, et al. Downregulated CMTM2 poses potential clinical significance in Hepatocellular Carcinoma. DNA Cell Biol. 2020;39(4):683–689. doi:10.1089/dna.2019.5237
  • Zhang S, Tian R, Bei C, et al. Down-regulated CMTM2 promotes epithelial-mesenchymal transition in Hepatocellular Carcinoma. OTT. 2020;13:5731–5741. doi:10.2147/OTT.S250370
  • Wang Y, Li J, Cui Y, et al. CMTM3, located at the critical tumor suppressor locus 16q22.1, is silenced by CpG methylation in carcinomas and inhibits tumor cell growth through inducing apoptosis. Cancer Res. 2009;69(12):5194–5201. doi:10.1158/0008-5472.CAN-08-3694
  • Wu J, Li L, Wu S, Xu B. CMTM family proteins 1–8: roles in cancer biological processes and potential clinical value. Cancer Biol Med. 2020;17(3):528–542. doi:10.20892/j.issn.2095-3941.2020.0032
  • Hu F, Yuan W, Wang X, et al. CMTM3 is reduced in prostate cancer and inhibits migration, invasion and growth of LNCaP cells. Clin Transl Oncol. 2015;17(8):632–639. doi:10.1007/s12094-015-1288-9
  • Li Z, Xie J, Wu J, et al. CMTM3 inhibits human testicular cancer cell growth through inducing cell-cycle arrest and apoptosis. PLoS One. 2014;9(2):e88965. doi:10.1371/journal.pone.0088965
  • Su Y, Lin Y, Zhang L, et al. CMTM3 inhibits cell migration and invasion and correlates with favorable prognosis in gastric cancer. Cancer Sci. 2014;105(1):26–34. doi:10.1111/cas.12304
  • Han T, Shu T, Dong S, et al. Chemokine-like factor-like MARVEL transmembrane domain-containing 3 expression is associated with a favorable prognosis in esophageal squamous cell carcinoma. Oncol Lett. 2017;13(5):2982–2988. doi:10.3892/ol.2017.5837
  • Zhou Z, Ma Z, Li Z, et al. CMTM3 overexpression predicts poor survival and promotes proliferation and migration in pancreatic cancer. J Cancer. 2021;12(19):5797–5806. doi:10.7150/jca.57082
  • Lu M, Huang Y, Sun W, Li P, Li L, Li L. miR-135b-5p promotes gastric cancer progression by targeting CMTM3. Int J Oncol. 2018;52(2):589–598. doi:10.3892/ijo.2017.4222
  • Yuan W, Li T, Mo X, et al. Knockdown of CMTM3 promotes metastasis of gastric cancer via the STAT3/Twist1/EMT signaling pathway. Oncotarget. 2016;7(20):29507–29519. doi:10.18632/oncotarget.8789
  • Yuan W, Wei F, Ouyang H, et al. CMTM3 suppresses chordoma progress through EGFR/STAT3 regulated EMT and TP53 signaling pathway. Cancer Cell Int. 2021;21(1):510. doi:10.1186/s12935-021-02159-5
  • Yuan W, Liu B, Wang X, et al. CMTM3 decreases EGFR expression and EGF-mediated tumorigenicity by promoting Rab5 activity in gastric cancer. Cancer Lett. 2017;386:77–86. doi:10.1016/j.canlet.2016.11.015
  • Li S, Gao P, Dai X, Ye L, Wang Z, Cheng H. New prognostic biomarker CMTM3 in low grade glioma and its immune infiltration. Ann Transl Med. 2022;10(4):206. doi:10.21037/atm-22-526
  • Li W, Zhang S. CKLF-like MARVEL transmembrane domain-containing member 3 (CMTM3) inhibits the proliferation and tumorigenisis in Hepatocellular Carcinoma cells. Oncol Res. 2017;25(2):285–293. doi:10.3727/096504016X14732523471442
  • Yu ZL, Zhu ZM. Comprehensive analysis of N6-methyladenosine -related long non-coding RNAs and immune cell infiltration in hepatocellular carcinoma. Bioengineered. 2021;12(1):1708–1724. doi:10.1080/21655979.2021.1923381
  • Xu RH, Wei W, Krawczyk M, et al. Circulating tumour DNA methylation markers for diagnosis and prognosis of hepatocellular carcinoma. Nat Mater. 2017;16(11):1155–1161. doi:10.1038/nmat4997
  • Bei C, Zhang Y, Wei R, et al. Clinical significance of CMTM4 expression in hepatocellular carcinoma. Onco Targets Ther. 2017;10:5439–5443. doi:10.2147/OTT.S149786
  • Kittler R, Putz G, Pelletier L, et al. An endoribonuclease-prepared siRNA screen in human cells identifies genes essential for cell division. Nature. 2004;432(7020):1036–1040. doi:10.1038/nature03159
  • Li M, Guo H, Wang Q, et al. Pancreatic stellate cells derived exosomal miR-5703 promotes pancreatic cancer by downregulating CMTM4 and activating PI3K/Akt pathway. Cancer Lett. 2020;490:20–30. doi:10.1016/j.canlet.2020.06.009
  • Zhu X, Zhang S, Tan S, et al. Expression of CMTM4 shows clinical significance in lung cancer. Transl Cancer Res. 2020;9(10):6214–6220. doi:10.21037/tcr-20-1254
  • Dai X, Bu X, Gao Y, et al. Energy status dictates PD-L1 protein abundance and anti-tumor immunity to enable checkpoint blockade. Mol Cell. 2021;81(11):2317–2331.e6. doi:10.1016/j.molcel.2021.03.037
  • Zhou L, Lu H, Zeng F, et al. Constructing a new prognostic signature of gastric cancer based on multiple data sets. Bioengineered. 2021;12(1):2820–2835. doi:10.1080/21655979.2021.1940030
  • Kong J,Tan S. CMTM4与肿瘤的研究进展 [Advances in the study of CMTM4 and tumors]. Chinese Journal of Oncology Prevention and Treatment. 2019;11(1):85–88. Chinese.
  • Kong J. CMTM4在肝细胞癌发生发展中的作用及机制研究 [The Role and Mechanism of CMTM4 in the Development of Hepatocellular Carcinoma]. China: Guilin Medical University; 2020. Chinese.
  • Shao L, Cui Y, Li H, et al. CMTM5 exhibits tumor suppressor activities and is frequently silenced by methylation in Carcinoma cell lines. Clin Cancer Res. 2007;13(19):5756–5762. doi:10.1158/1078-0432.CCR-06-3082
  • Chen Z, Cui N, Zhao J-S, et al. Expressions of ZNF436, β-catenin, EGFR, and CMTM5 in breast cancer and their clinical significances. Eur J Histochem. 2021;65(1). doi:10.4081/ejh.2021.3173
  • Yuan Y, Sheng Z, Liu Z, et al. CMTM5-v1 inhibits cell proliferation and migration by downregulating oncogenic EGFR signaling in prostate cancer cells. J Cancer. 2020;11(13):3762–3770. doi:10.7150/jca.42314
  • Li L, Hu Y, Chen D, et al. CMTM5 inhibits the development of prostate cancer via the EGFR/PI3K/AKT signaling pathway. Mol Med Rep. 2022;25(1):1–10. doi:10.3892/mmr.2021.12533
  • Chen F, Li Y, Qin N, et al. RNA-seq analysis identified hormone-related genes associated with prognosis of triple negative breast cancer. J Biomed Res. 2020;34(2):129–138. doi:10.7555/JBR.34.20190111
  • Bei C, Tan C, Zhu X, Wang Z, Tan S. Association between polymorphisms in CMTM family genes and Hepatocellular Carcinoma in Guangxi of China. DNA Cell Biol. 2018;37(8):691–696. doi:10.1089/dna.2018.4274
  • Xu G, Dang C. CMTM5 is downregulated and suppresses tumour growth in hepatocellular carcinoma through regulating PI3K-AKT signalling. Cancer Cell Int. 2017;17(1):113. doi:10.1186/s12935-017-0485-8
  • Zhao Y, Zhang M, Pu H, Guo S, Zhang S, Wang Y. Prognostic implications of pan-cancer CMTM6 expression and its relationship with the immune microenvironment. Front Oncol. 2020;10:585961. doi:10.3389/fonc.2020.585961
  • Liu Y, Li X, Zhang H, Zhang M, Wei Y. HuR up-regulates cell surface PD-L1 via stabilizing CMTM6 transcript in cancer. Oncogene. 2021;40(12):2230–2242. doi:10.1038/s41388-021-01689-6
  • Zhang C, Zhao S, Wang X. Co-expression of CMTM6 and PD-L1: a novel prognostic indicator of gastric cancer. Cancer Cell Int. 2021;21(1):78. doi:10.1186/s12935-020-01734-6
  • Nishi M, Shimada M, Yoshikawa K, et al. Impact of CKLF-like MARVEL transmembrane domain containing 6 (CMTM6) expression in gastric cancer. J Med Invest. 2021;68(3.4):362–367. doi:10.2152/jmi.68.362
  • Martinez-Morilla S, Zugazagoitia J, Wong PF, Kluger HM, Rimm DL. Quantitative analysis of CMTM6 expression in tumor microenvironment in metastatic melanoma and association with outcome on immunotherapy. Oncoimmunology. 2020;10(1):1864909. doi:10.1080/2162402X.2020.1864909
  • Zhu X, Qi G, Li C, et al. Expression and clinical significance of CMTM6 in Hepatocellular Carcinoma. DNA Cell Biol. 2019;38(2):193–197. doi:10.1089/dna.2018.4513
  • Huang Y, Zhu Y, Yang J, et al. CMTM6 inhibits tumor growth and reverses chemoresistance by preventing ubiquitination of p21 in hepatocellular carcinoma. Cell Death Dis. 2022;13(3):251. doi:10.1038/s41419-022-04676-1
  • Muranushi R, Araki K, Yokobori T, et al. High membrane expression of CMTM6 in hepatocellular carcinoma is associated with tumor recurrence. Cancer Sci. 2021;112(8):3314–3323. doi:10.1111/cas.15004
  • Huang X, Xiang L, Wang B, et al. CMTM6 promotes migration, invasion, and EMT by interacting with and stabilizing vimentin in hepatocellular carcinoma cells. J Transl Med. 2021;19(1):120. doi:10.1186/s12967-021-02787-5
  • Imamovic D, Vranic S. Novel regulators of PD-L1 expression in cancer: CMTM6 and CMTM4-a new avenue to enhance the therapeutic benefits of immune checkpoint inhibitors. Ann Transl Med. 2017;5(23):467. doi:10.21037/atm.2017.09.32
  • Li H, Liu YT, Chen L, et al. CMTM4 regulates epithelial-mesenchymal transition and PD-L1 expression in head and neck squamous cell carcinoma. Mol Carcinog. 2021;60(8):556–566. doi:10.1002/mc.23323
  • Wang Z, Peng Z, Liu Q, et al. Co-expression with membrane CMTM6/4 on tumor epithelium enhances the prediction value of PD-L1 on anti-PD-1/L1 therapeutic efficacy in gastric adenocarcinoma. Cancers. 2021;13(20):5175. doi:10.3390/cancers13205175
  • Yugawa K, Itoh S, Yoshizumi T, et al. CMTM6 stabilizes PD-L1 expression and is a new prognostic impact factor in Hepatocellular Carcinoma. Hepatol Commun. 2021;5(2):334–348. doi:10.1002/hep4.1643
  • Chui NNQ, Cheu JWS, Yuen VWH, et al. Inhibition of CMTM4 sensitizes cholangiocarcinoma and Hepatocellular Carcinoma to T cell–mediated antitumor immunity through PD‐L1. Hepatol Commun. 2022;6(1):178. doi:10.1002/hep4.1682
  • Mamessier E, Birnbaum DJ, Finetti P, Birnbaum D, Bertucci F. CMTM6 stabilizes PD-L1 expression and refines its prognostic value in tumors. Ann Transl Med. 2018;6(3):54. doi:10.21037/atm.2017.11.26
  • Rodriguez-Bravo V, Maciejowski J, Corona J, et al. Nuclear pores protect genome integrity by assembling a premitotic and Mad1-dependent anaphase inhibitor. Cell. 2014;156(5):1017–1031. doi:10.1016/j.cell.2014.01.010
  • Lu C, Zhao Y, Wang J, et al. Breast cancer cell-derived extracellular vesicles transfer miR-182-5p and promote breast carcinogenesis via the CMTM7/EGFR/AKT axis. Mol Med. 2021;27(1):78. doi:10.1186/s10020-021-00338-8
  • Xiao M, Hasmim M, Lequeux A, et al. Epithelial to mesenchymal transition regulates surface PD-L1 via CMTM6 and CMTM7 induction in breast cancer. Cancers. 2021;13(5):1165. doi:10.3390/cancers13051165
  • Liu Q, Su Y, Jiang GC, et al. Change of CMTM7 expression, a potential tumor suppressor, is associated with poor clinical outcome in human non-small cell lung cancer. Chin Med J. 2013;126(16):3006–3012.
  • Liu B, Lu Y, Zhang T, et al. CMTM7 as a novel molecule of ATG14L-Beclin1-VPS34 complex enhances autophagy by Rab5 to regulate tumorigenicity. Cell Commun Signal. 2021;19(1):77. doi:10.1186/s12964-021-00720-3
  • Zm H, Pl L, Y P, et al. Overexpression of CMTM7 inhibits cell growth and migration in liver cancer. Kaohsiung J Med Sci. 2019;35(6). doi:10.1002/kjm2.12058
  • Both J, Krijgsman O, Bras J, et al. Focal chromosomal copy number aberrations identify CMTM8 and GPR177 as new candidate driver genes in osteosarcoma. PLoS One. 2014;9(12):e115835. doi:10.1371/journal.pone.0115835
  • Jin C, Wang Y, Han W, et al. CMTM8 induces caspase-dependent and -independent apoptosis through a mitochondria-mediated pathway. J Cell Physiol. 2007;211(1):112–120. doi:10.1002/jcp.20914
  • Neal DE, Marsh C, Bennett MK, et al. Epidermal-growth-factor receptors in human bladder cancer: comparison of invasive and superficial tumours. Lancet. 1985;325(8425):366–368. doi:10.1016/s0140-6736(85)91386-8
  • Wu J, Sun Y, Xiong Z, et al. Influence of CMTM8 polymorphisms on lung cancer susceptibility in the Chinese Han population. Pharmacogenet Genomics. 2021;31(4):89–95. doi:10.1097/FPC.0000000000000426
  • Shi W, Zhang C, Ning Z, et al. CMTM8 as an LPA1-associated partner mediates lysophosphatidic acid-induced pancreatic cancer metastasis. Ann Transl Med. 2021;9(1):42. doi:10.21037/atm-20-1013
  • Yan M, Zhu X, Qiao H, Zhang H, Xie W, Cai J. Downregulated CMTM8 correlates with poor prognosis in gastric cancer patients. DNA Cell Biol. 2021;40(6):791–797. doi:10.1089/dna.2021.0110
  • Zeng X, Ma X, Guo H, et al. MicroRNA-582-5p promotes triple-negative breast cancer invasion and metastasis by antagonizing CMTM8. Bioengineered. 2021;12(2):10126–10135. doi:10.1080/21655979.2021.2000741
  • Zhang W, Mendoza MC, Pei X, et al. Down-regulation of CMTM8 induces epithelial-to-mesenchymal transition-like changes via c-MET/extracellular signal-regulated kinase (ERK) signaling. J Biol Chem. 2012;287(15):11850–11858. doi:10.1074/jbc.M111.258236
  • Zhang W, Qi H, Mo X, et al. CMTM8 is frequently downregulated in multiple solid tumors. Appl Immunohistochem Mol Morphol. 2017;25(2):122–128. doi:10.1097/PAI.0000000000000274
  • Liu LL, Zhang SW, Chao X, et al. Coexpression of CMTM6 and PD-L1 as a predictor of poor prognosis in macrotrabecular-massive hepatocellular carcinoma. Cancer Immunol Immunother. 2021;70(2):417–429. doi:10.1007/s00262-020-02691-9